Antibody-Proteolysis Targeting Chimera Conjugate Enables Selective Degradation of Receptor-Interacting Serine/Threonine-Protein Kinase 2 in HER2+ Cell Lines von Chan, Karina, Sathyamurthi, Preethi Soundarya, Queisser, Markus A., Mullin, Michael, Shrives, Harry, Coe, Diane M., Burley, Glenn A.

Volltext

α-Selective Organocatalytic Synthesis of 2-Deoxygalactosides von Balmond, Edward I., Coe, Diane M., Galan, M. Carmen, McGarrigle, Eoghan M.

Volltext

Hi-JAK-ing the ubiquitin system: The design and physicochemical optimisation of JAK PROTACs von Shah, Rishi R, Redmond, Joanna M, Mihut, Andrei, Menon, Malini, Evans, John P, Murphy, John A, Bartholomew, Michelle A, Coe, Diane M

Volltext

A 3,4-trans-Fused Cyclic Protecting Group Facilitates α-Selective Catalytic Synthesis of 2-Deoxyglycosides von Balmond, Edward I., Benito-Alifonso, David, Coe, Diane M., Alder, Roger W., McGarrigle, Eoghan M., Galan, M. Carmen

Volltext

Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor von Biggadike, Keith, Bledsoe, Randy K, Coe, Diane M, Cooper, Tony W.J, House, David, Iannone, Marie A, Macdonald, Simon J.F, Madauss, Kevin P, McLay, Iain M, Shipley, Tracy J, Taylor, Simon J, Tran, Thuy B, Uings, Iain J, Weller, Victoria, Williams, Shawn P

Volltext

Electrochemical Synthesis of Isoxazolines: Method and Mechanism von Holman, Samuel D. L., Wills, Alfie G., Fazakerley, Neal J., Poole, Darren L., Coe, Diane M., Berlouis, Leonard A., Reid, Marc

Volltext

Stereoselective Glycosylation of 2‑Nitrogalactals Catalyzed by a Bifunctional Organocatalyst von Medina, Sandra, Harper, Matthew J, Balmond, Edward I, Miranda, Silvia, Crisenza, Giacomo E. M, Coe, Diane M, McGarrigle, Eoghan M, Galan, M. Carmen

Volltext

Synthesis of α‑Substituted Vinylsulfonium Salts and Their Application as Annulation Reagents in the Formation of Epoxide- and Cyclopropane-Fused Heterocycles von Matlock, Johnathan V, Fritz, Sven P, Harrison, Stephen A, Coe, Diane M, McGarrigle, Eoghan M, Aggarwal, Varinder K

Volltext

Reaction of 1,1′-Divinyl Ferrocene with One-Electron Oxidants: Entry into Functionalised [4]Ferrocenophanes and Observation of an Isotope-Dependent Chemoselectivity Effect von Gleixner, Renate M., Joly, Kévin M., Tremayne, MaryJane, Kariuki, Benson M., Male, Louise, Coe, Diane M., Cox, Liam R.

Volltext

Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism von Wellaway, Christopher R, Baldwin, Ian R, Bamborough, Paul, Barker, Daniel, Bartholomew, Michelle A, Chung, Chun-wa, Dümpelfeld, Birgit, Evans, John P, Fazakerley, Neal J, Homes, Paul, Keeling, Steven P, Lewell, Xiao Q, McNab, Finlay W, Morley, Joanne, Needham, Deborah, Neu, Margarete, van Oosterhout, Antoon J. M, Pal, Anshu, Reinhard, Friedrich B. M, Rianjongdee, Francesco, Robertson, Craig M, Rowland, Paul, Shah, Rishi R, Sherriff, Emma B, Sloan, Lisa A, Teague, Simon, Thomas, Daniel A, Wellaway, Natalie, Wojno-Picon, Justyna, Woolven, James M, Coe, Diane M

Volltext

Synthesis and Evaluation of Small Molecule Inhibitors of the Androgen Receptor N‑Terminal Domain von Henry, Martyn C., Riley, Christopher M., Hunter, Irene, Elwood, Jessica M. L., Lopez-Fernandez, J. Daniel, Minty, Laura, Coe, Diane M., McEwan, Iain J., Jamieson, Craig

