Pharmacoperones as Novel Therapeutics for Diverse Protein Conformational Diseases von Tao, Ya-Xiong, Conn, P Michael

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Chaperoning G Protein-Coupled Receptors: From Cell Biology to Therapeutics von Tao, Ya-Xiong, Conn, P. Michael

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Quality Control Autophagy Degrades Soluble ERAD-Resistant Conformers of the Misfolded Membrane Protein GnRHR von Houck, Scott A., Ren, Hong Yu, Madden, Victoria J., Bonner, Jacob N., Conlin, Michael P., Janovick, Jo Ann, Conn, P. Michael, Cyr, Douglas M.

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Trafficking of G-protein-coupled receptors to the plasma membrane: insights for pharmacoperone drugs von Conn, P. Michael, Ulloa-Aguirre, Alfredo

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Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy von Jo Ann Janovick, Stewart, M. David, Jacob, Darla, Martin, L. D., Deng, Jian Min, Stewart, C. Allison, Wang, Ying, Cornea, Anda, Chavali, Lakshmi, Lopez, Suhujey, Mitalipov, Shoukhrat, Kang, Eunju, Lee, Hyo-Sang, Manna, Pulak R., Stocco, Douglas M., Behringer, Richard R., Conn, P. Michael

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Pharmacoperone rescue of vasopressin 2 receptor mutants reveals unexpected constitutive activity and coupling bias von Janovick, Jo Ann, Spicer, Timothy P, Bannister, Thomas D, Scampavia, Louis, Conn, P Michael

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Redirecting intracellular trafficking and the secretion pattern of FSH dramatically enhances ovarian function in mice von Wang, Huizhen, Larson, Melissa, Jablonka-Shariff, Albina, Pearl, Christopher A., Miller, William L., Conn, P. Michael, Boime, Irving, Kumar, T. Rajendra

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Therapeutic rescue of misfolded mutants: validation of primary high throughput screens for identification of pharmacoperone drugs von Janovick, Jo Ann, Park, Byung S, Conn, P Michael

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Pharmacologic Rescue of Conformationally‐Defective Proteins: Implications for the Treatment of Human Disease von Ulloa‐Aguirre, Alfredo, Janovick, Jo Ann, Brothers, Shaun P., Conn, P. Michael

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Salt bridge integrates GPCR activation with protein trafficking von Janovick, Jo Ann, Conn, P. Michael

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The human gonadotropin releasing hormone type I receptor is a functional intracellular GPCR expressed on the nuclear membrane von Re, Michelle, Pampillo, Macarena, Savard, Martin, Dubuc, Céléna, McArdle, Craig A, Millar, Robert P, Conn, P Michael, Gobeil, Jr, Fernand, Bhattacharya, Moshmi, Babwah, Andy V

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Rescue of Misrouted GnRHR Mutants Reveals Its Constitutive Activity von Janovick, Jo Ann, Pogozheva, Irina D, Mosberg, Henry I, Cornea, Anda, Conn, P. Michael

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Gonadotropin-releasing hormone receptor activates GTPase RhoA and inhibits cell invasion in the breast cancer cell line MDA-MB-231 von Aguilar-Rojas, Arturo, Huerta-Reyes, Maira, Maya-Núñez, Guadalupe, Arechavaleta-Velásco, Fabián, Conn, P Michael, Ulloa-Aguirre, Alfredo, Valdés, Jesús

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Molecular Mechanism of Action of Pharmacoperone Rescue of Misrouted GPCR Mutants: The GnRH Receptor von Janovick, Jo Ann, Patny, Akshay, Mosley, Ralph, Goulet, Mark T, Altman, Michael D, Rush, Thomas S, Cornea, Anda, Conn, P. Michael

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Human Loss-of-Function Gonadotropin-Releasing Hormone Receptor Mutants Retain Wild-Type Receptors in the Endoplasmic Reticulum: Molecular Basis of the Dominant-Negative Effect von Brothers, Shaun P, Cornea, Anda, Janovick, Jo Ann, Conn, P. Michael

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Mice Harboring Gnrhr E90K, a Mutation that Causes Protein Misfolding and Hypogonadotropic Hypogonadism in Humans, Exhibit Testis Size Reduction and Ovulation Failure von Stewart, M. David, Deng, Jian Ming, Stewart, C. Allison, Mullen, Rachael D, Wang, Ying, Lopez, Suhujey, Serna, M. Katalina, Huang, Cheng-Chiu, Janovick, Jo Ann, Pask, Andrew J, Schwartz, Robert J, Conn, P. Michael, Behringer, Richard R

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Measurement of Blood Volume in Adult Rhesus Macaques (Macaca mulatta) von Hobbs, Theodore R, Blue, Steven W, Park, Byung S, Greisel, Jennifer J, Conn, P Michael, Pau, Francis K-Y

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Endosome Signaling Part B von Conn, P. Michael

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Biochemical mechanism of pathogenesis of human gonadotropin-releasing hormone receptor mutants Thr104Ile and Tyr108Cys associated with familial hypogonadotropic hypogonadism von Maya-Núñez, Guadalupe, Janovick, Jo Ann, Aguilar-Rojas, Arturo, Jardón-Valadez, Eduardo, Leaños-Miranda, Alfredo, Zariñan, Teresa, Ulloa-Aguirre, Alfredo, Conn, P. Michael

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Assay strategies for identification of therapeutic leads that target protein trafficking von Conn, P. Michael, Spicer, Timothy P, Scampavia, Louis, Janovick, Jo Ann

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