CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity von Guo, W, Wang, H, Kumar Tharkeshwar, A, Couthouis, J, Braems, E, Masrori, P, Van Schoor, E, Fan, Y, Ahuja, K, Moisse, M, Jacquemyn, M, Furtado Madeiro da Costa, R, Gajjar, M, Balusu, S, Tricot, T, Fumagalli, L, Hersmus, N, Janky, R, Impens, Francis, Vanden Berghe, P, Ho, R, Thal, DR, Vandenberghe, R, Hegde, ML, Chandran, S, De Strooper, B, Daelemans, D, Van Damme, P, Van Den Bosch, L, Verfaillie, C

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The toxicity of an "artificial" amyloid is related to how it interacts with membranes von Couthouis, Julien, Marchal, Christelle, D'Angelo, Fabien, Berthelot, Karine, Cullin, Christophe

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Screening for toxic amyloid in yeast exemplifies the role of alternative pathway responsible for toxicity von Couthouis, J., Rébora, Karine, Immel, Françoise, Berthelot, Karine, Castroviejo, M., Cullin, Christophe

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Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways von Cirulli, ET, Lasseigne, BN, Petrovski, S, Sapp, PC, Dion, PA, Leblond, CS, Couthouis, J, Lu, YF, Wang, Q, Krueger, BJ, Ren, Z, Keebler, J, Han, Y, Levy, SE, Boone, BE, Wimbish, JR, Waite, LL, Jones, AL, Carulli, JP, Day-Williams, AG, Staropoli, JF, Xin, WW, Chesi, A, Raphael, AR, McKenna-Yasek, D, Cady, J, Vianney de Jong, JM, Kenna, KP, Smith, BN, Topp, S, Miller, J, Gkazi, A, FALS Sequencing Consortium, Al-Chalabi, A, van den Berg, LH, Veldink, J, Silani, V, Ticozzi, N, Shaw, CE, Baloh, RH, Appel, S, Simpson, E, Lagier-Tourenne, C, Pulst, SM, Gibson, S, Trojanowski, JQ, Elman, L, McCluskey, L, Grossman, M, Shneider, NA, Chung, WK, Ravits, JM, Glass, JD, Sims, KB, Van Deerlin, VM, Maniatis, T, Hayes, SD, Ordureau, A, Swarup, S, Landers, J, Baas, F, Allen, AS, Bedlack, RS, Harper, JW, Gitler, AD, Rouleau, GA, Brown, R, Harms, MB, Cooper, GM, Harris, T, Myers, RM, Goldstein, DB

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CRISPR–Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity von Kramer, Nicholas J., Haney, Michael S., Morgens, David W., Jovičić, Ana, Couthouis, Julien, Li, Amy, Ousey, James, Ma, Rosanna, Bieri, Gregor, Tsui, C. Kimberly, Shi, Yingxiao, Hertz, Nicholas T., Tessier-Lavigne, Marc, Ichida, Justin K., Bassik, Michael C., Gitler, Aaron D.

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LRRK2 modifies α-syn pathology and spread in mouse models and human neurons von Bieri, Gregor, Brahic, Michel, Bousset, Luc, Couthouis, Julien, Kramer, Nicholas J., Ma, Rosanna, Nakayama, Lisa, Monbureau, Marie, Defensor, Erwin, Schüle, Birgitt, Shamloo, Mehrdad, Melki, Ronald, Gitler, Aaron D.

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p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR) von Maor-Nof, Maya, Shipony, Zohar, Lopez-Gonzalez, Rodrigo, Nakayama, Lisa, Zhang, Yong-Jie, Couthouis, Julien, Blum, Jacob A., Castruita, Patricia A., Linares, Gabriel R., Ruan, Kai, Ramaswami, Gokul, Simon, David J., Nof, Aviv, Santana, Manuel, Han, Kyuho, Sinnott-Armstrong, Nasa, Bassik, Michael C., Geschwind, Daniel H., Tessier-Lavigne, Marc, Attardi, Laura D., Lloyd, Thomas E., Ichida, Justin K., Gao, Fen-Biao, Greenleaf, William J., Yokoyama, Jennifer S., Petrucelli, Leonard, Gitler, Aaron D.

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Loss of neuronal Tet2 enhances hippocampal-dependent cognitive function von Pratt, Karishma J.B., Shea, Jeremy M., Remesal-Gomez, Laura, Bieri, Gregor, Smith, Lucas K., Couthouis, Julien, Chen, Christopher P., Roy, Irena J., Gontier, Geraldine, Villeda, Saul A.

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Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts von Kramer, Nicholas J., Carlomagno, Yari, Zhang, Yong-Jie, Almeida, Sandra, Cook, Casey N., Gendron, Tania F., Prudencio, Mercedes, Van Blitterswijk, Marka, Belzil, Veronique, Couthouis, Julien, Paul, Joseph West, Goodman, Lindsey D., Daughrity, Lillian, Chew, Jeannie, Garrett, Aliesha, Pregent, Luc, Jansen-West, Karen, Tabassian, Lilia J., Rademakers, Rosa, Boylan, Kevin, Graff-Radford, Neill R., Josephs, Keith A., Parisi, Joseph E., Knopman, David S., Petersen, Ronald C., Boeve, Bradley F., Deng, Ning, Feng, Yanan, Cheng, Tzu-Hao, Dickson, Dennis W., Cohen, Stanley N., Bonini, Nancy M., Link, Christopher D., Gao, Fen-Biao, Petrucelli, Leonard, Gitler, Aaron D.

