Warburg and Krebs and related effects in cancer von Unterlass, Judith E, Curtin, Nicola J

Volltext

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase von Helleday, Thomas, Bryant, Helen E, Schultz, Niklas, Thomas, Huw D, Parker, Kayan M, Flower, Dan, Lopez, Elena, Kyle, Suzanne, Meuth, Mark, Curtin, Nicola J

Volltext

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM von HICKSON, Ian, YAN ZHAO, RICHARDSON, Caroline J, GREEN, Sharon J, MARTIN, Niall M. B, ORR, Alisdair I, REAPER, Philip M, JACKSON, Stephen P, CURTIN, Nicola J, SMITH, Graeme C. M

Volltext

Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1 von VEUGER, Stephany J, CURTIN, Nicola J, RICHARDSON, Caroline J, SMITH, Graeme C. M, DURKACZ, Barbara W

Volltext

Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer von Unterlass, Judith E, Baslé, Arnaud, Blackburn, Timothy J, Tucker, Julie, Cano, Céline, Noble, Martin E M, Curtin, Nicola J

Volltext

Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH) von Unterlass, Judith E, Wood, Robert J, Baslé, Arnaud, Tucker, Julie, Cano, Céline, Noble, Martin M E, Curtin, Nicola J

Volltext

Anticancer chemosensitization and radiosensitization by the novel Poly(ADP-ribose) polymerase-1 inhibitor AG14361 von CALABRESE, Christopher R, ALMASSY, Robert, LI, Jianke, MAEGLEY, Karen, NEWELL, David R, NOTARIANNI, Elena, STRATFORD, Ian J, SKALITZKY, Donald, THOMAS, Huw D, WANG, Ian-Zhen, WEBBER, Stephen E, WILLIAMS, Kaye J, BARTON, Stephanie, CURTIN, Nicola J, BATEY, Michael A, CALVERT, A. Hilary, CANAN-KOCH, Stacie, DURKACZ, Barbara W, HOSTOMSKY, Zdenek, KUMPF, Robert A, KYLE, Suzanne

Volltext

Discovery of Potent Chromen-4-one Inhibitors of the DNA-Dependent Protein Kinase (DNA-PK) Using a Small-Molecule Library Approach von Hardcastle, Ian R, Cockcroft, Xiaoling, Curtin, Nicola J, El-Murr, Marine Desage, Leahy, Justin J. J, Stockley, Martin, Golding, Bernard T, Rigoreau, Laurent, Richardson, Caroline, Smith, Graeme C. M, Griffin, Roger J

Volltext

The Novel Poly(ADP-Ribose) Polymerase Inhibitor, AG14361, Sensitizes Cells to Topoisomerase I Poisons by Increasing the Persistence of DNA Strand Breaks von Smith, Lisa M, Willmore, Elaine, Austin, Caroline A, Curtin, Nicola J

Volltext

Resistance-Modifying Agents. 9. Synthesis and Biological Properties of Benzimidazole Inhibitors of the DNA Repair Enzyme Poly(ADP-ribose) Polymerase von White, Alex W, Almassy, Robert, Calvert, A. Hilary, Curtin, Nicola J, Griffin, Roger J, Hostomsky, Zdenek, Maegley, Karen, Newell, David R, Srinivasan, Sheila, Golding, Bernard T

Volltext

Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair von VEUGER, Stephany J, CURTIN, Nicola J, SMITH, Graeme C. M, DURKACZ, Barbara W

Volltext

Novel Poly(ADP-ribose) Polymerase-1 Inhibitor, AG14361, Restores Sensitivity to Temozolomide in Mismatch Repair-Deficient Cells von CURTIN, Nicola J, WANG, Lan-Zhen, NEWELL, David R, YIAKOUVAKI, Anthie, KYLE, Suzanne, ARRIS, Christine A, CANAN-KOCH, Stacie, WEBBER, Stephen E, DURKACZ, Barbara W, CALVERT, Hilary A, HOSTOMSKY, Zdenek

Volltext

Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor von Newell, David R, Davies, Thomas G, Bentley, Johanne, Arris, Christine E, Boyle, F. Thomas, Curtin, Nicola J, Endicott, Jane A, Gibson, Ashleigh E, Golding, Bernard T, Griffin, Roger J, Hardcastle, Ian R, Jewsbury, Philip, Johnson, Louise N, Mesguiche, Veronique, Noble, Martin E.M, Tucker, Julie A, Wang, Lan, Whitfield, Hayley J

Volltext

Tricyclic Benzimidazoles as Potent Poly(ADP-ribose) Polymerase-1 Inhibitors von Skalitzky, Donald J, Marakovits, Joseph T, Maegley, Karen A, Ekker, Anne, Yu, Xiao-Hong, Hostomsky, Zdenek, Webber, Stephen E, Eastman, Brian W, Almassy, Robert, Li, Jianke, Curtin, Nicola J, Newell, David R, Calvert, A. Hilary, Griffin, Roger J, Golding, Bernard T

Volltext

Triple negative breast cancer: Proposals for a pragmatic definition and implications for patient management and trial design von Eiermann, W, Bergh, J, Cardoso, F, Conte, P, Crown, J, Curtin, N.J, Gligorov, J, Gusterson, B, Joensuu, H, Linderholm, B.K, Martin, M, Penault-Llorca, F, Pestalozzi, B.C, Razis, E, Sotiriou, C, Tjulandin, S, Viale, G

Volltext

Potentiation of Temozolomide and Topotecan Growth Inhibition and Cytotoxicity by Novel Poly(adenosine Diphosphoribose) Polymerase Inhibitors in a Panel of Human Tumor Cell Lines von DELANEY, C. A, WANG, L.-Z, KYLE, S, WHITE, A. W, CALVERT, A. H, CURTIN, N. J, DURKACZ, B. W, HOSTOMSKY, Z, NEWELL, D. R

Volltext

Differential effects of the poly (ADP-ribose) polymerase (PARP) inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro von BOWMAN, K. J, NEWELL, D. R, CALVERT, A. H, CURTIN, N. J

Volltext

Pemetrexed disodium, a novel antifolate with multiple targets von Curtin, NJ, Hughes, AN

Volltext

Potentiation of temozolomide-induced cytotoxicity: a comparative study of the biological effects of poly(ADP-ribose) polymerase inhibitors von Boulton, S, Pemberton, L C, Porteous, J K, Curtin, N J, Griffin, R J, Golding, B T, Durkacz, B W

Volltext

Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles von Arris, Christine E, Boyle, F. Thomas, Calvert, A. Hilary, Curtin, Nicola J, Endicott, Jane A, Garman, Elspeth F, Gibson, Ashleigh E, Golding, Bernard T, Grant, Sharon, Griffin, Roger J, Jewsbury, Philip, Johnson, Louise N, Lawrie, Alison M, Newell, David R, Noble, Martin E. M, Sausville, Edward A, Schultz, Robert, Yu, Wyatt

Volltext