2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity von Brown, Dean G., Maier, Donna L., Sylvester, Mark A., Hoerter, Tiffany N., Menhaji-Klotz, Elnaz, Lasota, Celina C., Hirata, Lee T., Wilkins, Deidre E., Scott, Clay W., Trivedi, Shephali, Chen, Tongming, McCarthy, Dennis J., Maciag, Carla M., Sutton, Evelynjeane J., Cumberledge, Jerry, Mathisen, Don, Roberts, John, Gupta, Anshul, Liu, Frank, Elmore, Charles S., Alhambra, Cristobal, Krumrine, Jennifer R., Wang, Xia, Ciaccio, Paul J., Wood, Michael W., Campbell, James B., Johansson, Magnus J., Xia, Jian, Wen, Xiaotian, Jiang, Ji, Wang, Xiaoping, Peng, Zuozhong, Hu, Tao, Wang, Jian

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