Predicting the Conformational Variability of Abl Tyrosine Kinase using Molecular Dynamics Simulations and Markov State Models von Meng, Yilin, Gao, Cen, Clawson, David K, Atwell, Shane, Russell, Marijane, Vieth, Michal, Roux, Benoît

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Preclinical assessment of galunisertib (LY2157299 monohydrate), a first-in-class transforming growth factor-β receptor type I inhibitor von Yingling, Jonathan M, McMillen, William T, Yan, Lei, Huang, Huocong, Sawyer, J Scott, Graff, Jeremy, Clawson, David K, Britt, Karen S, Anderson, Bryan D, Beight, Douglas W, Desaiah, Durisala, Lahn, Michael M, Benhadji, Karim A, Lallena, Maria J, Holmgaard, Rikke B, Xu, Xiaohong, Zhang, Faming, Manro, Jason R, Iversen, Philip W, Iyer, Chandrasekar V, Brekken, Rolf A, Kalos, Michael D, Driscoll, Kyla E

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Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor von King, Constance, Diaz, Henry, Barnard, Darlene, Barda, David, Clawson, David, Blosser, Wayne, Cox, Karen, Guo, Sherry, Marshall, Mark

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Synthesis and Pharmacological Characterization of C4‑(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)‑2-Amino-4-(1H‑1,... von Monn, James A, Prieto, Lourdes, Taboada, Lorena, Hao, Junliang, Reinhard, Matthew R, Henry, Steven S, Beadle, Christopher D, Walton, Lesley, Man, Teresa, Rudyk, Helene, Clark, Barry, Tupper, David, Baker, S. Richard, Lamas, Carlos, Montero, Carlos, Marcos, Alicia, Blanco, Jaime, Bures, Mark, Clawson, David K, Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A, Wang, Xushan, Carter, Joan H, Getman, Brian G, Catlow, John T, Swanson, Steven, Johnson, Bryan G, Shaw, David B, McKinzie, David L

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Discovery of 1‑(3,3-Dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)­pyrido[2,3‑d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a Pan-RAF Inhibitor with Minimal Paradoxi... von Henry, James R, Kaufman, Michael D, Peng, Sheng-Bin, Ahn, Yu Mi, Caldwell, Timothy M, Vogeti, Lakshminarayana, Telikepalli, Hanumaiah, Lu, Wei-Ping, Hood, Molly M, Rutkoski, Thomas J, Smith, Bryan D, Vogeti, Subha, Miller, David, Wise, Scott C, Chun, Lawrence, Zhang, Xiaoyi, Zhang, Youyan, Kays, Lisa, Hipskind, Philip A, Wrobleski, Aaron D, Lobb, Karen L, Clay, Julia M, Cohen, Jeffrey D, Walgren, Jennie L, McCann, Denis, Patel, Phenil, Clawson, David K, Guo, Sherry, Manglicmot, Danalyn, Groshong, Chris, Logan, Cheyenne, Starling, James J, Flynn, Daniel L

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Synthesis and Pharmacological Characterization of C4 β -Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S)-2-Amino-4-[(3-meth... von Monn, James A, Henry, Steven S, Massey, Steven M, Clawson, David K, Chen, Qi, Diseroad, Benjamin A, Bhardwaj, Rajni M, Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A, Wang, Xu-Shan, Carter, Joan H, Getman, Brian G, Adragni, Kofi, Broad, Lisa M, Sanger, Helene E, Ursu, Daniel, Catlow, John T, Swanson, Steven, Johnson, Bryan G, Shaw, David B, McKinzie, David L, Hao, Junliang

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Adenoviruses in fecal samples from asymptomatic rhesus macaques, United States von Roy, Soumitra, Sandhu, Arbansjit, Medina, Angelica, Clawson, David S, Wilson, James M

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Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S‑2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metab... von Monn, James A, Prieto, Lourdes, Taboada, Lorena, Pedregal, Concepcion, Hao, Junliang, Reinhard, Matt R, Henry, Steven S, Goldsmith, Paul J, Beadle, Christopher D, Walton, Lesley, Man, Teresa, Rudyk, Helene, Clark, Barry, Tupper, David, Baker, S. Richard, Lamas, Carlos, Montero, Carlos, Marcos, Alicia, Blanco, Jaime, Bures, Mark, Clawson, David K, Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A, Wang, Xushan, Carter, Joan H, Xiang, Chuanxi, Catlow, John T, Swanson, Steven, Sanger, Helen, Broad, Lisa M, Johnson, Michael P, Knopp, Kelly L, Simmons, Rosa M. A, Johnson, Bryan G, Shaw, David B, McKinzie, David L

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Defining Target Engagement Required for Efficacy In Vivo at the Retinoic Acid Receptor-Related Orphan Receptor C2 (RORγt) von Lugar, Charles W, Clarke, Christian A, Morphy, Richard, Rudyk, Helene, Sapmaz, Selma, Stites, Ryan E, Vaught, Grant M, Furness, Kelly, Broughton, Howard B, Durst, Greg L, Clawson, David K, Stout, Stephanie L, Guo, Sherry Y, Durbin, Jim D, Stayrook, Keith R, Edmondson, Denise D, Kikly, Kristy, New, Nicole E, Bina, Holly A, Chambers, Mark G, Shetler, Pamela, Chang, William Y, Chang, Veavi Ching-Yun, Barr, Rob, Gough, Wendy H, Steele, Jimmy P, Getman, Brian, Patel, Nita, Mathes, Brian M, Richardson, Timothy I

