Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking von Weischenfeldt, Joachim, Dubash, Taronish, Drainas, Alexandros P, Mardin, Balca R, Chen, Yuanyuan, Stütz, Adrian M, Waszak, Sebastian M, Bosco, Graziella, Halvorsen, Ann Rita, Raeder, Benjamin, Efthymiopoulos, Theocharis, Erkek, Serap, Siegl, Christine, Brenner, Hermann, Brustugun, Odd Terje, Dieter, Sebastian M, Northcott, Paul A, Petersen, Iver, Pfister, Stefan M, Schneider, Martin, Solberg, Steinar K, Thunissen, Erik, Weichert, Wilko, Zichner, Thomas, Thomas, Roman, Peifer, Martin, Helland, Aslaug, Ball, Claudia R, Jechlinger, Martin, Sotillo, Rocio, Glimm, Hanno, Korbel, Jan O

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NRG1 Fusions in KRAS Wild-Type Pancreatic Cancer von Heining, Christoph, Horak, Peter, Uhrig, Sebastian, Codo, Paula L, Klink, Barbara, Hutter, Barbara, Fröhlich, Martina, Bonekamp, David, Richter, Daniela, Steiger, Katja, Penzel, Roland, Endris, Volker, Ehrenberg, Karl Roland, Frank, Stephanie, Kleinheinz, Kortine, Toprak, Umut H, Schlesner, Matthias, Mandal, Ranadip, Schulz, Lothar, Lambertz, Helmut, Fetscher, Sebastian, Bitzer, Michael, Malek, Nisar P, Horger, Marius, Giese, Nathalia A, Strobel, Oliver, Hackert, Thilo, Springfeld, Christoph, Feuerbach, Lars, Bergmann, Frank, Schröck, Evelin, von Kalle, Christof, Weichert, Wilko, Scholl, Claudia, Ball, Claudia R, Stenzinger, Albrecht, Brors, Benedikt, Fröhling, Stefan, Glimm, Hanno

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Distinct Types of Tumor-Initiating Cells Form Human Colon Cancer Tumors and Metastases von Dieter, Sebastian M., Ball, Claudia R., Hoffmann, Christopher M., Nowrouzi, Ali, Herbst, Friederike, Zavidij, Oksana, Abel, Ulrich, Arens, Anne, Weichert, Wilko, Brand, Karsten, Koch, Moritz, Weitz, Jürgen, Schmidt, Manfred, von Kalle, Christof, Glimm, Hanno

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Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells von Voloshanenko, Oksana, Erdmann, Gerrit, Dubash, Taronish D., Augustin, Iris, Metzig, Marie, Moffa, Giusi, Hundsrucker, Christian, Kerr, Grainne, Sandmann, Thomas, Anchang, Benedikt, Demir, Kubilay, Boehm, Christina, Leible, Svenja, Ball, Claudia R., Glimm, Hanno, Spang, Rainer, Boutros, Michael

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YAP Orchestrates Heterotypic Endothelial Cell Communication via HGF/c-MET Signaling in Liver Tumorigenesis von Thomann, Stefan, Weiler, Sofia M. E., Marquard, Simone, Rose, Fabian, Ball, Claudia R., Toth, Marcell, Wei, Teng, Sticht, Carsten, Fritzsche, Sarah, Roessler, Stephanie, De La Torre, Carolina, Ryschich, Eduard, Ermakova, Olga, Mogler, Carolin, Kazdal, Daniel, Gretz, Norbert, Glimm, Hanno, Rempel, Eugen, Schirmacher, Peter, Breuhahn, Kai

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Cell-of-Origin DNA Methylation Signatures Are Maintained during Colorectal Carcinogenesis von Bormann, Felix, Rodríguez-Paredes, Manuel, Lasitschka, Felix, Edelmann, Dominic, Musch, Tanja, Benner, Axel, Bergman, Yehudit, Dieter, Sebastian M., Ball, Claudia R., Glimm, Hanno, Linhart, Heinz G., Lyko, Frank

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The notch target gene HEYL modulates metastasis forming capacity of colorectal cancer patient-derived spheroid cells in vivo von Weber, Sarah, Koschade, Sebastian E, Hoffmann, Christopher M, Dubash, Taronish D, Giessler, Klara M, Dieter, Sebastian M, Herbst, Friederike, Glimm, Hanno, Ball, Claudia R

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Comprehensive genomic access to vector integration in clinical gene therapy von Arens, Anne, Naldini, Luigi, Cattoglio, Claudia, Eckenberg, Ralph, Deichmann, Annette, Bartholomae, Cynthia C, Faber, Katrin, Nowrouzi, Ali, Paruzynski, Anna, Montini, Eugenio, Thrasher, Adrian J, Ali, Robin R, Saurin, William, Kirsten, Romy, Schwarzwaelder, Kerstin, Schmidt, Manfred, Balaggan, Kamaljit S, Glimm, Hanno, Gaspar, H Bobby, Cesana, Daniela, Biasco, Luca, Aiuti, Alessandro, Howe, Steven J, Recchia, Alessandra, Gabriel, Richard, Cohen-Haguenauer, Odile, Wang, Wei, Mavilio, Fulvio, Yáñez-Muñoz, Rafael J, von Kalle, Christof, Ball, Claudia R

