GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis von Regan-Komito, Daniel, Swann, James W., Demetriou, Philippos, Cohen, E. Suzanne, Horwood, Nicole J., Sansom, Stephen N., Griseri, Thibault

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Modelling bronchial epithelial-fibroblast cross-talk in idiopathic pulmonary fibrosis (IPF) using a human-derived in vitro air liquid interface (ALI) culture von Barron, Sarah L., Wyatt, Owen, O’Connor, Andy, Mansfield, David, Suzanne Cohen, E., Witkos, Tomasz M., Strickson, Sam, Owens, Róisín M.

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ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung von Schuijs, Martijn J., Png, Shaun, Richard, Arianne C., Tsyben, Anastasia, Hamm, Gregory, Stockis, Julie, Garcia, Celine, Pinaud, Silvain, Nicholls, Ashley, Ros, Xavier Romero, Su, Jing, Eldridge, Matthew D., Riedel, Angela, Serrao, Eva M., Rodewald, Hans-Reimer, Mack, Matthias, Shields, Jacqueline D., Cohen, E. Suzanne, McKenzie, Andrew N. J., Goodwin, Richard J. A., Brindle, Kevin M., Marioni, John C., Halim, Timotheus Y. F.

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Biological clustering supports both “Dutch” and “British” hypotheses of asthma and chronic obstructive pulmonary disease von Ghebre, Michael A., MSc, Bafadhel, Mona, PhD, Desai, Dhananjay, MBBS, Cohen, Suzanne E., PhD, Newbold, Paul, PhD, Rapley, Laura, PhD, Woods, Jo, PhD, Rugman, Paul, PhD, Pavord, Ian D., MD, Newby, Chris, PhD, Burton, Paul R., MD, May, Richard D., PhD, Brightling, Chris E., PhD

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A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue von Rana, Batika M J, Jou, Eric, Barlow, Jillian L, Rodriguez-Rodriguez, Noe, Walker, Jennifer A, Knox, Claire, Jolin, Helen E, Hardman, Clare S, Sivasubramaniam, Meera, Szeto, Aydan, Cohen, E Suzanne, Scott, Ian C, Sleeman, Matthew A, Chidomere, Chiamaka I, Cruz Migoni, Sara, Caamano, Jorge, Jorgensen, Helle F, Carobbio, Stefania, Vidal-Puig, Antonio, McKenzie, Andrew N J

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HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33 von Osbourn, Megan, Soares, Dinesh C., Vacca, Francesco, Cohen, E. Suzanne, Scott, Ian C., Gregory, William F., Smyth, Danielle J., Toivakka, Matilda, Kemter, Andrea M., le Bihan, Thierry, Wear, Martin, Hoving, Dennis, Filbey, Kara J., Hewitson, James P., Henderson, Holly, Gonzàlez-Cìscar, Andrea, Errington, Claire, Vermeren, Sonja, Astier, Anne L., Wallace, William A., Schwarze, Jürgen, Ivens, Alasdair C., Maizels, Rick M., McSorley, Henry J.

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A helminth-derived suppressor of ST2 blocks allergic responses von Vacca, Francesco, Chauché, Caroline, Jamwal, Abhishek, Hinchy, Elizabeth C, Heieis, Graham, Webster, Holly, Ogunkanbi, Adefunke, Sekne, Zala, Gregory, William F, Wear, Martin, Perona-Wright, Georgia, Higgins, Matthew K, Nys, Josquin A, Cohen, E Suzanne, McSorley, Henry J

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Interleukin-33 is activated by allergen- and necrosis-associated proteolytic activities to regulate its alarmin activity during epithelial damage von Scott, Ian C., Majithiya, Jayesh B., Sanden, Caroline, Thornton, Peter, Sanders, Philip N., Moore, Tom, Guscott, Molly, Corkill, Dominic J., Erjefält, Jonas S., Cohen, E. Suzanne

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Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction von England, Elizabeth, Rees, D. Gareth, Scott, Ian Christopher, Carmen, Sara, Chan, Denice T. Y., Chaillan Huntington, Catherine E., Houslay, Kirsty F., Erngren, Teodor, Penney, Mark, Majithiya, Jayesh B., Rapley, Laura, Sims, Dorothy A., Hollins, Claire, Hinchy, Elizabeth C., Strain, Martin D., Kemp, Benjamin P., Corkill, Dominic J., May, Richard D., Vousden, Katherine A., Butler, Robin J., Mustelin, Tomas, Vaughan, Tristan J., Lowe, David C., Colley, Caroline, Cohen, E. Suzanne

