RNA Splicing and Disease: Animal Models to Therapies von Montes, Matías, Sanford, Brianne L., Comiskey, Daniel F., Chandler, Dawn S.

Volltext

Transcriptome analysis discloses dysregulated genes in normal appearing tumor-adjacent thyroid tissues from patients with papillary thyroid carcinoma von He, Huiling, Liyanarachchi, Sandya, Li, Wei, Comiskey, Daniel F., Yan, Pearlly, Bundschuh, Ralf, Turkoglu, Altan M., Brock, Pamela, Ringel, Matthew D., de la Chapelle, Albert

Volltext

Identification of Rare Variants Predisposing to Thyroid Cancer von Wang, Yanqiang, Liyanarachchi, Sandya, Miller, Katherine E., Nieminen, Taina T., Comiskey, Daniel F., Li, Wei, Brock, Pamela, Symer, David E., Akagi, Keiko, DeLap, Katherine E., He, Huiling, Koboldt, Daniel C., de la Chapelle, Albert

Volltext

SRSF2 Regulation of MDM2 Reveals Splicing as a Therapeutic Vulnerability of the p53 Pathway von Comiskey, Dan F., Montes, Matias, Khurshid, Safiya, Singh, Ravi K., Chandler, Dawn S.

Volltext

Stress-induced alternative splice forms of MDM2 and MDMX modulate the p53-pathway in distinct ways von Jacob, Aishwarya G, Singh, Ravi K, Comiskey, Jr, Daniel F, Rouhier, Matthew F, Mohammad, Fuad, Bebee, Thomas W, Chandler, Dawn S

Volltext

Splicing factor SRSF1 negatively regulates alternative splicing of MDM2 under damage von Comiskey, Jr, Daniel F, Jacob, Aishwarya G, Singh, Ravi K, Tapia-Santos, Aixa S, Chandler, Dawn S

Volltext

Splice-switching of the insulin receptor pre-mRNA alleviates tumorigenic hallmarks in rhabdomyosarcoma von Khurshid, Safiya, Montes, Matias, Comiskey, Daniel F., Shane, Brianne, Matsa, Eleftheria, Jung, Francesca, Brown, Chelsea, Bid, Hemant Kumar, Wang, Ruoning, Houghton, Peter J., Roberts, Ryan, Rigo, Frank, Chandler, Dawn

Volltext

Characterizing the function of EPB41L4A in the predisposition to papillary thyroid carcinoma von Comiskey, Daniel F., He, Huiling, Liyanarachchi, Sandya, Sheikh, Mehek S., Hendrickson, Isabella V., Yu, Lianbo, Brock, Pamela L., de la Chapelle, Albert

Volltext

A novel essential splice site variant in SPTB in a large hereditary spherocytosis family von Nieminen, Taina T., Liyanarachchi, Sandya, Comiskey, Daniel F., Wang, Yanqiang, Li, Wei, Hendrickson, Isabella V., Brock, Pamela, Chapelle, Albert, He, Huiling

Volltext

Stress-Induced Isoforms of MDM2 and MDM4 Correlate with High-Grade Disease and an Altered Splicing Network in Pediatric Rhabdomyosarcoma von Jacob, Aishwarya G, O'Brien, Dennis, Singh, Ravi K, Comiskey, Daniel F, Littleton, Robert M, Mohammad, Fuad, Gladman, Jordan T, Widmann, Maria C, Jeyaraj, Selvi C, Bolinger, Cheryl, Anderson, James R, Barkauskas, Donald A, Boris-Lawrie, Kathleen, Chandler, Dawn S

Volltext

A Truncating Germline Mutation of TINF2 in Individuals with Thyroid Cancer or Melanoma Results in Longer Telomeres von He, Huiling, Li, Wei, Comiskey, Daniel F., Liyanarachchi, Sandya, Nieminen, Taina T., Wang, Yanqiang, DeLap, Katherine E., Brock, Pamela, de la Chapelle, Albert

