Integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions von Watson, C. T., Cohain, A. T., Griffin, R. S., Chun, Y., Grishin, A., Hacyznska, H., Hoffman, G. E., Beckmann, N. D., Shah, H., Dawson, P., Henning, A., Wood, R., Burks, A. W., Jones, S. M., Leung, D. Y. M., Sicherer, S., Sampson, H. A., Sharp, A. J., Schadt, E. E., Bunyavanich, S.

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Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations von Liu, Jimmy Z, van Sommeren, Suzanne, Huang, Hailiang, Ng, Siew C, Alberts, Rudi, Takahashi, Atsushi, Ripke, Stephan, Lee, James C, Jostins, Luke, Shah, Tejas, Abedian, Shifteh, Cheon, Jae Hee, Cho, Judy, Daryani, Naser E, Franke, Lude, Fuyuno, Yuta, Hart, Ailsa, Juyal, Ramesh C, Juyal, Garima, Kim, Won Ho, Morris, Andrew P, Poustchi, Hossein, Newman, William G, Midha, Vandana, Orchard, Timothy R, Vahedi, Homayon, Sood, Ajit, Sung, Joseph J Y, Malekzadeh, Reza, Westra, Harm-Jan, Yamazaki, Keiko, Yang, Suk-Kyun, Barrett, Jeffrey C, Franke, Andre, Alizadeh, Behrooz Z, Parkes, Miles, B K, Thelma, Daly, Mark J, Kubo, Michiaki, Anderson, Carl A, Weersma, Rinse K

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Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study von Cleynen, Isabelle, PhD, Boucher, Gabrielle, MSc, Jostins, Luke, PhD, Schumm, L Philip, MA, Zeissig, Sebastian, PhD, Ahmad, Tariq, PhD, Andersen, Vibeke, Prof, Andrews, Jane M, Prof, Annese, Vito, MD, Brand, Stephan, Prof, Brant, Steven R, MD, Cho, Judy H, Prof, Daly, Mark J, Prof, Dubinsky, Marla, MD, Duerr, Richard H, Prof, Ferguson, Lynnette R, Prof, Franke, Andre, Prof, Gearry, Richard B, Prof, Goyette, Philippe, PhD, Hakonarson, Hakon, Prof, Halfvarson, Jonas, MD, Hov, Johannes R, PhD, Huang, Hailang, PhD, Kennedy, Nicholas A, PhD, Kupcinskas, Limas, Prof, Lawrance, Ian C, Prof, Lee, James C, PhD, Satsangi, Jack, Prof, Schreiber, Stephan, Prof, Théâtre, Emilie, PhD, van der Meulen-de Jong, Andrea E, MD, Weersma, Rinse K, Prof, Wilson, David C, Prof, Parkes, Miles, PhD, Vermeire, Severine, Prof, Rioux, John D, Prof, Mansfield, John, MD, Silverberg, Mark S, PhD, Radford-Smith, Graham, PhD, McGovern, Dermot P B, Prof, Barrett, Jeffrey C, Dr, Lees, Charlie W, Dr