Volltext

Discovery of 6‑Amino-2-{[(1S)‑1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro‑8H‑purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7... von Biggadike, Keith, Ahmed, Mahbub, Ball, Doug I, Coe, Diane M, Dalmas Wilk, Deidre A, Edwards, Chris D, Gibbon, Bob H, Hardy, Charlotte J, Hermitage, Stephen A, Hessey, Joanne O, Hillegas, Aimee E, Hughes, Stephen C, Lazarides, Linos, Lewell, Xiao Q, Lucas, Amanda, Mallett, David N, Price, Mark A, Priest, Fiona M, Quint, Diana J, Shah, Poonam, Sitaram, Anesh, Smith, Stephen A, Stocker, Richard, Trivedi, Naimisha A, Tsitoura, Daphne C, Weller, Victoria

Volltext

Synthesis of Phosphoramides for the Lewis Base-Catalyzed Allylation and Aldol Addition Reactions von Denmark, Scott E, Su, Xiping, Nishigaichi, Yutaka, Coe, Diane M, Wong, Ken-Tsung, Winter, Stephen B. D, Choi, Jun Young

Volltext

Synthesis and Structure−Activity Relationships of Long-acting β2 Adrenergic Receptor Agonists Incorporating Metabolic Inactivation: An Antedrug Approach von Procopiou, Panayiotis A, Barrett, Victoria J, Bevan, Nicola J, Biggadike, Keith, Box, Philip C, Butchers, Peter R, Coe, Diane M, Conroy, Richard, Emmons, Amanda, Ford, Alison J, Holmes, Duncan S, Horsley, Helen, Kerr, Fern, Li-Kwai-Cheung, Anne-Marie, Looker, Brian E, Mann, Inderjit S, McLay, Iain M, Morrison, Valerie S, Mutch, Peter J, Smith, Claire E, Tomlin, Paula

Volltext

Potassium trimethylsilanolate induced cleavage of 1,3-oxazolidin-2- and 5-ones, and application to the synthesis of (R)-salmeterol von Coe, Diane M, Perciaccante, Rossana, Procopiou, Panayiotis A

Volltext

Chiral Phosphoramide-Catalyzed Enantioselective Addition of Allylic Trichlorosilanes to Aldehydes. Preparative and Mechanistic Studies with Monodentate Phosphorus-Based Amides von Denmark, Scott E, Fu, Jiping, Coe, Diane M, Su, Xiping, Pratt, Norman E, Griedel, Brian D

Volltext

Chemistry of Enoxysilacyclobutanes: Highly Selective Uncatalyzed Aldol Additions von Denmark, Scott E, Griedel, Brian D, Coe, Diane M, Schnute, Mark E

Volltext

A practical drug discovery project at the undergraduate level von Jonathan Fray, M., Macdonald, Simon J.F., Baldwin, Ian R., Barton, Nick, Brown, Jack, Campbell, Ian B., Churcher, Ian, Coe, Diane M., Cooper, Anthony W.J., Craven, Andrew P., Fisher, Gail, Inglis, Graham G.A., Kelly, Henry A., Liddle, John, Maxwell, Aoife C., Patel, Vipulkumar K., Swanson, Stephen, Wellaway, Natalie

Volltext

Pyrazolopyridines as potent PDE4B inhibitors: 5-Heterocycle SAR von Mitchell, Charlotte J., Ballantine, Stuart P., Coe, Diane M., Cook, Caroline M., Delves, Christopher J., Dowle, Mike D., Edlin, Chris D., Hamblin, J. Nicole, Holman, Stuart, Johnson, Martin R., Jones, Paul S., Keeling, Sue E., Kranz, Michael, Lindvall, Mika, Lucas, Fiona S., Neu, Margarete, Solanke, Yemisi E., Somers, Don O., Trivedi, Naimisha A., Wiseman, Joanne O.

Volltext

Synthesis and Structure−Activity Relationships of Long-acting β2 Adrenergic Receptor Agonists Incorporating Arylsulfonamide Groups von Procopiou, Panayiotis A, Barrett, Victoria J, Bevan, Nicola J, Biggadike, Keith, Butchers, Peter R, Coe, Diane M, Conroy, Richard, Edney, Dean D, Field, Rita N, Ford, Alison J, Guntrip, Stephen B, Looker, Brian E, McLay, Iain M, Monteith, Michael J, Morrison, Valerie S, Mutch, Peter J, Richards, Stephen A, Sasse, Rosemary, Smith, Claire E

Volltext