CREBBP histone acetyltransferase domain mutations predict response to mTOR inhibition in relapsed/refractory follicular lymphoma von Kumar, Emil Arjun, Korfi, Koorosh, Bewicke‐Copley, Findlay, Close, Karina, Heward, James, Witzig, Thomas, Leukam, Michael, Ansell, Stephen, Scott, Jessica, Clear, Andrew, Efeyan, Alejo, Green, Michael, Siebert, Reiner, Peck, Barrie, Calaminici, Maria, Wang, Jun, Smith, Sonali, Novak, Anne, Fitzgibbon, Jude, Okosun, Jessica

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Germline ERCC excision repair 6 like 2 (ERCC6L2) mutations lead to impaired erythropoiesis and reshaping of the bone marrow microenvironment von Armes, Hannah, Bewicke‐Copley, Findlay, Rio‐Machin, Ana, Di Bella, Doriana, Philippe, Céline, Wozniak, Anna, Tummala, Hemanth, Wang, Jun, Ezponda, Teresa, Prosper, Felipe, Dokal, Inderjeet, Vulliamy, Tom, Kilpivaara, Outi, Wartiovaara‐Kautto, Ulla, Fitzgibbon, Jude, Rouault‐Pierre, Kevin

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A local regulatory network around three NAC transcription factors in stress responses and senescence in Arabidopsis leaves von Hickman, Richard, Hill, Claire, Penfold, Christopher A., Breeze, Emily, Bowden, Laura, Moore, Jonathan D., Zhang, Peijun, Jackson, Alison, Cooke, Emma, Bewicke‐Copley, Findlay, Mead, Andrew, Beynon, Jim, Wild, David L., Denby, Katherine J., Ott, Sascha, Buchanan‐Wollaston, Vicky

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Extracellular vesicles released following heat stress induce bystander effect in unstressed populations von Bewicke-Copley, Findlay, Mulcahy, Laura Ann, Jacobs, Laura Ann, Samuel, Priya, Akbar, Naveed, Pink, Ryan Charles, Carter, David Raul Francisco

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Applications and analysis of targeted genomic sequencing in cancer studies von Bewicke-Copley, Findlay, Arjun Kumar, Emil, Palladino, Giuseppe, Korfi, Koorosh, Wang, Jun

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Acquired somatic variants in inherited myeloid malignancies von Armes, Hannah, Rio-Machin, Ana, Krizsán, Szilvia, Bödör, Csaba, Kaya, Fadimana, Bewicke-Copley, Findlay, Alnajar, Jenna, Walne, Amanda, Péterffy, Borbála, Tummala, Hemanth, Rouault-Pierre, Kevin, Dokal, Inderjeet, Vulliamy, Tom, Fitzgibbon, Jude

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P1254: BASELINE HLA‐DR‐RESTRICTED NEOANTIGEN BURDEN OF AML BLASTS IMPACTS ON HLA‐DR GENE EXPRESSION AT RELAPSE AFTER ALLOGENEIC STEM CELL TRANSPLANT von Charrot, Sarah, Ball, Jennifer, Copley, Findlay, Aries, James, Mee, Matthew, Theocharidis, Symeon, Heward, James, Gribben, John, Davies, Jeff

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P1253: REDUCED EXPRESSION OF THE CHEMOKINES CXCL2, CXCL3 AND CXCL8 PROVIDES A POTENTIAL MECHANISM PROMOTING IMMUNE EVASION FACILITATING AML RELAPSE FOLLOWING ALLOGENEIC HSCT von Charrot, Sarah, Ball, Jennifer, Copley, Findlay, Aries, James, Mee, Matthew, Theocharidis, Symeon, Heward, James, Gribben, John, Davies, Jeff

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The transcription factor DDIT3 is a potential driver of dyserythropoiesis in myelodysplastic syndromes von Berastegui, Nerea, Ainciburu, Marina, Romero, Juan P., Garcia-Olloqui, Paula, Alfonso-Pierola, Ana, Philippe, Céline, Vilas-Zornoza, Amaia, San Martin-Uriz, Patxi, Ruiz-Hernández, Raquel, Abarrategi, Ander, Ordoñez, Raquel, Alignani, Diego, Sarvide, Sarai, Castro-Labrador, Laura, Lamo-Espinosa, José M., San-Julian, Mikel, Jimenez, Tamara, López-Cadenas, Félix, Muntion, Sandra, Sanchez-Guijo, Fermin, Molero, Antonieta, Montoro, Maria Julia, Tazón, Bárbara, Serrano, Guillermo, Diaz-Mazkiaran, Aintzane, Hernaez, Mikel, Huerga, Sofía, Bewicke-Copley, Findlay, Rio-Machin, Ana, Maurano, Matthew T., Díez-Campelo, María, Valcarcel, David, Rouault-Pierre, Kevin, Lara-Astiaso, David, Ezponda, Teresa, Prosper, Felipe