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Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs von Lee, S Hong, Ripke, Stephan, Neale, Benjamin M, Faraone, Stephen V, Purcell, Shaun M, Perlis, Roy H, Mowry, Bryan J, Thapar, Anita, Goddard, Michael E, Witte, John S, Absher, Devin, Agartz, Ingrid, Akil, Huda, Amin, Farooq, Andreassen, Ole A, Anjorin, Adebayo, Anney, Richard, Anttila, Verneri, Arking, Dan E, Asherson, Philip, Azevedo, Maria H, Backlund, Lena, Badner, Judith A, Bailey, Anthony J, Banaschewski, Tobias, Barchas, Jack D, Barnes, Michael R, Barrett, Thomas B, Bass, Nicholas, Battaglia, Agatino, Bauer, Michael, Bayés, Mònica, Bellivier, Frank, Bergen, Sarah E, Berrettini, Wade, Betancur, Catalina, Bettecken, Thomas, Biederman, Joseph, Binder, Elisabeth B, Black, Donald W, Blackwood, Douglas H R, Bloss, Cinnamon S, Boehnke, Michael, Boomsma, Dorret I, Breen, Gerome, Breuer, René, Bruggeman, Richard, Cormican, Paul, Buccola, Nancy G, Buitelaar, Jan K, Bunney, William E, Buxbaum, Joseph D, Byerley, William F, Byrne, Enda M, Caesar, Sian, Cahn, Wiepke, Cantor, Rita M, Casas, Miguel, Chakravarti, Aravinda, Chambert, Kimberly, Choudhury, Khalid, Cichon, Sven, Cloninger, C Robert, Collier, David A, Cook, Edwin H, Coon, Hilary, Cormand, Bru, Corvin, Aiden, Coryell, William H, Craig, David W, Craig, Ian W, Crosbie, Jennifer, Cuccaro, Michael L, Curtis, David, Czamara, Darina, Datta, Susmita, Dawson, Geraldine, Day, Richard, De Geus, Eco J, Degenhardt, Franziska, Djurovic, Srdjan, Donohoe, Gary J, Doyle, Alysa E, Duan, Jubao, Dudbridge, Frank, Duketis, Eftichia, Ebstein, Richard P, Edenberg, Howard J, Elia, Josephine, Ennis, Sean, Etain, Bruno, Fanous, Ayman, Farmer, Anne E, Ferrier, I Nicol, Flickinger, Matthew, Fombonne, Eric, Foroud, Tatiana, Frank, Josef, Franke, Barbara, Fraser, Christine

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IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes von Momozawa, Yukihide, Dmitrieva, Julia, Théâtre, Emilie, Deffontaine, Valérie, Rahmouni, Souad, Charloteaux, Benoît, Crins, François, Docampo, Elisa, Elansary, Mahmoud, Gori, Ann-Stephan, Lecut, Christelle, Mariman, Rob, Mni, Myriam, Oury, Cécile, Altukhov, Ilya, Alexeev, Dmitry, Aulchenko, Yuri, Amininejad, Leila, Bouma, Gerd, Hoentjen, Frank, Löwenberg, Mark, Oldenburg, Bas, Pierik, Marieke J., vander Meulen-de Jong, Andrea E., Janneke van der Woude, C., Visschedijk, Marijn C., Lathrop, Mark, Hugot, Jean-Pierre, Weersma, Rinse K., De Vos, Martine, Franchimont, Denis, Vermeire, Severine, Kubo, Michiaki, Louis, Edouard, Georges, Michel

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Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis von Liu, Jimmy Z, Hov, Johannes Roksund, Folseraas, Trine, Ellinghaus, Eva, Rushbrook, Simon M, Doncheva, Nadezhda T, Andreassen, Ole A, Weersma, Rinse K, Weismüller, Tobias J, Eksteen, Bertus, Invernizzi, Pietro, Hirschfield, Gideon M, Gotthardt, Daniel Nils, Pares, Albert, Ellinghaus, David, Shah, Tejas, Juran, Brian D, Milkiewicz, Piotr, Rust, Christian, Schramm, Christoph, Müller, Tobias, Srivastava, Brijesh, Dalekos, Georgios, Nöthen, Markus M, Herms, Stefan, Winkelmann, Juliane, Mitrovic, Mitja, Braun, Felix, Ponsioen, Cyriel Y, Croucher, Peter J P, Sterneck, Martina, Teufel, Andreas, Mason, Andrew L, Saarela, Janna, Leppa, Virpi, Dorfman, Ruslan, Alvaro, Domenico, Floreani, Annarosa, Onengut-Gumuscu, Suna, Rich, Stephen S, Thompson, Wesley K, Schork, Andrew J, Næss, Sigrid, Thomsen, Ingo, Mayr, Gabriele, König, Inke R, Hveem, Kristian, Cleynen, Isabelle, Gutierrez-Achury, Javier, Ricaño-Ponce, Isis, van Heel, David, Björnsson, Einar, Sandford, Richard N, Durie, Peter R, Melum, Espen, Vatn, Morten H, Silverberg, Mark S, Duerr, Richard H, Padyukov, Leonid, Brand, Stephan, Sans, Miquel, Annese, Vito, Achkar, Jean-Paul, Boberg, Kirsten Muri, Marschall, Hanns-Ulrich, Chazouillères, Olivier, Bowlus, Christopher L, Wijmenga, Cisca, Schrumpf, Erik, Vermeire, Severine, Albrecht, Mario, Rioux, John D, Alexander, Graeme, Bergquist, Annika, Cho, Judy, Schreiber, Stefan, Manns, Michael P, Färkkilä, Martti, Dale, Anders M, Chapman, Roger W, Lazaridis, Konstantinos N, Franke, Andre, Anderson, Carl A, Karlsen, Tom H

