Selinexor reduces the expression of DNA damage repair proteins and sensitizes cancer cells to DNA damaging agents von Kashyap, Trinayan, Argueta, Christian, Unger, Thaddeus, Klebanov, Boris, Debler, Sophia, Senapedis, William, Crochiere, Marsha L, Lee, Margaret S, Kauffman, Michael, Shacham, Sharon, Landesman, Yosef

Volltext

XPO1 target occupancy measurements confirm the selinexor recommended phase 2 dose von Crochiere, Marsha L, Hannus, Stefan, Hansen, Kerrin, Becker, Frank, Baloglu, Erkan, Lee, Margaret, Kauffman, Michael, Shacham, Sharon, Landesman, Yosef

Volltext

A method for quantification of exportin-1 (XPO1) occupancy by Selective Inhibitor of Nuclear Export (SINE) compounds von Crochiere, Marsha L, Baloglu, Erkan, Klebanov, Boris, Donovan, Scott, Del Alamo, Diego, Lee, Margaret, Kauffman, Michael, Shacham, Sharon, Landesman, Yosef

Volltext

Identification of unique molecular subdomains in the perichondrium and periosteum and their role in regulating gene expression in the underlying chondrocytes von Bandyopadhyay, Amitabha, Kubilus, James K., Crochiere, Marsha L., Linsenmayer, Thomas F., Tabin, Clifford J.

Volltext

Cloning and Mitochondrial Localization of Full-Length D-AKAP2, a Protein Kinase A Anchoring Protein von Wang, Lin, Sunahara, Roger K., Krumins, Andrejs, Perkins, Guy, Crochiere, Marsha L., Mackey, Mason, Bell, Sean, Ellisman, Mark H., Taylor, Susan S.

Volltext

Perichondrial-mediated TGF-beta regulation of cartilage growth in avian long bone development von Crochiere, Marsha L, Kubilus, James K, Linsenmayer, Thomas F

Volltext

Identification and characterization of a previously undetected region between the perichondrium and periosteum of the developing avian limb von Crochiere, Marsha L., Kubilus, James K., Linsenmayer, Thomas F.

Volltext

XPO1 Target Occupancy Measurements Using Fluorescence Cross Correlation Spectroscopy Support the Selinexor Recommended Phase 2 Dose von Crochiere, Marsha L., Hannus, Stefan, Hansen, Kerrin, Becker, Frank, Baloglu, Erkan, Kauffman, Michael, Landesman, Yosef

Volltext

Development of a Pharmacodynamic Assay for XPO1 Occupancy Using Fluorescence Cross Correlation Spectroscopy (FCCS) von Crochiere, Marsha L., Hannus, Stefan, Hansen, Kerrin, Becker, Frank, Ellis, Joel, Lee, Margaret S., Landesman, Yosef

Volltext

Multiple mechanisms of perichondrial regulation of cartilage growth von Di Nino, Dana L., Crochiere, Marsha L., Linsenmayer, Thomas F.

Volltext

Abstract 3810: Selinexor (KPT-330), a novel selective inhibitor of nuclear export (SINE), shows single agent efficacy against alveolar soft part sarcoma (ASPS) in vivo von Crochiere, Marsha L., Kashyap, Trinayan, Klebanov, Boris, Senapedis, William, Alamo, Diego del, Tamir, Sharon, Baloglu, Erkan, McCauley, Dilara, Carlson, Robert, Kauffman, Michael, Shacham, Sharon, Demetri, George, Wagner, Andrew, Sicinska, Ewa, Gokhale, Prafulla, Kohl, Nancy, Saur, Amy, Landesman, Yosef

Volltext

Abstract A188: SINE resistant fibrosarcoma cells reveal changes in profile of gene expression, but continue to be sensitive to combination treatment by proteasome inhibition von Crochiere, Marsha L., Kashyap, Trinayan, Saint-Martin, Jean-Richard, Shechter, Sharon, Kalid, Ori, Shacham, Eran, Senapedis, William, Klebanov, Boris, Tamir, Sharon, del Alamo, Diego, Hamuza, Mwanasha, Golan, Gali, Baloglu, Erkan, McCauley, Dilara, Kauffman, Michael, Shacham, Sharon, Landesman, Yosef

Volltext

Oral Selinexor-Dexamethasone for Triple-Class Refractory Multiple Myeloma von Chari, Ajai, Vogl, Dan T, Gavriatopoulou, Maria, Nooka, Ajay K, Yee, Andrew J, Huff, Carol A, Moreau, Philippe, Dingli, David, Cole, Craig, Lonial, Sagar, Dimopoulos, Meletios, Stewart, A. Keith, Richter, Joshua, Vij, Ravi, Tuchman, Sascha, Raab, Marc S, Weisel, Katja C, Delforge, Michel, Cornell, Robert F, Kaminetzky, David, Hoffman, James E, Costa, Luciano J, Parker, Terri L, Levy, Moshe, Schreder, Martin, Meuleman, Nathalie, Frenzel, Laurent, Mohty, Mohamad, Choquet, Sylvain, Schiller, Gary, Comenzo, Raymond L, Engelhardt, Monika, Illmer, Thomas, Vlummens, Philip, Doyen, Chantal, Facon, Thierry, Karlin, Lionel, Perrot, Aurore, Podar, Klaus, Kauffman, Michael G, Shacham, Sharon, Li, Lingling, Tang, Shijie, Picklesimer, Carla, Saint-Martin, Jean-Richard, Crochiere, Marsha, Chang, Hua, Parekh, Samir, Landesman, Yosef, Shah, Jatin, Richardson, Paul G, Jagannath, Sundar

Volltext