CDK7 inhibitors as anticancer drugs von Sava, Georgina P., Fan, Hailing, Coombes, R. Charles, Buluwela, Lakjaya, Ali, Simak

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Mutation Analysis of Cell-Free DNA and Single Circulating Tumor Cells in Metastatic Breast Cancer Patients with High Circulating Tumor Cell Counts von Shaw, Jacqueline A, Guttery, David S, Hills, Allison, Fernandez-Garcia, Daniel, Page, Karen, Rosales, Brenda M, Goddard, Kate S, Hastings, Robert K, Luo, Jinli, Ogle, Olivia, Woodley, Laura, Ali, Simak, Stebbing, Justin, Coombes, R Charles

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ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment von Patel, Hetal, Periyasamy, Manikandan, Sava, Georgina P, Bondke, Alexander, Slafer, Brian W, Kroll, Sebastian H B, Barbazanges, Marion, Starkey, Richard, Ottaviani, Silvia, Harrod, Alison, Aboagye, Eric O, Buluwela, Laki, Fuchter, Matthew J, Barrett, Anthony G M, Coombes, R Charles, Ali, Simak

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Single Particle Automated Raman Trapping Analysis of Breast Cancer Cell-Derived Extracellular Vesicles as Cancer Biomarkers von Penders, Jelle, Nagelkerke, Anika, Cunnane, Eoghan M, Pedersen, Simon V, Pence, Isaac J, Coombes, R. Charles, Stevens, Molly M

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Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy von Hong, Sung Pil, Chan, Thalia E., Lombardo, Ylenia, Corleone, Giacomo, Rotmensz, Nicole, Bravaccini, Sara, Rocca, Andrea, Pruneri, Giancarlo, McEwen, Kirsten R., Coombes, R. Charles, Barozzi, Iros, Magnani, Luca

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A framework for the development of effective anti-metastatic agents von Anderson, Robin L., Balasas, Theo, Callaghan, Juliana, Coombes, R. Charles, Evans, Jeff, Hall, Jacqueline A., Kinrade, Sally, Jones, David, Jones, Paul S., Jones, Rob, Marshall, John F., Panico, Maria Beatrice, Shaw, Jacqui A., Steeg, Patricia S., Sullivan, Mark, Tong, Warwick, Westwell, Andrew D., Ritchie, James W. A.

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ABC-transporter upregulation mediates resistance to the CDK7 inhibitors THZ1 and ICEC0942 von Sava, Georgina P., Fan, Hailing, Fisher, Rosemary A., Lusvarghi, Sabrina, Pancholi, Sunil, Ambudkar, Suresh V., Martin, Lesley-Ann, Charles Coombes, R., Buluwela, Lakjaya, Ali, Simak

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SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2 von Peck, Barrie, Chen, Chun-Yuan, Ho, Ka-Kei, Di Fruscia, Paolo, Myatt, Stephen S, Coombes, R Charles, Fuchter, Matthew J, Hsiao, Chwan-Deng, Lam, Eric W-F

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Triple-negative breast cancer: therapeutic options von Cleator, Susan, Dr, Heller, Wolfgang, MD, Coombes, R Charles, Prof

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FOXA1 is a determinant of drug resistance in breast cancer cells von Kumar, Uttom, Ardasheva, Anastasia, Mahmud, Zimam, Coombes, R. Charles, Yagüe, Ernesto

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Plasma cell-free DNA (cfDNA) as a predictive and prognostic marker in patients with metastatic breast cancer von Fernandez-Garcia, Daniel, Hills, Allison, Page, Karen, Hastings, Robert K, Toghill, Bradley, Goddard, Kate S, Ion, Charlotte, Ogle, Olivia, Boydell, Anna Rita, Gleason, Kelly, Rutherford, Mark, Lim, Adrian, Guttery, David S, Coombes, R Charles, Shaw, Jacqueline A

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Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib von Coombes, R. C., Howell, Sacha, Lord, Simon R., Kenny, Laura, Mansi, Janine, Mitri, Zahi, Palmieri, Carlo, Chap, Linnea I., Richards, Paul, Gradishar, William, Sardesai, Sagar, Melear, Jason, O’Shaughnessy, Joyce, Ward, Patrick, Chalasani, Pavani, Arkenau, Tobias, Baird, Richard D., Jeselsohn, Rinath, Ali, Simak, Clack, Glen, Bahl, Ashwani, McIntosh, Stuart, Krebs, Matthew G.