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Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases von Franzén, Oscar, Ermel, Raili, Cohain, Ariella, Akers, Nicholas K., Di Narzo, Antonio, Talukdar, Husain A., Foroughi-Asl, Hassan, Giambartolomei, Claudia, Fullard, John F., Sukhavasi, Katyayani, Köks, Sulev, Gan, Li-Ming, Giannarelli, Chiara, Kovacic, Jason C., Betsholtz, Christer, Losic, Bojan, Michoel, Tom, Hao, Ke, Roussos, Panos, Skogsberg, Josefin, Ruusalepp, Arno, Schadt, Eric E., Björkegren, Johan L. M.

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MSR4 Implications of Cure Fractions on Costs of Cancer Care: An Innovative Application to Multi-Cancer Early Detection (MCED) Economic Modeling von Hathaway, C, Shah, N, Tyson, C, Cohain, A, Li, Y

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MSR64 Novel Empirical Methods to Derive Stage-Specific Dwell Time and Implications for Multi-Cancer Early Detection (MCED) Modeling von Shah, N, Hathaway, C, Tyson, C, Cohain, A, Li, Y

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Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population von Rivas, Manuel A, Avila, Brandon E, Koskela, Jukka, Huang, Hailiang, Stevens, Christine, Pirinen, Matti, Haritunians, Talin, Neale, Benjamin M, Kurki, Mitja, Ganna, Andrea, Graham, Daniel, Glaser, Benjamin, Peter, Inga, Atzmon, Gil, Barzilai, Nir, Levine, Adam P, Schiff, Elena, Pontikos, Nikolas, Weisburd, Ben, Lek, Monkol, Karczewski, Konrad J, Bloom, Jonathan, Minikel, Eric V, Petersen, Britt-Sabina, Beaugerie, Laurent, Seksik, Philippe, Cosnes, Jacques, Schreiber, Stefan, Bokemeyer, Bernd, Bethge, Johannes, Heap, Graham, Ahmad, Tariq, Plagnol, Vincent, Segal, Anthony W, Targan, Stephan, Turner, Dan, Saavalainen, Paivi, Farkkila, Martti, Kontula, Kimmo, Palotie, Aarno, Brant, Steven R, Duerr, Richard H, Silverberg, Mark S, Rioux, John D, Weersma, Rinse K, Franke, Andre, Jostins, Luke, Anderson, Carl A, Barrett, Jeffrey C, MacArthur, Daniel G, Jalas, Chaim, Sokol, Harry, Xavier, Ramnik J, Pulver, Ann, Cho, Judy H, McGovern, Dermot P B, Daly, Mark J

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HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44+ Natural Killer Cells in Ulcerative Colitis von Schwerk, Maria, Padoan, Benedetta, Schloer, Sebastian, Zecher, Britta F., Malsy, Jakob, Joshi, Vinita R., Möller, Kimberly J., Flomm, Jäger, Julia, Reinshagen, Konrad, Sandfort, Deborah, Steinert, Fenja, Tomuschat, Christian, Martin, Maureen P., Yuki, Yuko, Sauter, Jürgen, Schmidt, Alexander H., Giannou, Anastasios D., Sauter, Guido, Franke, Andre, Abraham, Clara, Achkar, Jean-Paul, Alizadeh, Behrooz, Amininejad, Leila, Andersen, Vibeke, Andrews, Jane M., Baidoo, Leonard, Baldassano, Robert N., Bampton, Peter A., Bewshea, Claire, BK, Thelma, Brain, Oliver, Brand, Stephan, Cheon, Jae Hee, Chew, Angela, Cohain, Ariella, Croft, Anthony, D'Amato, Mauro, Danese, Silvio, Daryani, Naser Ebrahim, Datta, Lisa Wu, Dubinsky, Marla, Duerr, Richard H., Edwards, Cathryn, Esaki, Motohiro, Franchimont, Denis, Franke, Andre, Georges, Michel, Gieger, Christian, Glas, Jürgen, Green, Todd, Guthery, Stephen L., Hakonarson, Hakon, Hanigan, Katherine, Hayward, Nicholas K., Hong, Myhunghee, Hu, Xinli, Jazayeri, Omid, Chandra Juyal, Ramesh, Karlsen, Tom H., Kennedy, Nicholas A., Kiudelis, Gediminas, Lamb, Christopher A., de Lange, Katrina M., Leja, Marcis, Lewis, Nina, Van Limbergen, Johan, Louis, Edouard, Mansfield, John, Mowat, Craig, Nöthen, Markus, Okou, David, Orchard, Timothy R., Parkes, Miles, Prescott, Natalie J., Rahier, Jean- Francois, Regueiro, Miguel, Rieder, Florian, Schadt, Eric E., Scharl, Michael, Scott, Regan, Sharma, Yashoda, Simms, Lisa A., Song, Kyuyoung, Sood, Ajit, Spain, Sarah L., Stronati, Laura, Sung, Joseph J.Y., Torres, Esther A., Vasiliauskas, Eric, Verspaget, Hein W., De Vos, Martine, Wang, Kai, Wang, Ming-Hsi, Wei, Zhi, Whiteman, David, Wilson, David C., Zhang, Hu, Zhang, Wei, Bunders, Madeleine J.

