Single-nucleotide polymorphisms associated with outcome in metastatic renal cell carcinoma treated with sunitinib von Beuselinck, B, Karadimou, A, Lambrechts, D, Claes, B, Wolter, P, Couchy, G, Berkers, J, Paridaens, R, Schöffski, P, Méjean, A, Verkarre, V, Lerut, E, de la Taille, A, Tourani, J-M, Bigot, P, Linassier, C, Négrier, S, Berger, J, Patard, J-J, Zucman-Rossi, J, Oudard, S

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RANK/OPG ratio of expression in primary clear-cell renal cell carcinoma is associated with bone metastasis and prognosis in patients treated with anti-VEGFR-TKIs von Beuselinck, B, Jean-Baptiste, J, Couchy, G, Job, S, De Reynies, A, Wolter, P, Théodore, C, Gravis, G, Rousseau, B, Albiges, L, Joniau, S, Verkarre, V, Lerut, E, Patard, J J, Schöffski, P, Méjean, A, Elaidi, R, Oudard, S, Zucman-Rossi, J

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Tumor molecular characteristics in patients (pts) with international metastatic renal cell carcinoma database consortium (IMDC) good (G) and intermediate/poor (I/P) risk von Beuselinck, B., Verbiest, A., Couchy, G., Job, S., de Reyniès, A., Caruso, S., Verkarre, V., Rioux-Leclercq, N., Schöffski, P., Vano, Y., Elaidi, R.-T., Lerut, E., Albersen, M., Oudard, S., Zucman-Rossi, J.

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Histological subtypes of hepatocellular carcinoma are related to gene mutations and molecular tumor classification von Calderaro, J, Couchy, G, Imbeaud, S, Amaddeo, G, Blanc, J.-F, Laurent, C, Hajji, Y, Azoulay, D, Bioulac-Sage, P, Zucman-Rossi, J

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Recurrent INHBE-GLI1 fusions in hepatocellular adenomas with sonic hedgehog pathway activation von Nault, J.C, Couchy, G, Balabaud, C, Morcrette, G, Caruso, S, Blanc, J.-F, Bacq, Y, Caldéraro, J, Paradis, V, Ramos, J, Gnemmi, V, Sturm, N, Savier, E, Chiche, L, Selves, J, Pilati, C, Laurent, A, DeMuret, A, Lebail, B, Rebouissou, S, Imbeaud, S, Bioulac-Sage, P, Letouze, E, Zucman-Rossi, J

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Genotype-Phenotype Correlation of CTNNB1 Mutations Reveals Different B-Catenin Activation Levels in Hepatocellular Tumors with High Activity Associated with Malignancy von Rebouissou, S, Franconi, A, Calderaro, J, Letouzé, E, Imbeaud, S, Pilati, C, Nault, J.-C, Couchy, G, Laurent, A, Balabaud, C, Bioulac-Sage, P, Zucman-Rossi, J

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Keratin 23 Represents a Novel Liver Injury Marker Reflecting the Severity of Ductular Reaction von Guldiken, N, Ensari, G.K, Lahiri, P, Couchy, G, Preisinger, C, Liedtke, C, Zimmermann, H.W, Ziol, M, Zucman-Rossi, J, Trautwein, C, Strnad, P

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P0480 : Role of the immune microenvironment during hepatocellular carcinoma von L’Hermitte, A, Pham, S, Anson, M, Denoyelle, A.-M, Couchy, G, Perret, C, Zucman-Rossi, J, Desdouets, C, Couty, J.-P

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Molecular subtypes of fully resected clear cell renal cell carcinoma are prognostic for risk of relapse and may impact adjuvant treatment von Roussel, E., Verbiest, A., Zucman-Rossi, J., Couchy, G., Caruso, S., De Wever, L., Baldewijns, M., Joniau, S., Albersen, M., Beuselinck, B.

