The biochemistry of Parkinson's disease von Cookson, Mark R

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DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy von THOMAS, Kelly Jean, MCCOY, Melissa K, BLACKINTON, Jeff, BEILINA, Alexandra, VAN DER BRUG, Marcel, SANDEBRING, Anna, MILLER, David, MARIC, Dragan, CEDAZO-MINGUEZ, Angel, COOKSON, Mark R

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α-Synuclein Locus Triplication Causes Parkinson's Disease von Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R., Lincoln, S., Crawley, A., Hanson, M., Maraganore, D., Adler, C., Cookson, M. R., Muenter, M., Baptista, M., Miller, D., Blancato, J., Hardy, J., Gwinn-Hardy, K.

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Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice von Pellegrini, Laura, Hauser, David N, Li, Yan, Mamais, Adamantios, Beilina, Alexandra, Kumaran, Ravindran, Wetzel, Andrea, Nixon-Abell, Jonathon, Heaton, George, Rudenko, Iakov, Alkaslasi, Mor, Ivanina, Natalie, Melrose, Heather L, Cookson, Mark R, Harvey, Kirsten

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Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1 von Sandebring, Anna, Thomas, Kelly Jean, Beilina, Alexandra, van der Brug, Marcel, Cleland, Megan M, Ahmad, Rili, Miller, David W, Zambrano, Ibardo, Cowburn, Richard F, Behbahani, Homira, Cedazo-Mínguez, Angel, Cookson, Mark R

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The Parkinson's Disease Protein DJ-1 Is Neuroprotective Due to Cysteine-Sulfinic Acid-Driven Mitochondrial Localization von Canet-Avilés, Rosa M., Wilson, Mark A., Miller, David W., Ahmad, Rili, McLendon, Chris, Bandyopadhyay, Sourav, Baptista, Melisa J., Ringe, Dagmar, Petsko, Gregory A., Cookson, Mark R.

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mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex von Dillman, Allissa A, Hauser, David N, Gibbs, J Raphael, Nalls, Michael A, McCoy, Melissa K, Rudenko, Iakov N, Galter, Dagmar, Cookson, Mark R

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Reduction of PINK1 or DJ‐1 impair mitochondrial motility in neurites and alter ER‐mitochondria contacts von Parrado‐Fernández, Cristina, Schreiner, Bernadette, Ankarcrona, Maria, Conti, Melissa M., Cookson, Mark R., Kivipelto, Miia, Cedazo‐Mínguez, Ángel, Sandebring‐Matton, Anna

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Transcriptomic profiling of the human brain reveals that altered synaptic gene expression is associated with chronological aging von Dillman, Allissa A., Majounie, Elisa, Ding, Jinhui, Gibbs, J. Raphael, Hernandez, Dena, Arepalli, Sampath, Traynor, Bryan J., Singleton, Andrew B., Galter, Dagmar, Cookson, Mark R.

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Mutations in PTEN-Induced Putative Kinase 1 Associated with Recessive Parkinsonism Have Differential Effects on Protein Stability von Beilina, Alexandra, Van Der Brug, Marcel, Ahmad, Rili, Kesavapany, Sashi, Miller, David W., Petsko, Gregory A., Cookson, Mark R.

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Parkin Protects against the Toxicity Associated with Mutant α-Synuclein: Proteasome Dysfunction Selectively Affects Catecholaminergic Neurons von Petrucelli, Leonard, O'Farrell, Casey, Lockhart, Paul J., Baptista, Melisa, Kehoe, Kathryn, Vink, Liselot, Choi, Peter, Wolozin, Benjamin, Farrer, Matthew, Hardy, John, Cookson, Mark R.

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α-Synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication von MILLER, D. W, HAGUE, S. M, CLARIMON, J, BAPTISTA, M, GWINN-HARDY, K, COOKSON, M. R, SINGLETON, A. B

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Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain von Hernandez, Dena G, Nalls, Mike A, Moore, Matthew, Chong, Sean, Dillman, Allissa, Trabzuni, Daniah, Gibbs, J. Raphael, Ryten, Mina, Arepalli, Sampath, Weale, Michael E, Zonderman, Alan B, Troncoso, Juan, O'Brien, Richard, Walker, Robert, Smith, Colin, Bandinelli, Stefania, Traynor, Bryan J, Hardy, John, Singleton, Andrew B, Cookson, Mark R

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An In Vitro Model of Parkinson's Disease: Linking Mitochondrial Impairment to Altered alpha -Synuclein Metabolism and Oxidative Damage von Sherer, Todd B, Betarbet, Ranjita, Stout, Amy K, Lund, Serena, Baptista, Melisa, Panov, Alexander V, Cookson, Mark R, Greenamyre, J. Timothy

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Intersecting pathways to neurodegeneration in Parkinson's disease: Effects of the pesticide rotenone on DJ-1, α-synuclein, and the ubiquitin–proteasome system von Betarbet, Ranjita, Canet-Aviles, Rosa M., Sherer, Todd B., Mastroberardino, Pier G., McLendon, Chris, Kim, Jin-Ho, Lund, Serena, Na, Hye-Mee, Taylor, Georgia, Bence, Neil F., Kopito, Ron, Seo, Byoung Boo, Yagi, Takao, Yagi, Akemi, Klinefelter, Gary, Cookson, Mark R., Greenamyre, J. Timothy

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Evolutionary and functional relationships within the DJ1 superfamily von Bandyopadhyay, Sourav, Cookson, Mark R

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Age-associated changes in gene expression in human brain and isolated neurons von Kumar, Azad, Gibbs, J. Raphael, Beilina, Alexandra, Dillman, Allissa, Kumaran, Ravindran, Trabzuni, Daniah, Ryten, Mina, Walker, Robert, Smith, Colin, Traynor, Bryan J, Hardy, John, Singleton, Andrew B, Cookson, Mark R

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RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways von van der Brug, Marcel P, Blackinton, Jeff, Chandran, Jayanth, Hao, Ling-Yang, Lal, Ashish, Mazan-Mamczarz, Krystyna, Martindale, Jennifer, Xie, Chengsong, Ahmad, Rili, Thomas, Kelly J, Beilina, Alexandra, Gibbs, J. Raphael, Ding, Jinhui, Myers, Amanda J, Zhan, Ming, Cai, Huaibin, Bonini, Nancy M, Gorospe, Myriam, Cookson, Mark R

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Mitochondria and Dopamine: New Insights into Recessive Parkinsonism von Shen, Jie, Cookson, Mark R.

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The expression of DJ‐1 (PARK7) in normal human CNS and idiopathic Parkinson’s disease von Bandopadhyay, Rina, Kingsbury, Ann E., Cookson, Mark R., Reid, Andrew R., Evans, Ian M., Hope, Andrew D., Pittman, Alan M., Lashley, Tammaryn, Canet‐Aviles, Rosa, Miller, David W., McLendon, Chris, Strand, Catherine, Leonard, Andrew J., Abou‐Sleiman, Patrick M., Healy, Daniel G., Ariga, Hiroyashi, Wood, Nicholas W., de Silva, Rohan, Revesz, Tamas, Hardy, John A., Lees, Andrew J.

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