Advances and challenges in therapeutic targeting of NRF2 von Dinkova-Kostova, Albena T., Copple, Ian M.

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Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy von Lister, Adam, Nedjadi, Taoufik, Kitteringham, Neil R, Campbell, Fiona, Costello, Eithne, Lloyd, Bryony, Copple, Ian M, Williams, Samantha, Owen, Andrew, Neoptolemos, John P, Goldring, Chris E, Park, B Kevin

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Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models von Weaver, Richard J., Blomme, Eric A., Chadwick, Amy E., Copple, Ian M., Gerets, Helga H. J., Goldring, Christopher E., Guillouzo, Andre, Hewitt, Philip G., Ingelman-Sundberg, Magnus, Jensen, Klaus Gjervig, Juhila, Satu, Klingmüller, Ursula, Labbe, Gilles, Liguori, Michael J., Lovatt, Cerys A., Morgan, Paul, Naisbitt, Dean J., Pieters, Raymond H. H., Snoeys, Jan, van de Water, Bob, Williams, Dominic P., Park, B. Kevin

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Role of Nrf2 in protection against acute kidney injury von Shelton, Luke M., Kevin Park, B., Copple, Ian M.

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Modulating the expression of tumor suppressor genes using activating oligonucleotide technologies as a therapeutic approach in cancer von Gregory, Georgina L., Copple, Ian M.

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Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2 von Olayanju, Adedamola, Copple, Ian M., Bryan, Holly K., Edge, George T., Sison, Rowena L., Wong, Min Wei, Lai, Zheng-Quan, Lin, Zhi-Xiu, Dunn, Karen, Sanderson, Christopher M., Alghanem, Ahmad F., Cross, Michael J., Ellis, Ewa C., Ingelman-Sundberg, Magnus, Malik, Hassan Z., Kitteringham, Neil R., Goldring, Christopher E., Park, B. Kevin

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Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity von Ghallab, Ahmed, Hassan, Reham, Hofmann, Ute, Friebel, Adrian, Hobloss, Zaynab, Brackhagen, Lisa, Begher-Tibbe, Brigitte, Myllys, Maiju, Reinders, Joerg, Overbeck, Nina, Sezgin, Selahaddin, Zühlke, Sebastian, Seddek, Abdel-latif, Murad, Walaa, Brecklinghaus, Tim, Kappenberg, Franziska, Rahnenführer, Jörg, González, Daniela, Goldring, Christopher, Copple, Ian M., Marchan, Rosemarie, Longerich, Thomas, Vucur, Mihael, Luedde, Tom, Urban, Stephan, Canbay, Ali, Schreiter, Thomas, Trauner, Michael, Akakpo, Jephte Y., Olyaee, Mojtaba, Curry, Steven C., Sowa, Jan-Peter, Jaeschke, Hartmut, Hoehme, Stefan, Hengstler, Jan G.

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Pharmacological Activation of Nrf2 Enhances Functional Liver Regeneration von Chan, Benjamin K.Y., Elmasry, Mohamed, Forootan, Shiva S., Russomanno, Giusy, Bunday, Tobias M., Zhang, Fang, Brillant, Nathalie, Starkey Lewis, Philip J., Aird, Rhona, Ricci, Emanuele, Andrews, Timothy D., Sison‐Young, Rowena L., Schofield, Amy L., Fang, Yongxiang, Lister, Adam, Sharkey, Jack W., Poptani, Harish, Kitteringham, Neil R., Forbes, Stuart J., Malik, Hassan Z., Fenwick, Stephen W., Park, B. Kevin, Goldring, Christopher E., Copple, Ian M.

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The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials von Mercer, Amy E., Copple, Ian M., Maggs, James L., O'Neill, Paul M., Park, B. Kevin

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Limitations of acetaminophen as a reference hepatotoxin for the evaluation of in vitro liver models von Livoti, Lucia A, Sison-Young, Rowena, Reddyhoff, Dennis, Fisher, Ciarán P, Gardner, Iain, Diaz-Nieto, Rafael, Goldring, Christopher E, Copple, Ian M

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The Nrf2-Keapl defence pathway : Role in protection against drug-induced toxicity von COPPLE, Ian M, GOLDRING, Christopher E, KITTERINGHAM, Neil R, PARK, B. Kevin

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The Nrf2–Keap1 defence pathway: Role in protection against drug-induced toxicity von Copple, Ian M, Goldring, Christopher E, Kitteringham, Neil R, Park, B. Kevin

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Gene Signatures Reduce the Stress of Preclinical Drug Hepatotoxicity Screening von Copple, Ian M., Park, B. Kevin, Goldring, Christopher E., Corey, Kathleen E., Malhi, Harmeet

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Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway von Copple, Ian M., Lister, Adam, Obeng, Akua D., Kitteringham, Neil R., Jenkins, Rosalind E., Layfield, Robert, Foster, Brian J., Goldring, Christopher E., Park, B. Kevin

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Biomarkers of NRF2 signalling: Current status and future challenges von Morgenstern, Christina, Lastres-Becker, Isabel, Demirdöğen, Birsen Can, Costa, Vera Marisa, Daiber, Andreas, Foresti, Roberta, Motterlini, Roberto, Kalyoncu, Sibel, Arioz, Burak I., Genc, Sermin, Jakubowska, Monika, Trougakos, Ioannis P., Piechota-Polanczyk, Aleksandra, Mickael, Michel, Santos, Marlene, Kensler, Thomas W., Cuadrado, Antonio, Copple, Ian M.

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A systems approach reveals species differences in hepatic stress response capacity von Russomanno, Giusy, Sison-Young, Rowena, Livoti, Lucia A, Coghlan, Hannah, Jenkins, Rosalind E, Kunnen, Steven J, Fisher, Ciarán P, Reddyhoff, Dennis, Gardner, Iain, Rehman, Adeeb H, Fenwick, Stephen W, Jones, Andrew R, Vermeil De Conchard, Guy, Simonin, Gilles, Bertheux, Helene, Weaver, Richard J, Johnson, Robert L, Liguori, Michael J, Clausznitzer, Diana, Stevens, James L, Goldring, Christopher E, Copple, Ian M

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Apigenin Attenuates Oxidative Injury in ARPE-19 Cells thorough Activation of Nrf2 Pathway von Yang, Yan, Yu, Haitao, Chen, Weiwei, Li, Min, Xu, Xin-rong, Hang, Li

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NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis von Lister, Adam, Bourgeois, Soline, Imenez Silva, Pedro H., Rubio-Aliaga, Isabel, Marbet, Philippe, Walsh, Joanne, Shelton, Luke M., Keller, Bettina, Verrey, Francois, Devuyst, Olivier, Giesbertz, Pieter, Daniel, Hannelore, Goldring, Christopher E., Copple, Ian M., Wagner, Carsten A., Odermatt, Alex

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Attenuation of doxorubicin-induced cardiotoxicity in a human in vitro cardiac model by the induction of the NRF-2 pathway von Tomlinson, Lauren, Lu, Zhen Qi, Bentley, Robert A, Colley, Helen E., Murdoch, Craig, Webb, Steven D., Cross, Michael J., Copple, Ian M., Sharma, Parveen

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The hepatotoxic metabolite of acetaminophen directly activates the Keap1‐Nrf2 cell defense system von Copple, Ian M., Goldring, Christopher E., Jenkins, Rosalind E., Chia, Alvin J. L., Randle, Laura E., Hayes, John D., Kitteringham, Neil R., Park, B. Kevin

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