Targeting MYC dependence in cancer by inhibiting BET bromodomains von Mertz, Jennifer A, Conery, Andrew R, Bryant, Barbara M, Sandy, Peter, Balasubramanian, Srividya, Mele, Deanna A, Bergeron, Louise, Sims, Robert J., III

Volltext

A kinase shRNA screen links LATS2 and the pRB tumor suppressor von Tschöp, Katrin, Conery, Andrew R, Litovchick, Larisa, Decaprio, James A, Settleman, Jeffrey, Harlow, Ed, Dyson, Nicholas

Volltext

CREBBP/EP300 acetyltransferase inhibition disrupts FOXA1-bound enhancers to inhibit the proliferation of ER+ breast cancer cells von Bommi-Reddy, Archana, Park-Chouinard, Sungmi, Mayhew, David N, Terzo, Esteban, Hingway, Aparna, Steinbaugh, Michael J, Wilson, Jonathan E, Sims, 3rd, Robert J, Conery, Andrew R

Volltext

Bromodomains: a new target class for drug development von Cochran, Andrea G., Conery, Andrew R., Sims, Robert J.

Volltext

Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma von Conery, Andrew R, Centore, Richard C, Neiss, Adrianne, Keller, Patricia J, Joshi, Shivangi, Spillane, Kerry L, Sandy, Peter, Hatton, Charlie, Pardo, Eneida, Zawadzke, Laura, Bommi-Reddy, Archana, Gascoigne, Karen E, Bryant, Barbara M, Mertz, Jennifer A, Sims, Robert J

Volltext

Regulation of GLI Underlies a Role for BET Bromodomains in Pancreatic Cancer Growth and the Tumor Microenvironment von Huang, Yinshi, Nahar, Sabikun, Nakagawa, Akifumi, Fernandez-Barrena, Maite G, Mertz, Jennifer A, Bryant, Barbara M, Adams, Curtis E, Mino-Kenudson, Mari, Von Alt, Kate N, Chang, Kevin, Conery, Andrew R, Hatton, Charlie, Sims, 3rd, Robert J, Fernandez-Zapico, Martin E, Wang, Xingpeng, Lillemoe, Keith D, Fernández-Del Castillo, Carlos, Warshaw, Andrew L, Thayer, Sarah P, Liss, Andrew S

Volltext

Small molecule targeting of chromatin writers in cancer von Conery, Andrew R., Rocnik, Jennifer L., Trojer, Patrick

Volltext

Nucleoside diphosphate kinase Nm23-H1 regulates chromosomal stability by activating the GTPase dynamin during cytokinesis von Conery, Andrew R., Sever, Sanja, Harlow, Ed

Volltext

High-throughput screens in diploid cells identify factors that contribute to the acquisition of chromosomal instability von Conery, Andrew R., Harlow, Ed

Volltext

Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition von Ghosh, Srimoyee, Taylor, Alexander, Chin, Melissa, Huang, Hon-Ren, Conery, Andrew R., Mertz, Jennifer A., Salmeron, Andres, Dakle, Pranal J., Mele, Deanna, Cote, Alexandre, Jayaram, Hari, Setser, Jeremy W., Poy, Florence, Hatzivassiliou, Georgia, DeAlmeida-Nagata, Denise, Sandy, Peter, Hatton, Charlie, Romero, F. Anthony, Chiang, Eugene, Reimer, Thornik, Crawford, Terry, Pardo, Eneida, Watson, Venita G., Tsui, Vickie, Cochran, Andrea G., Zawadzke, Laura, Harmange, Jean-Christophe, Audia, James E., Bryant, Barbara M., Cummings, Richard T., Magnuson, Steven R., Grogan, Jane L., Bellon, Steve F., Albrecht, Brian K., Sims, Robert J., Lora, Jose M.

Volltext

Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β-induced apoptosis von Conery, Andrew R., Cao, Yanna, Thompson, E. Aubrey, Townsend, Courtney M., Ko, Tien C., Luo, Kunxin

Volltext

Preclinical Anticancer Efficacy of BET Bromodomain Inhibitors Is Determined by the Apoptotic Response von Conery, Andrew R, Centore, Richard C, Spillane, Kerry L, Follmer, Nicole E, Bommi-Reddy, Archana, Hatton, Charlie, Bryant, Barbara M, Greninger, Patricia, Amzallag, Arnaud, Benes, Cyril H, Mertz, Jennifer A, Sims, 3rd, Robert J

