Subcutaneous checkpoint inhibition is equivalent to systemic delivery when combined with nelitolimod delivered via pressure-enabled drug delivery for depletion of intrahepatic myel... von Ghosh, Chandra C, Cournoyer, Lauren, Liu, Yujia, Ballarin, Alizee, Layman, Ilan B, LaPorte, Jason, Morrissey, Molly, Fraser, Kayla, Perati, Shriya, Cox, Bryan F, Yakirevich, Evgeny, Treaba, Diana O, Murtha, Timothy D, Guha, Prajna, Katz, Steven C, Davar, Diwakar

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A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat von Jarvis, Michael F, Burgard, Edward C, McGaraughty, Steve, Honore, Prisca, Lynch, Kevin, Brennan, Timothy J, Subieta, Alberto, Van Biesen, Tim, Cartmell, Jayne, Bianchi, Bruce, Niforatos, Wende, Kage, Karen, Yu, Haixia, Mikusa, Joe, Wismer, Carol T, Zhu, Chang Z, Chu, Katharine, Lee, Chih-Hung, Stewart, Andrew O, Polakowski, James, Cox, Bryan F, Kowaluk, Elizabeth, Williams, Michael, Sullivan, James, Faltynek, Connie

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Regional Delivery of Anti-PD-1 Agent for Colorectal Liver Metastases Improves Therapeutic Index and Anti-Tumor Activity von Chai, Louis F., Hardaway, John C., Heatherton, Kara R., O'Connell, Kyle P., Lopes, Mikayla C., Rabinowitz, Benjamin A., Ghosh, Chandra C., Guha, Prajna, Jaroch, David, Cox, Bryan F., Katz, Steven C.

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Potentiation of Temozolomide Cytotoxicity by Poly(ADP)Ribose Polymerase Inhibitor ABT-888 Requires a Conversion of Single-Stranded DNA Damages to Double-Stranded DNA Breaks von Liu, Xuesong, Shi, Yan, Guan, Ran, Donawho, Cherrie, Luo, Yanping, Palma, Joann, Zhu, Gui-Dong, Johnson, Eric F, Rodriguez, Luis E, Ghoreishi-Haack, Nayereh, Jarvis, Ken, Hradil, Vincent P, Colon-Lopez, Milagros, Cox, Bryan F, Klinghofer, Vered, Penning, Thomas, Rosenberg, Saul H, Frost, David, Giranda, Vincent L, Luo, Yan

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Diacylglycerol Acyltransferase 1 Inhibition Lowers Serum Triglycerides in the Zucker Fatty Rat and the Hyperlipidemic Hamster von King, Andrew J, Segreti, Jason A, Larson, Kelly J, Souers, Andrew J, Kym, Philip R, Reilly, Regina M, Zhao, Gang, Mittelstadt, Scott W, Cox, Bryan F

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The Utility of hERG and Repolarization Assays in Evaluating Delayed Cardiac Repolarization: Influence of Multi-Channel Block von Martin, Ruth L, McDermott, Jeff S, Salmen, Heinz J, Palmatier, Jason, Cox, Bryan F, Gintant, Gary A

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Electrophysiologic characterization of a novel hERG channel activator von Su, Zhi, Limberis, James, Souers, Andrew, Kym, Philip, Mikhail, Ann, Houseman, Kathryn, Diaz, Gilbert, Liu, Xiaoqin, Martin, Ruth L., Cox, Bryan F., Gintant, Gary A.

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Identification and Preliminary Characterization of a Potent, Safe, and Orally Efficacious Inhibitor of Acyl-CoA:Diacylglycerol Acyltransferase 1 von Yeh, Vince S. C, Beno, David W. A, Brodjian, Sevan, Brune, Michael E, Cullen, Steven C, Dayton, Brian D, Dhaon, Madhup K, Falls, Hugh D, Gao, Ju, Grihalde, Nelson, Hajduk, Philip, Hansen, T. Matthew, Judd, Andrew S, King, Andrew J, Klix, Russel C, Larson, Kelly J, Lau, Yau Y, Marsh, Kennan C, Mittelstadt, Scott W, Plata, Dan, Rozema, Michael J, Segreti, Jason A, Stoner, Eric J, Voorbach, Martin J, Wang, Xiaojun, Xin, Xili, Zhao, Gang, Collins, Christine A, Cox, Bryan F, Reilly, Regina M, Kym, Philip R, Souers, Andrew J

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Intra-arterial Pressure-Enabled Drug Delivery Significantly Increases Penetration of Glass Microspheres in a Porcine Liver Tumor Model von Jaroch, David B., Liu, Yujia, Kim, Alexander Y., Katz, Steven C., Cox, Bryan F., Hullinger, Thomas G.

