Defective homologous recombination in human cancers von Cerbinskaite, A, Mukhopadhyay, A, Plummer, E.R, Curtin, N.J, Edmondson, R.J

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558: p53 and other components of the DNA damage response as determinants of cell sensitivity to ATR inhibition von Middleton, F.K, Chen, T, Pollard, J.R, Curtin, N.J

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278 Chemosensitisation By, and Single Agent Activity of, ATR Inhibitor VE-821 in Human Breast Cancer Cells von Middleton, F.K, Chen, T, Pollard, J.R, Curtin, N.J

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348 Stability of PARP Inhibition by BMN 673 in Human PBMCs (and Leukaemic Cell Cultures) von Patterson, M.J, Murray, J, Curtin, N.J

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Triple negative breast cancer: Proposals for a pragmatic definition and implications for patient management and trial design von Eiermann, W, Bergh, J, Cardoso, F, Conte, P, Crown, J, Curtin, N.J, Gligorov, J, Gusterson, B, Joensuu, H, Linderholm, B.K, Martin, M, Penault-Llorca, F, Pestalozzi, B.C, Razis, E, Sotiriou, C, Tjulandin, S, Viale, G

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55P Evaluation of MDM2-p53 antagonists, nutlin-3 and RG7388, combined with the PARPi rucaparib in primary cultures of ovarian cancer von Zanjirband, M., Gentles, L., Curtin, N.J., O'Donnell, R.L., Lunec, J.

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245 INVITED PARP inhibitors in cancer treatment von Calvert, H, Plummer, E.R, Curtin, N.J, Edmondson, R, Drew, Y

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443 Development of potent inhibitors of DNA-dependent protein kinase (DNA-PK) von Clapham, K.M, Rennison, T, Rodriguez-Aristegui, S, Bardos, J, Curtin, N.J, Golding, B.T, Hardcastle, I.R, Newell, D.R, Cano, C, Griffin, R.J

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127 POSTER Development of potent water-soluble inhibitors of the DNA-dependent protein kinase (DNA-PK) von Cano, C, Curtin, N.J, Golding, B.T, Haggerty, K, Hardcastle, I.R, Hummersone, M, Menear, K, Richardson, C, Smith, G.C.M, Griffin, R.J

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Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer von Rigas, A C, Robson, C N, Curtin, N J

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Increased replication stress determines ATR inhibitor sensitivity in neuroblastoma cells von King, D, Southgate, H.E.D, Roetschke, S, Gravells, P, Fields, L, Watson, J.B, Chen, L, Chapman, D, Harrison, D, Yeomanson, D, Curtin, N.J, Tweddle, D.A, Bryant, H.E

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Dipyridamole-mediated reversal of multidrug resistance in MRP over-expressing human lung carcinoma cells in vitro von Curtin, N.J, Turner, D.P

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The role of inhibitors of poly(ADP-ribose) polymerase as resistance-modifying agents in cancer therapy von Griffin, R.J., Curtin, N.J., Newell, D.R., Golding, B.T., Durkacz, B.W., Calvert, A.H.

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478 Preclinical investigation of novel inhibitors of DNA dependent protein kinase von Batey, M.A., Zhao, Y., Thomas, H.D., Smith, G.C.M., Newell, D.R., Curtin, N.J.

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Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer von Eccles, S.A, Aboagye, E.O, Ali, S, Anderson, A.S, Armes, J, Berditchevski, F, Blaydes, J.P, Brennan, K, Brown, N.J, Bryant, H.E, Bundred, N.J, Burchell, J.M, Campbell, A.M, Carroll, J.S, Clarke, R.B, Coles, C.E, Cook, G.J.R, Cox, A, Curtin, N.J, Dekker, L.V, dos Santos Silva, I, Duffy, S.W, Easton, D.F, Eccles, D.M, Edwards, D.R, Edwards, J, Evans, D.G, Fenlon, D.F, Flanagan, J.M, Foster, C, Gallagher, W.M, Garcia-Closas, M, Gee, J.M.W, Gescher, A.J, Goh, V, Groves, A.M, Harvey, A.J, Harvie, M, Hennessy, B.T, Hiscox, S, Holen, I, Howell, S.J, Howell, A, Hubbard, G, Hulbert-Williams, N, Hunter, M.S, Jasani, B, Jones, L.J, Key, T.J, Kirwan, C.C, Kong, A, Kunkler, I.H, Langdon, S.P, Leach, M.O, Mann, D.J, Marshall, J.F, Martin, L.A, Martin, S.G, Macdougall, J.E, Miles, D.W, Miller, W.R, Morris, J.R, Moss, S.M, Mullan, P, Natrajan, R, O'Connor, J.P.B, O'Connor, R, Palmieri, C, Pharoah, P.D.P, Rakha, E.A, Reed, E, Robinson, S.P, Sahai, E, Saxton, J.M, Schmid, P, Smalley, M.J, Speirs, V, Stein, R, Stingl, J, Streuli, C.H, Tutt, A.N.J, Valikova, G, Walker, R.A, Watson, C.J, Williams, K.J, Young, L.S, Thompson, A.M

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Induction of remission in hepatocellular carcinoma with a new thymidylate synthase inhibitor, CB3717 von Bassendine, M.F., Curtin, N.J., Loose, H., Harris, A.L., James, O.F.W.

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Benzimidazole compounds von A.H. CALVERT, N.J. CURTIN, R.J. GRIFFIN

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Benzamide analogs, useful as PARP (ADP-ribosyltransferase, ADRPT) DNA repair enzyme inhibitors von A.H. CALVERT, N.J. CURTIN, R.J. GRIFFIN

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DNA-PK INHIBITORS von NEWELL, D.R, CALVERT, H.A, COCKCROFT, XIAO-LING FAN, MENEAR, KEITH ALLAN, HUMMERSONE, MARC G, GOLDING, B.T, CURTIN, N.J, GRIFFIN, ROGER, FRIGERIO, MARK, HARDCASTLE, I, DESAGE-EL MURR, MARINE, MARTIN, NIALL MORRISON BARR, SMITH, GRAEME CAMERON MURRAY

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DNA-PK INHIBITORS von NEWELL, D.R, CALVERT, H.A, GRIFFIN, R.J, MENEAR, KEITH ALLAN, HUMMERSONE, MARC G, HARDCASTLE, I.R, COCKCROFT, XIAO-LING F, GOLDING, B.T, CURTIN, N.J, FRIGERIO, MARK, DESAGE-EL MURR, MARINE, MARTIN, NIALL MORRISON BARR, SARAVANAN, KAPPUSAMY, SMITH, GRAEME CAMERON MURRAY

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