Highly efficient therapeutic gene editing of human hematopoietic stem cells von Wu, Yuxuan, Zeng, Jing, Roscoe, Benjamin P., Liu, Pengpeng, Yao, Qiuming, Lazzarotto, Cicera R., Clement, Kendell, Cole, Mitchel A., Luk, Kevin, Baricordi, Cristina, Shen, Anne H., Ren, Chunyan, Esrick, Erica B., Manis, John P., Dorfman, David M., Williams, David A., Biffi, Alessandra, Brugnara, Carlo, Biasco, Luca, Brendel, Christian, Pinello, Luca, Tsai, Shengdar Q., Wolfe, Scot A., Bauer, Daniel E.

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Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci von Canver, Matthew C, Lessard, Samuel, Pinello, Luca, Wu, Yuxuan, Ilboudo, Yann, Stern, Emily N, Needleman, Austen J, Galactéros, Frédéric, Brugnara, Carlo, Kutlar, Abdullah, McKenzie, Colin, Reid, Marvin, Chen, Diane D, Das, Partha Pratim, A Cole, Mitchel, Zeng, Jing, Kurita, Ryo, Nakamura, Yukio, Yuan, Guo-Cheng, Lettre, Guillaume, Bauer, Daniel E, Orkin, Stuart H

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Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis von Sher, Falak, Hossain, Mir, Seruggia, Davide, Schoonenberg, Vivien A. C., Yao, Qiuming, Cifani, Paolo, Dassama, Laura M. K., Cole, Mitchel A., Ren, Chunyan, Vinjamur, Divya S., Macias-Trevino, Claudio, Luk, Kevin, McGuckin, Connor, Schupp, Patrick G., Canver, Matthew C., Kurita, Ryo, Nakamura, Yukio, Fujiwara, Yuko, Wolfe, Scot A., Pinello, Luca, Maeda, Takahiro, Kentsis, Alex, Orkin, Stuart H., Bauer, Daniel E.

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CRISPRO: identification of functional protein coding sequences based on genome editing dense mutagenesis von Schoonenberg, Vivien A C, Cole, Mitchel A, Yao, Qiuming, Macias-Treviño, Claudio, Sher, Falak, Schupp, Patrick G, Canver, Matthew C, Maeda, Takahiro, Pinello, Luca, Bauer, Daniel E

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CRISPResso2 provides accurate and rapid genome editing sequence analysis von Clement, Kendell, Rees, Holly, Canver, Matthew C., Gehrke, Jason M., Farouni, Rick, Hsu, Jonathan Y., Cole, Mitchel A., Liu, David R., Joung, J. Keith, Bauer, Daniel E., Pinello, Luca

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ZNF410 represses fetal globin by singular control of CHD4 von Vinjamur, Divya S., Yao, Qiuming, Cole, Mitchel A., McGuckin, Connor, Ren, Chunyan, Zeng, Jing, Hossain, Mir, Luk, Kevin, Wolfe, Scot A., Pinello, Luca, Bauer, Daniel E.

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Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS von Yamauchi, Takuji, Masuda, Takeshi, Canver, Matthew C., Seiler, Michael, Semba, Yuichiro, Shboul, Mohammad, Al-Raqad, Mohammed, Maeda, Manami, Schoonenberg, Vivien A.C., Cole, Mitchel A., Macias-Trevino, Claudio, Ishikawa, Yuichi, Yao, Qiuming, Nakano, Michitaka, Arai, Fumio, Orkin, Stuart H., Reversade, Bruno, Buonamici, Silvia, Pinello, Luca, Akashi, Koichi, Bauer, Daniel E., Maeda, Takahiro

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Distinct nuclear compartment-associated genome architecture in the developing mammalian brain von Ahanger, Sajad Hamid, Delgado, Ryan N., Gil, Eugene, Cole, Mitchel A., Zhao, Jingjing, Hong, Sung Jun, Kriegstein, Arnold R., Nowakowski, Tomasz J., Pollen, Alex A., Lim, Daniel A.

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CRISPR-SURF: discovering regulatory elements by deconvolution of CRISPR tiling screen data von Hsu, Jonathan Y., Fulco, Charles P., Cole, Mitchel A., Canver, Matthew C., Pellin, Danilo, Sher, Falak, Farouni, Rick, Clement, Kendell, Guo, Jimmy A., Biasco, Luca, Orkin, Stuart H., Engreitz, Jesse M., Lander, Eric S., Joung, J. Keith, Bauer, Daniel E., Pinello, Luca

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Dual genome-wide coding and lncRNA screens in neural induction of induced pluripotent stem cells von Wu, David, Poddar, Aunoy, Ninou, Elpiniki, Hwang, Elizabeth, Cole, Mitchel A., Liu, S. John, Horlbeck, Max A., Chen, Jin, Replogle, Joseph M., Carosso, Giovanni A., Eng, Nicolas W.L., Chang, Jonghoon, Shen, Yin, Weissman, Jonathan S., Lim, Daniel A.

