Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3‑Kinase δ for the Treatment of Respiratory Disease von Down, Kenneth, Amour, Augustin, Baldwin, Ian R, Cooper, Anthony W. J, Deakin, Angela M, Felton, Leigh M, Guntrip, Stephen B, Hardy, Charlotte, Harrison, Zoë A, Jones, Katherine L, Jones, Paul, Keeling, Suzanne E, Le, Joelle, Livia, Stefano, Lucas, Fiona, Lunniss, Christopher J, Parr, Nigel J, Robinson, Ed, Rowland, Paul, Smith, Sarah, Thomas, Daniel A, Vitulli, Giovanni, Washio, Yoshiaki, Hamblin, J. Nicole

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A Turing Test for Molecular Generators von Bush, Jacob T, Pogany, Peter, Pickett, Stephen D, Barker, Mike, Baxter, Andrew, Campos, Sebastien, Cooper, Anthony W. J, Hirst, David, Inglis, Graham, Nadin, Alan, Patel, Vipulkumar K, Poole, Darren, Pritchard, John, Washio, Yoshiaki, White, Gemma, Green, Darren V. S

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Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening von Wellaway, Christopher R, Amans, Dominique, Bamborough, Paul, Barnett, Heather, Bit, Rino A, Brown, Jack A, Carlson, Neil R, Chung, Chun-wa, Cooper, Anthony W. J, Craggs, Peter D, Davis, Robert P, Dean, Tony W, Evans, John P, Gordon, Laurie, Harada, Isobel L, Hirst, David J, Humphreys, Philip G, Jones, Katherine L, Lewis, Antonia J, Lindon, Matthew J, Lugo, Dave, Mahmood, Mahnoor, McCleary, Scott, Medeiros, Patricia, Mitchell, Darren J, O’Sullivan, Michael, Le Gall, Armelle, Patel, Vipulkumar K, Patten, Chris, Poole, Darren L, Shah, Rishi R, Smith, Jane E, Stafford, Kayleigh A. J, Thomas, Pamela J, Vimal, Mythily, Wall, Ian D, Watson, Robert J, Wellaway, Natalie, Yao, Gang, Prinjha, Rab K

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Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease von Amour, Augustin, Barton, Nick, Cooper, Anthony W. J, Inglis, Graham, Jamieson, Craig, Luscombe, Christopher N, Morrell, Josie, Peace, Simon, Perez, David, Rowland, Paul, Tame, Chris, Uddin, Sorif, Vitulli, Giovanni, Wellaway, Natalie

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Lead Optimization Using Matched Molecular Pairs: Inclusion of Contextual Information for Enhanced Prediction of hERG Inhibition, Solubility, and Lipophilicity von Papadatos, George, Alkarouri, Muhammad, Gillet, Valerie J, Willett, Peter, Kadirkamanathan, Visakan, Luscombe, Christopher N, Bravi, Gianpaolo, Richmond, Nicola J, Pickett, Stephen D, Hussain, Jameed, Pritchard, John M, Cooper, Anthony W. J, Macdonald, Simon J. F

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Discovery of Potent, Efficient, and Selective Inhibitors of Phosphoinositide 3‑Kinase δ through a Deconstruction and Regrowth Approach von Barton, Nick, Convery, Máire, Cooper, Anthony W. J, Down, Kenneth, Hamblin, J. Nicole, Inglis, Graham, Peace, Simon, Rowedder, James, Rowland, Paul, Taylor, Jonathan A, Wellaway, Natalie

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Optimized Chemical Probes for REV-ERBα von Trump, Ryan P, Bresciani, Stefano, Cooper, Anthony W. J, Tellam, James P, Wojno, Justyna, Blaikley, John, Orband-Miller, Lisa A, Kashatus, Jennifer A, Boudjelal, Mohamed, Dawson, Helen C, Loudon, Andrew, Ray, David, Grant, Daniel, Farrow, Stuart N, Willson, Timothy M, Tomkinson, Nicholas C. O

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Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors von Hamblin, J. Nicole, Angell, Tony D.R., Ballantine, Stuart P., Cook, Caroline M., Cooper, Anthony W.J., Dawson, John, Delves, Christopher J., Jones, Paul S., Lindvall, Mika, Lucas, Fiona S., Mitchell, Charlotte J., Neu, Margarete Y., Ranshaw, Lisa E., Solanke, Yemisi E., Somers, Don O., Wiseman, Joanne O.

