Targeting Energy Metabolism in Cancer Stem Cells: Progress and Challenges in Leukemia and Solid Tumors von Jones, Courtney L., Inguva, Anagha, Jordan, Craig T.

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NOX2: determinant of acute myeloid leukemia survival von Jones, Courtney L

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Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells von Jones, Courtney L., Stevens, Brett M., D'Alessandro, Angelo, Reisz, Julie A., Culp-Hill, Rachel, Nemkov, Travis, Pei, Shanshan, Khan, Nabilah, Adane, Biniam, Ye, Haobin, Krug, Anna, Reinhold, Dominik, Smith, Clayton, DeGregori, James, Pollyea, Daniel A., Jordan, Craig T.

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The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition in AML Cells von Nechiporuk, Tamilla, Kurtz, Stephen E, Nikolova, Olga, Liu, Tingting, Jones, Courtney L, D'Alessandro, Angelo, Culp-Hill, Rachel, d'Almeida, Amanda, Joshi, Sunil K, Rosenberg, Mara, Tognon, Cristina E, Danilov, Alexey V, Druker, Brian J, Chang, Bill H, McWeeney, Shannon K, Tyner, Jeffrey W

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Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II von Jones, Courtney L., Stevens, Brett M., D'Alessandro, Angelo, Culp-Hill, Rachel, Reisz, Julie A., Pei, Shanshan, Gustafson, Annika, Khan, Nabilah, DeGregori, James, Pollyea, Daniel A., Jordan, Craig T.

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Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes von Stevens, Brett M., Khan, Nabilah, D’Alessandro, Angelo, Nemkov, Travis, Winters, Amanda, Jones, Courtney L., Zhang, Wei, Pollyea, Daniel A., Jordan, Craig T.

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Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells von Jones, Courtney L., Stevens, Brett M., D’Alessandro, Angelo, Reisz, Julie A., Culp-Hill, Rachel, Nemkov, Travis, Pei, Shanshan, Khan, Nabilah, Adane, Biniam, Ye, Haobin, Krug, Anna, Reinhold, Dominik, Smith, Clayton, DeGregori, James, Pollyea, Daniel A., Jordan, Craig T.

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The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells von Adane, Biniam, Ye, Haobin, Khan, Nabilah, Pei, Shanshan, Minhajuddin, Mohammad, Stevens, Brett M., Jones, Courtney L., D’Alessandro, Angelo, Reisz, Julie A., Zaberezhnyy, Vadym, Gasparetto, Maura, Ho, Tzu-Chieh, Kelly, Kathleen K., Myers, Jason R., Ashton, John M., Siegenthaler, Julie, Kume, Tsutomu, Campbell, Eric L., Pollyea, Daniel A., Becker, Michael W., Jordan, Craig T.

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Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicity von O'Brien, Cristiana, Ling, Tianyi, Berman, Jacob M, Culp-Hill, Rachel, Reisz, Julie A, Rondeau, Vincent, Jahangiri, Soheil, St-Germain, Jonathan, Macwan, Vinitha, Astori, Audrey, Zeng, Andy, Hong, Jun Young, Li, Meng, Yang, Min, Jana, Sadhan, Gamboni, Fabia, Tsao, Emily, Liu, Weiyi, Dick, John E, Lin, Hening, Melnick, Ari, Tikhonova, Anastasia, Arruda, Andrea, Minden, Mark D, Raught, Brian, D'Alessandro, Angelo, Jones, Courtney L

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Turning Down the Temperature on Leukemia Stem Cells von Jones, Courtney L

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Partition layer-modified substrates for reversible surface-enhanced Raman scattering detection of polycyclic aromatic hydrocarbons von Jones, Courtney L, Bantz, Kyle C, Haynes, Christy L

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Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia von Pollyea, Daniel A., Stevens, Brett M., Jones, Courtney L., Winters, Amanda, Pei, Shanshan, Minhajuddin, Mohammad, D’Alessandro, Angelo, Culp-Hill, Rachel, Riemondy, Kent A., Gillen, Austin E., Hesselberth, Jay R., Abbott, Diana, Schatz, Derek, Gutman, Jonathan A., Purev, Enkhtsetseg, Smith, Clayton, Jordan, Craig T.

