Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML von Puram, Rishi V., Kowalczyk, Monika S., de Boer, Carl G., Schneider, Rebekka K., Miller, Peter G., McConkey, Marie, Tothova, Zuzana, Tejero, Héctor, Heckl, Dirk, Järås, Marcus, Chen, Michelle C., Li, Hubo, Tamayo, Alfred, Cowley, Glenn S., Rozenblatt-Rosen, Orit, Al-Shahrour, Fatima, Regev, Aviv, Ebert, Benjamin L.

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β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis von Rosenbluh, Joseph, Nijhawan, Deepak, Cox, Andrew G., Li, Xingnan, Neal, James T., Schafer, Eric J., Zack, Travis I., Wang, Xiaoxing, Tsherniak, Aviad, Schinzel, Anna C., Shao, Diane D., Schumacher, Steven E., Weir, Barbara A., Vazquez, Francisca, Cowley, Glenn S., Root, David E., Mesirov, Jill P., Beroukhim, Rameen, Kuo, Calvin J., Goessling, Wolfram, Hahn, William C.

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(R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible von Losman, Julie-Aurore, Looper, Ryan E., Koivunen, Peppi, Lee, Sungwoo, Schneider, Rebekka K., McMahon, Christine, Cowley, Glenn S., Root, David E., Ebert, Benjamin L., Kaelin, William G.

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Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4CRBN activity von Sievers, Quinlan L., Gasser, Jessica A., Cowley, Glenn S., Fischer, Eric S., Ebert, Benjamin L.

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Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden von Stone, Meredith L., Chiappinelli, Katherine B., Li, Huili, Murphy, Lauren M., Travers, Meghan E., Topper, Michael J., Mathios, Dimitrios, Lim, Michael, Shih, Ie-Ming, Wang, Tian-Li, Hung, Chien-Fu, Bhargava, Vipul, Wiehagen, Karla R., Cowley, Glenn S., Bachman, Kurtis E., Strick, Reiner, Strissel, Pamela L., Baylin, Stephen B., Zahnow, Cynthia A.

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A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition von Whittaker, Steven R, Theurillat, Jean-Philippe, Van Allen, Eliezer, Wagle, Nikhil, Hsiao, Jessica, Cowley, Glenn S, Schadendorf, Dirk, Root, David E, Garraway, Levi A

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Cancer Vulnerabilities Unveiled by Genomic Loss von Nijhawan, Deepak, Zack, Travis I., Ren, Yin, Strickland, Matthew R., Lamothe, Rebecca, Schumacher, Steven E., Tsherniak, Aviad, Besche, Henrike C., Rosenbluh, Joseph, Shehata, Shyemaa, Cowley, Glenn S., Weir, Barbara A., Goldberg, Alfred L., Mesirov, Jill P., Root, David E., Bhatia, Sangeeta N., Beroukhim, Rameen, Hahn, William C.

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SQSTM1 Is a Pathogenic Target of 5q Copy Number Gains in Kidney Cancer von Li, Lianjie, Shen, Chuan, Nakamura, Eijiro, Ando, Kiyohiro, Signoretti, Sabina, Beroukhim, Rameen, Cowley, Glenn S., Lizotte, Patrick, Liberzon, Ella, Bair, Steven, Root, David E., Tamayo, Pablo, Tsherniak, Aviad, Cheng, Su-Chun, Tabak, Barbara, Jacobsen, Anders, Hakimi, A. Ari, Schultz, Nikolaus, Ciriello, Giovanni, Sander, Chris, Hsieh, James J., Kaelin, William G.

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Combined Pan-RAF and MEK Inhibition Overcomes Multiple Resistance Mechanisms to Selective RAF Inhibitors von Whittaker, Steven R, Cowley, Glenn S, Wagner, Steve, Luo, Flora, Root, David E, Garraway, Levi A

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The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity von Ramirez-Ortiz, Zaida G, Prasad, Amit, Griffith, Jason W, Pendergraft, William F, Cowley, Glenn S, Root, David E, Tai, Melissa, Luster, Andrew D, El Khoury, Joseph, Hacohen, Nir, Means, Terry K

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Synthetic lethal screening in the mammalian central nervous system identifies Gpx6 as a modulator of Huntington’s disease von Shema, Reut, Kulicke, Ruth, Cowley, Glenn S., Stein, Rachael, Root, David E., Heiman, Myriam

