Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy von Sharma, Meenu, Khong, Hiep, Fa’ak, Faisal, Bentebibel, Salah-Eddine, Janssen, Louise M. E., Chesson, Brent C., Creasy, Caitlin A., Forget, Marie-Andrée, Kahn, Laura Maria S., Pazdrak, Barbara, Karki, Binisha, Hailemichael, Yared, Singh, Manisha, Vianden, Christina, Vennam, Srinivas, Bharadwaj, Uddalak, Tweardy, David J., Haymaker, Cara, Bernatchez, Chantale, Huang, Shixia, Rajapakshe, Kimal, Coarfa, Cristian, Hurwitz, Michael E., Sznol, Mario, Hwu, Patrick, Hoch, Ute, Addepalli, Murali, Charych, Deborah H., Zalevsky, Jonathan, Diab, Adi, Overwijk, Willem W.

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Multi-modal molecular programs regulate melanoma cell state von Andrews, Miles C., Oba, Junna, Wu, Chang-Jiun, Zhu, Haifeng, Karpinets, Tatiana, Creasy, Caitlin A., Forget, Marie-Andrée, Yu, Xiaoxing, Song, Xingzhi, Mao, Xizeng, Robertson, A. Gordon, Romano, Gabriele, Li, Peng, Burton, Elizabeth M., Lu, Yiling, Sloane, Robert Szczepaniak, Wani, Khalida M., Rai, Kunal, Lazar, Alexander J., Haydu, Lauren E., Bustos, Matias A., Shen, Jianjun, Chen, Yueping, Morgan, Margaret B., Wargo, Jennifer A., Kwong, Lawrence N., Haymaker, Cara L., Grimm, Elizabeth A., Hwu, Patrick, Hoon, Dave S. B., Zhang, Jianhua, Gershenwald, Jeffrey E., Davies, Michael A., Futreal, P. Andrew, Bernatchez, Chantale, Woodman, Scott E.

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Genomic Correlates of Outcome in Tumor-Infiltrating Lymphocyte Therapy for Metastatic Melanoma von Creasy, Caitlin A, Meng, Yuzhong Jeff, Forget, Marie-Andrée, Karpinets, Tatiana, Tomczak, Katarzyna, Stewart, Chip, Torres-Cabala, Carlos A, Pilon-Thomas, Shari, Sarnaik, Amod A, Mulé, James J, Garraway, Levi, Bustos, Matias, Zhang, Jianhua, Patel, Sapna P, Diab, Adi, Glitza, Isabella C, Yee, Cassian, Tawbi, Hussein, Wong, Michael K, McQuade, Jennifer, Hoon, Dave S B, Davies, Michael A, Hwu, Patrick, Amaria, Rodabe N, Haymaker, Cara, Beroukhim, Rameen, Bernatchez, Chantale

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Exposure to anti‐PD‐1 causes functional differences in tumor‐infiltrating lymphocytes in rare solid tumors von Creasy, Caitlin A., Forget, Marie‐Andrée, Singh, Gopal, Tapia, Coya, Xu, Mingxuan, Stephen, Bettzy, Sabir, Sharjeel, Meric‐Bernstam, Funda, Haymaker, Cara, Bernatchez, Chantale, Naing, Aung

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Utilizing T-cell Activation Signals 1, 2, and 3 for Tumor-infiltrating Lymphocytes (TIL) Expansion: The Advantage Over the Sole Use of Interleukin-2 in Cutaneous and Uveal Melanoma von Tavera, René J, Forget, Marie-Andrée, Kim, Young Uk, Sakellariou-Thompson, Donastas, Creasy, Caitlin A, Bhatta, Ankit, Fulbright, Orenthial J, Ramachandran, Renjith, Thorsen, Shawne T, Flores, Esteban, Wahl, Arely, Gonzalez, Audrey M, Toth, Christopher, Wardell, Seth, Mansaray, Rahmatu, Radvanyi, Laszlo G, Gombos, Dan S, Patel, Sapna P, Hwu, Patrick, Amaria, Rodabe N, Bernatchez, Chantale, Haymaker, Cara

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Abstract PR15: CD74 regulated inflammatory pattern is associated with TIL growth and favorable response to adoptive immunotherapy von Dai-Ogata, Creasy, Caitlin A., Kim, Sun-Hee, Roszik, Jason, Hwu, Patrick, Grimm, Elizabeth A., Bernatchez, Chantale, Ekmekcioglu, Suhendan

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Abstract PR03: Nongenomic BAP1 aberrancy drives highly aggressive cutaneous melanoma phenotype von Zhu, Haifeng, Oba, Junna, Yu, Xiaoxing, Creasy, Caitlin A., Forget, Marie-Andrée, Carapeto, Fernando, Haymaker, Cara L., Wu, Chang-Jiun, Karpinets, Tatiana V., Wang, Wei-Lien, Tetzlaff, Michael T., Lazar, Alexander J., Mills, Gordon B., Moore, Amanda R., Chen, Yu, Zhang, Jianhua, Gershenwald, Jeffrey E., Wargo, Jennifer A., Bernatchez, Chantale, Hwu, Patrick, Futreal, P. Andrew, Woodman, Scott E.