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Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn’s disease and leads to impaired CFB cleavage and phagocytosis von Stamps, Dalton T, Dube, Shishir, Li, Dalin, Yang, Shaohong, Landers, Carol J, Mengesha, Emebet, Murali, Ramachandran, Potdar, Alka A, Wolf, Andrea J, Botwin, Gregory J, Khrom, Michelle, Faubion, William A, Sandler, Robert S, Sartor, R Balfour, Brant, Steven R, Rioux, John D, Schumm, L Philip, Silverberg, Mark S, Zaghiyan, Karen, Melmed, Gil Y, Vasiliauskas, Eric A, Syal, Gaurav, Bonthala, Nirupama N, Targan, Stephan R, Michelsen, Kathrin S, Ahmad, Tariq, Amininejad, Leila, Andersen, Vibeke, Aumais, Guy, Baidoo, Leonard, Bayless, Theodore M, Bethge, Johannes, Boucher, Gabrielle, Brand, Stephan, Chew, Angela, Cho, Judy H, Cohain, Ariella, Jong, Dirk De, Denson, Lee A, Dewit, Olivier, D'Inca, Renata, Edwards, Cathryn, Ellinghaus, David, Festen, Eleonora A, Florin, Tim, Gieger, Christian, Goyette, Philippe, Green, Todd, Griffiths, Anne M, Hakonarson, Hakon, Hanigan, Katherine, Hart, Ailsa, Hayward, Nicholas K, Hugot, Jean-Pierre, Hui, Ken Y, Imielinski, Marcin, Jonaitis, Laimas, Jostins, Luke, Kiudelis, Gediminas, Krishnaprasad, Krupa, Kugathasan, Subra, Lee, James C, Lees, Charlie W, Leja, Marcis, Louis, Edouard, Mitrovic, Mitja, Ng, Aylwin, Ng, Siew C, Evelyn Ng, Sok Meng, Nikolaus, Susanna, Oikonomou, Ioannis, Phillips, Anne, Ponsioen, Cyriel Y, Prescott, Natalie J, Raychaudhuri, Soumya, Rieder, Florian, Rioux, John D, Ripke, Stephan, Russell, Richard K, Sanderson, Jeremy D, Satsangi, Jack, Schreiber, Stefan, Philip Schumm, L, Scott, Regan, Silverberg, Mark S, Simms, Lisa A, Spain, Sarah L, Sventoraityte, Jurgita, Torkvist, Leif, Tremelling, Mark, Vasiliauskas, Eric, Vermeire, Severine, Walters, Thomas, Wang, Kai, Wang, Ming-Hsi, Wei, Zhi, Winkelmann, Juliane, Zhang, Clarence K, Zhang, Wei, Zhao, Zhen Z

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Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci von Miller, Clint L., Pjanic, Milos, Wang, Ting, Nguyen, Trieu, Cohain, Ariella, Lee, Jonathan D., Perisic, Ljubica, Hedin, Ulf, Kundu, Ramendra K., Majmudar, Deshna, Kim, Juyong B., Wang, Oliver, Betsholtz, Christer, Ruusalepp, Arno, Franzén, Oscar, Assimes, Themistocles L., Montgomery, Stephen B., Schadt, Eric E., Björkegren, Johan L.M., Quertermous, Thomas

