Specific inhibition of myostatin activation is beneficial in mouse models of SMA therapy von Long, Kimberly K, O'Shea, Karen M, Khairallah, Ramzi J, Howell, Kelly, Paushkin, Sergey, Chen, Karen S, Cote, Shaun M, Webster, Micah T, Stains, Joseph P, Treece, Erin, Buckler, Alan, Donovan, Adriana

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A Randomized Phase 1 Safety, Pharmacokinetic and Pharmacodynamic Study of the Novel Myostatin Inhibitor Apitegromab (SRK-015): A Potential Treatment for Spinal Muscular Atrophy von Barrett, Doreen, Bilic, Sanela, Chyung, Yung, Cote, Shaun M., Iarrobino, Ryan, Kacena, Katherine, Kalra, Ashish, Long, Kimberly, Nomikos, George, Place, Amy, Still, James Gordon, Vrishabhendra, Leela

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Binding Efficiency of Protein–Protein Complexes von Day, Eric S, Cote, Shaun M, Whitty, Adrian

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Preclinical Safety Assessment and Toxicokinetics of Apitegromab, an Antibody Targeting Proforms of Myostatin for the Treatment of Muscle-Atrophying Disease von Welsh, Brian T., Cote, Shaun M., Meshulam, Deborah, Jackson, Justin, Pal, Ajai, Lansita, Janice, Kalra, Ashish

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Comprehensive Experimental and Computational Analysis of Binding Energy Hot Spots at the NF-κB Essential Modulator/IKKβ Protein–Protein Interface von Golden, Mary S, Cote, Shaun M, Sayeg, Marianna, Zerbe, Brandon S, Villar, Elizabeth A, Beglov, Dmitri, Sazinsky, Stephen L, Georgiadis, Rosina M, Vajda, Sandor, Kozakov, Dima, Whitty, Adrian

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A Sensitive and Selective Immunoassay for the Quantitation of Serum Latent Myostatin after In Vivo Administration of SRK-015, a Selective Inhibitor of Myostatin Activation von Cote, Shaun M., Jackson, Justin, Pirruccello-Straub, Michelle, Carven, Gregory J., Wawersik, Stefan

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Mutation of Nonessential Cysteines Shows That the NF-κB Essential Modulator Forms a Constitutive Noncovalent Dimer That Binds IκB Kinase‑β with High Affinity von Cote, Shaun M, Gilmore, Thomas D, Shaffer, Robert, Weber, Urs, Bollam, Rishitha, Golden, Mary S, Glover, Kimberley, Herscovitch, Melanie, Ennis, Thomas, Allen, Karen N, Whitty, Adrian

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Selective Inhibition of Repulsive Guidance Molecule C/Hemojuvelin (RGMc/HJV) with SRK-256 to Mobilize Iron in Functional Iron Deficiency von Cortes, Leslie K., Nicholls, Samantha B., Streich, Frederick C., Boston, Chris, Pal, Ajai, Regmi, Bimal, Cote, Shaun M., Canonico, Kaleigh, Qatanani, Mo

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Apitegromab in Spinal Muscular Atrophy (SMA): An Analysis of Multiple Efficacy Endpoints in the TOPAZ Trial (P15-5.005) von Crawford, Thomas, Darras, Basil, Day, John, Song, Guochen, Nomikos, George, Place, Amy, Barrett, Doreen, Bilic, Sanela, O‘Neil, Janet, Kertesz, Nathalie, Cote, Shaun, Patel, Jagdish, Chyung, Yung

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Safety and Efficacy of Apitegromab in Patients With Spinal Muscular Atrophy Types 2 and 3: The Phase 2 TOPAZ Study von Crawford, Thomas O, Darras, Basil T, Day, John W, Dunaway Young, Sally, Duong, Tina, Nelson, Leslie L, Barrett, Doreen, Song, Guochen, Bilic, Sanela, Cote, Shaun, Sadanowicz, Mara, Iarrobino, Ryan, Xu, Tiina J, O'Neil, Janet, Rossello, José, Place, Amy, Kertesz, Nathalie, Nomikos, George, Chyung, Yung

