Selectively Targeting the Kinome-Conserved Lysine of PI3Kδ as a General Approach to Covalent Kinase Inhibition von Dalton, Samuel E, Dittus, Lars, Thomas, Daniel A, Convery, Máire A, Nunes, Joao, Bush, Jacob T, Evans, John P, Werner, Thilo, Bantscheff, Marcus, Murphy, John A, Campos, Sebastien

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Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells von Baba, T, Convery, P A, Matsumura, N, Whitaker, R S, Kondoh, E, Perry, T, Huang, Z, Bentley, R C, Mori, S, Fujii, S, Marks, J R, Berchuck, A, Murphy, S K

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Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2‑((4-(Benzo[d]­thiazol-5-ylamino)-6‑(tert-butylsulfonyl)­quinazolin-7-yl)ox... von Haile, Pamela A, Casillas, Linda N, Votta, Bartholomew J, Wang, Gren Z, Charnley, Adam K, Dong, Xiaoyang, Bury, Michael J, Romano, Joseph J, Mehlmann, John F, King, Bryan W, Erhard, Karl F, Hanning, Charles R, Lipshutz, David B, Desai, Biva M, Capriotti, Carol A, Schaeffer, Michelle C, Berger, Scott B, Mahajan, Mukesh K, Reilly, Michael A, Nagilla, Rakesh, Rivera, Elizabeth J, Sun, Helen H, Kenna, John K, Beal, Allison M, Ouellette, Michael T, Kelly, Mike, Stemp, Gillian, Convery, Máire A, Vossenkämper, Anna, MacDonald, Thomas T, Gough, Peter J, Bertin, John, Marquis, Robert W

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The Identification and Pharmacological Characterization of 6‑(tert-Butylsulfonyl)‑N‑(5-fluoro‑1H‑indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of... von Haile, Pamela A, Votta, Bartholomew J, Marquis, Robert W, Bury, Michael J, Mehlmann, John F, Singhaus, Robert, Charnley, Adam K, Lakdawala, Ami S, Convery, Máire A, Lipshutz, David B, Desai, Biva M, Swift, Barbara, Capriotti, Carol A, Berger, Scott B, Mahajan, Mukesh K, Reilly, Michael A, Rivera, Elizabeth J, Sun, Helen H, Nagilla, Rakesh, Beal, Allison M, Finger, Joshua N, Cook, Michael N, King, Bryan W, Ouellette, Michael T, Totoritis, Rachel D, Pierdomenico, Maria, Negroni, Anna, Stronati, Laura, Cucchiara, Salvatore, Ziółkowski, Bartłomiej, Vossenkämper, Anna, MacDonald, Thomas T, Gough, Peter J, Bertin, John, Casillas, Linda N

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Optimization of Potent and Selective Cyclohexyl Acid ERAP1 Inhibitors Using Structure- and Property-Based Drug Design von Hryczanek, Ross P., Hackett, Andrew S., Rowland, Paul, Chung, Chun-wa, Convery, Máire A., Holmes, Duncan S., Hutchinson, Jonathan P., Kitchen, Semra, Korczynska, Justyna, Law, Robert P., Lea, Jonathan D., Liddle, John, Lonsdale, Richard, Neu, Margarete, Nickels, Leng, Phillipou, Alex, Rowedder, James E., Schneck, Jessica L., Scott-Stevens, Paul, Sheehan, Hester, Tayler, Chloe L., Temponeras, Ioannis, Tinworth, Christopher P., Walker, Ann L., Wojno-Picon, Justyna, Young, Robert J., Lindsay, David M., Stratikos, Efstratios

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Design and Development of a Macrocyclic Series Targeting Phosphoinositide 3‑Kinase δ von Spencer, Jonathan A, Baldwin, Ian R, Barton, Nick, Chung, Chun-Wa, Convery, Máire A, Edwards, Christopher D, Jamieson, Craig, Mallett, David N, Rowedder, James E, Rowland, Paul, Thomas, Daniel A, Hardy, Charlotte J

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Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors von Haffner, Curt D, Charnley, Adam K, Aquino, Christopher J, Casillas, Linda, Convery, Máire A, Cox, Julie A, Elban, Mark A, Goodwin, Nicole C, Gough, Peter J, Haile, Pamela A, Hughes, Terry V, Knapp-Reed, Beth, Kreatsoulas, Constantine, Lakdawala, Ami S, Li, Huijie, Lian, Yiqian, Lipshutz, David, Mehlmann, John F, Ouellette, Michael, Romano, Joseph, Shewchuk, Lisa, Shu, Arthur, Votta, Bartholomew J, Zhou, Huiqiang, Bertin, John, Marquis, Robert W

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Crystal structures of human RIP2 kinase catalytic domain complexed with ATP-competitive inhibitors: Foundations for understanding inhibitor selectivity von Charnley, Adam K., Convery, Máire A., Lakdawala Shah, Ami, Jones, Emma, Hardwicke, Philip, Bridges, Angela, Ouellette, Michael, Totoritis, Rachel, Schwartz, Benjamin, King, Bryan W., Wisnoski, David D., Kang, James, Eidam, Patrick M., Votta, Bartholomew J., Gough, Peter J., Marquis, Robert W., Bertin, John, Casillas, Linda

