Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling von Li, Nan, Wang, Yifan, Neri, Shinya, Zhen, Yuanli, Fong, Lon Wolf R., Qiao, Yawei, Li, Xu, Chen, Zhen, Stephan, Clifford, Deng, Weiye, Ye, Rui, Jiang, Wen, Zhang, Shuxing, Yu, Yonghao, Hung, Mien-Chie, Chen, Junjie, Lin, Steven H.

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Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition von Zhao, Na, Powell, Reid T., Yuan, Xueying, Bae, Goeun, Roarty, Kevin P., Stossi, Fabio, Strempfl, Martina, Toneff, Michael J., Johnson, Hannah L., Mani, Sendurai A., Jones, Philip, Stephan, Clifford C., Rosen, Jeffrey M.

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GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer von Vijay, Geraldine Vidhya, Zhao, Na, Den Hollander, Petra, Toneff, Mike J, Joseph, Robiya, Pietila, Mika, Taube, Joseph H, Sarkar, Tapasree R, Ramirez-Pena, Esmeralda, Werden, Steven J, Shariati, Maryam, Gao, Ruli, Sobieski, Mary, Stephan, Clifford C, Sphyris, Nathalie, Miura, Noayuki, Davies, Peter, Chang, Jeffrey T, Soundararajan, Rama, Rosen, Jeffrey M, Mani, Sendurai A

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Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo von Fan, Fan, Ghosh, Susmita, Powell, Reid, Roszik, Jason, Park, Yongsun, Sobieski, Mary, Sorokin, Alexey, Stephan, Clifford, Kopetz, Scott, Ellis, Lee M, Bhattacharya, Rajat

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A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells von Guo, Lei, Li, Jia, Zeng, Hongxiang, Guzman, Anna G., Li, Tingting, Lee, Minjung, Zhou, Yubin, Goodell, Margaret A., Stephan, Clifford, Davies, Peter J. A., Dawson, Mark A, Sun, Deqiang, Huang, Yun

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GSK3[beta] regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer von Vijay, Geraldine Vidhya, Zhao, Na, Den Hollander, Petra, Toneff, Mike J, Joseph, Robiya, Pietila, Mika, Taube, Joseph H, Sarkar, Tapasree R, Ramirez-Pena, Esmeralda, Werden, Steven J, Shariati, Maryam, Gao, Ruli, Sobieski, Mary, Stephan, Clifford C, Sphyris, Nathalie, Miura, Noayuki, Davies, Peter, Chang, Jeffrey T, Soundararajan, Rama, Rosen, Jeffrey M, Mani, Sendurai A

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Cystic fibrosis cell models for high-throughput analysis and drug screening von Liu, Aidi, Chokshi, Mithil, Nguyen, Nghi, Powell, Reid T., Stephan, Clifford C., Bao, Gang

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A transgenic mouse model of Down syndrome acute lymphoblastic leukemia identifies targetable vulnerabilities von Junco, Jacob J, Rochette, Max, Alozie, Michelle, Rashid, Raushan, Terrell, Maci, Zorman, Barry, Sumazin, Pavel, Rowland, Lauren, Dettorre, Gino, Powell, Reid T, Stephan, Clifford C, Davies, Peter J, Martinez-Moczygemba, Margarita, Yang, Jun J, Rabin, Karen R

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Chemical genetic analysis of enoxolone inhibition of Clostridioides difficile toxin production reveals adenine deaminase and ATP synthase as antivirulence targets von Marreddy, Ravi K.R., Phelps, Gregory A., Churion, Kelly, Picker, Jonathan, Powell, Reid, Cherian, Philip T., Bowling, John J., Stephan, Clifford C., Lee, Richard E., Hurdle, Julian G.

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Spatial mapping of the biologic effectiveness of scanned particle beams: towards biologically optimized particle therapy von Guan, Fada, Bronk, Lawrence, Titt, Uwe, Lin, Steven H., Mirkovic, Dragan, Kerr, Matthew D., Zhu, X. Ronald, Dinh, Jeffrey, Sobieski, Mary, Stephan, Clifford, Peeler, Christopher R., Taleei, Reza, Mohan, Radhe, Grosshans, David R.

