Discovery of a Selective S1P1 Receptor Agonist Efficacious at Low Oral Dose and Devoid of Effects on Heart Rate von Demont, Emmanuel H, Andrews, Benjamin I, Bit, Rino A, Campbell, Colin A, Cooke, Jason W. B, Deeks, Nigel, Desai, Sapna, Dowell, Simon J, Gaskin, Pam, Gray, James R. J, Haynes, Andrea, Holmes, Duncan S, Kumar, Umesh, Morse, Mary A, Osborne, Greg J, Panchal, Terry, Patel, Bela, Perboni, Alcide, Taylor, Simon, Watson, Robert, Witherington, Jason, Willis, Robert

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Optimization of the Preparation of (R)‑3,5-Bis(trifluoromethyl)-α-methyl‑N‑methylbenzylamine l‑(−)-Malic Acid Salt through Classical Resolution von Brandel, Clément M, Cooke, Jason W. B, Horan, Richard A. J, Mallet, Franck P, Stevens, David R

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Asymmetric synthesis of beta-amino-gamma-substituted-gamma-butyrolactones: double diastereoselective conjugate addition of homochiral lithium amides to homochiral alpha,beta-unsatu... von Cailleau, Thaïs, Cooke, Jason W B, Davies, Stephen G, Ling, Kenneth B, Naylor, Alan, Nicholson, Rebecca L, Price, Paul D, Roberts, Paul M, Russell, Angela J, Smith, Andrew D, Thomson, James E

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Development of an Efficient Large-Scale Synthesis for a 4H-imidazo[5,1-c][1,4]benzoxazine-3-carboxamide Derivative for Depression and Anxiety von Giubellina, Nicola, Stabile, Paolo, Laval, Gilles, Perboni, Alcide D, Cimarosti, Zadeo, Westerduin, Pieter, Cooke, Jason W. B

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Process Research and Development of a Dihydropyrimidine Dehydrogenase Inactivator:  Large-Scale Preparation of Eniluracil Using a Sonogashira Coupling von Cooke, Jason W. B, Bright, Robert, Coleman, Mark J, Jenkins, Kevin P

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An Efficient, Practical Approach to the Synthesis of 2,4-Disubstituted Thiazoles and Oxazoles:  Application to the Synthesis of GW475151 von Hermitage, Stephen A, Cardwell, Kevin S, Chapman, Tim, Cooke, Jason W. B, Newton, Rebecca

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The Fit For Purpose Development of S1P1 Receptor Agonist GSK2263167 Using a Robinson Annulation and Saegusa Oxidation to Access an Advanced Phenol Intermediate von Harris, Robert M, Andrews, Benjamin I, Clark, Stacy, Cooke, Jason W. B, Gray, John C. S, Ng, Stephanie Q. Q

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A Novel and Selective Approach to Enantiomerically Pure Bicyclic-Trans-Lactams via a Titanium Enolate of a Thiopyridyl Ester von Cooke, Jason W. B, Berry, Malcolm B, Caine, Darren M, Cardwell, Kevin S, Cook, John S, Hodgson, Anne

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Development of an Efficient Large-Scale Synthesis for a 4 H -imidazo[5,1- c ][1,4]benzoxazine-3-carboxamide Derivative for Depression and Anxiety von Giubellina, Nicola, Stabile, Paolo, Laval, Gilles, Perboni, Alcide D., Cimarosti, Zadeo, Westerduin, Pieter, Cooke, Jason W. B.

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The Fit For Purpose Development of S1P 1 Receptor Agonist GSK2263167 Using a Robinson Annulation and Saegusa Oxidation to Access an Advanced Phenol Intermediate von Harris, Robert M., Andrews, Benjamin I., Clark, Stacy, Cooke, Jason W. B., Gray, John C. S., Ng, Stephanie Q. Q.

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Asymmetric synthesis of 4-amino-γ-butyrolactones via lithium amide conjugate addition von Abraham, Elin, Cooke, Jason W.B., Davies, Stephen G., Naylor, Alan, Nicholson, Rebecca L., Price, Paul. D., Smith, Andrew D.