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Therapy-Resistant Acute Myeloid Leukemia Stem Cells Are Resensitized to Venetoclax + Azacitidine by Targeting Fatty Acid Desaturases 1 and 2 von Culp-Hill, Rachel, Stevens, Brett M, Jones, Courtney L, Pei, Shanshan, Dzieciatkowska, Monika, Minhajuddin, Mohammad, Jordan, Craig T, D'Alessandro, Angelo

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Enriching for human acute myeloid leukemia stem cells using reactive oxygen species-based cell sorting von Stevens, Brett M., O’Brien, Cristiana, Jordan, Craig T., Jones, Courtney L.

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Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells von Jones, Courtney L., Stevens, Brett M., Pollyea, Daniel A., Culp-Hill, Rachel, Reisz, Julie A., Nemkov, Travis, Gehrke, Sarah, Gamboni, Fabia, Krug, Anna, Winters, Amanda, Pei, Shanshan, Gustafson, Annika, Ye, Haobin, Inguva, Anagha, Amaya, Maria, Minhajuddin, Mohammad, Abbott, Diana, Becker, Michael W., DeGregori, James, Smith, Clayton A., D’Alessandro, Angelo, Jordan, Craig T.

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Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia von Pei, Shanshan, Pollyea, Daniel A, Gustafson, Annika, Stevens, Brett M, Minhajuddin, Mohammad, Fu, Rui, Riemondy, Kent A, Gillen, Austin E, Sheridan, Ryan M, Kim, Jihye, Costello, James C, Amaya, Maria L, Inguva, Anagha, Winters, Amanda, Ye, Haobin, Krug, Anna, Jones, Courtney L, Adane, Biniam, Khan, Nabilah, Ponder, Jessica, Schowinsky, Jeffrey, Abbott, Diana, Hammes, Andrew, Myers, Jason R, Ashton, John M, Nemkov, Travis, D'Alessandro, Angelo, Gutman, Jonathan A, Ramsey, Haley E, Savona, Michael R, Smith, Clayton A, Jordan, Craig T

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Fatty acid metabolism underlies venetoclax resistance in acute myeloid leukemia stem cells von Stevens, Brett M, Jones, Courtney L, Pollyea, Daniel A, Culp-Hill, Rachel, D'Alessandro, Angelo, Winters, Amanda, Krug, Anna, Abbott, Diana, Goosman, Madeline, Pei, Shanshan, Ye, Haobin, Gillen, Austin E, Becker, Michael W, Savona, Michael R, Smith, Clayton, Jordan, Craig T

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The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness von Thomas, Geethu Emily, Egan, Grace, García-Prat, Laura, Botham, Aaron, Voisin, Veronique, Patel, Parasvi S., Hoff, Fieke W., Chin, Jordan, Nachmias, Boaz, Kaufmann, Kerstin B., Khan, Dilshad H., Hurren, Rose, Wang, Xiaoming, Gronda, Marcela, MacLean, Neil, O’Brien, Cristiana, Singh, Rashim P., Jones, Courtney L., Harding, Shane M., Raught, Brian, Arruda, Andrea, Minden, Mark D., Bader, Gary D., Hakem, Razq, Kornblau, Steve, Dick, John E., Schimmer, Aaron D.

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Introductions to the community: Early-career researchers in the time of COVID-19 von Agudo, Judith, Cheng, Chia-Wei, Jones, Courtney L., Avgustinova, Alexandra, Rodriguez-Fraticelli, Alejo E., Storer, Mekayla

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SIRT5 IS A DRUGGABLE METABOLIC VULNERABILITY IN ACUTE MYELOID LEUKEMIA von Yan, Dongqing, Franzini, Anca, Pomicter, Anthony D, Halverson, Brayden J, Antelope, Orlando, Mason, Clinton C, Ahmann, Jonathan M, Senina, Anna V, Vellore, Nadeem A, Jones, Courtney L, Zabriskie, Matthew S, Than, Hein, Xiao, Michael J, van Scoyk, Alexandria, Patel, Ami B, Clair, Phillip M, Heaton, William L, Owen, Shawn C, Andersen, Joshua L, Egbert, Christina M, Reisz, Julie A, D'Alessandro, Angelo, Cox, James E, Gantz, Kevin C, Redwine, Hannah M, Iyer, Siddharth M, Khorashad, Jamshid S, Rajabi, Nima, Olsen, Christian A, O'Hare, Thomas, Deininger, Michael W

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