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Glucocorticoid Receptor Modulators Informed by Crystallography Lead to a New Rationale for Receptor Selectivity, Function, and Implications for Structure-Based Design von Carson, Matthew W, Luz, John G, Suen, Chen, Montrose, Chahrzad, Zink, Richard, Ruan, Xiaoping, Cheng, Christine, Cole, Harlan, Adrian, Mary D, Kohlman, Dan T, Mabry, Thomas, Snyder, Nancy, Condon, Brad, Maletic, Milan, Clawson, David, Pustilnik, Anna, Coghlan, Michael J

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Viracept (Nelfinavir Mesylate, AG1343):  A Potent, Orally Bioavailable Inhibitor of HIV-1 Protease von Kaldor, Stephen W, Kalish, Vincent J, Davies, Jay F, Shetty, Bhasker V, Fritz, James E, Appelt, Krzysztof, Burgess, Jeffrey A, Campanale, Kristina M, Chirgadze, Nickolay Y, Clawson, David K, Dressman, Bruce A, Hatch, Steven D, Khalil, Deborah A, Kosa, Maha B, Lubbehusen, Penny P, Muesing, Mark A, Patick, Amy K, Reich, Siegfried H, Su, Kenneth S, Tatlock, John H

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GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: In vitro profile and in vivo analgesic efficacy von Martinez-Perez, Jose A., Iyengar, Smriti, Shannon, Harlan E., Bleakman, David, Alt, Andrew, Clawson, David K., Arnold, Brian M., Bell, Michael G., Bleisch, Thomas J., Castaño, Ana M., Del Prado, Miriam, Dominguez, Esteban, Escribano, Ana M., Filla, Sandra A., Ho, Ken H., Hudziak, Kevin J., Jones, Carrie K., Mateo, Ana, Mathes, Brian M., Mattiuz, Edward L., Ogden, Ann Marie L., Simmons, Rosa Maria A., Stack, Douglas R., Stratford, Robert E., Winter, Mark A., Wu, Zhipei, Ornstein, Paul L.

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Construction of gene transfer vectors based on simian adenovirus 7 von ROY, Soumitra, CLAWSON, David S, ADAM, Virginie S, MEDINA, Angelica, WILSON, James M

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Optimization of a Dihydropyrrolopyrazole Series of Transforming Growth Factor-β Type I Receptor Kinase Domain Inhibitors: Discovery of an Orally Bioavailable Transforming Growth Fa... von Li, Hong-yu, McMillen, William T, Heap, Charles R, McCann, Denis J, Yan, Lei, Campbell, Robert M, Mundla, Sreenivasa R, King, Chi-Hsin R, Dierks, Elizabeth A, Anderson, Bryan D, Britt, Karen S, Huss, Karen L, Voss, Matthew D, Wang, Yan, Clawson, David K, Yingling, Jonathan M, Sawyer, J. Scott

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Polyvagal and Global Cytokine Theory of Safety and Threat Covid-19 – Plan B von Hanscom, David, Clawson, David Roger, Porges, Stephen W., Bunnage, Ray, Aria, Les, Lederman, Steve, Taylor, James, Carter, C. Sue

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Complete nucleotide sequences and genome organization of four chimpanzee adenoviruses von Roy, Soumitra, Gao, Guangping, Clawson, David S, Vandenberghe, Luk H, Farina, Steven F, Wilson, James M

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Dihydropyrrolopyrazole Transforming Growth Factor-β Type I Receptor Kinase Domain Inhibitors:  A Novel Benzimidazole Series with Selectivity versus Transforming Growth Factor-β Typ... von Li, Hong-yu, Wang, Yan, Heap, Charles R, King, Chi-Hsin R, Mundla, Sreenivasa R, Voss, Matthew, Clawson, David K, Yan, Lei, Campbell, Robert M, Anderson, Bryan D, Wagner, Jill R, Britt, Karen, Lu, Ku X, McMillen, William T, Yingling, Jonathan M

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Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal t... von Burkholder, Timothy P., Clayton, Joshua R., Rempala, Mark E., Henry, James R., Knobeloch, John M., Mendel, David, McLean, Johnathan A., Hao, Yan, Barda, David A., Considine, Eileen L., Uhlik, Mark T., Chen, Yuefeng, Ma, Liandong, Bloem, Laura J., Akunda, Jacqueline K., McCann, Denis J., Sanchez-Felix, Manuel, Clawson, David K., Lahn, Michael M., Starling, James J.

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Use of chimeric adenoviral vectors to assess capsid neutralization determinants von Roy, Soumitra, Clawson, David S., Calcedo, Roberto, Lebherz, Corinna, Sanmiguel, Julio, Wu, Di, Wilson, James M.

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Oncogenes, growth factors and phorbol esters regulate Raf-1 through common mechanisms von BARNARD, D, DIAZ, B, CLAWSON, D, MARSHALL, M

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