AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer von Kubli, Shawn P., Bassi, Christian, Roux, Cecilia, Wakeham, Andrew, Göbl, Christoph, Zhou, Wenjing, Jafari, Soode Moghadas, Snow, Bryan, Jones, Lisa, Palomero, Luis, Thu, Kelsie L., Cassetta, Luca, Soong, Daniel, Berger, Thorsten, Ramachandran, Parameswaran, Baniasadi, Shakiba P., Duncan, Gordon, Lindzen, Moshit, Yarden, Yosef, Herranz, Carmen, Lazaro, Conxi, Chu, Mandy F., Haight, Jillian, Tinto, Paul, Silvester, Jennifer, Cescon, David W., Petit, Anna, Pettersson, Sven, Pollard, Jeffrey W., Mak, Tak W., Pujana, Miguel A., Cappello, Paola, Gorrini, Chiara

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Association Between BRCA1 and BRCA2 Mutations and Survival in Women With Invasive Epithelial Ovarian Cancer von Bolton, Kelly L, Chenevix- Trench, Georgia, Goh, Cindy, Sadetzki, Siegal, Ramus, Susan J, Karlan, Beth Y, Lambrechts, Diether, Despierre, Evelyn, Barrowdale, Daniel, McGuffog, Lesley, Healey, Sue, Easton, Douglas F, Sinilnikova, Olga, Benítez, Javier, García, María J, Neuhausen, Susan, Gail, Mitchell H, Hartge, Patricia, Peock, Susan, Frost, Debra, Evans, D. Gareth, Eeles, Rosalind, Godwin, Andrew K, Daly, Mary B, Kwong, Ava, Ma, Edmond S. K, Lázaro, Conxi, Blanco, Ignacio, Montagna, Marco, D'Andrea, Emma, Nicoletto, Maria Ornella, Johnatty, Sharon E, Kjær, Susanne Krüger, Jensen, Allan, Høgdall, Estrid, Goode, Ellen L, Fridley, Brooke L, Loud, Jennifer T, Greene, Mark H, Mai, Phuong L, Chetrit, Angela, Lubin, Flora, Hirsh-Yechezkel, Galit, Glendon, Gord, Andrulis, Irene L, Toland, Amanda E, Senter, Leigha, Gore, Martin E, Gourley, Charlie, Michie, Caroline O, Song, Honglin, Tyrer, Jonathan, Whittemore, Alice S, McGuire, Valerie, Sieh, Weiva, Kristoffersson, Ulf, Olsson, Håkan, Borg, Åke, Levine, Douglas A, Steele, Linda, Beattie, Mary S, Chan, Salina, Nussbaum, Robert L, Moysich, Kirsten B, Gross, Jenny, Cass, Ilana, Walsh, Christine, Li, Andrew J, Leuchter, Ronald, Gordon, Ora, Garcia-Closas, Montserrat, Gayther, Simon A, Chanock, Stephen J, Antoniou, Antonis C, Pharoah, Paul D. P, EMBRACE, kConFab Investigators, and The Cancer Genome Atlas Research Network, for the

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Using antisense oligonucleotides for the physiological modulation of the alternative splicing of NF1 exon 23a during PC12 neuronal differentiation von Biayna, Josep, Mazuelas, Helena, Gel, Bernat, Terribas, Ernest, Dumbovic, Gabrijela, Rosas, Inma, Fernández-Rodriguez, Juana, Blanco, Ignacio, Castellanos, Elisabeth, Carrió, Meritxell, Lazaro, Conxi, Serra, Eduard

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Editorial: Hereditary Breast and Ovarian Cancer: Current Concepts of Prevention and Treatment von Grabenstetter, Anne, Lazaro, Conxi, Turashvili, Gulisa

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Multigene panel testing for hereditary breast and ovarian cancer in the province of Ontario von Lerner-Ellis, Jordan, Mighton, Chloe, Lazaro, Conxi, Watkins, Nicholas, Di Gioacchino, Vanessa, Wong, Andrew, Chang, Martin C., Charames, George S.