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Factor Xa Inhibitors:  S1 Binding Interactions of a Series of N-{(3S)-1-[(1S)-1-Methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamides von Chan, Chuen, Borthwick, Alan D, Brown, David, Burns-Kurtis, Cynthia L, Campbell, Matthew, Chaudry, Laiq, Chung, Chun-wa, Convery, Máire A, Hamblin, J. Nicole, Johnstone, Lisa, Kelly, Henry A, Kleanthous, Savvas, Patikis, Angela, Patel, Champa, Pateman, Anthony J, Senger, Stefan, Shah, Gita P, Toomey, John R, Watson, Nigel S, Weston, Helen E, Whitworth, Caroline, Young, Robert J, Zhou, Ping

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Botulinum Toxin A in Tissue Expander Breast Reconstruction: A Double-blinded Randomized Controlled Trial von Lemaine, Valerie, Lohse, Christine M., Mandrekar, Jay N., Ramaker, Sheri A., Convery, Phyllis A., Nguyen, Minh Doan, Tran, Nho V.

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Transitioning to Remote Recruitment and Intervention: A Tale of Two Palliative Care Research Studies Enrolling Underserved Populations During COVID-19 von Brody, Abraham A., Convery, Kimberly A., Kline, Danielle M., Fink, Regina M., Fischer, Stacy M.

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Crystal structure of the Holliday junction resolving enzyme T7 endonuclease I von Phillips, Simon E.V, Hadden, Jonathan M, Convery, Máire A, Déclais, Anne-Cécile, Lilley, David M.J

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Arylsulfonamides: A study of the relationship between activity and conformational preferences for a series of factor Xa inhibitors von Senger, Stefan, Convery, Máire A., Chan, Chuen, Watson, Nigel S.

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CSAR 2014: A Benchmark Exercise Using Unpublished Data from Pharma von Carlson, Heather A, Smith, Richard D, Damm-Ganamet, Kelly L, Stuckey, Jeanne A, Ahmed, Aqeel, Convery, Maire A, Somers, Donald O, Kranz, Michael, Elkins, Patricia A, Cui, Guanglei, Peishoff, Catherine E, Lambert, Millard H, Dunbar, James B

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Sulfonamide-related conformational effects and their importance in structure-based design von Senger, Stefan, Chan, Chuen, Convery, Máire A., Hubbard, Julia A., Shah, Gita P., Watson, Nigel S., Young, Robert J.

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The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs von Watson, Nigel S., Adams, Carl, Belton, David, Brown, David, Burns-Kurtis, Cynthia L., Chaudry, Laiq, Chan, Chuen, Convery, Máire A., Davies, David E., Exall, Anne M., Harling, John D., Irvine, Stephanie, Irving, Wendy R., Kleanthous, Savvas, McLay, Iain M., Pateman, Anthony J., Patikis, Angela N., Roethke, Theresa J., Senger, Stefan, Stelman, Gary J., Toomey, John R., West, Robert I., Whittaker, Caroline, Zhou, Ping, Young, Robert J.

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Structure- and property-based design of factor Xa inhibitors: Pyrrolidin-2-ones with acyclic alanyl amides as P4 motifs von Young, Robert J., Campbell, Matthew, Borthwick, Alan D., Brown, David, Burns-Kurtis, Cynthia L., Chan, Chuen, Convery, Máire A., Crowe, Miriam C., Dayal, Satish, Diallo, Hawa, Kelly, Henry A., Paul King, N., Kleanthous, Savvas, Mason, Andrew M., Mordaunt, Jackie E., Patel, Champa, Pateman, Anthony J., Senger, Stefan, Shah, Gita P., Smith, Paul W., Watson, Nigel S., Weston, Helen E., Zhou, Ping

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GSK137, a potent small-molecule BCL6 inhibitor with in vivo activity, suppresses antibody responses in mice von Pearce, Andrew C., Bamford, Mark J., Barber, Ruth, Bridges, Angela, Convery, Maire A., Demetriou, Constantinos, Evans, Sian, Gobbetti, Thomas, Hirst, David J., Holmes, Duncan S., Hutchinson, Jonathan P., Jayne, Sandrine, Lezina, Larissa, McCabe, Michael T., Messenger, Cassie, Morley, Joanne, Musso, Melissa C., Scott-Stevens, Paul, Manso, Ana Sousa, Schofield, Jennifer, Slocombe, Tom, Somers, Don, Walker, Ann L., Wyce, Anastasia, Zhang, Xi-Ping, Wagner, Simon D.

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Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs von Young, Robert J., Adams, Carl, Blows, Mike, Brown, David, Burns-Kurtis, Cynthia L., Chan, Chuen, Chaudry, Laiq, Convery, Máire A., Davies, David E., Exall, Anne M., Foster, Graham, Harling, John D., Hortense, Eric, Irvine, Stephanie, Irving, Wendy R., Jackson, Steve, Kleanthous, Savvas, Pateman, Anthony J., Patikis, Angela N., Roethka, Theresa J., Senger, Stefan, Stelman, Gary J., Toomey, John R., West, Robert I., Whittaker, Caroline, Zhou, Ping, Watson, Nigel S.

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The crystal structure of a high affinity RNA stem-loop complexed with the bacteriophage MS2 capsid: further challenges in the modeling of ligand-RNA interactions von Horn, Wilf T, Convery, Máire A, Stonehouse, Nicola J, Adams, Chris J, Liljas, Lars, Phillips, Simon E V, Stockley, Peter G

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