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Utility of hERG Assays as Surrogate Markers of Delayed Cardiac Repolarization and QT Safety von Gintant, Gary A., Su, Zhi, Martin, Ruth L., Cox, Bryan F.

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Pressure-Enabled Drug Delivery (PEDD) of a class C TLR9 agonist in combination with checkpoint inhibitor therapy in a murine pancreatic cancer model von Capacio, Benedict A, Shankara Narayanan, Jayanth S, Vicente, Diego A, Liu, Yujia, LaPorte, Jason P, Cox, Bryan F, Jaroch, David B, Katz, Steven C, White, Rebekah R

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Pharmacological MRI in awake rats reveals neural activity in area postrema and nucleus tractus solitarius: Relevance as a potential biomarker for detecting drug-induced emesis von Chin, Chih-Liang, Fox, Gerard B., Hradil, Vincent P., Osinski, Mark A., McGaraughty, Steve P., Skoubis, Pamela D., Cox, Bryan F., Luo, Yanping

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Distinct spatiotemporal pattern of CNS lesions revealed by USPIO-enhanced MRI in MOG-induced EAE rats implicates the involvement of spino-olivocerebellar pathways von Chin, Chih-Liang, Pai, Madhavi, Bousquet, Peter F, Schwartz, Annette J, O'Connor, Elizabeth M, Nelson, Christine M, Hradil, Vincent P, Cox, Bryan F, McRae, Bradford L, Fox, Gerard B

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The [ 3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K... von Diaz, Gilbert J., Daniell, Katina, Leitza, Sandra T., Martin, Ruth L., Su, Zhi, McDermott, Jeffrey S., Cox, Bryan F., Gintant, Gary A.

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ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models von DONAWHO, Cherrie K, YAN LUO, FERGUSON, Debra C, GHOREISHI-HAACK, Nayereh S, GRIMM, David R, GUAN, Ran, HAN, Edward K, HOLLEY-SHANKS, Rhonda R, HRISTOV, Boris, IDLER, Kenneth B, JARVIS, Ken, JOHNSON, Eric F, YANPING LUO, KLEINBERG, Lawrence R, KLINGHOFER, Vered, LASKO, Loren M, XUESONG LIU, MARSH, Kennan C, MCGONIGAL, Thomas P, MEULBROEK, Jonathan A, OLSON, Amanda M, PALMA, Joann P, RODRIGUEZ, Luis E, PENNING, Thomas D, YAN SHI, STAVROPOULOS, Jason A, TSURUTANI, Alan C, ZHU, Gui-Dong, ROSENBERG, Saul H, GIRANDA, Vincent L, FROST, David J, BAUCH, Joy L, BOUSKA, Jennifer J, BONTCHEVA-DIAZ, Velitchka D, COX, Bryan F, DEWEESE, Theodore L, DILLEHAY, Larry E

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Regional infusion of a class C TLR9 agonist enhances liver tumor microenvironment reprogramming and MDSC reduction to improve responsiveness to systemic checkpoint inhibition von Ghosh, Chandra C., Heatherton, Kara R., Connell, Kyle P. O’, Alexander, Ian S., Greer, Deborah A., LaPorte, Jason, Guha, Prajna, Cox, Bryan F., Katz, Steven C.

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Pressure-enabled delivery of gemcitabine in an orthotopic pancreatic cancer mouse model von Shankara Narayanan, Jayanth S., Vicente, Diego A., Ray, Partha, Chai, Louis F., Erdem, Suna, Carr, Matthew J., Capacio, Benedict A., Cox, Bryan F., Jaroch, David B., Katz, Steven C., White, Rebekah R.

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Antigen Receptor T Cells (CAR-T) Effectively Control Tumor Growth in a Colorectal Liver Metastasis Model von Chai, Louis F., Hardaway, John C., Heatherton, Kara R., O'Connell, Kyle P., LaPorte, Jason P., Guha, Prajna, Lopes, Mikayla C., Rabinowitz, Benjamin A., Jaroch, David, Cox, Bryan F., Knight, Robert, Katz, Steven C.

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Effect of the Multitargeted Receptor Tyrosine Kinase Inhibitor, ABT-869 [N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N′-(2-fluoro-5-methylphenyl)urea], on Blood Pressure in Conscious R... von Franklin, Pamela H, Banfor, Patricia N, Tapang, Paul, Segreti, Jason A, Widomski, Deborah L, Larson, Kelly J, Noonan, William T, Gintant, Gary A, Davidsen, Steven K, Albert, Daniel H, Fryer, Ryan M, Cox, Bryan F

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Effects of selective dopamine receptor subtype agonists on cardiac contractility and regional haemodynamics in rats von Polakowski, James S, Segreti, Jason A, Cox, Bryan F, Hsieh, Gin C, Kolasa, Teodozyj, Moreland, Robert B, Brioni, Jorge D

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