How May GIP Enhance the Therapeutic Efficacy of GLP-1? von Samms, Ricardo J., Coghlan, Matthew P., Sloop, Kyle W.

Volltext

Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist von Willard, Francis S., Douros, Jonathan D., Gabe, Maria, Showalter, Aaron D., Wainscott, David B., Suter, Todd M., Capozzi, Megan E., van der Velden, Wijnand J. C., Stutsman, Cynthia, Cardona, Guemalli R., Urva, Shweta, Emmerson, Paul J., Holst, Jens J., D'Alessio, David A., Coghlan, Matthew P., Rosenkilde, Mette M., Campbell, Jonathan E., Sloop, Kyle W.

Volltext

Long-term scarring outcomes and safety of patients treated with NovoSorbⓇ Biodegradable Temporizing Matrix (BTM): An observational cohort study von Lo, C.H., Wagstaff, M.J.D., Barker, T.M., Damkat-Thomas, L., Salerno, S., Holden, D., Concannon, E., Heath, K., Coghlan, P., Cleland, H.

Volltext

Distinct Functional Contributions by the Conserved Domains of the Malaria Parasite Alveolin IMC1h von Coghlan, Michael P, Tremp, Annie Z, Saeed, Sadia, Vaughan, Cara K, Dessens, Johannes T

Volltext

Stimulation of Hepatocyte Glucose Metabolism by Novel Small Molecule Glucokinase Activators von BROCKLEHURST, Katy J, PAYNE, Victoria A, AGIUS, Loranne, DAVIES, Rick A, CARROLL, Debra, VERTIGAN, Helen L, WIGHTMAN, Heather J, ALSTON, Susan, WADDELL, Ian D, LEIGHTON, Brendan, COGHLAN, Matthew P

Volltext

Structural determinants of dual incretin receptor agonism by tirzepatide von Sun, Bingfa, Willard, Francis S, Feng, Dan, Alsina-Fernandez, Jorge, Chen, Qi, Vieth, Michal, Ho, Joseph D, Showalter, Aaron D, Stutsman, Cynthia, Ding, Liyun, Suter, Todd M, Dunbar, James D, Carpenter, John W, Mohammed, Faiz Ahmad, Aihara, Eitaro, Brown, Robert A, Bueno, Ana B, Emmerson, Paul J, Moyers, Julie S, Kobilka, Tong Sun, Coghlan, Matthew P, Kobilka, Brian K, Sloop, Kyle W

Volltext

Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the GIPR Region von Bowker, Nicholas, Hansford, Robert, Burgess, Stephen, Foley, Christopher N., Auyeung, Victoria P. W., Erzurumluoglu, A. Mesut, Stewart, Isobel D., Wheeler, Eleanor, Pietzner, Maik, Gribble, Fiona, Reimann, Frank, Bhatnagar, Pallav, Coghlan, Matthew P., Wareham, Nicholas J., Langenberg, Claudia

Volltext

Use of CRISPR/Cas9-engineered INS-1 pancreatic β cells to define the pharmacology of dual GIPR/GLP-1R agonists von Naylor, Jacqueline, Suckow, Arthur T, Seth, Asha, Baker, David J, Sermadiras, Isabelle, Ravn, Peter, Howes, Rob, Li, Jianliang, Snaith, Mike R, Coghlan, Matthew P, Hornigold, David C

Volltext

142-OR: Tirzepatide, a Dual GIP and GLP-1 Receptor Agonist, Mediates Its Anorexigenic Effect in Mice Due to a Reduction in Homeostatic and Reward-Related Feeding von COSGROVE, RICHARD, ANTONELLIS, MEGHAN P., DROZ, BRIAN, ROELL, WILLIAM C., SLOOP, KYLE, MOYERS, JULIE, COGHLAN, MATTHEW P., EMMERSON, PAUL, COSKUN, TAMER, SAMMS, RICARDO J.

Volltext

Development and characterisation of a novel glucagon like peptide-1 receptor antibody von Biggs, Emma K., Liang, Lihuan, Naylor, Jacqueline, Madalli, Shimona, Collier, Rachel, Coghlan, Matthew P., Baker, David J., Hornigold, David C., Ravn, Peter, Reimann, Frank, Gribble, Fiona M.

Volltext

c-Jun Is a JNK-independent Coactivator of the PU.1 Transcription Factor von Behre, G, Whitmarsh, A J, Coghlan, M P, Hoang, T, Carpenter, C L, Zhang, D E, Davis, R J, Tenen, D G

Volltext

Atypical Protein Kinases Cλ and -ζ Associate with the GTP-Binding Protein Cdc42 and Mediate Stress Fiber Loss von Coghlan, Matthew P., Chou, Margaret M., Carpenter, Christopher L.

