Single-molecule spatial transcriptome profiling of the mammalian heart von Liu, Yuening, Coles, Annabelle, Wu, Jerry D., Neininger-Castro, Abigail C., Rune, Julia, Kosuri, Pallav

Volltext

Abstract P1185: Spatial Transcriptome Profiling In The Mouse Heart With Single-Cell Resolution von Liu, Yuening, Coles, Annabelle, Neininger-Castro, Abigail, Rune, Julia, Lee, Richard T, Kosuri, Pallav

Volltext

The valency of fatty acid conjugates impacts siRNA pharmacokinetics, distribution, and efficacy in vivo von Biscans, Annabelle, Coles, Andrew, Echeverria, Dimas, Khvorova, Anastasia

Volltext

Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo von Biscans, Annabelle, Coles, Andrew, Haraszti, Reka, Echeverria, Dimas, Hassler, Matthew, Osborn, Maire, Khvorova, Anastasia

Volltext

Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways von Osborn, Maire F, Coles, Andrew H, Biscans, Annabelle, Haraszti, Reka A, Roux, Loic, Davis, Sarah, Ly, Socheata, Echeverria, Dimas, Hassler, Matthew R, Godinho, Bruno M D C, Nikan, Mehran, Khvorova, Anastasia

Volltext

Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen von Poole, Andrew, Karuppiah, Vijaykumar, Hartt, Annabelle, Haidar, Jaafar N., Moureau, Sylvie, Dobrzycki, Tomasz, Hayes, Conor, Rowley, Christopher, Dias, Jorge, Harper, Stephen, Barnbrook, Keir, Hock, Miriam, Coles, Charlotte, Yang, Wei, Aleksic, Milos, Lin, Aimee Bence, Robinson, Ross, Dukes, Joe D., Liddy, Nathaniel, Van der Kamp, Marc, Plowman, Gregory D., Vuidepot, Annelise, Cole, David K., Whale, Andrew D., Chillakuri, Chandramouli

Volltext

Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier von Godinho, Bruno M.D.C., Henninger, Nils, Bouley, James, Alterman, Julia F., Haraszti, Reka A., Gilbert, James W., Sapp, Ellen, Coles, Andrew H., Biscans, Annabelle, Nikan, Mehran, Echeverria, Dimas, DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia

Volltext

Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O‑Phosphocholine‑N‑docosahexaenoyl‑l‑serine siRNA Conjugate in Mouse Brain von Nikan, Mehran, Osborn, Maire F, Coles, Andrew H, Biscans, Annabelle, Godinho, Bruno M.D.C, Haraszti, Reka A, Sapp, Ellen, Echeverria, Dimas, DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia

Volltext

PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs von Godinho, Bruno M.D.C., Knox, Emily G., Hildebrand, Samuel, Gilbert, James W., Echeverria, Dimas, Kennedy, Zachary, Haraszti, Reka A., Ferguson, Chantal M., Coles, Andrew H., Biscans, Annabelle, Caiazzi, Jillian, Alterman, Julia F., Hassler, Matthew R., Khvorova, Anastasia

Volltext

Evaluation of daily disposable senofilcon A contact lenses in a symptomatic population von Bishop, Meredith Jansen, Sun, Chung-Kai, Coles-Brennan, Chantal, Gallois-Bernos, Annabelle

Volltext

Generating an iPSC line (with isogenic control) from the PBMCs of an ACTA1 (p.Gly148Asp) nemaline myopathy patient von Houweling, Peter J., Coles, Chantal A., Tiong, Chrystal F., Nielsen, Bridget, Graham, Alison, McDonald, Penny, Suter, Annabelle, Piers, Adam T., Forbes, Robin, Ryan, Monique M., Howden, Sara E., Lamandé, Shireen R., North, Kathryn N.

