Crosstalk and signaling switches in mitogen-activated protein kinase cascades von Fey, Dirk, Croucher, David R, Kolch, Walter, Kholodenko, Boris N

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MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer von Cipponi, Arcadi, Goode, David L., Bedo, Justin, McCabe, Mark J., Pajic, Marina, Croucher, David R., Rajal, Alvaro Gonzalez, Junankar, Simon R., Saunders, Darren N., Lobachevsky, Pavel, Papenfuss, Anthony T., Nessem, Danielle, Nobis, Max, Warren, Sean C., Timpson, Paul, Cowley, Mark, Vargas, Ana C., Qiu, Min R., Generali, Daniele G., Keerthikumar, Shivakumar, Nguyen, Uyen, Corcoran, Niall M., Long, Georgina Y., Blay, Jean-Yves, Thomas, David M.

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Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients von Fey, Dirk, Halasz, Melinda, Dreidax, Daniel, Kennedy, Sean P, Hastings, Jordan F, Rauch, Nora, Munoz, Amaya Garcia, Pilkington, Ruth, Fischer, Matthias, Westermann, Frank, Kolch, Walter, Kholodenko, Boris N, Croucher, David R

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Revisiting the biological roles of PAI2 (SERPINB2) in cancer von Ranson, Marie, Croucher, David R, Saunders, Darren N, Lobov, Sergei

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Bimolecular complementation affinity purification (BiCAP) reveals dimer-specific protein interactions for ERBB2 dimers von Croucher, David R, Iconomou, Mary, Hastings, Jordan F, Kennedy, Sean P, Han, Jeremy Z R, Shearer, Robert F, McKenna, Jessie, Wan, Adrian, Lau, Joseph, Aparicio, Samuel, Saunders, Darren N

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Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer von Kennedy, Sean P, Han, Jeremy Z R, Portman, Neil, Nobis, Max, Hastings, Jordan F, Murphy, Kendelle J, Latham, Sharissa L, Cadell, Antonia L, Miladinovic, Dushan, Marriott, Gabriella R, O'Donnell, Yolande E I, Shearer, Robert F, Williams, James T, Munoz, Amaya Garcia, Cox, Thomas R, Watkins, D Neil, Saunders, Darren N, Timpson, Paul, Lim, Elgene, Kolch, Walter, Croucher, David R

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Structure-based mechanism of preferential complex formation by apoptosis signal-regulating kinases von Trevelyan, Sarah J., Brewster, Jodi L., Burgess, Abigail E., Crowther, Jennifer M., Cadell, Antonia L., Parker, Benjamin L., Croucher, David R., Dobson, Renwick C. J., Murphy, James M., Mace, Peter D.

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Tyrosine Phosphorylation Profiling Reveals the Signaling Network Characteristics of Basal Breast Cancer Cells von HOCHGRÄFE, Falko, LUXI ZHANG, SHEARER, Robert, NAIR, Radhika, SWARBRICK, Alexander, FARATIAN, Dana, MULLEN, Peter, HARRISON, David J, BIANKIN, Andrew V, SUTHERLAND, Robert L, RAFTERY, Mark J, DALY, Roger J, O'TOOLE, Sandra A, BROWNE, Brigid C, PINESE, Mark, PORTA CUBAS, Ana, LEHRBACH, Gillian M, CROUCHER, David R, RICKWOOD, Danny, BOULGHOURJIAN, Alice

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A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma von Rajal, Alvaro Gonzalez, Marzec, Kamila A., McCloy, Rachael A., Nobis, Max, Chin, Venessa, Hastings, Jordan F., Lai, Kaitao, Kennerson, Marina, Hughes, William E., Vaghjiani, Vijesh, Timpson, Paul, Cain, Jason E., Watkins, D. Neil, Croucher, David R., Burgess, Andrew

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Involvement of Lyn and the Atypical Kinase SgK269/PEAK1 in a Basal Breast Cancer Signaling Pathway von CROUCHER, David R, HOCHGRÄFE, Falko, SHEARER, Robert, GALLEGO-ORTEGA, David, SAUNDERS, Darren N, SWARBRICK, Alexander, DALY, Roger J, LUXI ZHANG, LING LIU, LYONS, Ruth J, RICKWOOD, Danny, TACTACAN, Carole M, BROWNE, Brigid C, ALI, Naveid, CHAN, Howard