Volltext

The discovery, isolation and identification of aldosterone: reflections on emerging regulation and function von Tait, Sylvia A.S, Tait, James F, Coghlan, John P

Volltext

GIPR agonism mediates weight-independent insulin sensitization by tirzepatide in obese mice von Samms, Ricardo J., Christe, Michael E., Collins, Kyla A. L., Pirro, Valentina, Droz, Brian A., Holland, Adrienne K., Friedrich, Jessica L., Wojnicki, Samantha, Konkol, Debra L., Cosgrove, Richard, Furber, Ellen P. S. Conceicao, Ruan, Xiaoping, O'Farrell, Libbey S., Long, Annie M., Dogra, Mridula, Willency, Jill A., Lin, Yanzhu, Ding, Liyun, Cheng, Christine C., Cabrera, Over, Briere, Daniel A., Alsina-Fernandez, Jorge, Gimeno, Ruth E., Moyers, Julie S., Coskun, Tamer, Coghlan, Matthew P., Sloop, Kyle W., Roell, William C.

Volltext

Neurturin and a GLP-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty Rats von Trevaskis, James L, Sacramento, Chester Bittencourt, Jouihan, Hani, Ali, Safina, Le Lay, John, Oldham, Stephanie, Bhagroo, Nicholas, Boland, Brandon B, Cann, Jennifer, Chang, Yuan, O'Day, Terrence, Howard, Victor, Reers, Christina, Winzell, Maria Sorhede, Smith, David M, Feigh, Michael, Barkholt, Pernille, Schreiter, Kay, Austen, Matthias, Andag, Uwe, Thompson, Simon, Jermutus, Lutz, Coghlan, Matthew P, Grimsby, Joseph, Dohrmann, Cord, Rhodes, Christopher J, Rondinone, Cristina M, Sharma, Arun

Volltext

Reply to commentary by R Duggleby (2019) von Steele, Edward J., Al-Mufti, Shirwan, Augustyn, Kenneth A., Chandrajith, Rohana, Coghlan, John P., Coulson, S.G., Ghosh, Sudipto, Gillman, Mark, Gorczynski, Reginald M., Klyce, Brig, Louis, Godfrey, Mahanama, Kithsiri, Oliver, Keith R., Padron, Julio, Qu, Jiangwen, Schuster, John A., Smith, W.E., Snyder, Duane P., Steele, Julian A., Stewart, Brent J., Temple, Robert, Tokoro, Gensuke, Tout, Christopher A., Unzicker, Alexander, Wainwright, Milton, Wallis, Jamie, Wallis, Daryl H., Wallis, Max K., Wetherall, John, Wickramasinghe, D.T., Wickramasinghe, J.T., Wickramasinghe, N. Chandra, Liu, Yongsheng

Volltext

The effect of relaxin on collagen metabolism in the nonpregnant rat pubic symphysis: the influence of estrogen and progesterone in regulating relaxin activity von Samuel, C S, Butkus, A, Coghlan, J P, Bateman, J F

Volltext

Use of lithium and SB‐415286 to explore the role of glycogen synthase kinase‐3 in the regulation of glucose transport and glycogen synthase von MacAulay, Katrina, Hajduch, Eric, Blair, Anne S., Coghlan, Matthew P., Smith, Stephen A., Hundal, Harinder S.

Volltext

Biobanks of blood from donors and recipients of blood products von Reesink, H. W., Engelfriet, C. P., Hyland, C. A., Coghlan, P., Tait, B., Wsolak, M., Keller, A. J., Henn, G., Mayr, W. R., Thomas, I., Osselaer, J.-C., Lambermont, M., Beaten, M., Wendel, S., Qiu, Y., Georgsen, J., Krusius, T., Mäki, T., Andreu, G., Morel, P., Lefrère, J.-J., Rebulla, P., Giovanelli, S., Butti, B., Lecchi, L., Mozzi, F., Van Hilten, J. A., Zwaginga, J. J., Flanagan, P., Flesland, Ø., Brojer, E., Łętowska, M., Åkerblom, O., Norda, R., Prowse, C., Dow, B., Jarvis, L., Davidson, F., Kleinman, S., Bianco, C., Stramer, S. L., Dodd, R. Y., Busch, M. P.

Volltext

Logistics of platelet concentrateses von Pearson, H., Davis, K. G., Wood, E. M., Coghlan, P. J., Leitner, G. C., Höcker, P., Panzer, S., Mayr, W. R., Devine, D. V., Hume, H., Howe, D., Turek, P., Chabanel, A., Lee, K., Bardiaux, L., Proust, F., Waller, C., Francois, A., Mercadier, A., Cazenave, J. P., Andreu, G., Politis, C., Katsea, P., Richardson, C., Stavropoulou-Gioka, A., Lin, C. K., Ohto, H., Miyata, S., Satake, M., Vrielink, H., Pietersz, R. N. I., Ghosh, S., Scott, R., Brojer, E., Letowska, M., Zupanska, B., Zhiburt, E., Lozano, M., Mazzara, R., Cid, J., Norda, R., Knutson, F., MacLennan, S., Gesinde, M., Szczepiorkowski, Z. M., AuBuchon, J. P., Mantha, S., Eisenbarth, S., Champion, M., Snyder, E.

Volltext