Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials von Viney, Nicholas J, BSc, van Capelleveen, Julian C, MD, Geary, Richard S, PhD, Xia, Shuting, MS, Tami, Joseph A, PharmD, Yu, Rosie Z, PhD, Marcovina, Santica M, Prof, Hughes, Steven G, MD, Graham, Mark J, MS, Crooke, Rosanne M, PhD, Crooke, Stanley T, MD, Witztum, Joseph L, Prof, Stroes, Erik S, Prof, Tsimikas, Sotirios, Prof

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Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index von Shen, Wen, De Hoyos, Cheryl L., Migawa, Michael T., Vickers, Timothy A., Sun, Hong, Low, Audrey, Bell, Thomas A., Rahdar, Meghdad, Mukhopadhyay, Swagatam, Hart, Christopher E., Bell, Melanie, Riney, Stan, Murray, Susan F., Greenlee, Sarah, Crooke, Rosanne M., Liang, Xue-hai, Seth, Punit P., Crooke, Stanley T.

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Antisense inhibition of apolipoprotein (a) to lower plasma lipoprotein (a) levels in humans von Graham, Mark J., Viney, Nick, Crooke, Rosanne M., Tsimikas, Sotirios

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Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides von Graham, Mark J, Lee, Richard G, Brandt, Teresa A, Tai, Li-Jung, Fu, Wuxia, Peralta, Raechel, Yu, Rosie, Hurh, Eunju, Paz, Erika, McEvoy, Bradley W, Baker, Brenda F, Pham, Nguyen C, Digenio, Andres, Hughes, Steven G, Geary, Richard S, Witztum, Joseph L, Crooke, Rosanne M, Tsimikas, Sotirios

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Targeting APOC3 in the Familial Chylomicronemia Syndrome von Gaudet, Daniel, Brisson, Diane, Tremblay, Karine, Alexander, Veronica J, Singleton, Walter, Hughes, Steven G, Geary, Richard S, Baker, Brenda F, Graham, Mark J, Crooke, Rosanne M, Witztum, Joseph L

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Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebo-controlled phase 1 study von Tsimikas, Sotirios, Prof, Viney, Nicholas J, BSc, Hughes, Steven G, MBBS, Singleton, Walter, MD, Graham, Mark J, MS, Baker, Brenda F, PhD, Burkey, Jennifer L, PhD, Yang, Qingqing, MS, Marcovina, Santica M, Prof, Geary, Richard S, PhD, Crooke, Rosanne M, PhD, Witztum, Joseph L, Prof

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Antisense Oligonucleotide Inhibition of Apolipoprotein C-III Reduces Plasma Triglycerides in Rodents, Nonhuman Primates, and Humans von Graham, Mark J, Lee, Richard G, Bell, Thomas A, Fu, Wuxia, Mullick, Adam E, Alexander, Veronica J, Singleton, Walter, Viney, Nick, Geary, Richard, Su, John, Baker, Brenda F, Burkey, Jennifer, Crooke, Stanley T, Crooke, Rosanne M

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Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis von Miao, Ji, Ling, Alisha V., Manthena, Praveen V., Gearing, Mary E., Graham, Mark J., Crooke, Rosanne M., Croce, Kevin J., Esquejo, Ryan M., Clish, Clary B., Vicent, David, Biddinger, Sudha B.

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ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors von Gordts, Philip L S M, Nock, Ryan, Son, Ni-Huiping, Ramms, Bastian, Lew, Irene, Gonzales, Jon C, Thacker, Bryan E, Basu, Debapriya, Lee, Richard G, Mullick, Adam E, Graham, Mark J, Goldberg, Ira J, Crooke, Rosanne M, Witztum, Joseph L, Esko, Jeffrey D

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Antisense-Mediated Lowering of Plasma Apolipoprotein C-III by Volanesorsen Improves Dyslipidemia and Insulin Sensitivity in Type 2 Diabetes von Digenio, Andres, Dunbar, Richard L, Alexander, Veronica J, Hompesch, Marcus, Morrow, Linda, Lee, Richard G, Graham, Mark J, Hughes, Steven G, Yu, Rosie, Singleton, Walter, Baker, Brenda F, Bhanot, Sanjay, Crooke, Rosanne M

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Antisense technology: an overview and prospectus von Crooke, Stanley T., Baker, Brenda F., Crooke, Rosanne M., Liang, Xue-hai

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Role of Insulin in the Regulation of Proprotein Convertase Subtilisin/Kexin Type 9 von Miao, Ji, Manthena, Praveen V, Haas, Mary E, Ling, Alisha V, Shin, Dong-Ju, Graham, Mark J, Crooke, Rosanne M, Liu, Jingwen, Biddinger, Sudha B

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Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice von Graham, Mark J., Lemonidis, Kristina M., Whipple, Charles P., Subramaniam, Amuthakannan, Monia, Brett P., Crooke, Stanley T., Crooke, Rosanne M.

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Antisense oligonucleotide–mediated inhibition of angiopoietin-like protein 3 increases reverse cholesterol transport in mice von Bell, Thomas A., Liu, Mingxia, Donner, Aaron J., Lee, Richard G., Mullick, Adam E., Crooke, Rosanne M.

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Antisense technology: A review von Crooke, Stanley T., Liang, Xue-Hai, Baker, Brenda F., Crooke, Rosanne M.

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Apolipoprotein CIII links islet insulin resistance to β-cell failure in diabetes von Åvall, Karin, Ali, Yusuf, Leibiger, Ingo B., Leibiger, Barbara, Moede, Tilo, Paschen, Meike, Dicker, Andrea, Daré, Elisabetta, Köhler, Martin, Ilegems, Erwin, Abdulreda, Midhat H., Graham, Mark, Crooke, Rosanne M., Tay, Vanessa S. Y., Refai, Essam, Nilsson, Stefan K., Jacob, Stefan, Selander, Lars, Berggren, Per-Olof, Juntti-Berggren, Lisa

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Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B von KASTELEIN, John J. P, WEDEL, Mark K, BAKER, Brenda F, SU, John, BRADLEY, Joann D, YU, Rosie Z, CHUANG, Emil, GRAHAM, Mark J, CROOKE, Rosanne M

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Antisense Oligonucleotide Directed to Human Apolipoprotein B-100 Reduces Lipoprotein(a) Levels and Oxidized Phospholipids on Human Apolipoprotein B-100 Particles in Lipoprotein(a)... von MERKI, Esther, GRAHAM, Mark J, MULLICK, Adam E, MILLER, Elizabeth R, CROOKE, Rosanne M, PITAS, Robert E, WITZTUM, Joseph L, TSIMIKAS, Sotirios

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Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation von Lord, Caleb C., Ferguson, Daniel, Thomas, Gwynneth, Brown, Amanda L., Schugar, Rebecca C., Burrows, Amy, Gromovsky, Anthony D., Betters, Jenna, Neumann, Chase, Sacks, Jessica, Marshall, Stephanie, Watts, Russell, Schweiger, Martina, Lee, Richard G., Crooke, Rosanne M., Graham, Mark J., Lathia, Justin D., Sakaguchi, Takuya F., Lehner, Richard, Haemmerle, Guenter, Zechner, Rudolf, Brown, J. Mark

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Antisense oligonucleotides targeting angiotensinogen: insights from animal studies von Wu, Chia-Hua, Wang, Ya, Ma, Murong, Mullick, Adam E, Crooke, Rosanne M, Graham, Mark J, Daugherty, Alan, Lu, Hong S

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