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The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants von Rio-Machin, Ana, Vulliamy, Tom, Hug, Nele, Walne, Amanda, Tawana, Kiran, Cardoso, Shirleny, Ellison, Alicia, Pontikos, Nikolas, Wang, Jun, Tummala, Hemanth, Al Seraihi, Ahad Fahad H., Alnajar, Jenna, Bewicke-Copley, Findlay, Armes, Hannah, Barnett, Michael, Bloor, Adrian, Bödör, Csaba, Bowen, David, Fenaux, Pierre, Green, Andrew, Hallahan, Andrew, Hjorth-Hansen, Henrik, Hossain, Upal, Killick, Sally, Lawson, Sarah, Layton, Mark, Male, Alison M., Marsh, Judith, Mehta, Priyanka, Mous, Rogier, Nomdedéu, Josep F., Owen, Carolyn, Pavlu, Jiri, Payne, Elspeth M., Protheroe, Rachel E., Preudhomme, Claude, Pujol-Moix, Nuria, Renneville, Aline, Russell, Nigel, Saggar, Anand, Sciuccati, Gabriela, Taussig, David, Toze, Cynthia L., Uyttebroeck, Anne, Vandenberghe, Peter, Schlegelberger, Brigitte, Ripperger, Tim, Steinemann, Doris, Wu, John, Mason, Joanne, Page, Paula, Akiki, Susanna, Reay, Kim, Cavenagh, Jamie D., Plagnol, Vincent, Caceres, Javier F., Fitzgibbon, Jude, Dokal, Inderjeet

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Targeting lysine demethylase 5 (KDM5) in mantle cell lymphoma von Xu, Danmei, Bewicke-Copley, Findlay, Close, Karina, Okosun, Jessica, Gale, Robert Peter, Apperley, Jane, Weinstock, David M., Wendel, Hans-Guido, Fitzgibbon, Jude

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Genetic heterogeneity highlighted by differential FDG-PET response in diffuse large B-cell lymphoma von Araf, Shamzah, Korfi, Koorosh, Bewicke-Copley, Findlay, Wang, Jun, Cogliatti, Sergio, Kumar, Emil, Forrer, Flavio, Barrington, Sally F., Graham, Trevor A., Scott, David W., Rimsza, Lisa M., Davies, Andrew, Johnson, Peter, Okosun, Jessica, Fitzgibbon, Jude, Fehr, Martin

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ACSNI: An unsupervised machine-learning tool for prediction of tissue-specific pathway components using gene expression profiles von Anene, Chinedu Anthony, Khan, Faraz, Bewicke-Copley, Findlay, Maniati, Eleni, Wang, Jun

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Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes von Casado, Pedro, Rio-Machin, Ana, Miettinen, Juho J., Bewicke-Copley, Findlay, Rouault-Pierre, Kevin, Krizsan, Szilvia, Parsons, Alun, Rajeeve, Vinothini, Miraki-Moud, Farideh, Taussig, David C., Bödör, Csaba, Gribben, John, Heckman, Caroline, Fitzgibbon, Jude, Cutillas, Pedro R.

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Meta-analysis using a novel database, miRStress, reveals miRNAs that are frequently associated with the radiation and hypoxia stress-responses von Jacobs, Laura Ann, Bewicke-Copley, Findlay, Poolman, Mark Graham, Pink, Ryan Charles, Mulcahy, Laura Ann, Baker, Isabel, Beaman, Ellie-May, Brooks, Travis, Caley, Daniel Paul, Cowling, William, Currie, James Michael Stevenson, Horsburgh, Jessica, Kenehan, Lottie, Keyes, Emma, Leite, Daniel, Massa, Davide, McDermott-Rouse, Adam, Samuel, Priya, Wood, Hannah, Kadhim, Munira, Carter, David Raul Francisco

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Characterising Tumour and Microenvironmental Responses to R-CHOP in Immunocompetent Mouse Models of DLBCL von Maybury, Bernard D, Bewicke-Copley, Findlay, Johnson, Peter, Fitzgibbon, Jude, Calado, Dinis Pedro

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The Genomic Landscape of Actinic Keratosis von Thomson, Jason, Bewicke-Copley, Findlay, Anene, Chinedu Anthony, Gulati, Abha, Nagano, Ai, Purdie, Karin, Inman, Gareth J., Proby, Charlotte M., Leigh, Irene M., Harwood, Catherine A., Wang, Jun

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KDM5 inhibition offers a novel therapeutic strategy for the treatment of KMT2D mutant lymphomas von Heward, James, Koniali, Lola, D'Avola, Annalisa, Close, Karina, Yeomans, Alison, Philpott, Martin, Dunford, James, Rahim, Tahrima, Al Seraihi, Ahad F., Wang, Jun, Korfi, Koorosh, Araf, Shamzah, Iqbal, Sameena, Bewicke-Copley, Findlay, Kumar, Emil, Barisic, Darko, Calaminici, Maria, Clear, Andrew, Gribben, John, Johnson, Peter, Neve, Richard, Cutillas, Pedro, Okosun, Jessica, Oppermann, Udo, Melnick, Ari, Packham, Graham, Fitzgibbon, Jude

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Defining an Optimized Workflow for Enriching and Analyzing Residual Tumor Populations Using Intracellular Markers von Coulter, Eve M., Bewicke-Copley, Findlay, Mossner, Maximilian, Graham, Trevor A., Fitzgibbon, Jude, Okosun, Jessica

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The Paradoxical Efficacy of KDM6 Inhibition in Germinal Centre B-Cell Lymphomas von Close, Karina, Armes, Hannah, Kumar, Emil, Bewicke-Copley, Findlay, Cribbs, Adam, Dunford, James, Philpott, Martin, Oppermann, Udo, Heward, James, Fitzgibbon, Jude

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