Carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6) in Pancreatic Ductal Adenocarcinoma (PDA): An integrative analysis of a novel therapeutic target von Pandey, Ritu, Zhou, Muhan, Islam, Shariful, Chen, Baowei, Barker, Natalie K, Langlais, Paul, Srivastava, Anup, Luo, Moulun, Cooke, Laurence S., Weterings, Eric, Mahadevan, Daruka

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Alisertib added to rituximab and vincristine is synthetic lethal and potentially curative in mice with aggressive DLBCL co-overexpressing MYC and BCL2 von Mahadevan, Daruka, Morales, Carla, Cooke, Laurence S, Manziello, Ann, Mount, David W, Persky, Daniel O, Fisher, Richard I, Miller, Thomas P, Qi, Wenqing

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Reciprocal feedback inhibition of the androgen receptor and PI3K as a novel therapy for castrate-sensitive and -resistant prostate cancer von Qi, Wenqing, Morales, Carla, Cooke, Laurence S, Johnson, Benny, Somer, Bradley, Mahadevan, Daruka

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A novel small molecule inhibitor of the DNA repair protein Ku70/80 von Weterings, Eric, Gallegos, Alfred C., Dominick, Lauren N., Cooke, Laurence S., Bartels, Trace N., Vagner, Josef, Matsunaga, Terry O., Mahadevan, Daruka

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Disruption of Aneuploidy and Senescence Induced by Aurora Inhibition Promotes Intrinsic Apoptosis in Double Hit or Double Expressor Diffuse Large B-cell Lymphomas von Islam, Shariful, Qi, Wenqing, Morales, Carla, Cooke, Laurence, Spier, Catherine, Weterings, Eric, Mahadevan, Daruka

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Aurora A Inhibitor (MLN8237) plus Vincristine plus Rituximab Is Synthetic Lethal and a Potential Curative Therapy in Aggressive B-cell Non-Hodgkin Lymphoma von MAHADEVAN, Daruka, STEJSKAL, Amy, COOKE, Laurence S, MANZIELLO, Ann, MORALES, Carla, PERSKY, Daniel O, FISHER, Richard I, MILLER, Thomas P, WENQING QI

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AT9283, a novel aurora kinase inhibitor, suppresses tumor growth in aggressive B-cell lymphomas von Qi, Wenqing, Liu, Xiaobing, Cooke, Laurence S., Persky, Daniel O., Miller, Thomas P., Squires, Matthew, Mahadevan, Daruka

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Aurora inhibitor MLN8237 in combination with docetaxel enhances apoptosis and anti-tumor activity in mantle cell lymphoma von Qi, Wenqing, Cooke, Laurence S., Liu, Xiaobing, Rimsza, Lisa, Roe, Denise J., Persky, Ann Manziolli. Daniel O., Miller, Thomas P., Mahadevan, Daruka

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Novel receptor tyrosine kinase targeted combination therapies for imatinib-resistant gastrointestinal stromal tumors (GIST) von Mahadevan, Daruka, Theiss, Noah, Morales, Carla, Stejskal, Amy E, Cooke, Laurence S, Zhu, Min, Kurtzman, Drew, Swart, Rachel, Ong, Evan, Qi, Wenqing

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Alisertib (MLN8237) an investigational agent suppresses Aurora A and B activity, inhibits proliferation, promotes endo-reduplication and induces apoptosis in T-NHL cell lines suppo... von Qi, Wenqing, Spier, Catherine, Liu, Xiaobing, Agarwal, Amit, Cooke, Laurence S, Persky, Daniel O, Chen, Deyu, Miller, Thomas P, Mahadevan, Daruka

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The c-Met receptor tyrosine kinase inhibitor MP470 radiosensitizes glioblastoma cells von Welsh, James W, Mahadevan, Daruka, Ellsworth, Ron, Cooke, Laurence, Bearss, David, Stea, Baldassarre

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Design and Activity of a Murine and Humanized Anti-CEACAM6 Single-Chain Variable Fragment in the Treatment of Pancreatic Cancer von RILEY, Christopher J, ENGELHARDT, Kevin P, NAGLE, Raymond B, GAREWAL, Harinder, VON HOFF, Daniel D, MAHADEVAN, Daruka, SALDANHA, Jose W, WENQING QI, COOKE, Laurence S, YINGTING ZHU, NARAYAN, Satya T, SHAKALYA, Kishore, CROCE, Kimiko Della, GEORGIEV, Ivan G

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Novel mutational and pathway signatures in relapsed/refractory colorectal cancer patients von Johnson, Benny, Cooke, Laurence, Mahadevan, Daruka

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Novel mutational and pathway signatures in relapsed/refractory colorectal cancer patients von Johnson, Benny, Cooke, Laurence, Mahadevan, Daruka

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Drug-induced aneuploidy and polyploidy is a mechanism of disease relapse in MYC/BCL2-addicted diffuse large B-cell lymphoma von Islam, Shariful, Paek, Andrew L, Hammer, Michael, Rangarajan, Savithri, Ruijtenbeek, Robert, Cooke, Laurence, Weterings, Eric, Mahadevan, Daruka

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Multi-Omics of Aurora Inhibition Induced Polyploidy Reveals Mechanisms of Disease Relapse in MYC/BCL2-Addicted High Grade B-Cell Lymphoma von Islam, Shariful, Paek, Andrew, Hammer, Michael, Rangarajan, Savithri, Ruijtenbeek, Robert, Cooke, Laurence, Weterings, Eric, Mahadevan, Daruka

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TP53 Mutations as a Driver of Metastasis Signaling in Advanced Cancer Patients von Pandey, Ritu, Johnson, Nathan, Cooke, Laurence, Johnson, Benny, Chen, Yuliang, Pandey, Manjari, Chandler, Jason, Mahadevan, Daruka

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Co-targeting aurora kinase with PD-L1 and PI3K abrogates immune checkpoint mediated proliferation in peripheral T-cell lymphoma: a novel therapeutic strategy von Islam, Shariful, Vick, Eric, Huber, Bryan, Morales, Carla, Spier, Catherine, Cooke, Laurence, Weterings, Eric, Mahadevan, Daruka

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Next generation sequencing identifies 'interactome' signatures in relapsed and refractory metastatic colorectal cancer von Johnson, Benny, Cooke, Laurence, Mahadevan, Daruka

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RX-3117, a Novel Nucleoside Analog Targeting UCK2 Is Active Alone and Synergistic with Ibrutinib and Bendamustine in ABC and DH/DP- Diffuse Large B-Cell Lymphoma von Islam, Shariful, Zahid, Umar, Cooke, Laurence, Lee, Young Bok, Kim, Deog Joong, Benaim, Ely, Mahadevan, Daruka

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