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A mechanistic framework for cardiometabolic and coronary artery diseases von Koplev, Simon, Seldin, Marcus, Sukhavasi, Katyayani, Ermel, Raili, Pang, Shichao, Zeng, Lingyao, Bankier, Sean, Di Narzo, Antonio, Cheng, Haoxiang, Meda, Vamsidhar, Ma, Angela, Talukdar, Husain, Cohain, Ariella, Amadori, Letizia, Argmann, Carmen, Houten, Sander M, Franzén, Oscar, Mocci, Giuseppe, Meelu, Omar A, Ishikawa, Kiyotake, Whatling, Carl, Jain, Anamika, Jain, Rajeev Kumar, Gan, Li-Ming, Giannarelli, Chiara, Roussos, Panos, Hao, Ke, Schunkert, Heribert, Michoel, Tom, Ruusalepp, Arno, Schadt, Eric E, Kovacic, Jason C, Lusis, Aldon J, Björkegren, Johan L M

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Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity von Morgan, Ruth A., Beck, Katharina R., Nixon, Mark, Homer, Natalie Z. M., Crawford, Andrew A., Melchers, Diana, Houtman, René, Meijer, Onno C., Stomby, Andreas, Anderson, Anna J., Upreti, Rita, Stimson, Roland H., Olsson, Tommy, Michoel, Tom, Cohain, Ariella, Ruusalepp, Arno, Schadt, Eric E., Björkegren, Johan L. M., Andrew, Ruth, Kenyon, Christopher J., Hadoke, Patrick W. F., Odermatt, Alex, Keen, John A., Walker, Brian R.

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High-density mapping of the MHC identifies a shared role for HLA-DRB101:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis von Goyette, Philippe, Boucher, Gabrielle, Mallon, Dermot, Ellinghaus, Eva, Jostins, Luke, Huang, Hailiang, Ripke, Stephan, Gusareva, Elena S, Annese, Vito, Hauser, Stephen L, Oksenberg, Jorge R, Thomsen, Ingo, Leslie, Stephen, Daly, Mark J, Van Steen, Kristel, Duerr, Richard H, Barrett, Jeffrey C, McGovern, Dermot P B, Schumm, L Philip, Traherne, James A, Carrington, Mary N, Kosmoliaptsis, Vasilis, Karlsen, Tom H, Franke, Andre, Rioux, John D

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Carbonyl reductase 1 catalyzes 20 beta-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity von Morgan, R.A., Beck, K.R., Nixon, M., Homer, N.Z.M., Crawford, A.A., Melchers, D., Houtman, R., Meijer, O.C., Stomby, A., Anderson, A.J., Upreti, R., Stimson, R.H., Olsson, T., Michoel, T., Cohain, A., Ruusalepp, A., Schadt, E.E., Bjorkegren, J.L.M., Andrew, R., Kenyon, C.J., Hadoke, P.W.F., Odermatt, A., Keen, J.A., Walker, B.R.

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Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach von Mendelson, MM, Marioni, RE, Joehanes, R, Liu, C, Hedman, ÅK, Aslibekyan, S, Demerath, EW, Guan, W, Zhi, D, Yao, C, Huan, T, Willinger, C, Chen, B, Courchesne, P, Multhaup, M, Irvin, MR, Cohain, A, Schadt, EE, Grove, ML, Bressler, J, North, K, Sundström, J, Gustafsson, S, Shah, S, McRae, AF, Harris, SE, Gibson, J, Redmond, P, Corley, J, Murphy, L, Starr, JM, Kleinbrink, E, Lipovich, L, Visscher, PM, Wray, NR, Krauss, RM, Fallin, D, Feinberg, A, Absher, DM, Fornage, M, Pankow, JS, Lind, L, Fox, C, Ingelsson, E, Arnett, DK, Boerwinkle, E, Liang, L, Levy, D, Deary, IJ

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Novel third stage protocol https://www.youtube.com/watch?v=AAJPW4p6rzU reduces postpartum hemorrhage at vaginal birth von Cohain, Judy Slome

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SP-0766: The radiologist prospective von Lev-Cohain, N.

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