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ZNF410 Represses Fetal Globin By Devoted Control of CHD4/NuRD von Vinjamur, Divya S, Yao, Qiuming, Cole, Mitchel A., McGuckin, Connor, Ren, Chunyan, Zeng, Jing, Hossain, Mir, Pinello, Luca, Bauer, Daniel E

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Comprehensive Integrated Genomic Perturbations Reveal Molecular Mechanisms of Red Blood Cell Trait Associations von Wu, Yuxuan, Cole, Mitchel A., Mousas, Abdou, Zeng, Jing, Yao, Qiuming, Vinjamur, Divya, Kurita, Ryo, Nakamura, Yukio, Pinello, Luca, Lettre, Guillame, Bauer, Daniel E.

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Accurate and rapid analysis of genome editing data from nucleases and base editors with CRISPResso2 von Clement, Kendell, Rees, Holly, Canver, Matthew C., Gehrke, Jason M., Farouni, Rick, Hsu, Jonathan Y, Cole, Mitchel A., Liu, David R., Joung, J. Keith, Bauer, Daniel E., Pinello, Luca

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Rational Targeting of a NuRD Sub-Complex for Fetal Hemoglobin Induction Following Comprehensive in Situ Mutagenesis von Hossain, Mir, Sher, Falak, Seruggia, Davide, Schoonenberg, Vivien, Cole, Mitchel A., Cifani, Paolo, Dassama, Laura, Macias-Trevino, Claudio, Canver, Matthew C., Kurita, Ryo, Nakamura, Yukio, Pinello, Luca, Maeda, Takahiro, Kentsis, Alex, Orkin, Stuart H., Bauer, Daniel E.

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High-Resolution CRISPR Functional Genomics Reveals Critical Vulnerabilities of the NuRD Complex for Fetal Hemoglobin Control von Sher, Falak, Schoonenberg, Vivien, Cole, Mitchel A., Macias-Trevino, Claudio, Cifani, Paolo, Schupp, Patrick G, Canver, Matthew C., Kurita, Ryo, Nakamura, Yukio, Orkin, Stuart, Kentsis, Alex, Pinello, Luca, Maeda, Takahiro, Bauer, Daniel E.

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Highly Efficient Therapeutic Gene Editing of BCL11A enhancer in Human Hematopoietic Stem Cells from ß-Hemoglobinopathy Patients for Fetal Hemoglobin Induction von Zeng, Jing, Bauer, Daniel E., Wu, Yuxuan, Roscoe, Benjamin P, Liu, Pengpeng, Yao, Qiuming, Lazzarrotto, Cicera, Clement, M. Kendell, Cole, Mitchel A., Luk, Kevin, Baricordi, Cristina, Esrick, Erica B., Manis, John P, Dorfma, David, Williams, David A., Biffi, Alessandra, Brugnara, Carlo, Biasco, Luca, Brendel, Christian, Pinello, Luca, Tsai, Shengdar, Wolfe, Scot A.

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Genome-Wide CRISPR/Cas9 Screen Reveals That the Dcps Scavenger Decapping Enzyme Is Essential for AML Cell Survival von Yamauchi, Takuji, Masuda, Takeshi, Canver, Matthew C., Seiler, Michael, Shboul, Mohammad, Maeda, Manami, Schoonenberg, Vivien, Cole, Mitchel A., Macias-Trevino, Claudio, Semba, Yuichiro, Ishikawa, Yuichi, Nakano, Michitaka, Arai, Fumio, Orkin, Stuart, Reversade, Bruno, Buonamici, Silvia, Pinello, Luca, Akashi, Koichi, Bauer, Daniel E., Maeda, Takahiro

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Genome-Wide CRISPR Screen Identifies PAICS, An Enzyme Involved in De Novo Purine Synthesis, As a Potential Target for AML Therapy von Yamauchi, Takuji, Miyawaki, Kohta, Semba, Yuichiro, Nakao, Fumihiko, Sugio, Takeshi, Sasaki, Kensuke, Nogami, Junpei, Schoonenberg, Vivien A.C., Cole, Mitchel A., Macias-Trevino, Claudio, Yao, Qiuming, Canver, Matthew C., Osborne, Simon, Pinello, Luca, Taylor, Debbie, Bauer, Daniel E., Akashi, Koichi, Takahiro, Maeda

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Airway epithelial compression promotes airway smooth muscle proliferation and contraction von Lan, Bo, Mitchel, Jennifer A, O'Sullivan, Michael J, Park, Chan Young, Kim, Jae Hun, Cole, William C, Butler, James P, Park, Jin-Ah

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Net Primary Productivity of Subalpine Meadows in Yosemite National Park in Relation to Climate Variability von Moore, Peggy E., van Wagtendonk, Jan W., Yee, Julie L., McClaran, Mitchel P., Cole, David N., McDougald, Neil K., Brooks, Matthew L.

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