Targeting Cancer-Associated Fibroblasts in the Bone Marrow Prevents Resistance to CART-Cell Therapy in Multiple Myeloma von Sakemura, Reona, Hefazi, Mehrdad, Siegler, Elizabeth L., Cox, Michelle J., Larson, Daniel P., Hansen, Michael J., Roman, Claudia Manriquez, Schick, Kendall J, Can, Ismail, Tapper, Erin E., Horvei, Paulina, Adada, Mohamad M., Bezerra, Evandro D., Fonkoua, Lionel Aurelien Kankeu, Ruff, Michael W., Nevala, Wendy K., Walters, Denise K., Parikh, Sameer A., Lin, Yi, Jelinek, Diane F., Kay, Neil E., Bergsagel, P. Leif, Kenderian, Saad S.

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IL-4 drives exhaustion of CD8+ CART cells von Stewart, Carli M., Siegler, Elizabeth L., Sakemura, R. Leo, Cox, Michelle J., Huynh, Truc, Kimball, Brooke, Mai, Long, Can, Ismail, Manriquez Roman, Claudia, Yun, Kun, Sirpilla, Olivia, Girsch, James H., Ogbodo, Ekene, Mohammed Ismail, Wazim, Gaspar-Maia, Alexandre, Budka, Justin, Kim, Jenny, Scholler, Nathalie, Mattie, Mike, Filosto, Simone, Kenderian, Saad S.

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GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts von Sterner, Rosalie M., Sakemura, Reona, Cox, Michelle J., Yang, Nan, Khadka, Roman H., Forsman, Cynthia L., Hansen, Michael J., Jin, Fang, Ayasoufi, Katayoun, Hefazi, Mehrdad, Schick, Kendall J., Walters, Denise K., Ahmed, Omar, Chappell, Dale, Sahmoud, Tarek, Durrant, Cameron, Nevala, Wendy K., Patnaik, Mrinal M., Pease, Larry R., Hedin, Karen E., Kay, Neil E., Johnson, Aaron J., Kenderian, Saad S.

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Leukemic extracellular vesicles induce chimeric antigen receptor T cell dysfunction in chronic lymphocytic leukemia von Cox, Michelle J., Lucien, Fabrice, Sakemura, Reona, Boysen, Justin C., Kim, Yohan, Horvei, Paulina, Manriquez Roman, Claudia, Hansen, Michael J., Tapper, Erin E., Siegler, Elizabeth L., Forsman, Cynthia, Crotts, Sydney B., Schick, Kendall J., Hefazi, Mehrdad, Ruff, Michael W., Can, Ismail, Adada, Mohamad, Bezerra, Evandro, Kankeu Fonkoua, Lionel Aurelien, Nevala, Wendy K., Braggio, Esteban, Ding, Wei, Parikh, Sameer A., Kay, Neil E., Kenderian, Saad S.

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Challenges of chimeric antigen receptor T-cell therapy in chronic lymphocytic leukemia: lessons learned von Can, Ismail, Cox, Michelle J., Siegler, Elizabeth L., Sakemura, Reona, Kenderian, Saad S.

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Using CRISPR/Cas9 to Knock Out GM-CSF in CAR-T Cells von Sterner, Rosalie M, Cox, Michelle J, Sakemura, Reona, Kenderian, Saad S

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GM-CSF disruption in CART cells modulates T cell activation and enhances CART cell anti-tumor activity von Cox, Michelle J., Manriquez Roman, Claudia, Tapper, Erin E., Siegler, Elizabeth L., Chappell, Dale, Durrant, Cameron, Ahmed, Omar, Sinha, Sutapa, Mwangi, Raphael, Scott, Nancy S., Hefazi, Mehrdad, Schick, Kendall J., Horvei, Paulina, Ruff, Michael W., Can, Ismail, Adada, Mohamad, Bezerra, Evandro, Kankeu Fonkoua, Lionel Aurelien, Parikh, Sameer A., Kay, Neil E., Sakemura, Reona, Kenderian, Saad S.