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Route Selection and Process Development for a 5-Piperazinylquinaldine Derivative for the Treatment of Depression and Anxiety von Cimarosti, Zadeo, Giubellina, Nicola, Stabile, Paolo, Laval, Gilles, Tinazzi, Francesco, Maton, William, Pachera, Roberta, Russo, Paola, Moretti, Ramona, Rossi, Sara, Cooke, Jason W. B., Westerduin, Pieter

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Discovery of a Selective S1P 1 Receptor Agonist Efficacious at Low Oral Dose and Devoid of Effects on Heart Rate von Demont, Emmanuel H., Andrews, Benjamin I., Bit, Rino A., Campbell, Colin A., Cooke, Jason W. B., Deeks, Nigel, Desai, Sapna, Dowell, Simon J., Gaskin, Pam, Gray, James R. J., Haynes, Andrea, Holmes, Duncan S., Kumar, Umesh, Morse, Mary A., Osborne, Greg J., Panchal, Terry, Patel, Bela, Perboni, Alcide, Taylor, Simon, Watson, Robert, Witherington, Jason, Willis, Robert

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Efficient synthesis of 2-trihalomethyl-5-cyanopyridines von Cooke, Jason WB, Coleman, Mark J, Caine, Darren M, Jenkins, Kevin P

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Asymmetric Synthesis of 4-Amino-γ-butyrolactones via Lithium Amide Conjugate Addition von Abraham, Elin, Cooke, Jason W. B., Davies, Stephen G., Naylor, Alan, Nicholson, Rebecca L., Price, Paul D., Smith, Andrew D.

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Asymmetric Synthesis of 4-Amino-γ-butyrolactones via Lithium Amide Conjugate Addition von Abraham, Elin, Cooke, Jason W. B., Davies, Stephen G., Naylor, Alan, Nicholson, Rebecca L., Price, Paul D., Smith, Andrew D.

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Synthesis of (.+-.)-Solanapyrones A and B von Lygo, Barry, Bhatia, Mohamed, Cooke, Jason W. B., Hirst, David J.

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ChemInform Abstract: An Efficient, Practical Approach to the Synthesis of 2,4-Disubstituted Thiazoles and Oxazoles: Application to the Synthesis of GW475151 von Hermitage, Stephen A., Cardwell, Kevin S., Chapman, Tim, Cooke, Jason W. B., Newton, Rebecca

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Timing of radiotherapy after radical prostatectomy (RADICALS-RT): a randomised, controlled phase 3 trial von Parker, Christopher C, Clarke, Noel W, Cook, Adrian D, Kynaston, Howard G, Petersen, Peter Meidahl, Catton, Charles, Cross, William, Logue, John, Parulekar, Wendy, Payne, Heather, Persad, Rajendra, Pickering, Holly, Saad, Fred, Anderson, Juliette, Bahl, Amit, Bottomley, David, Brasso, Klaus, Chahal, Rohit, Cooke, Peter W, Eddy, Ben, Gibbs, Stephanie, Goh, Chee, Gujral, Sandeep, Heath, Catherine, Henderson, Alastair, Jaganathan, Ramasamy, Jakobsen, Henrik, James, Nicholas D, Kanaga Sundaram, Subramanian, Lees, Kathryn, Lester, Jason, Lindberg, Henriette, Money-Kyrle, Julian, Morris, Stephen, O'Sullivan, Joe, Ostler, Peter, Owen, Lisa, Patel, Prashant, Pope, Alvan, Popert, Richard, Raman, Rakesh, Røder, Martin Andreas, Sayers, Ian, Simms, Matthew, Wilson, Jim, Zarkar, Anjali, Parmar, Mahesh K B, Sydes, Matthew R

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Fitness, but not physical activity, is related to functional integrity of brain networks associated with aging von Voss, Michelle W., Weng, Timothy B., Burzynska, Agnieszka Z., Wong, Chelsea N., Cooke, Gillian E., Clark, Rachel, Fanning, Jason, Awick, Elizabeth, Gothe, Neha P., Olson, Erin A., McAuley, Edward, Kramer, Arthur F.

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