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The Forkhead Box M1 protein regulates BRIP1 expression and DNA damage repair in epirubicin treatment von Monteiro, L J, Khongkow, P, Kongsema, M, Morris, J R, Man, C, Weekes, D, Koo, C-Y, Gomes, A R, Pinto, P H, Varghese, V, Kenny, L M, Charles Coombes, R, Freire, R, Medema, R H, Lam, E W-F

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Performance of a novel spectroscopy-based tool for adjuvant therapy decision-making in hormone receptor-positive breast cancer: a validation study von Coombes, R Charles, Angelou, Christina, Al-Khalili, Zamzam, Hart, William, Francescatti, Darius, Wright, Nicholas, Ellis, Ian, Green, Andrew, Rakha, Emad, Shousha, Sami, Amrania, Hemmel, Phillips, Chris C., Palmieri, Carlo

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Noninvasive detection of activating estrogen receptor 1 (ESR1) mutations in estrogen receptor-positive metastatic breast cancer von Guttery, David S, Page, Karen, Hills, Allison, Woodley, Laura, Marchese, Stephanie D, Rghebi, Basma, Hastings, Robert K, Luo, Jinli, Pringle, J Howard, Stebbing, Justin, Coombes, R Charles, Ali, Simak, Shaw, Jacqueline A

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Shallow WGS of individual CTCs identifies actionable targets for informing treatment decisions in metastatic breast cancer von Fernandez-Garcia, Daniel, Nteliopoulos, Georgios, Hastings, Robert K., Rushton, Amelia, Page, Karen, Allsopp, Rebecca C., Ambasager, Bana, Gleason, Kelly, Guttery, David S., Ali, Simak, Charles Coombes, R., Shaw, Jacqueline A.

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A Pooled Analysis of Bone Marrow Micrometastasis in Breast Cancer von Braun, Stephan, Vogl, Florian D, Naume, Bjørn, Janni, Wolfgang, Osborne, Michael P, Coombes, R. Charles, Schlimok, Günter, Diel, Ingo J, Gerber, Bernd, Gebauer, Gerhard, Pierga, Jean-Yves, Marth, Christian, Oruzio, Daniel, Wiedswang, Gro, Solomayer, Erich-Franz, Kundt, Günther, Strobl, Barbara, Fehm, Tanja, Wong, George Y.C, Bliss, Judith, Vincent-Salomon, Anne, Pantel, Klaus

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Influence of plasma processing on recovery and analysis of circulating nucleic acids von Page, Karen, Guttery, David S, Zahra, Nathalie, Primrose, Lindsay, Elshaw, Shona R, Pringle, J Howard, Blighe, Kevin, Marchese, Stephanie D, Hills, Allison, Woodley, Laura, Stebbing, Justin, Coombes, R Charles, Shaw, Jacqueline A

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Mammosphere formation assay from human breast cancer tissues and cell lines von Lombardo, Ylenia, de Giorgio, Alexander, Coombes, Charles R, Stebbing, Justin, Castellano, Leandro

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estrogen receptor-α-induced microRNA signature regulates itself and its transcriptional response von Castellano, Leandro, Giamas, Georgios, Jacob, Jimmy, Coombes, R. Charles, Lucchesi, Walter, Thiruchelvam, Paul, Barton, Geraint, Jiao, Long R, Wait, Robin, Waxman, Jonathan, Hannon, Gregory J, Stebbing, Justin

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