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Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors von Lahiguera, Álvaro, Hyroššová, Petra, Figueras, Agnès, Garzón, Diana, Moreno, Roger, Soto‐Cerrato, Vanessa, McNeish, Iain, Serra, Violeta, Lazaro, Conxi, Barretina, Pilar, Brunet, Joan, Menéndez, Javier, Matias‐Guiu, Xavier, Vidal, August, Villanueva, Alberto, Taylor‐Harding, Barbie, Tanaka, Hisashi, Orsulic, Sandra, Junza, Alexandra, Yanes, Oscar, Muñoz‐Pinedo, Cristina, Palomero, Luís, Pujana, Miquel Àngel, Perales, José Carlos, Viñals, Francesc

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Evaluation of CNV detection tools for NGS panel data in genetic diagnostics von Moreno-Cabrera, Jose Marcos, del Valle, Jesus, Castellanos, Elisabeth, Feliubadalo, Lidia, Pineda, Marta, Brunet, Joan, Serra, Eduard, Capella, Gabriel, Lazaro, Conxi, Gel, Bernat

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Correction to: Multigene panel testing for hereditary breast and ovarian cancer in the province of Ontario von Lerner-Ellis, Jordan, Mighton, Chloe, Lazaro, Conxi, Watkins, Nicholas, Di Gioacchino, Vanessa, Wong, Andrew, Chang, Martin C., Charames, George S.

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FANCM c.5791C>T nonsense mutation (rs144567652) induces exon skipping, affects DNA repair activity and is a familial breast cancer risk factor von Peterlongo, Paolo, Catucci, Irene, Colombo, Mara, Caleca, Laura, Mucaki, Eliseos, Bogliolo, Massimo, Marin, Maria, Damiola, Francesca, Bernard, Loris, Pensotti, Valeria, Volorio, Sara, Dall'Olio, Valentina, Meindl, Alfons, Bartram, Claus, Sutter, Christian, Surowy, Harald, Sornin, Valérie, Dondon, Marie-Gabrielle, Eon-Marchais, Séverine, Stoppa-Lyonnet, Dominique, Andrieu, Nadine, Sinilnikova, Olga M, Mitchell, Gillian, James, Paul A, Thompson, Ella, Marchetti, Marina, Verzeroli, Cristina, Tartari, Carmen, Capone, Gabriele Lorenzo, Putignano, Anna Laura, Genuardi, Maurizio, Medici, Veronica, Marchi, Isabella, Federico, Massimo, Tognazzo, Silvia, Matricardi, Laura, Agata, Simona, Dolcetti, Riccardo, Della Puppa, Lara, Cini, Giulia, Gismondi, Viviana, Viassolo, Valeria, Perfumo, Chiara, Mencarelli, Maria Antonietta, Baldassarri, Margherita, Peissel, Bernard, Roversi, Gaia, Silvestri, Valentina, Rizzolo, Piera, Spina, Francesca, Vivanet, Caterina, Tibiletti, Maria Grazia, Caligo, Maria Adelaide, Gambino, Gaetana, Tommasi, Stefania, Pilato, Brunella, Tondini, Carlo, Corna, Chiara, Bonanni, Bernardo, Barile, Monica, Osorio, Ana, Benitez, Javier, Balestrino, Luisa, Ottini, Laura, Manoukian, Siranoush, Pierotti, Marco A, Renieri, Alessandra, Varesco, Liliana, Couch, Fergus J, Wang, Xianshu, Devilee, Peter, Hilbers, Florentine S, van Asperen, Christi J, Viel, Alessandra, Montagna, Marco, Cortesi, Laura, Diez, Orland, Balmaña, Judith, Hauke, Jan, Schmutzler, Rita K, Papi, Laura, Pujana, Miguel Angel, Lázaro, Conxi, Falanga, Anna, Offit, Kenneth, Vijai, Joseph, Campbell, Ian, Burwinkel, Barbara, Kvist, Anders, Ehrencrona, Hans, Mazoyer, Sylvie, Pizzamiglio, Sara, Verderio, Paolo, Surralles, Jordi, Rogan, Peter K, Radice, Paolo

