In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions von Burstein, S R, Valsecchi, F, Kawamata, H, Bourens, M, Zeng, R, Zuberi, A, Milner, T A, Cloonan, S M, Lutz, C, Barrientos, A, Manfredi, G

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Synthesis and antiproliferative action of a novel series of maprotiline analogues von McNamara, Y.M., Bright, S.A., Byrne, A.J., Cloonan, S.M., McCabe, T., Williams, D.C., Meegan, M.J.

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281 Cancer: a less depressing outlook? Using antidepressants to induce autophagic programmed cell death in a resistant strain of Burkitt's lymphoma von Cloonan, S, Williams, D.C

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EP16.04-004 Impact of Gender on Cellular Response to Cigarette Smoke Extract von Ariznabarreta, O.P., O'Dowd, N., Williams, N., Cloonan, S., Sheils, O., Baird, A.-M.

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C74 ADVANCES IN TRANSLATIONAL COPD: Iron Loading Is Increased In Lung Tissue Of COPD Patients von Venkatesan, S, Zhou, X, Cloonan, S M, Olsson, H K

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420: Extracellular polysaccharides are metabolo-stimulatory ligands that favor Pseudomonas aeruginosa iron scavenging von Khan, I., Tomlinson, K., Fields, B., Rosenberg, G., Yehezkel, D., Kim, K., Cloonan, S., Avraham, R., Prince, A., Riquelme, S.

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Impact of Gender on Cellular Response to Cigarette Smoke Extract von Ariznabarreta, OP, O'Dowd, N, Williams, N, Cloonan, S, Sheils, O, Baird, AM

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Hepatitis B Virus–Specific and Global T-Cell Dysfunction in Chronic Hepatitis B von Park, Jang-June, Wong, David K, Wahed, Abdus S, Lee, William M, Feld, Jordan J, Terrault, Norah, Khalili, Mandana, Sterling, Richard K, Kowdley, Kris V, Bzowej, Natalie, Lau, Daryl T, Kim, W. Ray, Smith, Coleman, Carithers, Robert L, Torrey, Keith W, Keith, James W, Levine, Danielle L, Traum, Daniel, Ho, Suzanne, Valiga, Mary E, Johnson, Geoffrey S, Doo, Edward, Lok, Anna S.F, Chang, Kyong-Mi

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Clinical Management of Ebola Virus Disease in the United States and Europe von Uyeki, Timothy M, Mehta, Aneesh K, Davey, Richard T, Liddell, Allison M, Wolf, Timo, Vetter, Pauline, Schmiedel, Stefan, Grünewald, Thomas, Jacobs, Michael, Arribas, Jose R, Evans, Laura, Hewlett, Angela L, Brantsaeter, Arne B, Ippolito, Giuseppe, Rapp, Christophe, Hoepelman, Andy I.M, Gutman, Julie

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Assessment of transcript reconstruction methods for RNA-seq von Steijger, Tamara, Abril, Josep F, Engström, Pär G, Kokocinski, Felix, Hubbard, Tim J, Guigó, Roderic, Harrow, Jennifer, Bertone, Paul

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B60 SMOKING AND PARTICULATES IMPACT ON LUNG HEALTH: Differential And Tissue Specific Autophagic Responses To Cigarette Smoke Exposure von Pabon, M A, Malick, F, Ma, K C, Mizumura, K, Hisata, S, Lam, H C, Choi, M, Choi, A M K, Cloonan, S M

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Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study von McArdle, Patrick F, Malik, Rainer, Algra, Ale, Amouyel, Philippe, Anderson, Christopher D, Arsava, Ethem Murat, Ay, Hakan, Blanton, Susan H, Brown, Robert D, Burgess, Annette I, Chasman, Daniel I, Chen, Wei-Min, Cheng, Yu-Ching, Cotlarciuc, Ioana, Cruchaga, Carlos, Dave, Tushar, Dawson, Jesse, Delavaran, Hossein, Dell, Cameron A, Dichgans, Martin, Doheny, Kimberly F, Dong, Chuanhui, Duggan, David J, Fornage, Myriam, Frossard, Philippe M, Gamble, Dale M, Giralt-Steinhauer, Eva, Grewal, Raji P, Han, Buhm, Hankey, Graeme J, Heitsch, Laura, Higgins, Peter, Hopewell, Jemma C, Horenstein, Richard B, Howard, George, Ingelsson, Erik, Jackson, Rebecca D, Jern, Christina, Jood, Katarina, Kahn, Muhammad S, Kappelle, L Jaap, Kardia, Sharon L R, Keene, Keith L, Kissela, Brett M, Labovitz, Daniel, Lee, Cue Hyunkyu, Lee, Jin-Moo, Lehm, Manuel, Levi, Christopher, Leys, Didier, Maguire, Jane, Manichaikul, Ani, McClure, Leslie A, Mola-Caminal, Marina, Montaner, Joan, Müller-Nurasyid, Martina, Nalls, Mike A, O'Connell, Jeffrey R, O'Donnell, Martin, Papanicolaou, George J, Paré, Guillaume, Pera, Joanna, Peters, Annette, Rabionet, Raquel, Raffeld, Miriam R, Rannikmäe, Kristiina, Rasheed, Asif, Rexrode, Kathryn, Rolfs, Arndt, Rose, Lynda M, Sacco, Ralph L, Schmidt, Reinhold, Schürks, Markus, Segal, Helen C, Seiler, Stephan, Shuldiner, Alan R, Silver, Brian, Slowik, Agnieszka, Smith, Jennifer A, Söderholm, Martin, Sparks, Mary J, Sudlow, Cathie LM, Tajuddin, Salman M, Talbert, Robert L, Tatlisumak, Turgut, Thorsteindottir, Unnur, Tiedt, Steffen, Trompet, Stella, Waldenberger, Melanie, Wang, Liyong, Wassertheil-Smoller, Sylvia, Weir, David R, Wiggins, Kerri L, Wloch-Kopec, Dorota, Woodfield, Rebecca, Xu, Huichun, Zonderman, Alan B, Worrall, Bradford B, Kittner, Steven J, Arnett, Donna K Arnett

