Improved structural variant interpretation for hereditary cancer susceptibility using long-read sequencing von Thibodeau, My Linh, O’Neill, Kieran, Dixon, Katherine, Reisle, Caralyn, Mungall, Karen L., Krzywinski, Martin, Shen, Yaoqing, Lim, Howard J., Cheng, Dean, Tse, Kane, Wong, Tina, Chuah, Eric, Fok, Alexandra, Sun, Sophie, Renouf, Daniel, Schaeffer, David F., Cremin, Carol, Chia, Stephen, Young, Sean, Pandoh, Pawan, Pleasance, Stephen, Pleasance, Erin, Mungall, Andrew J., Moore, Richard, Yip, Stephen, Karsan, Aly, Laskin, Janessa, Marra, Marco A., Schrader, Kasmintan A., Jones, Steven J. M.

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Burden of hereditary cancer susceptibility in unselected patients with pancreatic ductal adenocarcinoma referred for germline screening von Cremin, Carol, Lee, Michael Kuan‐Ching, Hong, Quan, Hoeschen, Carolyn, Mackenzie, Anna, Dixon, Katherine, McCullum, Mary, Nuk, Jennifer, Kalloger, Steve, Karasinska, Joanna, Scudamore, Charles, Kim, Peter T. W., Donnellan, Fergal, Lam, Eric C. S., Lim, Howard J., Neben, Cynthia L., Stedden, Will, Zhou, Alicia Y., Schaeffer, David F., Sun, Sophie, Renouf, Daniel J., Schrader, Kasmintan A.

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CDKN2A founder mutation in pancreatic ductal adenocarcinoma patients without cutaneous features of Familial Atypical Multiple Mole Melanoma (FAMMM) syndrome von Cremin, Carol, Howard, Sarah, Le, Lyly, Karsan, Aly, Schaeffer, David F, Renouf, Daniel, Schrader, Kasmintan A

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Lynch syndrome-chasing a better ascertainment rate in British Columbia von Cremin, Carol, Bashash, Morteza, Armstrong, Linlea, Gill, Sharlene, Huntsman, David, Bajdik, Chris

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Unselected germline screening in pancreatic adenocarcinoma yields high rates of pathogenic and likely pathogenic variants (PV) in hereditary cancer susceptibility genes von Cremin, Carol, Lee, Michael, Hong, Quan, Hoeschen, Carolyn, Kalloger, Steve, Karasinska, Joanna, Mackenzie, Anna, McCullum, Mary, Nuk, Jennifer E, Topham, James Thomas, Sun, Sophie, Schaeffer, David F., Renouf, Daniel John, Schrader, Kasmintan A

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A novel online genomic counseling and variant interpretation certificate: Learning design, learning analytics, and evaluation von Macfadyen, Leah P., Austin, Jehannine, Cao, Ping, Cheng, John, Cremin, Carol, Duong, Linda, Elliott, Alison M., Guimond, Colleen, Lim, Shur, Race, Simone, Rajan‐Babu, Indhu‐Shree, Richardson, Anastasia, Wainstein, Tasha, Zahir, Farah, Birch, Patricia H.

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Thorough in silico and in vitro cDNA analysis of 21 putative BRCA1 and BRCA2 splice variants and a complex tandem duplication in BRCA2 allowing the identification of activated cryp... von Baert, Annelot, Machackova, Eva, Coene, Ilse, Cremin, Carol, Turner, Kristin, Portigal‐Todd, Cheryl, Asrat, Marie Jill, Nuk, Jennifer, Mindlin, Allison, Young, Sean, MacMillan, Andree, Maerken, Tom, Trbusek, Martin, McKinnon, Wendy, Wood, Marie E., Foulkes, William D., Santamariña, Marta, la Hoya, Miguel, Foretova, Lenka, Poppe, Bruce, Vral, Anne, Rosseel, Toon, Leeneer, Kim, Vega, Ana, Claes, Kathleen B. M.

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CDKN2A founder mutation in pancreatic ductal adenocarcinoma patients without cutaneous features of Familial Atypical Multiple Mole Melanoma von Schaeffer, David F, Howard, Sarah, Renouf, Daniel, Karsan, Aly, Schrader, Kasmintan A, Cremin, Carol, Le, Lyly

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Validation of predictive models for germline mutations in DNA mismatch repair genes in colorectal cancer von Monzon, Jose G., Cremin, Carol, Armstrong, Linlea, Nuk, Jennifer, Young, Sean, Horsman, Doug E., Garbutt, Kristy, Bajdik, Chris D., Gill, Sharlene

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Abstract 5226: Genomic analysis of pancreatic ductal adenocarcinoma in a patient with MUTYH-associated polyposis von Schrader, Kasmintan A., Chu’ng, Carolyn, Zhao, Eric, Wong, Hui-li, Shen, Yaoqing, Jones, Martin, Thomson, Tom, Lim, Howard, Young, Sean, Cremin, Carol, Holt, Robert, Eirew, Peter, Karasinska, Joanna, Schein, Jacquie, Zhao, Yongjun, Mungall, Andy, Moore, Richard, Ma, Yussanne, Fok, Alexandra, Roscoe, Robyn, Yip, Stephen, Mitchell, Gillian, Karsan, Aly, Jones, Steven, Schaeffer, David, Laskin, Janessa, Marra, Marco, Renouf, Daniel