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Correction to Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease von Amour, Augustin, Barton, Nick, Cooper, Anthony W. J, Inglis, Graham, Jamieson, Craig, Luscombe, Christopher N, Morrell, Josie, Peace, Simon, Perez, David, Rowland, Paul, Tame, Christopher J, Uddin, Sorif, Vitulli, Giovanni, Wellaway, Natalie

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Correction to Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease von Amour, Augustin, Barton, Nick, Cooper, Anthony W. J, Inglis, Graham, Jamieson, Craig, Luscombe, Christopher N, Morrell, Josie, Peace, Simon, Perez, David, Rowland, Paul, Tame, Christopher J, Uddin, Sorif, Vitulli, Giovanni, Wellaway, Natalie

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N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: Indazoles as phenol isosteres with improved pharmacokinetics von Bamborough, Paul, Angell, Richard M., Bhamra, Inder, Brown, David, Bull, James, Christopher, John A., Cooper, Anthony W.J., Fazal, Lynsey H., Giordano, Ilaria, Hind, Lucy, Patel, Vipulkumar K., Ranshaw, Lisa E., Sims, Martin J., Skone, Philip A., Smith, Kathryn J., Vickerstaff, Emma, Washington, Melanie

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Adjoint approach to calculating shape gradients for three-dimensional magnetic confinement equilibria. Part 2. Applications von Paul, Elizabeth J., Antonsen, Thomas, Landreman, Matt, Cooper, W. Anthony

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Synthesis of Arrays Using Low Molecular Weight MPEG-Assisted Mitsunobu Reaction von Figlus, Marek, Wellaway, Natalie, Cooper, Anthony W. J, Sollis, Steven L, Hartley, Richard C

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Analysis of Neighborhood Behavior in Lead Optimization and Array Design von Papadatos, George, Cooper, Anthony W. J, Kadirkamanathan, Visakan, Macdonald, Simon J. F, McLay, Iain M, Pickett, Stephen D, Pritchard, John M, Willett, Peter, Gillet, Valerie J

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Synthesis of dibenzylamino-1-methylcyclohexanol and dibenzylamino-1-trifluoromethylcyclohexanol isomers von Jones, D Heulyn, Bresciani, Stefano, Tellam, James P, Wojno, Justyna, Cooper, Anthony W J, Kennedy, Alan R, Tomkinson, Nicholas C O

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A practical drug discovery project at the undergraduate level von Jonathan Fray, M., Macdonald, Simon J.F., Baldwin, Ian R., Barton, Nick, Brown, Jack, Campbell, Ian B., Churcher, Ian, Coe, Diane M., Cooper, Anthony W.J., Craven, Andrew P., Fisher, Gail, Inglis, Graham G.A., Kelly, Henry A., Liddle, John, Maxwell, Aoife C., Patel, Vipulkumar K., Swanson, Stephen, Wellaway, Natalie

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Quinolines as a novel structural class of potent and selective PDE4 inhibitors: Optimisation for oral administration von Lunniss, Christopher J., Cooper, Anthony W.J., Eldred, Colin D., Kranz, Michael, Lindvall, Mika, Lucas, Fiona S., Neu, Margarete, Preston, Alex G.S., Ranshaw, Lisa E., Redgrave, Alison J., Ed Robinson, J., Shipley, Tracy J., Solanke, Yemisi E., Somers, Don O., Wiseman, Joanne O.

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Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation von Pariollaud, Marie, Gibbs, Julie E, Hopwood, Thomas W, Brown, Sheila, Begley, Nicola, Vonslow, Ryan, Poolman, Toryn, Guo, Baoqiang, Saer, Ben, Jones, D Heulyn, Tellam, James P, Bresciani, Stefano, Tomkinson, Nicholas Co, Wojno-Picon, Justyna, Cooper, Anthony Wj, Daniels, Dion A, Trump, Ryan P, Grant, Daniel, Zuercher, William, Willson, Timothy M, MacDonald, Andrew S, Bolognese, Brian, Podolin, Patricia L, Sanchez, Yolanda, Loudon, Andrew Si, Ray, David W

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Adjoint approach to calculating shape gradients for three-dimensional magnetic confinement equilibria. Part II: Applications von Paul, Elizabeth J, Antonsen, Thomas, Jr, Landreman, Matt, Cooper, W Anthony

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Three-dimensional anisotropic pressure free boundary equilibria von Cooper, W.A., Hirshman, S.P., Merkel, P., Graves, J.P., Kisslinger, J., Wobig, H.F.G., Narushima, Y., Okamura, S., Watanabe, K.Y.

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