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Development of a Clinically Relevant Reporter for Chimeric Antigen Receptor T-cell Expansion, Trafficking, and Toxicity von Sakemura, Reona, Bansal, Aditya, Siegler, Elizabeth L., Hefazi, Mehrdad, Yang, Nan, Khadka, Roman H., Newsom, Alysha N., Hansen, Michael J., Cox, Michelle J., Roman, Claudia Manriquez, Schick, Kendall J., Can, Ismail, Tapper, Erin E., Nevala, Wendy K., Adada, Mohamad M., Bezerra, Evandro D., Fonkoua, Lionel Aurelien Kankeu, Horvei, Paulina, Ruff, Michael W., Parikh, Sameer A., Pandey, Mukesh K., DeGrado, Timothy R., Suksanpaisan, Lukkana, Kay, Neil E., Peng, Kah-Whye, Russell, Stephen J., Kenderian, Saad S.

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Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography von Sakemura, Reona, Cox, Michelle J, Bansal, Aditya, Roman, Claudia Manriquez, Hefazi, Mehrdad, Vernon, Cynthia J, Glynn, Dianna L, Pandey, Mukesh K, DeGrado, Timothy R, Siegler, Elizabeth L, Kenderian, Saad S

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AXL Inhibition Improves the Antitumor Activity of Chimeric Antigen Receptor T Cells von Sakemura, R Leo, Hefazi, Mehrdad, Cox, Michelle J, Siegler, Elizabeth L, Sinha, Sutapa, Hansen, Michael J, Stewart, Carli M, Feigin, Jennifer M, Manriquez Roman, Claudia, Schick, Kendall J, Can, Ismail, Tapper, Erin E, Horvei, Paulina, Adada, Mohamad M, Bezerra, Evandro D, Kankeu Fonkoua, Lionel Aurelien, Ruff, Michael W, Forsman, Cynthia L, Nevala, Wendy K, Boysen, Justin C, Tschumper, Renee C, Grand, Cory L, Kuchimanchi, Kameswara R, Mouritsen, Lars, Foulks, Jason M, Warner, Steven L, Call, Timothy G, Parikh, Sameer A, Ding, Wei, Kay, Neil E, Kenderian, Saad S

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Mesenchymal stromal cells with chimaeric antigen receptors for enhanced immunosuppression von Sirpilla, Olivia, Sakemura, R. Leo, Hefazi, Mehrdad, Huynh, Truc N., Can, Ismail, Girsch, James H., Tapper, Erin E., Cox, Michelle J., Schick, Kendall J., Manriquez-Roman, Claudia, Yun, Kun, Stewart, Carli M., Ogbodo, Ekene J., Kimball, Brooke L., Mai, Long K., Gutierrez-Ruiz, Omar L., Rodriguez, Makena L., Gluscevic, Martina, Larson, Daniel P., Abel, Alex M., Wierson, Wesley A., Olivier, Gloria, Siegler, Elizabeth L., Kenderian, Saad S.

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Identification of IL-4 As a Key Regulator of CAR T-Cell Exhaustion Using Functional Genomics and Correlates of the Zuma-1 Clinical Trial von Stewart, Carli M., Cox, Michelle J., Sakemura, Reona Leo, Ogbodo, Ekene J., Can, Ismail, Manriquez-Roman, Claudia, Yun, Kun, Sirpilla, Olivia, Girsch, James H., Huynh, Truc, Siegler, Elizabeth L., Kim, Jenny J, Mattie, Mike, Scholler, Nathalie, Filosto, Simone, Kenderian, Saad S.

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Chimeric Antigen Receptor Engineering of Mesenchymal Stromal Cells (CAR-MSC) Enhance Immunosuppression and Outcomes in Graft Versus Host Disease (GvHD) Preclinical Models von Sirpilla, Olivia, Sakemura, Reona Leo, Hefazi, Mehrdad, Girsch, James H., Huynh, Truc, Cox, Michelle J., Schick, Kendall J., Manriquez-Roman, Claudia, Can, Ismail, Yun, Kun, Stewart, Carli M., Ogbodo, Ekene J., Siegler, Elizabeth L., Kenderian, Saad S.

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Differential Susceptibility to Senescence in CART Cells Based on Co-Stimulatory Signaling von Can, Ismail, Sakemura, Reona Leo, Manriquez-Roman, Claudia, Sirpilla, Olivia, Stewart, Carli M., Yun, Kun, Cox, Michelle J., Huynh, Truc, Girsch, James H., Ogbodo, Ekene J., Kankeu Fonkoua, Lionel A., Hefazi, Mehrdad, Ruff, Michael W., Boysen, Justin C., Siegler, Elizabeth L., Ekiz, Atakan, Kenderian, Saad S., Kay, Neil E.