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Stratifying esophago-gastric cancer treatment using a patient-derived organoid-based threshold von Schmäche, Tim, Fohgrub, Juliane, Klimova, Anna, Laaber, Karin, Drukewitz, Stephan, Merboth, Felix, Hennig, Alexander, Seidlitz, Therese, Herbst, Friederike, Baenke, Franziska, Ada, Anne-Marlen, Groß, Thomas, Wenzel, Carina, Ball, Claudia R, Praetorius, Christian, Schmidt, Thomas, Ringelband-Schilling, Barbara, Koschny, Ronald, Stenzinger, Albrecht, Roeder, Ingo, Jaeger, Dirk, Zeissig, Sebastian, Welsch, Thilo, Aust, Daniela, Glimm, Hanno, Folprecht, Gunnar, Weitz, Jürgen, Haag, Georg M, Stange, Daniel E

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Let’s get functional: Drug sensitivity profiling to enable precision sarcoma medicine von Ball, Claudia R., Fröhling, Stefan

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Virotherapy combined with anti-PD-1 transiently reshapes the tumor immune environment and induces anti-tumor immunity in a preclinical PDAC model von Veinalde, Rūta, Pidelaserra-Martí, Gemma, Moulin, Coline, Tan, Chin Leng, Schäfer, Theresa E, Kang, Na, Ball, Claudia R, Leichsenring, Jonas, Stenzinger, Albrecht, Kaderali, Lars, Jäger, Dirk, Ungerechts, Guy, Engeland, Christine E

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A vector-encoded bispecific killer engager to harness virus-activated NK cells as anti-tumor effectors von Floerchinger, Alessia, Klein, Jessica E., Finkbeiner, Maximiliane S. C., Schäfer, Theresa E., Fuchs, Gwendolin, Doerner, Johannes, Zirngibl, Hubert, Ackermann, Maximilian, Kvasnicka, Hans M., Chester, Kerry A., Jäger, Dirk, Ball, Claudia R., Ungerechts, Guy, Engeland, Christine E.

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Extensive Methylation of Promoter Sequences Silences Lentiviral Transgene Expression During Stem Cell Differentiation In Vivo von Herbst, Friederike, Ball, Claudia R, Tuorto, Francesca, Nowrouzi, Ali, Wang, Wei, Zavidij, Oksana, Dieter, Sebastian M, Fessler, Sylvia, van der Hoeven, Franciscus, Kloz, Ulrich, Lyko, Frank, Schmidt, Manfred, von Kalle, Christof, Glimm, Hanno

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Succession of transiently active tumor‐initiating cell clones in human pancreatic cancer xenografts von Ball, Claudia R, Oppel, Felix, Ehrenberg, Karl Roland, Dubash, Taronish D, Dieter, Sebastian M, Hoffmann, Christopher M, Abel, Ulrich, Herbst, Friederike, Koch, Moritz, Werner, Jens, Bergmann, Frank, Ishaque, Naveed, Schmidt, Manfred, von Kalle, Christof, Scholl, Claudia, Fröhling, Stefan, Brors, Benedikt, Weichert, Wilko, Weitz, Jürgen, Glimm, Hanno

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Colorectal cancer‐initiating cells caught in the act von Dieter, Sebastian M, Glimm, Hanno, Ball, Claudia R

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Transforming growth factor beta receptor 2 (TGFBR2) changes sialylation in the microsatellite unstable (MSI) Colorectal cancer cell line HCT116 von Lee, Jennifer, Ballikaya, Seda, Schönig, Kai, Ball, Claudia R, Glimm, Hanno, Kopitz, Juergen, Gebert, Johannes

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You Can Count on This: Barcoded Hematopoietic Stem Cells von Glimm, Hanno, Ball, Claudia R., von Kalle, Christof

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Targeted BiTE Expression by an Oncolytic Vector Augments Therapeutic Efficacy Against Solid Tumors von Speck, Tobias, Heidbuechel, Johannes P W, Veinalde, Rūta, Jaeger, Dirk, von Kalle, Christof, Ball, Claudia R, Ungerechts, Guy, Engeland, Christine E

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Stem-Cell Gene Therapy for the Wiskott–Aldrich Syndrome von Boztug, Kaan, Schmidt, Manfred, Schwarzer, Adrian, Banerjee, Pinaki P, Díez, Inés Avedillo, Dewey, Ricardo A, Böhm, Marie, Nowrouzi, Ali, Ball, Claudia R, Glimm, Hanno, Naundorf, Sonja, Kühlcke, Klaus, Blasczyk, Rainer, Kondratenko, Irina, Maródi, László, Orange, Jordan S, von Kalle, Christof, Klein, Christoph

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Systematic Generation of Patient-Derived Tumor Models in Pancreatic Cancer von Ehrenberg, Karl Roland, Gao, Jianpeng, Oppel, Felix, Frank, Stephanie, Kang, Na, Dieter, Sebastian M, Herbst, Friederike, Möhrmann, Lino, Dubash, Taronish D, Schulz, Erik R, Strakerjahn, Hendrik, Giessler, Klara M, Weber, Sarah, Oberlack, Ava, Rief, Eva-Maria, Strobel, Oliver, Bergmann, Frank, Lasitschka, Felix, Weitz, Jürgen, Glimm, Hanno, Ball, Claudia R

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