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B45 COPD: PATHOGENESIS: Mitophagy-Regulated Necroptosis Contributes To The Pathogenesis Of Chronic Obstructive Pulmonary Disease von Mizumura, K, Cloonan, S M, Nakahira, K, Bhashyam, A R, Cervo, M, Owen, C A, Mahmood, A, Washko, G R, Hashimoto, S, Ryter, S, Choi, A M K

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B44 COPD: GENETICS: The COPD Susceptibility Gene Ireb2 Regulates Mitochondrial Responses To Cigarette Smoke von Cloonan, S M, Glass, K, Bhashyam, A R, Cervo, M, Quackenbusch, J, Mahmood, A, Silverman, E K, Choi, A M K

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B45 COPD: PATHOGENESIS: The Modified Disaccharide Trehalose Reverses Cigarette Smoke-Induced COPD von Cloonan, S M, Lam, H C, Bhashyam, A R, Haspel, J A, Cervo, M, Parameswaran, H, Owen, C A, Mahmood, A, Choi, A M K

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COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls von Rannikmäe, Kristiina, Sivakumaran, Vhinoth, Millar, Henry, Malik, Rainer, Anderson, Christopher D, Chong, Mike, Dave, Tushar, Falcone, Guido J, Fernandez-Cadenas, Israel, Jimenez-Conde, Jordi, Lindgren, Arne, Montaner, Joan, OʼDonnell, Martin, Paré, Guillaume, Radmanesh, Farid, Rost, Natalia S, Slowik, Agnieszka, Söderholm, Martin, Traylor, Matthew, Pulit, Sara L, Seshadri, Sudha, Worrall, Brad B, Woo, Daniel, Markus, Hugh S, Mitchell, Braxton D, Dichgans, Martin, Rosand, Jonathan, Sudlow, Cathie L.M

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Therapeutic Potential of Heme Oxygenase-1/Carbon Monoxide in Lung Disease von Constantin, Myrna, Choi, Alexander J. S., Cloonan, Suzanne M., Ryter, Stefan W.

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B59 NOVEL GENES AND GENE EFFECTS IN COPD: Linking The COPD Susceptibility Gene Iron-Responsive Element Binding Protein 2 (irp2) With Pathological Outcomes In Experimental COPD von Cloonan, S M, Glass, K, Laucho-Contreras, M, Bhashyam, A R, Cervo, M, Pabon, M, Konrad, C, Polverino, F, Siempos, I I, Perez, E, Mizumura, K, Ghosh, M, Parameswaran, H, Williams, N, Rooney, K T, Chen, Z-H, Goldklang, M P, Yuan, G-C, Moore, S, DeMeo, D L, Rouault, T A, D'Armiento, J M, Schon, E, Manfredi, G, Quackenbush, J, Mahmood, A, Silverman, E K, Owen, C A, Choi, A M K

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Association Between Severe Serum Alanine Aminotransferase Flares and Hepatitis B e Antigen Seroconversion and HBV DNA Decrease in Untreated Patients With Chronic HBV Infection von Brahmania, Mayur, Lombardero, Manuel, Hansen, Bettina E., Terrault, Norah A., Lok, Anna S., Perrillo, Robert P., Belle, Steven H., Di Bisceglie, Adrian M., Feld, Jordan J., Lee, William M., Fried, Michael W., Janssen, Harry L.A., Lau, Daryl T-Y., Chung, Raymond T., Roberts, Lewis R., Hassan, Mohamed A., Lisker-Melman, Mauricio, Wong, David K., Juan, Joshua, Yim, Colina, Patel, Keyur, Murakami, Carol S., Do, Son, Han, Steven-Huy B., Tran, Tram T., Khalili, Mandana, Cooper, Stewart L., Fontana, Robert J., Tsai, Naoky, Younoszai, Barak, Muir, Andrew, Evon, Donna, Darling, Jama M., Carithers, Robert C., Shuhart, Margaret, Kowdley, Kris V., Wang, Chia C., Sterling, Richard K., Ghany, Marc G., Liang, T. Jake, Hoofnagle, Jay H., Doo, Edward, Chang, Kyong-Mi, Park, Jang-June, Wahed, Abdus, Cloonan, Yona, Kleiner, David

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Determination of hepatitis B phenotype using biochemical and serological markers von Di Bisceglie, A. M., Lombardero, M., Teckman, J., Roberts, L., Janssen, H. L. A., Belle, S. H., Hoofnagle, J. H., Lau, Daryl T‐Y, Chung, Raymond T., Smith, Coleman I., ‐Melman, Mauricio, Wong, David K., Juan, Joshua, Feld, Jordan, Yim, Colina, Heathcote, Jenny, Lee, William M., Perrillo, Robert, Do, Son, Han, Steven‐Huy B., Tran, Tram T., Terrault, Norah A., Khalili, Mandana, Cooper, Stewart L., Lok, Anna Suk‐Fong, Fontana, Robert J., Fried, Michael W., Patel, Keyur, Evon, Donna, Carithers, Robert C., Shuhart, Margaret, Kowdley, Kris V., Wang, Chia C., Sterling, Richard K., Ghany, Marc G., Jake Liang, T., Doo, Edward, Chang, Kyong‐Mi, Park, Jang‐June, Wahed, Abdus, Cloonan, Yona, Kleiner, David

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