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Immunosuppressive Monocyte Modulation of CAR T Cell Functions and Impact on Response to CART19 von Yun, Kun, Sakemura, Reona Leo, Cox, Michelle J., Huynh, Truc, Manriquez-Roman, Claudia, Sirpilla, Olivia, Stewart, Carli M., Girsch, James H., Ogbodo, Ekene J., Can, Ismail, Kimball, Brooke, Kankeu Fonkoua, Lionel A., Hefazi, Mehrdad, Ruff, Michael W., Siegler, Elizabeth L., Mattie, Mike, Nguyen-Mau, Sao-Mai, Filosto, Simone, Kenderian, Saad S.

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Efficient Gene Editing of CART Cells with CRISPR-Cas12a for Enhanced Antitumor Efficacy von Siegler, Elizabeth L., Simone, Brandon W, Sakemura, Reona, Tapper, Erin E., Horvei, Paulina, Cox, Michelle J., Hefazi, Mehrdad, Manriquez Roman, Claudia, Can, Ismail, Schick, Kendall J., Ruff, Michael W., Ekker, Stephen C, Kenderian, Saad S.

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Favorable Modulation of Chimeric Antigen Receptor T Cells Safety and Efficacy By the Non-Covalent BTK Inhibitor Vecabrutinib von Adada, Mohamad M., Sakemura, Reona, Cox, Michelle J., Manriquez-Roman, Caludia, Siegler, Elizabeth L., Tapper, Erin E., Stewart, Carli M., Schick, Kendall J., Can, Ismail, Ogbodo, Ekene J., Bezerra, Evandro D., Kankeu Fonkoua, Lionel A., Hefazi, Mehrdad, Ruff, Michael W., Taverna, Pietro, Fox, Judith A., Olivier, Gloria, Slager, Susan L., Ding, Wei, Parikh, Sameer A., Kay, Neil E., Kenderian, Saad S.

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Optimized Inhibition of GM-CSF in Preclinical Models of Anti-CD19 Chimeric Antigen Receptor T Cell Therapy von Bezerra, Evandro D., Sakemura, Reona, Girsch, James, Stewart, Carli M., Awatramani, Gunjan A, Manriquez-Roman, Claudia, Schick, Kendall J., Can, Ismail, Ogbodo, Ekene J., Tapper, Erin E., Siegler, Elizabeth L., Adada, Mohamad M., Kankeu Fonkoua, Lionel A., Hefazi, Mehrdad, Ruff, Michael W., Slager, Susan L., Parikh, Sameer A., Kay, Neil E., Durrant, Cameron, Ahmed, Omar, Chappell, Dale, Cox, Michelle J., Kenderian, Saad S.

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CD19 Antigen Occupancy on Cancer Cells with the CD19 Monoclonal Antibody Tafasitamab Improves the Activation, Antitumor Efficacy, and Safety Profile of CART19 Cell Therapy von Sakemura, Reona Leo, Manriquez-Roman, Claudia, Horvei, Paulina, Cox, Michelle J., Huynh, Truc, Girsch, James H., Sirpilla, Olivia, Yun, Kun, Stewart, Carli M., Can, Ismail, Ogbodo, Ekene J., Adada, Mohamad M., Kankeu Fonkoua, Lionel A., Hefazi, Mehrdad, Ruff, Michael W., Ilieva-Babinsky, Kristina, Augsberger, Christian, Patra-Kneuer, Maria, Heitmüller, Christina, Steidl, Stefan, Parikh, Sameer A., Ding, Wei, Kay, Neil E., Nowakowski, Grzegorz S., Siegler, Elizabeth L., Kenderian, Saad S.

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TNFR2 As a Target to Improve CD19-Directed CART Cell Fitness and Antitumor Activity in Large B Cell Lymphoma von Manriquez Roman, Claudia, Cox, Michelle J., Sakemura, Reona, Yun, Kun, Adada, Mohamad M., Siegler, Elizabeth L., Sirpilla, Olivia, Tapper, Erin E., Stewart, Carli M., Ogbodo, Ekene J., Can, Ismail, Schick, Kendall J., Bezerra, Evandro D., Kankeu Fonkoua, Lionel A., Hefazi, Mehrdad, Ruff, Michael W., Ding, Wei, Parikh, Sameer A., Slager, Susan L., Kay, Neil E., Olivier, Gloria, Scholler, Nathalie, Bot, Adrian, Mattie, Mike, Kim, Jenny J., Filosto, Simone, Kenderian, Saad S.

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