Fully Automated Continuous Flow Synthesis of Highly Functionalized Imidazo[1,2-a] Heterocycles von Herath, Ananda, Dahl, Russell, Cosford, Nicholas D. P

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One-Step Continuous Flow Synthesis of Highly Substituted Pyrrole-3-carboxylic Acid Derivatives via in Situ Hydrolysis of tert-Butyl Esters von Herath, Ananda, Cosford, Nicholas D. P

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2‑Aminopyridines via Reaction of Pyridine N‑Oxides and Activated Isocyanides von Vamos, Mitchell, Cosford, Nicholas D. P

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Identification and Development of a New Positron Emission Tomography Ligand 4‑(2-Fluoro-4‑[11C]methoxyphenyl)-5-((1-methyl‑1H‑pyrazol-3-yl)methoxy)picolinamide for Imaging Metabotr... von Yamasaki, Tomoteru, Zhang, Xiaofei, Kumata, Katsushi, Zhang, Yiding, Deng, Xiaoyun, Fujinaga, Masayuki, Chen, Zhen, Mori, Wakana, Hu, Kuan, Wakizaka, Hidekatsu, Hatori, Akiko, Xie, Lin, Ogawa, Masanao, Nengaki, Nobuki, Van, Richard, Shao, Yihan, Sheffler, Douglas J, Cosford, Nicholas D. P, Liang, Steven H, Zhang, Ming-Rong

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Rapid Multistep Synthesis of 1,2,4-Oxadiazoles in a Single Continuous Microreactor Sequence von Grant, Daniel, Dahl, Russell, Cosford, Nicholas D. P

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Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis von Welsh, Kate, Milutinovic, Snezana, Ardecky, Robert J, Gonzalez-Lopez, Marcos, Ganji, Santhi Reddy, Teriete, Peter, Finlay, Darren, Riedl, Stefan, Matsuzawa, Shu-Ichi, Pinilla, Clemencia, Houghten, Richard, Vuori, Kristiina, Reed, John C, Cosford, Nicholas D P

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Continuous-flow synthesis of highly functionalized imidazo-oxadiazoles facilitated by microfluidic extraction von Herath, Ananda, Cosford, Nicholas D P

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Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins von Finlay, Darren, Teriete, Peter, Vamos, Mitchell, Cosford, Nicholas D P, Vuori, Kristiina

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Design and Synthesis of Systemically Active Metabotropic Glutamate Subtype‑2 and -3 (mGlu2/3) Receptor Positive Allosteric Modulators (PAMs): Pharmacological Characterization and A... von Dhanya, Raveendra-Panickar, Sheffler, Douglas J, Dahl, Russell, Davis, Melinda, Lee, Pooi San, Yang, Li, Nickols, Hilary Highfield, Cho, Hyekyung P, Smith, Layton H, D’Souza, Manoranjan S, Conn, P. Jeffrey, Der-Avakian, Andre, Markou, Athina, Cosford, Nicholas D. P

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Perturbation of the c‑Myc–Max Protein–Protein Interaction via Synthetic α‑Helix Mimetics von Jung, Kwan-Young, Wang, Huabo, Teriete, Peter, Yap, Jeremy L, Chen, Lijia, Lanning, Maryanna E, Hu, Angela, Lambert, Lester J, Holien, Toril, Sundan, Anders, Cosford, Nicholas D. P, Prochownik, Edward V, Fletcher, Steven

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Synthesis and Preliminary Studies of a Novel Negative Allosteric Modulator, 7‑((2,5-Dioxopyrrolidin-1-yl)methyl)-4-(2-fluoro-4‑[11C]methoxyphenyl) quinoline-2-carboxamide, for Imag... von Zhang, Xiaofei, Kumata, Katsushi, Yamasaki, Tomoteru, Cheng, Ran, Hatori, Akiko, Ma, Longle, Zhang, Yiding, Xie, Lin, Wang, Lu, Kang, Hye Jin, Sheffler, Douglas J, Cosford, Nicholas D. P, Zhang, Ming-Rong, Liang, Steven H

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Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Ne... von Ren, Huiyu, Bakas, Nicole A, Vamos, Mitchell, Chaikuad, Apirat, Limpert, Allison S, Wimer, Carina D, Brun, Sonja N, Lambert, Lester J, Tautz, Lutz, Celeridad, Maria, Sheffler, Douglas J, Knapp, Stefan, Shaw, Reuben J, Cosford, Nicholas D. P

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Cell Survival and Cell Death at the Intersection of Autophagy and Apoptosis: Implications for Current and Future Cancer Therapeutics von Bata, Nicole, Cosford, Nicholas D. P

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Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia von Bata, Nicole, Chaikuad, Apirat, Bakas, Nicole A, Limpert, Allison S, Lambert, Lester J, Sheffler, Douglas J, Berger, Lena M, Liu, Guoxiong, Yuan, Cunxiang, Wang, Li, Peng, Yi, Dong, Jing, Celeridad, Maria, Layng, Fabiana, Knapp, Stefan, Cosford, Nicholas D. P

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Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP) von Sidique, Shyama, Ardecky, Robert, Su, Ying, Narisawa, Sonoko, Brown, Brock, Millán, José Luis, Sergienko, Eduard, Cosford, Nicholas D.P.

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Potent, Selective, and Orally Available Benzoisothiazolone Phosphomannose Isomerase Inhibitors as Probes for Congenital Disorder of Glycosylation Ia von Dahl, Russell, Bravo, Yalda, Sharma, Vandana, Ichikawa, Mie, Dhanya, Raveendra-Panickar, Hedrick, Michael, Brown, Brock, Rascon, Justin, Vicchiarelli, Michael, Mangravita-Novo, Arianna, Yang, Li, Stonich, Derek, Su, Ying, Smith, Layton H, Sergienko, Eduard, Freeze, Hudson H, Cosford, Nicholas D. P

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Structure–activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase von Sidique, Shyama, Shiryaev, Sergey A., Ratnikov, Boris I., Herath, Ananda, Su, Ying, Strongin, Alex Y., Cosford, Nicholas D.P.

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Orally Active Metabotropic Glutamate Subtype 2 Receptor Positive Allosteric Modulators: Structure–Activity Relationships and Assessment in a Rat Model of Nicotine Dependence von Sidique, Shyama, Dhanya, Raveendra-Panickar, Sheffler, Douglas J, Nickols, Hilary Highfield, Yang, Li, Dahl, Russell, Mangravita-Novo, Arianna, Smith, Layton H, D’Souza, Manoranjan S, Semenova, Svetlana, Conn, P. Jeffrey, Markou, Athina, Cosford, Nicholas D. P

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Chemical Biology Investigation of Cell Death Pathways Activated by Endoplasmic Reticulum Stress Reveals Cytoprotective Modulators of ASK1 von Kim, InKi, Shu, Chih-Wen, Xu, Wenjie, Shiau, Chung-Wai, Grant, Daniel, Vasile, Stefan, Cosford, Nicholas D.P., Reed, John C.

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Small Molecules Can Selectively Inhibit Ephrin Binding to the EphA4 and EphA2 Receptors von Noberini, Roberta, Koolpe, Mitchell, Peddibhotla, Satyamaheshwar, Dahl, Russell, Su, Ying, Cosford, Nicholas D.P., Roth, Gregory P., Pasquale, Elena B.

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