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Abstract 6425: Functional roles of enhancers in immune microenvironment & immunotherapy response von Rai, Kunal, Maitituoheti, Mayinuer, Shi, Alvin, Tang, Ming, Ho, Li-Lun, Kreidieh, Firas Youssef, Terranova, Christopher, Galani, Kyriakitsa, Keung, Emily Z., Creasy, Caitlin A., Wu, Manrong, Chen, Jiajia, Chen, Nana, Singh, Anand K., Chaudhri, Apoorvi, Anvar, Nazanin E., Tarrantino, Giuseppe, Yang, Jiekun, Sarkar, Sharmistha, Jiang, Shan, Malke, Jared, Haydu, Lauren, Burton, Elizabeth, Davies, Michael A., Gershenwald, Jeffrey E., Hwu, Patrick, Lazar, Alexander, Cheah, Jaime H., Soule, Christian K., Levine, Stuart S., Bernatchez, Chantale, Saladi, Srinivas V., Liu, David, Tawbi, Hussein, Wargo, Jennifer, Boland, Genevieve M., Kellis, Manolis

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Identification of distinct immune landscapes using an automated nine-color multiplex immunofluorescence staining panel and image analysis in paraffin tumor tissues von Parra, Edwin R., Zhai, Jie, Tamegnon, Auriole, Zhou, Nicolas, Pandurengan, Renganayaki Krishna, Barreto, Carmelia, Jiang, Mei, Rice, David C., Creasy, Caitlin, Vaporciyan, Ara A., Hofstetter, Wayne L., Tsao, Anne S., Wistuba, Ignacio I., Sepesi, Boris, Haymaker, Cara

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Structural and Mechanical Improvements to Bone Are Strain Dependent with Axial Compression of the Tibia in Female C57BL/6 Mice von Berman, Alycia G, Clauser, Creasy A, Wunderlin, Caitlin, Hammond, Max A, Wallace, Joseph M

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PD-L1 expression and prognostic impact in glioblastoma von Nduom, Edjah K, Wei, Jun, Yaghi, Nasser K, Huang, Neal, Kong, Ling-Yuan, Gabrusiewicz, Konrad, Ling, Xiaoyang, Zhou, Shouhao, Ivan, Cristina, Chen, Jie Qing, Burks, Jared K, Fuller, Greg N, Calin, George A, Conrad, Charles A, Creasy, Caitlin, Ritthipichai, Krit, Radvanyi, Laszlo, Heimberger, Amy B

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4-1BB Agonist Focuses CD8 + Tumor-Infiltrating T-Cell Growth into a Distinct Repertoire Capable of Tumor Recognition in Pancreatic Cancer von Sakellariou-Thompson, Donastas, Forget, Marie-Andrée, Creasy, Caitlin, Bernard, Vincent, Zhao, Li, Kim, Young Uk, Hurd, Mark W, Uraoka, Naohiro, Parra, Edwin Roger, Kang, Ya'an, Bristow, Christopher A, Rodriguez-Canales, Jaime, Fleming, Jason B, Varadhachary, Gauri, Javle, Milind, Overman, Michael J, Alvarez, Hector A, Heffernan, Timothy P, Zhang, Jianhua, Hwu, Patrick, Maitra, Anirban, Haymaker, Cara, Bernatchez, Chantale

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Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy von Cascone, Tina, McKenzie, Jodi A., Mbofung, Rina M., Punt, Simone, Wang, Zhe, Xu, Chunyu, Williams, Leila J., Wang, Zhiqiang, Bristow, Christopher A., Carugo, Alessandro, Peoples, Michael D., Li, Lerong, Karpinets, Tatiana, Huang, Lu, Malu, Shruti, Creasy, Caitlin, Leahey, Sara E., Chen, Jiong, Chen, Yuan, Pelicano, Helen, Bernatchez, Chantale, Gopal, Y.N. Vashisht, Heffernan, Timothy P., Hu, Jianhua, Wang, Jing, Amaria, Rodabe N., Garraway, Levi A., Huang, Peng, Yang, Peiying, Wistuba, Ignacio I., Woodman, Scott E., Roszik, Jason, Davis, R. Eric, Davies, Michael A., Heymach, John V., Hwu, Patrick, Peng, Weiyi

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Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy von Peng, Weiyi, Chen, Jie Qing, Liu, Chengwen, Malu, Shruti, Creasy, Caitlin, Tetzlaff, Michael T, Xu, Chunyu, McKenzie, Jodi A, Zhang, Chunlei, Liang, Xiaoxuan, Williams, Leila J, Deng, Wanleng, Chen, Guo, Mbofung, Rina, Lazar, Alexander J, Torres-Cabala, Carlos A, Cooper, Zachary A, Chen, Pei-Ling, Tieu, Trang N, Spranger, Stefani, Yu, Xiaoxing, Bernatchez, Chantale, Forget, Marie-Andree, Haymaker, Cara, Amaria, Rodabe, McQuade, Jennifer L, Glitza, Isabella C, Cascone, Tina, Li, Haiyan S, Kwong, Lawrence N, Heffernan, Timothy P, Hu, Jianhua, Bassett, Jr, Roland L, Bosenberg, Marcus W, Woodman, Scott E, Overwijk, Willem W, Lizée, Gregory, Roszik, Jason, Gajewski, Thomas F, Wargo, Jennifer A, Gershenwald, Jeffrey E, Radvanyi, Laszlo, Davies, Michael A, Hwu, Patrick