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CTNND1 is involved in germline predisposition to early-onset gastric cancer by affecting cell-to-cell interactions von Herrera-Pariente, Cristina, Bonjoch, Laia, Muñoz, Jenifer, Fernàndez, Guerau, Soares de Lima, Yasmin, Mahmood, Romesa, Cuatrecasas, Miriam, Ocaña, Teresa, Lopez-Prades, Sandra, Llargués-Sistac, Gemma, Domínguez-Rovira, Xavier, Llach, Joan, Luzko, Irina, Díaz-Gay, Marcos, Lazaro, Conxi, Brunet, Joan, Castillo-Manzano, Carmen, García-González, María Asunción, Lanas, Angel, Carrillo, Marta, Hernández San Gil, Raquel, Quintero, Enrique, Sala, Nuria, Llort, Gemma, Aguilera, Lara, Carot, Laura, Diez-Redondo, Pilar, Jover, Rodrigo, Ramon y Cajal, Teresa, Cubiella, Joaquín, Castells, Antoni, Balaguer, Francesc, Bujanda, Luis, Castellví-Bel, Sergi, Moreira, Leticia

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Haplotype analysis of the internationally distributed BRCA1 c.3331_3334delCAAG founder mutation reveals a common ancestral origin in Iberia von Tuazon, Anna Marie De Asis, Lott, Paul, Bohorquez, Mabel, Benavides, Jennyfer, Ramirez, Carolina, Criollo, Angel, Estrada-Florez, Ana, Mateus, Gilbert, Velez, Alejandro, Carmona, Jenny, Olaya, Justo, Garcia, Elisha, Polanco-Echeverry, Guadalupe, Stultz, Jacob, Alvarez, Carolina, Tapia, Teresa, Ashton-Prolla, Patricia, Vega, Ana, Lazaro, Conxi, Tornero, Eva, Martinez-Bouzas, Cristina, Infante, Mar, De La Hoya, Miguel, Diez, Orland, Browning, Brian L., Rannala, Bruce, Teixeira, Manuel R., Carvallo, Pilar, Echeverry, Magdalena, Carvajal-Carmona, Luis G.

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Mutational Heterogeneity in APC and KRAS Arises at the Crypt Level and Leads to Polyclonality in Early Colorectal Tumorigenesis von Gausachs, Mireia, Borras, Ester, Chang, Kyle, Gonzalez, Sara, Azuara, Daniel, Delgado Amador, Axel, Lopez-Doriga, Adriana, San Lucas, F Anthony, Sanjuan, Xavier, Paules, Maria J, Taggart, Melissa W, Davies, Gareth E, Ehli, Erik A, Fowler, Jerry, Moreno, Victor, Pineda, Marta, You, Y Nancy, Lynch, Patrick M, Lazaro, Conxi, Navin, Nicholas E, Scheet, Paul A, Hawk, Ernest T, Capella, Gabriel, Vilar, Eduardo

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Systematic Collaborative Reanalysis of Genomic Data Improves Diagnostic Yield in Neurologic Rare Diseases von Bullich, Gemma, Matalonga, Leslie, Pujadas, Montserrat, Papakonstantinou, Anastasios, Piscia, Davide, Tonda, Raúl, Artuch, Rafael, Gallano, Pia, Garrabou, Glòria, González, Juan R, Grinberg, Daniel, Guitart, Míriam, Laurie, Steven, Lázaro, Conxi, Luengo, Cristina, Martí, Ramon, Milà, Montserrat, Ovelleiro, David, Parra, Genís, Pujol, Aurora, Tizzano, Eduardo, Macaya, Alfons, Palau, Francesc, Ribes, Antònia, Pérez-Jurado, Luis A, Beltran, Sergi

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Modification of BRCA1-associated breast cancer risk by HMMR overexpression von Mateo, Francesca, He, Zhengcheng, Mei, Lin, de Garibay, Gorka Ruiz, Herranz, Carmen, García, Nadia, Lorentzian, Amanda, Baiges, Alexandra, Blommaert, Eline, Gómez, Antonio, Mirallas, Oriol, Garrido-Utrilla, Anna, Palomero, Luis, Espín, Roderic, Extremera, Ana I., Soler-Monsó, M. Teresa, Petit, Anna, Li, Rong, Brunet, Joan, Chen, Ke, Tan, Susanna, Eaves, Connie J., McCloskey, Curtis, Hakem, Razq, Khokha, Rama, Lange, Philipp F., Lázaro, Conxi, Maxwell, Christopher A., Pujana, Miquel Angel

