Asymmetric Fluorination Approach to the Scalable Synthesis of a SYK Inhibitor von Curtis, Neil R, Davies, Suzanne H, Gray, Matthew, Leach, Stuart G, McKie, Ross A, Vernon, Lois E, Walkington, Andrew J

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Investigation of Synthetic Routes to a Key Benzopyran Intermediate of a 5HT4 Agonist von Rassias, Geracimos, Stevenson, Neil G, Curtis, Neil R, Northall, John M, Gray, Matthew, Prodger, Jeremy C, Walker, Andrew J

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Synthesis of (+)-Obtusenyne von Mak, S. Y. Frankie, Curtis, Neil R., Payne, Andrew N., Congreve, Miles S., Wildsmith, Andrew J., Francis, Craig L., Davies, John E., Pascu, Sofia I., Burton, Jonathan W., Holmes, Andrew B.

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Selective Continuous Flow Iodination Guided by Direct Spectroscopic Observation of Equilibrating Aryl Lithium Regioisomers von Dunn, Anna L, Leitch, David C, Journet, Michel, Martin, Michael, Tabet, Elie A, Curtis, Neil R, Williams, Glynn, Goss, Charles, Shaw, Tony, O’Hare, Bernie, Wade, Charles, Toczko, Matthew A, Liu, Peng

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Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor von Liddle, John, Atkinson, Francis L., Barker, Michael D., Carter, Paul S., Curtis, Neil R., Davis, Rob P., Douault, Clement, Dickson, Marion C., Elwes, Dorothy, Garton, Neil S., Gray, Matthew, Hayhow, Thomas G., Hobbs, Clare I., Jones, Emma, Leach, Stuart, Leavens, Karen, Lewis, Huw D., McCleary, Scott, Neu, Margarete, Patel, Vipulkumar K., Preston, Alex G.S., Ramirez-Molina, Cesar, Shipley, Tracy J., Skone, Philip A., Smithers, Nick, Somers, Donald O., Walker, Ann L., Watson, Robert J., Weingarten, Gordon G.

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Orally Efficacious NR2B-Selective NMDA Receptor Antagonists von Claiborne, Christopher F, McCauley, John A, Libby, Brian E, Curtis, Neil R, Diggle, Helen J, Kulagowski, Janusz J, Michelson, Stuart R, Anderson, Kenneth D, Claremon, David A, Freidinger, Roger M, Bednar, Rodney A, Mosser, Scott D, Gaul, Stanley L, Connolly, Thomas M, Condra, Cindra L, Bednar, Bohumil, Stump, Gary L, Lynch, Joseph J, Macaulay, Alison, Wafford, Keith A, Koblan, Kenneth S, Liverton, Nigel J

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Stereocontrolled Syntheses of Epimeric 3-Aryl-6-phenyl-1-oxa-7-azaspiro[4.5]decane NK-1 Receptor Antagonist Precursors von Kulagowski, Janusz J, Curtis, Neil R, Swain, Christopher J, Williams, Brian J

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Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the... von Leeson, Paul D, Baker, Raymond, Carling, Robert W, Curtis, Neil R, Moore, Kevin W, Williams, Brian J, Foster, Alan C, Donald, Angus E, Kemp, John A, Marshall, George R

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3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine:  An Antagonist with High Affinity and Selectivity for the Human Dopamine D4 Receptor von Kulagowski, Janusz J, Broughton, Howard B, Curtis, Neil R, Mawer, Ian M, Ridgill, Mark P, Baker, Raymond, Emms, Frances, Freedman, Stephen B, Marwood, Rosemarie, Patel, Shil, Patel, Smita, Ragan, C. Ian, Leeson, Paul D

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A Flow Process Built upon a Batch Foundation—Preparation of a Key Amino Alcohol Intermediate via Multistage Continuous Synthesis von Lim, John Jin, Arrington, Kenneth, Dunn, Anna L., Leitch, David C., Andrews, Ian, Curtis, Neil R., Hughes, Mark J., Tray, Daniel R., Wade, Charles E., Whiting, Matthew P., Goss, Charles, Liu, Yangmu Chloe, Roesch, Brian M.

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3'-(Arylmethyl)- and 3'-(Aryloxy)-3-phenyl-4-hydroxyquinolin- 2(1H)-ones: Orally Active Antagonists of the Glycine Site on the NMDA Receptor von Kulagowski, Janusz J, Baker, Raymond, Curtis, Neil R, Mawer, Ian M, Moseley, Angela M, Ridgill, Mark P, Rowley, Michael, Stansfield, Ian, Leeson, Paul D

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Thiazoles and thiopyridines: novel series of high affinity h5HT7 ligands von THOMSON, Christopher G, BEER, Margaret S, CURTIS, Neil R, DIGGLE, Helen J, HANDFORD, Emma, KULAGOWSKI, Janusz J

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A facile gold(I)-catalysed intramolecular alkyne hydroarylation approach to methyl 5-amino-2H-1-benzopyran-8-carboxylate derivatives von Curtis, Neil R., Prodger, Jeremy C., Rassias, Geracimos, Walker, Andrew J.

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An intramolecular hydrosilation approach to hexahydrooxonins related to obtusenyne. Effect of catalyst and conditions on stereoselectivity von Curtis, Neil R., Holmes, Andrew B.

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Investigation of Synthetic Routes to a Key Benzopyran Intermediate of a 5HT 4 Agonist von Rassias, Geracimos, Stevenson, Neil G., Curtis, Neil R., Northall, John M., Gray, Matthew, Prodger, Jeremy C., Walker, Andrew J.

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8-Azabicyclo[3.2.1]oct-3-en-2-ones via asymmetric 1,3-dipolar cycloaddition of a homochiral 3-oxidopyridinium betaine von Curtis, Neil R., Ball, Richard G., Kulagowski, Janusz J.

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Studies towards the synthesis of obtusenyne. Synthesis of the hexahydrooxonin nucleus von Curtis, Neil R., Holmes, Andrew B., Looney, Mark G.

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Thiazoles and thiopyridines: novel series of high affinity h5HT 7 ligands von Thomson, Christopher G., Beer, Margaret S., Curtis, Neil R., Diggle, Helen J., Handford, Emma, Kulagowski, Janusz J.

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Thiazoles and thiopyridines: novel series of high affinity h5HT(7) ligands von Thomson, Christopher G, Beer, Margaret S, Curtis, Neil R, Diggle, Helen J, Handford, Emma, Kulagowski, Janusz J

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A Synthesis of (+)-Obtusenyne von Mak, S. Y., Curtis, Neil R., Payne, Andrew N., Congreve, Miles S., Francis, Craig L., Burton, Jonathan W., Holmes, Andrew B.

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