Volltext

Multiethnic genome‐wide association study of differentiated thyroid cancer in the EPITHYR consortium von Truong, Thérèse, Lesueur, Fabienne, Sugier, Pierre‐Emmanuel, Guibon, Julie, Xhaard, Constance, Karimi, Mojgan, Kulkarni, Om, Lucotte, Elise A., Bacq‐Daian, Delphine, Boland‐Auge, Anne, Mulot, Claire, Laurent‐Puig, Pierre, Schvartz, Claire, Guizard, Anne‐Valérie, Ren, Yan, Adjadj, Elisabeth, Rachédi, Frédérique, Borson‐Chazot, Francoise, Ortiz, Rosa Maria, Lence‐Anta, Juan J., Pereda, Celia María, Comiskey, Daniel F., He, Huiling, Liyanarachchi, Sandya, Chapelle, Albert, Elisei, Rossella, Gemignani, Federica, Thomsen, Hauke, Forsti, Asta, Herzig, Anthony F., Leutenegger, Anne‐Louise, Rubino, Carole, Ostroumova, Evgenia, Kesminiene, Ausrele, Boutron‐Ruault, Marie‐Christine, Deleuze, Jean‐François, Guénel, Pascal, Vathaire, Florent

Volltext

Clinical implications of GWAS variants associated with differentiated thyroid cancer von Jendrzejewski, Jarosław P., Sworczak, Krzysztof, Comiskey, Daniel F., De la Chapelle, Albert

Volltext

Regulation of photoreceptor gene transcription via a highly conserved transcriptional regulatory element by vsx gene products von Pan, Yi, Comiskey, Daniel F, Kelly, Lisa E, Chandler, Dawn S, El-Hodiri, Heithem M

Volltext

Abstract B45: Therapeutic potential of splicing in RMS: SRSF2 binding modulation controls MDM2 alternative splicing von Montes, Matias I., Comiskey, Daniel F., Khurshid, Safiya, Chandler, Dawn S.

Volltext

A novel mouse model of rhabdomyosarcoma underscores the dichotomy of MDM2-ALT1 function in vivo von Comiskey Jr, D F, Jacob, A G, Sanford, B L, Montes, M, Goodwin, A K, Steiner, H, Matsa, E, Tapia-Santos, A S, Bebee, T W, Grieves, J, La Perle, K, Boyaka, P, Chandler, D S

Volltext

Abstract 4156: Multiple rare germline variants in a thyroid cancer family von Nieminen, Taina T., Comiskey, Daniel F., Wang, Yanqiang, Liyanarachchi, Sandya, Brock, Pamela, Peltomaki, Paivi, He, Huiling, Chapelle, Albert de la

Volltext

Abstract 4140: The dual role of MDM2-ALT1 as both a suppressor and driver of oncogenesis is highlighted in a new RMS mouse model von Comiskey, Daniel F., Jacob, Aishwarya G., Montes, Matias, Perle, Krista La, Boyaka, Prosper N., Chandler, Dawn S.

Volltext

Abstract LB-014: Targeting insulin receptor splicing as a therapeutic intervention for pediatric rhabdomyosarcoma von Chandler, Dawn S., Brown, Chelsea, Bid, Hemant, Bebee, Thomas, Comiskey, Daniel F., Rigo, Frank, Houghton, Peter J.

Volltext

Stress-Induced Isoforms of MDM2 and MDM4 Correlate with High-Grade Disease and an Altered Splicing Network in Pediatric Rhabdomyosarcoma12 von Jacob, Aishwarya G, O'Brien, Dennis, Singh, Ravi K, Comiskey, Daniel F, Littleton, Robert M, Mohammad, Fuad, Gladman, Jordan T, Widmann, Maria C, Jeyaraj, Selvi C, Bolinger, Cheryl, Anderson, James R, Barkauskas, Donald A, Boris-Lawrie, Kathleen, Chandler, Dawn S

Volltext