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EphA2- and HDAC-Targeted Combination Therapy in Endometrial Cancer von Joseph, Robiya, Dasari, Santosh K, Umamaheswaran, Sujanitha, Mangala, Lingegowda S, Bayraktar, Emine, Rodriguez-Aguayo, Cristian, Wu, Yutuan, Nguyen, Nghi, Powell, Reid T, Sobieski, Mary, Liu, Yuan, Kim, Mark Seungwook, Corvigno, Sara, Foster, Katherine, Hanjra, Pahul, Vu, Thanh Chung, Chowdhury, Mamur A, Amero, Paola, Stephan, Clifford, Lopez-Berestein, Gabriel, Westin, Shannon N, Sood, Anil K

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Therapeutically actionable signaling node to rescue AURKA driven loss of primary cilia in VHL-deficient cells von Chowdhury, Pratim, Perera, Dimuthu, Powell, Reid T., Talley, Tia, Tripathi, Durga Nand, Park, Yong Sung, Mancini, Michael A., Davies, Peter, Stephan, Clifford, Coarfa, Cristian, Dere, Ruhee

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Comprehensive pharmacogenomic profiling of human papillomavirus-positive and -negative squamous cell carcinoma identifies sensitivity to aurora kinase inhibition in KMT2D mutants von Kalu, Nene N., Mazumdar, Tuhina, Peng, Shaohua, Tong, Pan, Shen, Li, Wang, Jing, Banerjee, Upasana, Myers, Jeffrey N., Pickering, Curtis R., Brunell, David, Stephan, Clifford C., Johnson, Faye M.

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Combination of EphA2- and Wee1-Targeted Therapies in Endometrial Cancer von Dasari, Santosh K, Joseph, Robiya, Umamaheswaran, Sujanitha, Mangala, Lingegowda S, Bayraktar, Emine, Rodriguez-Aguayo, Cristian, Wu, Yutuan, Nguyen, Nghi, Powell, Reid T, Sobieski, Mary, Liu, Yuan, Chowdhury, Mamur A, Amero, Paola, Stephan, Clifford, Lopez-Berestein, Gabriel, Westin, Shannon N, Sood, Anil K

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Interpreting the biological effects of protons as a function of physical quantity: linear energy transfer or microdosimetric lineal energy spectrum? von Guan, Fada, Bronk, Lawrence, Kerr, Matthew, Li, Yuting, Braby, Leslie A., Sobieski, Mary, Wang, Xiaochun, Zhang, Xiaodong, Stephan, Clifford, Grosshans, David R., Mohan, Radhe

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Author Correction: Therapeutically actionable signaling node to rescue AURKA driven loss of primary cilia in VHL-deficient cells von Chowdhury, Pratim, Perera, Dimuthu, Powell, Reid T., Talley, Tia, Tripathi, Durga Nand, Park, Yong Sung, Mancini, Michael A., Davies, Peter, Stephan, Clifford, Coarfa, Cristian, Dere, Ruhee

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Tie2-FGFR1 Interaction Induces Adaptive PI3K Inhibitor Resistance by Upregulating Aurora A/PLK1/CDK1 Signaling in Glioblastoma von Li, Xiaolong, Martinez-Ledesma, Emmanuel, Zhang, Chen, Gao, Feng, Zheng, Siyuan, Ding, Jie, Wu, Shaofang, Nguyen, Nghi, Clifford, Stephan C, Wen, Patrick Y, Ligon, Keith L, Yung, W K Alfred, Koul, Dimpy

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Estrogen-induced transcription at individual alleles is independent of receptor level and active conformation but can be modulated by coactivators activity von Stossi, Fabio, Dandekar, Radhika D, Mancini, Maureen G, Gu, Guowei, Fuqua, Suzanne A W, Nardone, Agostina, De Angelis, Carmine, Fu, Xiaoyong, Schiff, Rachel, Bedford, Mark T, Xu, Wei, Johansson, Hans E, Stephan, Clifford C, Mancini, Michael A

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High-throughput screening against protein:protein interaction interfaces reveals anti-cancer therapeutics as potent modulators of the voltage-gated Na+ channel complex von Wadsworth, Paul A., Folorunso, Oluwarotimi, Nguyen, Nghi, Singh, Aditya K., D’Amico, Daniela, Powell, Reid T., Brunell, David, Allen, John, Stephan, Clifford, Laezza, Fernanda

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Evolution of cisplatin resistance through coordinated metabolic reprogramming of the cellular reductive state von Yu, Wangie, Chen, Yunyun, Putluri, Nagireddy, Osman, Abdullah, Coarfa, Cristian, Putluri, Vasanta, Kamal, Abu H. M., Asmussen, Jennifer Kay, Katsonis, Panagiotis, Myers, Jeffrey N., Lai, Stephen Y., Lu, Wuhao, Stephan, Clifford C., Powell, Reid T., Johnson, Faye M., Skinner, Heath D., Kazi, Jawad, Ahmed, Kazi Mokim, Hu, Linghao, Threet, Addison, Meyer, Matthew D., Bankson, James A., Wang, Tony, Davis, Jack, Parker, Kirby R., Harris, Madison A., Baek, Mokryun L., Echeverria, Gloria V., Qi, Xiaoli, Wang, Jin, Frederick, Andy I., Walsh, Alex J., Lichtarge, Olivier, Frederick, Mitchell J., Sandulache, Vlad C.

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