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Evaluation of copy-number variants as modifiers of breast and ovarian cancer risk for BRCA1 pathogenic variant carriers von Walker, Logan C, Marquart, Louise, Pearson, John F, Wiggins, George A R, O'Mara, Tracy A, Parsons, Michael T, Barrowdale, Daniel, McGuffog, Lesley, Dennis, Joe, Benitez, Javier, Slavin, Thomas P, Radice, Paolo, Frost, Debra, Godwin, Andrew K, Meindl, Alfons, Schmutzler, Rita Katharina, Isaacs, Claudine, Peshkin, Beth N, Caldes, Trinidad, Hogervorst, Frans Bl, Lazaro, Conxi, Jakubowska, Anna, Montagna, Marco, Chen, Xiaoqing, Offit, Kenneth, Hulick, Peter J, Andrulis, Irene L, Lindblom, Annika, Nussbaum, Robert L, Nathanson, Katherine L, Chenevix-Trench, Georgia, Antoniou, Antonis C, Couch, Fergus J, Spurdle, Amanda B

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Genetic Screening for TLR7 Variants in Young and Previously Healthy Men With Severe COVID-19 von Solanich, Xavier, Vargas-Parra, Gardenia, van der Made, Caspar I., Simons, Annet, Schuurs-Hoeijmakers, Janneke, Antoli, Arnau, del Valle, Jesus, Rocamora-Blanch, Gemma, Setien, Fernando, Esteller, Manel, van Reijmersdal, Simon V., Riera-Mestre, Antoni, Sabater-Riera, Joan, Capella, Gabriel, van de Veerdonk, Frank L., van der Hoven, Ben, Corbella, Xavier, Hoischen, Alexander, Lazaro, Conxi

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POLE and POLD1 mutations in 529 kindred with familial colorectal cancer and/or polyposis: review of reported cases and recommendations for genetic testing and surveillance von Bellido, Fernando, Pineda, Marta, Aiza, Gemma, Valdés-Mas, Rafael, Navarro, Matilde, Puente, Diana A., Pons, Tirso, González, Sara, Iglesias, Silvia, Darder, Esther, Piñol, Virginia, Soto, José Luís, Valencia, Alfonso, Blanco, Ignacio, Urioste, Miguel, Brunet, Joan, Lázaro, Conxi, Capellá, Gabriel, Puente, Xose S., Valle, Laura

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The Average Cumulative Risks of Breast and Ovarian Cancer for Carriers of Mutations in BRCA1 and BRCA2 Attending Genetic Counseling Units in Spain von Milne, Roger L, Osorio, Ana, Cajal, Teresa Ramón Y, Vega, Ana, Llort, Gemma, de la Hoya, Miguel, Díez, Orland, Alonso, M Carmen, Lazaro, Conxi, Blanco, Ignacio, Sánchez-de-Abajo, Ana, Caldés, Trinidad, Blanco, Ana, Graña, Begoña, Durán, Mercedes, Velasco, Eladio, Chirivella, Isabel, Cardeñosa, Eva Esteban, Tejada, María-Isabel, Beristain, Elena, Miramar, María-Dolores, Calvo, María-Teresa, Martínez, Eduardo, Guillén, Carmen, Salazar, Raquel, San Román, Carlos, Antoniou, Antonis C, Urioste, Miguel, Benítez, Javier

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Response to letter entitled: Re: ERCC3 a new ovarian cancer susceptibility gene? von Stradella, Agostina, del Valle, Jesús, Brunet, Joan, Lázaro, Conxi

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Boosting care and knowledge about hereditary cancer: European Reference Network on Genetic Tumour Risk Syndromes von Vos, Janet R., Giepmans, Lisette, Röhl, Claas, Geverink, Nicoline, Hoogerbrugge, Nicoline

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