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P0266 : Adeno-Associated Virus 2 (AAV2) induces recurrent insertional mutagenesis in Human Hepatocellular Carcinomas von Nault, J.C, Datta, S, Franconi, A, Imbeaud, S, Mallet, M, Couchy, G, Letouzé, E, Pilati, C, Verret, B, Blanc, J.F, Balabaud, C, Calderaro, J, Laurent, A, Lextexier, M, Bioulac-Sage, P, Calvo, F, Zucman-Rossi, J

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Nosology and Molecular Classification of Hepatocellular Adenomas von Nault, J.C, Couchy, G, Bioulac-Sage, P, Bacq, Y, Calderaro, J, Paradis, V, Ramos, J, Scoazec, J.-Y, Leteurtre, E, Sturm, N, Guettier, C, Fabre, M, Savier, E, Chiche, L, Labrune, P, Selves, J, Wendum, D, Morcrette, G, Gelabale, E, Pilati, C, Laurent, A, De Muret, A, Blanc, J.-F, Le Bail, B, Imbeaud, S, Balabaud, C, Rebouissou, S, Zucman-Rossi, J

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G05 : Exome sequencing of 243 liver tumors identifies new mutational signatures and potential therapeutic targets von Schulze, K, Imbeaud, S, Letouzé, E, Alexandrov, L.B, Calderaro, J, Rebouissou, S, Couchy, G, Meiller, C, Soysouvanh, F, Calatayud, A.-L, Pinyol, R, Pelletier, L, Balabaud, C, Laurent, A, Blanc, J.-F, Mazzaferro, V, Calvo, F, Villanueva, A, Nault, J.-C, Bioulac-Sage, P, Stratton, M.R, Llovet, J.M, Zucman-Rossi, J

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1073 INTEGRATED GENOMIC ANALYSIS IN HEPATOCELLULAR ADENOMA von Pilati, C, Imbeaud, S, Boulai, A, Poussin, K, Morcrette, G, Couchy, G, Calderaro, J, Bioulac-Sage, P, Letouz'e, E, Zucman- Rossi, J

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134 CONSTITUTIVELY ACTIVE GP130 MUTANTS CAUSE INFLAMMATORY ADENOMAS IN LIVER (IHCA): FUNCTIONAL ANALYSIS AND IDENTIFICATION OF JANUS KINASE 1 AS A POTENTIAL THERAPEUTIC TARGET von Amessou, M, Poussin, K, Couchy, G, Rebouissou, S, Zucman-Rossi, J

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958 DIAGNOSIS OF BENIGN HEPATOCELLULAR TUMORS/VALUE OF A SIMPLE ALGORITHM BASED ON SPECIFIC HISTOCHEMICAL MARKERS PERFORMED ON LIVER BIOPSIES, COMPARED WITH SURGICAL SPECIMEN von Bioulac-Sage, P, Cubel, G, Le Bail, B, Couchy, G, Balabaud, C, Zucman-Rossi, J

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1478P Clearseq1-4 classifier in localized and metastatic clear-cell renal cell carcinoma (ccRCC) von Kinget, L., Roussel, E., Verbiest, A.T.L., Lambrechts, D., Boeckx, B., Zucman-Rossi, J., Couchy, G., Caruso, S., Baldewijns, M., De Wever, L., Albersen, M., Beuselinck, B.

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7115 POSTER DISCUSSION ABCB-1 and VEGFR-3 Single Nucleotide Polymorphisms (SNPs) and Outcome on Sunitinib (SUN) Treatment in Metastatic Clear Cell Renal Cell Carcinoma (RCC) von Beuselinck, B, Karadimou, A, Couchy, G, Claes, B, Lambrechts, D, Berkers, J, Paridaens, R, Schöffski, P, Zucman-Rossi, J, Oudard, S

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76 A MOLECULAR SIGNATURE AND ALGORITHM FOR THE DIAGNOSIS AND PROGNOSIS OF HEPATOCELLULAR TUMORS von Nault, J.-C, de Reyniès, A, Couchy, G, Tran Van Nhieu, J, Decaens, T, Laurent, A, Franco, D, Saric, J, Blanc, J.-F, Balabaud, C, Bioulac-Sage, P, Laurent-Puig, P, Zucman-Rossi, J

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Prognostic impact of clear cell renal cell carcinoma molecular subtypes determined on formalin-fixed paraffin-embedded tissue samples on outcome after complete surgical metastasect... von Roussel, E., Kinget, L., Verbiest, A., Boeckx, B., Couchy, G., Caruso, S., Zucman-Rossi, J., Baldewijns, M., Joniau, S., Van Poppel, H., Lambrechts, D., Albersen, M., Beuselinck, B.

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684P Molecular underpinnings of glandular tropism in metastatic clear cell renal cell carcinoma von Roussel, E., Kinget, L., Verbiest, A.T.L., Zucman-Rossi, J., Couchy, G., Caruso, S., Baldewijns, M., Joniau, S., Van Poppel, H., Albersen, M., Beuselinck, B.

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