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Manipulating the tumor microenvironment ex vivo for enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy von Chacon, Jessica Ann, Sarnaik, Amod A, Chen, Jie Qing, Creasy, Caitlin, Kale, Charuta, Robinson, John, Weber, Jeffrey, Hwu, Patrick, Pilon-Thomas, Shari, Radvanyi, Laszlo

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Prospective Analysis of Adoptive TIL Therapy in Patients with Metastatic Melanoma: Response, Impact of Anti-CTLA4, and Biomarkers to Predict Clinical Outcome von Forget, Marie-Andrée, Haymaker, Cara, Hess, Kenneth R, Meng, Yuzhong Jeff, Creasy, Caitlin, Karpinets, Tatiana, Fulbright, Orenthial J, Roszik, Jason, Woodman, Scott E, Kim, Young Uk, Sakellariou-Thompson, Donastas, Bhatta, Ankit, Wahl, Arely, Flores, Esteban, Thorsen, Shawne T, Tavera, René J, Ramachandran, Renjith, Gonzalez, Audrey M, Toth, Christopher L, Wardell, Seth, Mansaray, Rahmatu, Patel, Vruti, Carpio, Destiny Joy, Vaughn, Carol, Farinas, Chantell M, Velasquez, Portia G, Hwu, Wen-Jen, Patel, Sapna P, Davies, Michael A, Diab, Adi, Glitza, Isabella C, Tawbi, Hussein, Wong, Michael K, Cain, Suzanne, Ross, Merrick I, Lee, Jeffrey E, Gershenwald, Jeffrey E, Lucci, Anthony, Royal, Richard, Cormier, Janice N, Wargo, Jennifer A, Radvanyi, Laszlo G, Torres-Cabala, Carlos A, Beroukhim, Rameen, Hwu, Patrick, Amaria, Rodabe N, Bernatchez, Chantale

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Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma von Kalaora, Shelly, Wolf, Yochai, Feferman, Tali, Barnea, Eilon, Greenstein, Erez, Reshef, Dan, Tirosh, Itay, Reuben, Alexandre, Patkar, Sushant, Levy, Ronen, Quinkhardt, Juliane, Omokoko, Tana, Qutob, Nouar, Golani, Ofra, Zhang, Jianhua, Mao, Xizeng, Song, Xingzhi, Bernatchez, Chantale, Haymaker, Cara, Forget, Marie-Andrée, Creasy, Caitlin, Greenberg, Polina, Carter, Brett W, Cooper, Zachary A, Rosenberg, Steven A, Lotem, Michal, Sahin, Ugur, Shakhar, Guy, Ruppin, Eytan, Wargo, Jennifer A, Friedman, Nir, Admon, Arie, Samuels, Yardena

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Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy von Terranova, Christopher J., Tang, Ming, Maitituoheti, Mayinuer, Raman, Ayush T., Ghosh, Archit K., Schulz, Jonathan, Amin, Samir B., Orouji, Elias, Tomczak, Katarzyna, Sarkar, Sharmistha, Oba, Junna, Creasy, Caitlin, Wu, Chang-Jiun, Khan, Samia, Lazcano, Rossana, Wani, Khalida, Singh, Anand, Barrodia, Praveen, Zhao, Dongyu, Chen, Kaifu, Haydu, Lauren E., Wang, Wei-Lien, Lazar, Alexander J., Woodman, Scott E., Bernatchez, Chantale, Rai, Kunal

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187 Multi-omic single-cell profiling demonstrates that competition for fatty acids and fatty acid oxidation enables tumor-infiltrating lymphocyte function and survival von Paniagua, Melisa Angela, Haymaker, Cara, Adolacion, Jay R, An, Xingyue, Creasy, Caitlin, Fathi, Mohsen, Rezvan, Ali, Geiger, Tamar, Harel, Michal, Robinson, Jonathan, Amritkar, Amit, Woodman, Scott, Hwu, Patrick, Bernatchez, Chantale, Varadarajan, Navin

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Integrated profiling of T cells and tumor cells demonstrates metabolic adaptation essential for melanoma cell therapy von Martinez-Paniagua, Melisa A, Haymaker, Cara, Adolacion, Jay R T, An, Xingyue, Bandey, Irfan N, Creasy, Caitlin, Geiger, Tamar, Harel, Michal, Robinson, Jonathan, Nielsen, Jens B, Amritkar, Amit, Woodman, Scott, Roysam, Badrinath, Hwu, Patrick, Bernatchez, Chantale, Varadarajan, Navin

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