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Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia von Järås, Marcus, Miller, Peter G, Chu, Lisa P, Puram, Rishi V, Fink, Emma C, Schneider, Rebekka K, Al-Shahrour, Fatima, Peña, Pablo, Breyfogle, L Jordan, Hartwell, Kimberly A, McConkey, Marie E, Cowley, Glenn S, Root, David E, Kharas, Michael G, Mullally, Ann, Ebert, Benjamin L

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A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor von Eller, Carla, Heydmann, Laura, Colpitts, Che C., El Saghire, Houssein, Piccioni, Federica, Jühling, Frank, Majzoub, Karim, Pons, Caroline, Bach, Charlotte, Lucifora, Julie, Lupberger, Joachim, Nassal, Michael, Cowley, Glenn S., Fujiwara, Naoto, Hsieh, Sen-Yung, Hoshida, Yujin, Felli, Emanuele, Pessaux, Patrick, Sureau, Camille, Schuster, Catherine, Root, David E., Verrier, Eloi R., Baumert, Thomas F.

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Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8⁺ T-cell effector differentiation von Godec, Jernej, Cowley, Glenn S., Barnitz, R. Anthony, Root, David E., Sharpe, Arlene H., Haining, W. Nicholas

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The methyltransferase domain of DNMT1 is an essential domain in acute myeloid leukemia independent of DNMT3A mutation von Bhogal, Balpreet, Weir, Barbara A., Crescenzo, Ramona, Marien, Ann, Kwon, Min Chul, Philippar, Ulrike, Cowley, Glenn S.

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The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection von Filone, Claire Marie, Caballero, Ignacio S, Dower, Ken, Mendillo, Marc L, Cowley, Glenn S, Santagata, Sandro, Rozelle, Daniel K, Yen, Judy, Rubins, Kathleen H, Hacohen, Nir, Root, David E, Hensley, Lisa E, Connor, John

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Defining a Cancer Dependency Map von Tsherniak, Aviad, Vazquez, Francisca, Montgomery, Phil G., Weir, Barbara A., Kryukov, Gregory, Cowley, Glenn S., Gill, Stanley, Harrington, William F., Pantel, Sasha, Krill-Burger, John M., Meyers, Robin M., Ali, Levi, Goodale, Amy, Lee, Yenarae, Jiang, Guozhi, Hsiao, Jessica, Gerath, William F.J., Howell, Sara, Merkel, Erin, Ghandi, Mahmoud, Garraway, Levi A., Root, David E., Golub, Todd R., Boehm, Jesse S., Hahn, William C.

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Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis von Nandakumar, Satish K, McFarland, Sean K, Mateyka, Laura M, Lareau, Caleb A, Ulirsch, Jacob C, Ludwig, Leif S, Agarwal, Gaurav, Engreitz, Jesse M, Przychodzen, Bartlomiej, McConkey, Marie, Cowley, Glenn S, Doench, John G, Maciejewski, Jaroslaw P, Ebert, Benjamin L, Root, David E, Sankaran, Vijay G

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Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells von Meyers, Robin M, Bryan, Jordan G, McFarland, James M, Weir, Barbara A, Sizemore, Ann E, Xu, Han, Dharia, Neekesh V, Montgomery, Phillip G, Cowley, Glenn S, Pantel, Sasha, Goodale, Amy, Lee, Yenarae, Ali, Levi D, Jiang, Guozhi, Lubonja, Rakela, Harrington, William F, Strickland, Matthew, Wu, Ting, Hawes, Derek C, Zhivich, Victor A, Wyatt, Meghan R, Kalani, Zohra, Chang, Jaime J, Okamoto, Michael, Stegmaier, Kimberly, Golub, Todd R, Boehm, Jesse S, Vazquez, Francisca, Root, David E, Hahn, William C, Tsherniak, Aviad

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MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells von Kryukov, Gregory V., Wilson, Frederick H., Ruth, Jason R., Paulk, Joshiawa, Tsherniak, Aviad, Marlow, Sara E., Vazquez, Francisca, Weir, Barbara A., Fitzgerald, Mark E., Tanaka, Minoru, Bielski, Craig M., Scott, Justin M., Dennis, Courtney, Cowley, Glenn S., Boehm, Jesse S., Root, David E., Golub, Todd R., Clish, Clary B., Bradner, James E., Hahn, William C., Garraway, Levi A.

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