Volltext

Correction: Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma von Conery, Andrew R, Centore, Richard C, Neiss, Adrianne, Keller, Patricia J, Joshi, Shivangi, Spillane, Kerry L, Sandy, Peter, Hatton, Charlie, Pardo, Eneida, Zawadzke, Laura, Bommi-Reddy, Archana, Gascoigne, Karen E, Bryant, Barbara M, Mertz, Jennifer A, Sims, Robert J

Volltext

Abstract A18: Targeting epigenetic dysregulation in bladder cancer through inhibition of EZH2 von Keller, Patricia J., Meyer, Rosana, Greenwald, Emily, Han, Xinwei, Conery, Andrew R., Mertz, Jennifer A., Trojer, Patrick

Volltext

Abstract 2126: Therapeutic potential of CPI-0209 von Wu, Rentian, Zhao, Feng, Keller, Patricia J., Mertz, Jennifer A., McGrath, John P., Bryant, Barbara, Conery, Andrew R., Sun, Kaiming, Wang, Jing, Trojer, Patrick

Volltext

Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300 von Crawford, Terry D, Romero, F. Anthony, Lai, Kwong Wah, Tsui, Vickie, Taylor, Alexander M, de Leon Boenig, Gladys, Noland, Cameron L, Murray, Jeremy, Ly, Justin, Choo, Edna F, Hunsaker, Thomas L, Chan, Emily W, Merchant, Mark, Kharbanda, Samir, Gascoigne, Karen E, Kaufman, Susan, Beresini, Maureen H, Liao, Jiangpeng, Liu, Wenfeng, Chen, Kevin X, Chen, Zhongguo, Conery, Andrew R, Côté, Alexandre, Jayaram, Hariharan, Jiang, Ying, Kiefer, James R, Kleinheinz, Tracy, Li, Yingjie, Maher, Jonathan, Pardo, Eneida, Poy, Florence, Spillane, Kerry L, Wang, Fei, Wang, Jian, Wei, Xiaocang, Xu, Zhaowu, Xu, Zhongya, Yen, Ivana, Zawadzke, Laura, Zhu, Xiaoyu, Bellon, Steven, Cummings, Richard, Cochran, Andrea G, Albrecht, Brian K, Magnuson, Steven

Volltext

Abstract 4351: Single-cell RNA sequencing reveals transcriptomic heterogeneity in response to epigenetic inhibitors von Conery, Andrew R., Park, Sungmi, Steinbaugh, Michael J., Bryant, Barbara M., Apte, Shruti, Keller, Patricia J., Yuan, C. C., Bradley, Bill, Bommi-Reddy, Archana, Sims, Robert J.

Volltext

Abstract 4722: Efficacy of a novel EP300/CBP histone acetyltransferase inhibitor in hormone responsive breast cancer von Bommi-Reddy, Archana, Wilson, Jonathan, Huhn, Annissa J., Terzo, Esteban, Poy, Florence, Park, Sungmi, Steinbaugh, Michael J., Bryant, Barbara M., Conery, Andrew R., Cummings, Richard, Levell, Julian, Sims, Robert J.

Volltext

Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637) von Taylor, Alexander M, Côté, Alexandre, Hewitt, Michael C, Pastor, Richard, Leblanc, Yves, Nasveschuk, Christopher G, Romero, F. Anthony, Crawford, Terry D, Cantone, Nico, Jayaram, Hariharan, Setser, Jeremy, Murray, Jeremy, Beresini, Maureen H, de Leon Boenig, Gladys, Chen, Zhongguo, Conery, Andrew R, Cummings, Richard T, Dakin, Leslie A, Flynn, E. Megan, Huang, Oscar W, Kaufman, Susan, Keller, Patricia J, Kiefer, James R, Lai, Tommy, Li, Yingjie, Liao, Jiangpeng, Liu, Wenfeng, Lu, Henry, Pardo, Eneida, Tsui, Vickie, Wang, Jian, Wang, Yongyun, Xu, Zhaowu, Yan, Fen, Yu, Dong, Zawadzke, Laura, Zhu, Xiaoqin, Zhu, Xiaoyu, Sims, Robert J, Cochran, Andrea G, Bellon, Steve, Audia, James E, Magnuson, Steven, Albrecht, Brian K

Volltext

Abstract 4749: Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma von Keller, Patricia J., Conery, Andrew R., Centore, Richard C., Bommi-Reddy, Archana, Gascoigne, Karen E., Bryant, Barbara M., Mertz, Jennifer A., Sims, Robert J.

Volltext