Abstract 1646: IK-930, a paralog-selective TEAD inhibitor for treating YAP/TAZ-TEAD dependent cancers von Young, Nathan, Punkosdy, George, Cavanaugh, Jill, Bantle, Collin, Constan, Alex, Li, Bin, Conley, James, Sanchez-Martin, Marta, Xu, Lan, McGovern, Karen, Castro, Alfredo, Zhang, Michelle, Ecsedy, Jeffrey

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Abstract 2156: IK-930 is a novel TEAD inhibitor for the treatment of cancers harboring mutations in the Hippo signal transduction pathway von Amidon, Benjamin S., Sanchez-Martin, Marta, Bartolini, Wilmin, Syed, Sakeena, McGovern, Karen, Xu, Lan, Ecsedy, Jeffrey, Zhang, X. Michelle, Constan, Alex, Castro, Alfredo C.

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Recommendations from a global cross-company data sharing initiative on the incorporation of recovery phase animals in safety assessment studies to support first-in-human clinical t... von Sewell, Fiona, Chapman, Kathryn, Baldrick, Paul, Brewster, David, Broadmeadow, Alan, Brown, Paul, Burns-Naas, Leigh Ann, Clarke, Janet, Constan, Alex, Couch, Jessica, Czupalla, Oliver, Danks, Andy, DeGeorge, Joseph, de Haan, Lolke, Hettinger, Klaudia, Hill, Marilyn, Festag, Matthias, Jacobs, Abby, Jacobson-Kram, David, Kopytek, Stephan, Lorenz, Helga, Moesgaard, Sophia Gry, Moore, Emma, Pasanen, Markku, Perry, Rick, Ragan, Ian, Robinson, Sally, Schmitt, Petra M., Short, Brian, Lima, Beatriz Silva, Smith, Diane, Sparrow, Sue, van Bekkum, Yvette, Jones, David

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The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacy von MCLAY, Lain M, HALLEY, Frank, FOSTER, Martyn, HELE, David, JAYYOSI, Zaid, KELLEY, Mike, MASLEN, Chris, MILLER, Glen, OULDELHKIM, Marie-Claude, PAGE, Kenneth, PHIPPS, Simon, POLLOCK, Kenneth, SOUNESS, John E, PORTER, Barry, RATCLIFFE, Andrew J, REDFORD, Elisabeth J, WEBBER, Stephen, SLATER, Bryan, THYBAUD, Veronique, WILSHER, Nicola, MCKENNA, Jeffrey, BENNING, Veronique, BIRRELL, Mark, BURTON, Brenda, BELVISI, Maria, COLLIS, Alan, CONSTAN, Alex

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Data Resource Profile: Self-reported data in the Million Veteran Program: survey development and insights from the first 850 736 participants von Nguyen, Xuan-Mai T, Whitbourne, Stacey B, Li, Yanping, Quaden, Rachel M, Song, Rebecca J, Nguyen, Hai-Nam A, Harrington, Kelly, Djousse, Luc, Brewer, Jessica V V, Deen, Jennifer, Muralidhar, Sumitra, Ramoni, Rachel B, Cho, Kelly, Casas, Juan P, Tsao, Philip S, Gaziano, John M

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Association of Kidney Comorbidities and Acute Kidney Failure With Unfavorable Outcomes After COVID-19 in Individuals With the Sickle Cell Trait von Verma, Anurag, Huffman, Jennifer E, Gao, Lina, Minnier, Jessica, Wu, Wen-Chih, Cho, Kelly, Ho, Yuk-Lam, Gorman, Bryan R, Pyarajan, Saiju, Rajeevan, Nallakkandi, Garcon, Helene, Joseph, Jacob, McGeary, John E, Suzuki, Ayako, Reaven, Peter D, Wan, Emily S, Lynch, Julie A, Petersen, Jeffrey M, Meigs, James B, Freiberg, Matthew S, Gatsby, Elise, Lynch, Kristine E, Zekavat, Seyedeh Maryam, Natarajan, Pradeep, Dalal, Sharvari, Jhala, Darshana N, Arjomandi, Mehrdad, Bonomo, Robert A, Thompson, Trevor K, Pathak, Gita A, Zhou, Jin J, Donskey, Curtis J, Madduri, Ravi K, Wells, Quinn S, Gelernter, Joel, Huang, Rose D. L, Polimanti, Renato, Chang, Kyong-Mi, Liao, Katherine P, Tsao, Philip S, Sun, Yan V, Wilson, Peter W. F, O’Donnell, Christopher J, Hung, Adriana M, Gaziano, J. Michael, Hauger, Richard L, Iyengar, Sudha K, Luoh, Shiuh-Wen

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Identifying intragenic functional modules of genomic variations associated with cancer phenotypes by learning representation of association networks von Kim, Minsu, Huffman, Jennifer E, Justice, Amy, Goethert, Ian, Agasthya, Greeshma, Danciu, Ioana

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Fibromuscular Dysplasia and Abdominal Aortic Aneurysms Are Dimorphic Sex-Specific Diseases With Shared Complex Genetic Architecture von Katz, Alexander E., Yang, Min-Lee, Levin, Michael G., Tcheandjieu, Catherine, Mathis, Michael, Hunker, Kristina, Blackburn, Susan, Eliason, Jonathan L., Coleman, Dawn M., Fendrikova-Mahlay, Natalia, Gornik, Heather L., Karmakar, Monita, Hill, Hannah, Xu, Chang, Zawistowski, Matthew, Brummett, Chad M., Zoellner, Sebastian, Zhou, Xiang, O’Donnell, Christopher J., Douglas, Julie A., Assimes, Themistocles L., Tsao, Phillip S., Li, Jun Z., Damrauer, Scott M., Stanley, James C., Ganesh, Santhi K.

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