Ten things you should know about protein kinases: IUPHAR Review 14 von Fabbro, Doriano, Cowan‐Jacob, Sandra W, Moebitz, Henrik

Volltext

The specificity of asciminib, a potential treatment for chronic myeloid leukemia, as a myristate-pocket binding ABL inhibitor and analysis of its interactions with mutant forms of... von Manley, Paul W., Barys, Louise, Cowan-Jacob, Sandra W.

Volltext

Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1 von Schoepfer, Joseph, Jahnke, Wolfgang, Berellini, Giuliano, Buonamici, Silvia, Cotesta, Simona, Cowan-Jacob, Sandra W, Dodd, Stephanie, Drueckes, Peter, Fabbro, Doriano, Gabriel, Tobias, Groell, Jean-Marc, Grotzfeld, Robert M, Hassan, A. Quamrul, Henry, Chrystèle, Iyer, Varsha, Jones, Darryl, Lombardo, Franco, Loo, Alice, Manley, Paul W, Pellé, Xavier, Rummel, Gabriele, Salem, Bahaa, Warmuth, Markus, Wylie, Andrew A, Zoller, Thomas, Marzinzik, Andreas L, Furet, Pascal

Volltext

The allosteric inhibitor ABL001 enables dual targeting of BCR–ABL1 von Wylie, Andrew A., Schoepfer, Joseph, Jahnke, Wolfgang, Cowan-Jacob, Sandra W., Loo, Alice, Furet, Pascal, Marzinzik, Andreas L., Pelle, Xavier, Donovan, Jerry, Zhu, Wenjing, Buonamici, Silvia, Hassan, A. Quamrul, Lombardo, Franco, Iyer, Varsha, Palmer, Michael, Berellini, Giuliano, Dodd, Stephanie, Thohan, Sanjeev, Bitter, Hans, Branford, Susan, Ross, David M., Hughes, Timothy P., Petruzzelli, Lilli, Vanasse, K. Gary, Warmuth, Markus, Hofmann, Francesco, Keen, Nicholas J., Sellers, William R.

Volltext

Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl von Weisberg, Ellen, Manley, Paul W., Breitenstein, Werner, Brüggen, Josef, Cowan-Jacob, Sandra W., Ray, Arghya, Huntly, Brian, Fabbro, Doriano, Fendrich, Gabriele, Hall-Meyers, Elizabeth, Kung, Andrew L., Mestan, Jürgen, Daley, George Q., Callahan, Linda, Catley, Laurie, Cavazza, Cara, Mohammed, Azam, Neuberg, Donna, Wright, Renee D., Gilliland, D. Gary, Griffin, James D.

Volltext

Microseed matrix screening for optimization in protein crystallization: what have we learned? von D'Arcy, Allan, Bergfors, Terese, Cowan-Jacob, Sandra W., Marsh, May

Volltext

Genotypic variation in phenological plasticity: Reciprocal common gardens reveal adaptive responses to warmer springs but not to fall frost von Cooper, Hillary F., Grady, Kevin C., Cowan, Jacob A., Best, Rebecca J., Allan, Gerard J., Whitham, Thomas G.

Volltext

In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants von O'HARE, Thomas, WALTERS, Denise K, DRUKER, Brian J, STOFFREGEN, Eric P, TAIPING JIA, MANLEY, Paul W, MESTAN, Jürgen, COWAN-JACOB, Sandra W, LEE, Francis Y, HEINRICH, Michael C, DEININGER, Michael W. N

Volltext

The Dawn of Allosteric BCR-ABL1 Drugs: From a Phenotypic Screening Hit to an Approved Drug von Teng, Mingxing, Luskin, Marlise R, Cowan-Jacob, Sandra W, Ding, Qiang, Fabbro, Doriano, Gray, Nathanael S

Volltext

Second generation inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukaemia von Weisberg, Ellen, Manley, Paul W., Cowan-Jacob, Sandra W., Hochhaus, Andreas, Griffin, James D.

Volltext

The Crystal Structure of a c-Src Complex in an Active Conformation Suggests Possible Steps in c-Src Activation von Cowan-Jacob, Sandra W., Fendrich, Gabriele, Manley, Paul W., Jahnke, Wolfgang, Fabbro, Doriano, Liebetanz, Janis, Meyer, Thomas

Volltext

Ectomycorrhizal (dipterocarp) and arbuscular mycorrhizal (non‐dipterocarp) tree hosts and their relative distribution in a tropical forest predict soil bacterial communities von Cowan, Jacob A., Gehring, Catherine A., Axelsson, E. Petter, Ilstedt, Ulrik, Subbiah, Vijay Kumar, Grady, Kevin C.

Volltext

Structural resemblances and comparisons of the relative pharmacological properties of imatinib and nilotinib von Manley, Paul W., Stiefl, Nikolaus, Cowan-Jacob, Sandra W., Kaufman, Susan, Mestan, Jürgen, Wartmann, Markus, Wiesmann, Marion, Woodman, Richard, Gallagher, Neil

Volltext

AMN107 (nilotinib): a novel and selective inhibitor of BCR-ABL von Weisberg, E, Manley, P, Mestan, J, Cowan-Jacob, S, Ray, A, Griffin, J D

Volltext

Invasive and native grasses exert negative plant–soil feedbacks on the woody shrub Artemisia tridentata von Cowan, Jacob A., Grady, Kevin C., Dijkstra, Paul, Schwartz, Egbert, Gehring, Catherine A.

Volltext

Solution Conformations and Dynamics of ABL Kinase-Inhibitor Complexes Determined by NMR Substantiate the Different Binding Modes of Imatinib/Nilotinib and Dasatinib von Vajpai, Navratna, Strauss, André, Fendrich, Gabriele, Cowan-Jacob, Sandra W., Manley, Paul W., Grzesiek, Stephan, Jahnke, Wolfgang

Volltext

Correspondence on “Synergy and Antagonism between Allosteric and Active‐Site Inhibitors of Abl Tyrosine Kinase” von Jahnke, Wolfgang, Paladini, Johannes, Habazettl, Judith M., Wiget, Andrea, Loo, Alice, Cowan Jacob, Sandra W., Grzesiek, Stephan, Manley, Paul W.

Volltext

Imatinib: a selective tyrosine kinase inhibitor von Manley, P.W., Cowan-Jacob, S.W., Buchdunger, E., Fabbro, D., Fendrich, G., Furet, P., Meyer, T., Zimmermann, J.

Volltext

Type II Inhibitors Targeting CDK2 von Alexander, Leila T, Möbitz, Henrik, Drueckes, Peter, Savitsky, Pavel, Fedorov, Oleg, Elkins, Jonathan M, Deane, Charlotte M, Cowan-Jacob, Sandra W, Knapp, Stefan

Volltext

Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors von Zhang, Jianming, Adrián, Francisco J., Jahnke, Wolfgang, Cowan-Jacob, Sandra W., Li, Allen G., Iacob, Roxana E., Sim, Taebo, Powers, John, Dierks, Christine, Sun, Fangxian, Guo, Gui-Rong, Ding, Qiang, Okram, Barun, Choi, Yongmun, Wojciechowski, Amy, Deng, Xianming, Liu, Guoxun, Fendrich, Gabriele, Strauss, André, Vajpai, Navratna, Grzesiek, Stephan, Tuntland, Tove, Liu, Yi, Bursulaya, Badry, Azam, Mohammad, Manley, Paul W., Engen, John R., Daley, George Q., Warmuth, Markus, Gray, Nathanael S.

Volltext