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Safety and Efficacy of Apitegromab in Patients With Spinal Muscular Atrophy Types 2 and 3: The Phase 2 TOPAZ Study

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Relationship of pharmacokinetics and pharmacodynamics to apitegromab efficacy in patients with later-onset spinal muscular atrophy (Types 2 and 3 SMA): Results from the TOPAZ study von Crawford, Thomas, Place, Amy, Barrett, Doreen, Cote, Shaun, Nomikos, George, Song, Guochen, Bilic, Sanela, Kalra, Ashish, Sadanowicz, Mara, O'Neil, Janet, Iarrobino, Ryan, Kertesz, Nathalie, Chyung, Yung

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Ligand‐Induced Conformational Change Propagates NEMO‐Mediated NF‐kB Signaling von Shaffer, Robert, Cote, Shaun, Allen, Karen, Whitty, Adrian

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An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis von Jackson, Justin W, Frederick C Streich, Jr, Pal, Ajai, Coricor, George, Boston, Chris, Brueckner, Christopher T, Canonico, Kaleigh, Chapron, Christopher, Cote, Shaun, Dagbay, Kevin B, Danehy, Jr, Francis T, Kavosi, Mania, Kumar, Sandeep, Lin, Susan, Littlefield, Christopher, Looby, Kailyn, Manohar, Rohan, Martin, Constance J, Wood, Marcie, Zawadzka, Agatha, Wawersik, Stefan, Nicholls, Samantha B, Datta, Abhishek, Buckler, Alan, Schürpf, Thomas, Carven, Gregory J, Qatanani, Mohammed, Fogel, Adam I

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Mutation of Non‐Essential Cysteines Leads to Highly Soluble and Active Recombinant Full‐Length NEMO von Cote, Shaun M, Herscovitch, Melanie, Prenovitz, Robert, Ennis, Thomas, Gilmore, Thomas D., Whitty, Adrian

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Mutation of Non-Essential Cysteines Shows that NF-κB Essential Modulator (NEMO) Forms a Constitutive Noncovalent Dimer that Binds IκB Kinase-β (IKKβ) with High Affinity von Cote, Shaun M., Gilmore, Thomas D., Shaffer, Robert, Weber, Urs, Bollam, Rishitha, Golden, Mary S., Glover, Kimberley, Herscovitch, Melanie, Ennis, Thomas, Allen, Karen N., Whitty, Adrian

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A Randomized Phase 1 Safety, Pharmacokinetic and Pharmacodynamic Study of the Novel Myostatin Inhibitor Apitegromab (SRK-015): A Potential Treatment for Spinal Muscular Atrophy von Of, Adis Journals On Behalf, Barrett, Doreen, Bilic, Sanela, Chyung, Yung, Cote, Shaun M., Iarrobino, Ryan, Kacena, Katherine, Kalra, Ashish, Long, Kimberly, Nomikos, George, Place, Amy, Still, James Gordon, Vrishabhendra, Leela

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Synthesis and application of organomercury haptens for enzyme-linked immunoassay of inorganic and organic mercury von Prudenté, Caryn K., Sirios, Rebekah S., Cote, Shaun

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SELECTIVE AND POTENT INHIBITORY ANTIBODIES OF MYOSTATIN ACTIVATION von CHAPRON, Christopher, HUANG, Yan, CANONICO, Kaleigh, COTE, Shaun M, JACKSON, Justin William, DANEHY JR., Francis, STREICH JR., Frederick C, KUMAR, Sandeep, KAVOSI, Mania, FULHAM, Melissa

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Selective and potent inhibitors of myostatin activation von CHAPRON, CHRISTOPHER, STREICH, FREDERICK C, JACKSON, JUSTIN WILLIAM, KUMAR, SANDEEP, HUANG, YAN, FULHAM, MELISSA, KAVOSI, MANIA, CANONICO, KALEIGH, DANEHY, FRANCIS, COTE, SHAUN M

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