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Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis von Papanicolaou, Michael, Parker, Amelia L., Yam, Michelle, Filipe, Elysse C., Wu, Sunny Z., Chitty, Jessica L., Wyllie, Kaitlin, Tran, Emmi, Mok, Ellie, Nadalini, Audrey, Skhinas, Joanna N., Lucas, Morghan C., Herrmann, David, Nobis, Max, Pereira, Brooke A., Law, Andrew M. K., Castillo, Lesley, Murphy, Kendelle J., Zaratzian, Anaiis, Hastings, Jordan F., Croucher, David R., Lim, Elgene, Oliver, Brian G., Mora, Fatima Valdes, Parker, Benjamin L., Gallego-Ortega, David, Swarbrick, Alexander, O’Toole, Sandra, Timpson, Paul, Cox, Thomas R.

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A zebrafish functional genomics model to investigate the role of human A20 variants in vivo von Cultrone, Daniele, Zammit, Nathan W., Self, Eleanor, Postert, Benno, Han, Jeremy Z. R., Bailey, Jacqueline, Warren, Joanna, Croucher, David R., Kikuchi, Kazu, Bogdanovic, Ozren, Chtanova, Tatyana, Hesselson, Daniel, Grey, Shane T.

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The extracellular matrix as a key regulator of intracellular signalling networks von Hastings, Jordan F, Skhinas, Joanna N, Fey, Dirk, Croucher, David R, Cox, Thomas R

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Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages von Munoz, Marcia A, Fletcher, Emma K, Skinner, Oliver P, Jurczyluk, Julie, Kristianto, Esther, Hodson, Mark P, Sun, Shuting, Ebetino, Frank H, Croucher, David R, Hansbro, Philip M, Center, Jacqueline R, Rogers, Michael J

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Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2 von Nguyen, Tina, Lau, Anthony, Bier, Julia, Cooke, Kristen C, Lenthall, Helen, Ruiz-Diaz, Stephanie, Avery, Danielle T, Brigden, Henry, Zahra, David, Sewell, William A, Droney, Luke, Okada, Satoshi, Asano, Takaki, Abolhassani, Hassan, Chavoshzadeh, Zahra, Abraham, Roshini S, Rajapakse, Nipunie, Klee, Eric W, Church, Joseph A, Williams, Andrew, Wong, Melanie, Burkhart, Christoph, Uzel, Gulbu, Croucher, David R, James, David E, Ma, Cindy S, Brink, Robert, Tangye, Stuart G, Deenick, Elissa K

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Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma von Phimmachanh, Monica, Han, Jeremy Z. R., O'Donnell, Yolande E., Latham, Sharissa L., Croucher, David R.

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t-PA, but not desmoteplase, induces plasmin-dependent opening of a blood-brain barrier model under normoxic and ischaemic conditions von Freeman, Roxann, Niego, Be׳eri, R. Croucher, David, Pedersen, Lars O, Medcalf, Robert L

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The Under-Appreciated Promiscuity of the Epidermal Growth Factor Receptor Family von Kennedy, Sean P, Hastings, Jordan F, Han, Jeremy Z R, Croucher, David R

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Nedd4 controls animal growth by regulating IGF-1 signaling von Cao, Xiao R, Lill, Nancy L, Boase, Natasha, Shi, Peijun P, Croucher, David R, Shan, Hongbo, Qu, Jing, Sweezer, Eileen M, Place, Trenton, Kirby, Patricia A, Daly, Roger J, Kumar, Sharad, Yang, Baoli

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Functional characterization of cancer-associated Gab1 mutations von Ortiz-Padilla, C, Gallego-Ortega, D, Browne, B C, Hochgräfe, F, Caldon, C E, Lyons, R J, Croucher, D R, Rickwood, D, Ormandy, C J, Brummer, T, Daly, R J

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