Volltext

Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization A... von Godinho, Bruno M.D.C., Gilbert, James W., Haraszti, Reka A., Coles, Andrew H., Biscans, Annabelle, Roux, Loic, Nikan, Mehran, Echeverria, Dimas, Hassler, Matthew, Khvorova, Anastasia

Volltext

Real-world performance and accuracy of stress echocardiography: the EVAREST observational multi-centre study von Woodward, William, Dockerill, Cameron, McCourt, Annabelle, Upton, Ross, O'Driscoll, Jamie, Balkhausen, Katrin, Chandrasekaran, Badrinathan, Firoozan, Soroosh, Kardos, Attila, Wong, Kenneth, Woodward, Gary, Sarwar, Rizwan, Sabharwal, Nikant, Benedetto, Elena, Spagou, Nancy, Sharma, Rajan, Augustine, Daniel, Tsiachristas, Apostolos, Senior, Roxy, Leeson, Paul, Boardman, Henry, d’Arcy, Joanna, Abraheem, Abraheem, Banypersad, Sanjay, Boos, Christopher, Bulugahapitiya, Sudantha, Butts, Jeremy, Coles, Duncan, Easaw, Jacob, Hamdan, Haytham, Jamil-Copley, Shahnaz, Kanaganayagam, Gajen, Mwambingu, Tom, Pantazis, Antonis, Papachristidis, Alexandros, Rajani, Ronak, Rasheed, Muhammad Amer, Razvi, Naveed A, Rekhraj, Sushma, Ripley, David P, Rose, Kathleen, Scheuermann-Freestone, Michaela, Schofield, Rebecca, Sultan, Ayyaz

Volltext

Long-term outcomes after stress echocardiography in real-world practice: a 5-year follow-up of the UK EVAREST study von Woodward, William, Johnson, Casey L, Krasner, Samuel, O'Driscoll, Jamie, McCourt, Annabelle, Dockerill, Cameron, Balkhausen, Katrin, Chandrasekaran, Badrinathan, Firoozan, Soroosh, Kardos, Attila, Sabharwal, Nikant, Sarwar, Rizwan, Senior, Roxy, Sharma, Rajan, Wong, Kenneth, Augustine, Daniel X, Leeson, Paul

Volltext

Therapeutic high affinity T cell receptor targeting a KRAS G12D cancer neoantigen von Poole, Andrew, Karuppiah, Vijaykumar, Hartt, Annabelle, Haidar, Jaafar N, Moureau, Sylvie, Dobrzycki, Tomasz, Hayes, Conor, Rowley, Christopher, Dias, Jorge, Harper, Stephen, Barnbrook, Keir, Hock, Miriam, Coles, Charlotte, Yang, Wei, Aleksic, Milos, Lin, Aimee Bence, Robinson, Ross, Dukes, Joe D, Liddy, Nathaniel, Van der Kamp, Marc, Plowman, Gregory D, Vuidepot, Annelise, Cole, David K, Whale, Andrew D, Chillakuri, Chandramouli

Volltext

Real world hospital costs following stress echocardiography in the UK: a costing study from the EVAREST/BSE-NSTEP multi-entre study von Johnson, Casey L, Woodward, William, McCourt, Annabelle, Dockerill, Cameron, Krasner, Samuel, Monaghan, Mark, Senior, Roxy, Augustine, Daniel X, Paton, Maria, O'Driscoll, Jamie, Oxborough, David, Pearce, Keith, Robinson, Shaun, Willis, James, Sharma, Rajan, Tsiachristas, Apostolos, Leeson, Paul

Volltext

One pot synthesis of η3-butadienyl complexes of Mo(II) or W(II): Crystal structure of [MoCl(CO)2(η3-CH2C(CONHCH2CCH)CCH2)(2,2′-bipyridine)] von Hodson, Annabelle G.W., Coles, Simon J., Hursthouse, Michael B.

Volltext

One pot synthesis of η 3-butadienyl complexes of Mo(II) or W(II): Crystal structure of [MoCl(CO) 2(η 3-CH 2C(CONHCH 2C CH)C CH 2)(2,2′-bipyridine)] von Hodson, Annabelle G.W., Coles, Simon J., Hursthouse, Michael B.

Volltext

CONJUGATED OLIGONUCLEOTIDES von HASSLER, Matthew, HARASZTI, Reka, COLES, Andrew, KHVOROVA, Anastasia, NIKAN, Mehran, ARONIN, Neil, BISCANS, Annabelle, OSBORN, Maire, TURANOV, Anton

Volltext bestellen

Conjugated oligonucleotides von Coles, Andrew, Osborn, Maire, Nikan, Mehran, Hassler, Matthew, Aronin, Neil, Biscans, Annabelle, Khvorova, Anastasia, Turanov, Anton, Haraszti, Reka

Volltext bestellen