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The IL-33:ST2 axis is unlikely to play a central fibrogenic role in idiopathic pulmonary fibrosis von Stephenson, Katherine E, Porte, Joanne, Kelly, Aoife, Wallace, William A, Huntington, Catherine E, Overed-Sayer, Catherine L, Cohen, E Suzanne, Jenkins, R Gisli, John, Alison E

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Severe exacerbations in moderate-to-severe asthmatics are associated with increased pro-inflammatory and type 1 mediators in sputum and serum von Ghebre, Michael A, Pang, Pee Hwee, Desai, Dhananjay, Hargadon, Beverley, Newby, Chris, Woods, Joanne, Rapley, Laura, Cohen, Suzanne E, Herath, Athula, Gaillard, Erol A, May, Richard D, Brightling, Chris E

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Development of an antibody that neutralizes soluble IgE and eliminates IgE expressing B cells von Nyborg, Andrew C, Zacco, Anna, Ettinger, Rachel, Jack Borrok, M, Zhu, Jie, Martin, Tom, Woods, Rob, Kiefer, Christine, Bowen, Michael A, Suzanne Cohen, E., Herbst, Ronald, Wu, Herren, Coats, Steven

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Dendritic Cell-Derived TSLP Negatively Regulates HIF-1α and IL-1β During Dectin-1 Signaling von Elder, Matthew J, Webster, Steve J, Fitzmaurice, Timothy J, Shaunak, Aran S D, Steinmetz, Martin, Chee, Ronnie, Mallat, Ziad, Cohen, E Suzanne, Williams, David L, Gaston, J S Hill, Goodall, Jane C

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Host Immunity Influences the Composition of Murine Gut Microbiota von Van Averbeke, Vincent, Berkell, Matilda, Mysara, Mohamed, Rodriguez-Ruiz, Juan Pablo, Xavier, Basil Britto, De Winter, Fien H R, Jongers, Bart 's, Jairam, Ravi Kumar, Hotterbeekx, An, Goossens, Herman, Cohen, E Suzanne, Malhotra-Kumar, Surbhi, Kumar-Singh, Samir

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Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation von Cohen, E. Suzanne, Scott, Ian C., Majithiya, Jayesh B., Rapley, Laura, Kemp, Benjamin P., England, Elizabeth, Rees, D. Gareth, Overed-Sayer, Catherine L., Woods, Joanne, Bond, Nicholas J., Veyssier, Christel Séguy, Embrey, Kevin J., Sims, Dorothy A., Snaith, Michael R., Vousden, Katherine A., Strain, Martin D., Chan, Denice T. Y., Carmen, Sara, Huntington, Catherine E., Flavell, Liz, Xu, Jianqing, Popovic, Bojana, Brightling, Christopher E., Vaughan, Tristan J., Butler, Robin, Lowe, David C., Higazi, Daniel R., Corkill, Dominic J., May, Richard D., Sleeman, Matthew A., Mustelin, Tomas

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Airway Interleukin-33 and type 2 cytokines in adult patients with acute asthma von Poulsen, Nadia Nicholine, Bjerregaard, Asger, Khoo, Siew-Kim, Laing, Ingrid A., Le Souëf, Peter, Backer, Vibeke, Rapley, Laura, Cohen, Suzanne E., Barrett, Lucy, Thompson, Philip, Baltic, Svetlana, Porsbjerg, Celeste

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Identifying neighborhood characteristics associated with diabetes and hypertension control in an urban African-American population using geo-linked electronic health records von Lê-Scherban, Félice, Ballester, Lance, Castro, Juan C, Cohen, Suzanne, Melly, Steven, Moore, Kari, Buehler, James W

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Early mucosal events promote distinct mucosal and systemic antibody responses to live attenuated influenza vaccine von Thwaites, Ryan S., Uruchurtu, Ashley S. S., Negri, Victor Augusti, Cole, Megan E., Singh, Nehmat, Poshai, Nelisa, Jackson, David, Hoschler, Katja, Baker, Tina, Scott, Ian C., Ros, Xavier Romero, Cohen, Emma Suzanne, Zambon, Maria, Pollock, Katrina M., Hansel, Trevor T., Openshaw, Peter J. M.

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Prospects to translate the biology of IL-33 and ST2 during organ transplantation into therapeutics to treat graft-versus-host disease von Scott, Ian C, Houslay, Kirsty F, Cohen, E Suzanne

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Population pharmacokinetic/target engagement modelling of tozorakimab in healthy volunteers and patients with chronic obstructive pulmonary disease von Sadiq, Muhammad Waqas, Yu, Hongtao, Åstrand, Magnus, Scott, Ian C., Williams, Adam, Hewitt, Lisa, White, Nicholas, Killick, Helen, Gavala, Monica, Cohen, E. Suzanne, Reid, Fred, Kell, Chris, Pandya, Hitesh, Jimenez, Eulalia

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