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Integrating Tumor Sequencing Into Clinical Practice for Patients With Mismatch Repair-Deficient Lynch Syndrome Spectrum Cancers von Dixon, Katherine, Asrat, Mary-Jill, Bedard, Angela C., Binnington, Kristin, Compton, Katie, Cremin, Carol, Heidary, Nili, Lohn, Zoe, Lovick, Niki, McCullum, Mary, Mindlin, Allison, O'Loughlin, Melanie, Petersen, Tammy, Portigal-Todd, Cheryl, Scott, Jenna, St-Martin, Genevieve, Thompson, Jennifer, Turnbull, Ruth, Mung, Sze Wing, Hong, Quan, Bezeau, Marjorie, Bosdet, Ian, Tucker, Tracy, Young, Sean, Yip, Stephen, Aubertin, Gudrun, Blood, Katherine A., Nuk, Jennifer, Sun, Sophie, Schrader, Kasmintan A.

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Integrating Tumor Sequencing Into Clinical Practice for Patients With Mismatch Repair-Deficient Lynch Syndrome Spectrum Cancers von Dixon, Katherine, Asrat, Mary-Jill, Bedard, Angela C., Binnington, Kristin, Compton, Katie, Cremin, Carol, Heidary, Nili, Lohn, Zoe, Lovick, Niki, Mccullum, Mary, Mindlin, Allison, O'Loughlin, Melanie, Petersen, Tammy, Portigal-Todd, Cheryl, Scott, Jenna, St-Martin, Genevieve, Thompson, Jennifer, Turnbull, Ruth, Mung, Sze Wing, Hong, Quan, Bezeau, Marjorie, Bosdet, Ian, Tucker, Tracy, Young, Sean, Yip, Stephen, Aubertin, Gudrun, Blood, Katherine A., Nuk, Jennifer, Sun, Sophie, Schrader, Kasmintan A.

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Base excision repair deficiency signatures implicate germline and somatic MUTYH aberrations in pancreatic ductal adenocarcinoma and breast cancer oncogenesis von Thibodeau, My Linh, Zhao, Eric Y, Reisle, Caralyn, Ch'ng, Carolyn, Wong, Hui-Li, Shen, Yaoqing, Jones, Martin R, Lim, Howard J, Young, Sean, Cremin, Carol, Pleasance, Erin, Zhang, Wei, Holt, Robert, Eirew, Peter, Karasinska, Joanna, Kalloger, Steve E, Taylor, Greg, Majounie, Elisa, Bonakdar, Melika, Zong, Zusheng, Bleile, Dustin, Chiu, Readman, Birol, Inanc, Gelmon, Karen, Lohrisch, Caroline, Mungall, Karen L, Mungall, Andrew J, Moore, Richard, Ma, Yussanne P, Fok, Alexandra, Yip, Stephen, Karsan, Aly, Huntsman, David, Schaeffer, David F, Laskin, Janessa, Marra, Marco A, Renouf, Daniel J, Jones, Steven J M, Schrader, Kasmintan A

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TERT Mutations in Patients with Squamous Cell Carcinoma of the Tongue and Refractory Anemia von Aubert, Geraldine, Hills, Mark, Cremin, Carol, Vulto, Irma, McGillivray, Barbara, Lansdorp, Peter M.

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The identification of Lynch syndrome in British Columbia von Cremin, Carol M, Armstrong, Linlea, Gill, Sharlene, Huntsman, David, Bajdik, Chris

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Hereditary breast and ovarian cancers von Carroll, June C, Cremin, Carol, Allanson, Judith, Blaine, Sean M, Dorman, Heather, Gibbons, Clare A, Grimshaw, Jeremy, Honeywell, Christina, Meschino, Wendy S, Permaul, Joanne, Wilson, Brenda J

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Huntington disease von Allanson, Judith, Dorman, Heather, Blaine, Sean M., Cremin, Carol, Gibbons, Clare A., Honeywell, Christina, Meschino, Wendy S., Permaul, Joanne, Carroll, June C.

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Genetics: factor V Leiden von Cremin, Carol, Carroll, June C, Allanson, Judith, Blaine, Sean M, Dorman, Heather, Gibbons, Clare A, Honeywell, Christina, Meschino, Wendy S, Permaul, Joanne, Wilson, Brenda J

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Genetics: familial melanoma von Cremin, Carol, Blaine, Sean M, Allanson, Judith, Dorman, Heather, Gibbons, Clare A, Honeywell, Christina, Meschino, Wendy S, Permaul, Joanne, Carroll, June C

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Genetics: Hereditary colorectal cancer von Blaine, Sean M., Cremin, Carol, Allanson, Judith, Dorman, Heather, Gibbons, Clare A., Honeywell, Christina, Meschino, Wendy S., Permaul, Joanne, Carroll, June C.

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