The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML von Vetrie, David, Helgason, G. Vignir, Copland, Mhairi

Volltext

Improving outcomes in chronic myeloid leukemia through harnessing the immunological landscape von Hsieh, Ya-Ching, Kirschner, Kristina, Copland, Mhairi

Volltext

The application of BH3 mimetics in myeloid leukemias von Parry, Narissa, Wheadon, Helen, Copland, Mhairi

Volltext

Defining niche interactions to target chronic myeloid leukemia stem cells von Mitchell, Rebecca, Copland, Mhairi

Volltext

Targeting hedgehog in hematologic malignancy von Irvine, David A., Copland, Mhairi

Volltext

CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy von Kinstrie, Ross, Horne, Gillian A., Morrison, Heather, Irvine, David, Munje, Chinmay, Castañeda, Eduardo Gómez, Moka, Hothri A., Dunn, Karen, Cassels, Jennifer E., Parry, Narissa, Clarke, Cassie J., Scott, Mary T., Clark, Richard E., Holyoake, Tessa L., Wheadon, Helen, Copland, Mhairi

Volltext

BRD4-mediated repression of p53 is a target for combination therapy in AML von Latif, Anne-Louise, Newcombe, Ashley, Li, Sha, Gilroy, Kathryn, Robertson, Neil A., Lei, Xue, Stewart, Helen J. S., Cole, John, Terradas, Maria Terradas, Rishi, Loveena, McGarry, Lynn, McKeeve, Claire, Reid, Claire, Clark, William, Campos, Joana, Kirschner, Kristina, Davis, Andrew, Lopez, Jonathan, Sakamaki, Jun-ichi, Morton, Jennifer P., Ryan, Kevin M., Tait, Stephen W. G., Abraham, Sheela A., Holyoake, Tessa, Higgins, Brian, Huang, Xu, Blyth, Karen, Copland, Mhairi, Chevassut, Timothy J. T., Keeshan, Karen, Adams, Peter D.

Volltext

Treatment of blast phase chronic myeloid leukaemia: A rare and challenging entity von Copland, Mhairi

Volltext

Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells von Abraham, Sheela A., Hopcroft, Lisa E. M., Carrick, Emma, Drotar, Mark E., Dunn, Karen, Williamson, Andrew J. K., Korfi, Koorosh, Baquero, Pablo, Park, Laura E., Scott, Mary T., Pellicano, Francesca, Pierce, Andrew, Copland, Mhairi, Nourse, Craig, Grimmond, Sean M., Vetrie, David, Whetton, Anthony D., Holyoake, Tessa L.

Volltext

Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia von Zhang, Bin, Nguyen, Le Xuan Truong, Li, Ling, Zhao, Dandan, Kumar, Bijender, Wu, Herman, Lin, Allen, Pellicano, Francesca, Hopcroft, Lisa, Su, Yu-Lin, Copland, Mhairi, Holyoake, Tessa L, Kuo, Calvin J, Bhatia, Ravi, Snyder, David S, Ali, Haris, Stein, Anthony S, Brewer, Casey, Wang, Huafeng, McDonald, Tinisha, Swiderski, Piotr, Troadec, Estelle, Chen, Ching-Cheng, Dorrance, Adrienne, Pullarkat, Vinod, Yuan, Yate-Ching, Perrotti, Danilo, Carlesso, Nadia, Forman, Stephen J, Kortylewski, Marcin, Kuo, Ya-Huei, Marcucci, Guido

Volltext

Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing von Zarou, Martha M., Rattigan, Kevin M., Sarnello, Daniele, Shokry, Engy, Dawson, Amy, Ianniciello, Angela, Dunn, Karen, Copland, Mhairi, Sumpton, David, Vazquez, Alexei, Helgason, G. Vignir

Volltext

Implementing the EffTox dose-finding design in the Matchpoint trial von Brock, Kristian, Billingham, Lucinda, Copland, Mhairi, Siddique, Shamyla, Sirovica, Mirjana, Yap, Christina

Volltext

Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells von Rattigan, Kevin M., Brabcova, Zuzana, Sarnello, Daniele, Zarou, Martha M., Roy, Kiron, Kwan, Ryan, de Beauchamp, Lucie, Dawson, Amy, Ianniciello, Angela, Khalaf, Ahmed, Kalkman, Eric R., Scott, Mary T., Dunn, Karen, Sumpton, David, Michie, Alison M., Copland, Mhairi, Tardito, Saverio, Gottlieb, Eyal, Vignir Helgason, G.

Volltext

Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile von Cramer-Morales, Kimberly, Nieborowska-Skorska, Margaret, Scheibner, Kara, Padget, Michelle, Irvine, David A., Sliwinski, Tomasz, Haas, Kimberly, Lee, Jaewoong, Geng, Huimin, Roy, Darshan, Slupianek, Artur, Rassool, Feyruz V., Wasik, Mariusz A., Childers, Wayne, Copland, Mhairi, Müschen, Markus, Civin, Curt I., Skorski, Tomasz

Volltext

Activating p53 abolishes self-renewal of quiescent leukaemic stem cells in residual CML disease von Scott, Mary T., Liu, Wei, Mitchell, Rebecca, Clarke, Cassie J., Kinstrie, Ross, Warren, Felix, Almasoudi, Hassan, Stevens, Thomas, Dunn, Karen, Pritchard, John, Drotar, Mark E., Michie, Alison M., Jørgensen, Heather G., Higgins, Brian, Copland, Mhairi, Vetrie, David

Volltext

Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progression von Lucas, Claire M., Harris, Robert J., Giannoudis, Athina, Copland, Mhairi, Slupsky, Joseph R., Clark, Richard E.

Volltext

The Antiproliferative Activity of Kinase Inhibitors in Chronic Myeloid Leukemia Cells Is Mediated by FOXO Transcription Factors von Pellicano, Francesca, Scott, Mary T., Helgason, G. Vignir, Hopcroft, Lisa E. M., Allan, Elaine K., Aspinall‐O'Dea, Mark, Copland, Mhairi, Pierce, Andrew, Huntly, Brian J. P., Whetton, Anthony D., Holyoake, Tessa L.

Volltext

Interrogation of novel CDK2/9 inhibitor fadraciclib (CYC065) as a potential therapeutic approach for AML von Chantkran, Wittawat, Hsieh, Ya-Ching, Zheleva, Daniella, Frame, Sheelagh, Wheadon, Helen, Copland, Mhairi

Volltext

DNMT inhibitors reverse a specific signature of aberrant promoter DNA methylation and associated gene silencing in AML von Lund, Kirstin, Cole, John J, VanderKraats, Nathan D, McBryan, Tony, Pchelintsev, Nikolay A, Clark, William, Copland, Mhairi, Edwards, John R, Adams, Peter D

Volltext

Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche von Dawson, Amy, Zarou, Martha M., Prasad, Bodhayan, Bittencourt-Silvestre, Joana, Zerbst, Désirée, Himonas, Ekaterini, Hsieh, Ya-Ching, van Loon, Isabel, Blanco, Giovanny Rodriguez, Ianniciello, Angela, Kerekes, Zsombor, Krishnan, Vaidehi, Agarwal, Puneet, Almasoudi, Hassan, McCluskey, Laura, Hopcroft, Lisa E. M., Scott, Mary T., Baquero, Pablo, Dunn, Karen, Vetrie, David, Copland, Mhairi, Bhatia, Ravi, Coffelt, Seth B., Tiong, Ong Sin, Wheadon, Helen, Zanivan, Sara, Kirschner, Kristina, Helgason, G. Vignir

Volltext