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LRRK2 modifies [alpha]-syn pathology and spread in mouse models and human neurons von Bieri, Gregor, Brahic, Michel, Bousset, Luc, Couthouis, Julien, Kramer, Nicholas J, Ma, Rosanna, Nakayama, Lisa

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Loss of neuronal Tet2 enhances hippocampal-dependent cognitive function von Pratt, Karishma J.B., Shea, Jeremy M., Remesal-Gomez, Laura, Bieri, Gregor, Smith, Lucas K., Couthouis, Julien, Chen, Christopher P., Roy, Irena J., Gontier, Geraldine, Villeda, Saul A.

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Variants in KIAA0825 underlie autosomal recessive postaxial polydactyly von Ullah, Irfan, Kakar, Naseebullah, Schrauwen, Isabelle, Hussain, Shabir, Chakchouk, Imen, Liaqat, Khurram, Acharya, Anushree, Wasif, Naveed, Santos-Cortez, Regie Lyn P., Khan, Saadullah, Aziz, Abdul, Lee, Kwanghyuk, Couthouis, Julien, Horn, Denise, Kragesteen, Bjørt K., Spielmann, Malte, Thiele, Holger, Nickerson, Deborah A., Bamshad, Michael J., Gitler, Aaron D., Ahmad, Jamil, Ansar, Muhammad, Borck, Guntram, Ahmad, Wasim, Leal, Suzanne M.

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Phenotypic Heterogeneity among GBA p.R202X Carriers in Lewy Body Spectrum Disorders von Napolioni, Valerio, Fredericks, Carolyn A, Kim, Yongha, Channappa, Divya, Khan, Raiyan R, Kim, Lily H, Zafar, Faria, Couthouis, Julien, Davidzon, Guido A, Mormino, Elizabeth C, Gitler, Aaron D, Montine, Thomas J, Schüle, Birgitt, Greicius, Michael D

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CRISPR–Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptiderepeat- protein toxicity von Kramer, Nicholas J, Haney, Michael S, Morgens, David W, Jovičić, Ana, Couthouis, Julien, Li, Amy, Ousey, James, Ma, Rosanna, Bieri, Gregor, Tsui, C Kimberly, Shi, Yingxiao, Hertz, Nicholas T, Tessier-Lavigne, Marc, Ichida, Justin K, Bassik, Michael C, Gitler, Aaron D

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Exome sequencing identifies a DNAJB6 mutation in a family with dominantly-inherited limb-girdle muscular dystrophy von Couthouis, Julien, Raphael, Alya R, Siskind, Carly, Findlay, Andrew R, Buenrostro, Jason D, Greenleaf, William J, Vogel, Hannes, Day, John W, Flanigan, Kevin M, Gitler, Aaron D

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IDENTIFICATION OF AN ITGA7 VARIANT ASSOCIATED WITH ALZHEIMER’S DISEASE AND MULTIPLE OTHER NEURODEGENERATIVE DISEASES von Khan, Raiyan R., Napolioni, Valerio, Altmann, Andre, Seeley, William W., Montine, Thomas J., Coppola, Giovanni, Chen, Jason A., Plowey, Edward D., Channappa, Divya, Gitler, Aaron D., Couthouis, Julien, Flanagan, Margaret E., Greicius, Michael D.

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Exome sequencing to identify de novo mutations in sporadic ALS trios von Chesi, Alessandra, Staahl, Brett T, Jovičić, Ana, Couthouis, Julien, Fasolino, Maria, Raphael, Alya R, Yamazaki, Tomohiro, Elias, Laura, Polak, Meraida, Kelly, Crystal, Williams, Kelly L, Fifita, Jennifer A, Maragakis, Nicholas J, Nicholson, Garth A, King, Oliver D, Reed, Robin, Crabtree, Gerald R, Blair, Ian P, Glass, Jonathan D, Gitler, Aaron D

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Confirming Pathogenicity of the F386L PSEN1 Variant in a South Asian Family With Early-Onset Alzheimer Disease von Eger, Sarah J., Le Guen, Yann, Khan, Raiyan R., Hall, Jacob N., Kennedy, Gabriel, Zaharchuk, Greg, Couthouis, Julien, Brooks, William S., Velakoulis, Dennis, Napolioni, Valerio, Belloy, Michaël E., Dalgard, Clifton L., Mormino, Elizabeth C., Gitler, Aaron D., Greicius, Michael D.

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Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts associated with c9FTD/ALS von Kramer, Nicholas J., Carlomagno, Yari, Zhang, Yong-Jie, Almeida, Sandra, Cook, Casey N., Gendron, Tania F., Prudencio, Mercedes, Van Blitterswijk, Marka, Belzil, Veronique, Couthouis, Julien, Paul, Joseph West, Goodman, Lindsey D., Daughrity, Lillian, Chew, Jeannie, Garrett, Aliesha, Pregent, Luc, Jansen-West, Karen, Tabassian, Lilia J., Rademakers, Rosa, Boylan, Kevin, Graff-Radford, Neill R., Josephs, Keith A., Parisi, Joseph E., Knopman, David S., Petersen, Ronald C., Boeve, Bradley F., Deng, Ning, Feng, Yanan, Cheng, Tzu-Hao, Dickson, Dennis W., Cohen, Stanley N., Bonini, Nancy M., Link, Christopher D., Gao, Fen-Biao, Petrucelli, Leonard, Gitler, Aaron D.

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Exome sequencing to identify de novo mutations in sporadic ALS trios von Chesi, Alessandra, Staahl, Brett T, Jovicic, Ana, Couthouis, Julien, Fasolino, Maria, Raphael, Alya R, Yamazaki, Tomohiro, Elias, Laura, Polak, Meraida, Kelly, Crystal, Williams, Kelly L, Fifita, Jennifer A, Maragakis, Nicholas J, Nicholson, Garth A, King, Oliver D, Reed, Robin, Crabtree, Gerald R, Blair, Ian P, Glass, Jonathan D, Gitler, Aaron D

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