Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV von Sheahan, Timothy P., Sims, Amy C., Leist, Sarah R., Schäfer, Alexandra, Won, John, Brown, Ariane J., Montgomery, Stephanie A., Hogg, Alison, Babusis, Darius, Clarke, Michael O., Spahn, Jamie E., Bauer, Laura, Sellers, Scott, Porter, Danielle, Feng, Joy Y., Cihlar, Tomas, Jordan, Robert, Denison, Mark R., Baric, Ralph S.

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Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease von Agostini, Maria L, Andres, Erica L, Sims, Amy C, Graham, Rachel L, Sheahan, Timothy P, Lu, Xiaotao, Smith, Everett Clinton, Case, James Brett, Feng, Joy Y, Jordan, Robert, Ray, Adrian S, Cihlar, Tomas, Siegel, Dustin, Mackman, Richard L, Clarke, Michael O, Baric, Ralph S, Denison, Mark R

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GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses von Lo, Michael K., Jordan, Robert, Arvey, Aaron, Sudhamsu, Jawahar, Shrivastava-Ranjan, Punya, Hotard, Anne L., Flint, Mike, McMullan, Laura K., Siegel, Dustin, Clarke, Michael O., Mackman, Richard L., Hui, Hon C., Perron, Michel, Ray, Adrian S., Cihlar, Tomas, Nichol, Stuart T., Spiropoulou, Christina F.

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Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1‑f][triazin-4-amino] Adenine C‑Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses von Siegel, Dustin, Hui, Hon C, Doerffler, Edward, Clarke, Michael O, Chun, Kwon, Zhang, Lijun, Neville, Sean, Carra, Ernest, Lew, Willard, Ross, Bruce, Wang, Queenie, Wolfe, Lydia, Jordan, Robert, Soloveva, Veronica, Knox, John, Perry, Jason, Perron, Michel, Stray, Kirsten M, Barauskas, Ona, Feng, Joy Y, Xu, Yili, Lee, Gary, Rheingold, Arnold L, Ray, Adrian S, Bannister, Roy, Strickley, Robert, Swaminathan, Swami, Lee, William A, Bavari, Sina, Cihlar, Tomas, Lo, Michael K, Warren, Travis K, Mackman, Richard L

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Preclinical Characterization of GS-9669, a Thumb Site II Inhibitor of the Hepatitis C Virus NS5B Polymerase von FENAUX, Martijn, ENG, Stacey, LAZERWITH, Scott E, LEW, Willard, QI LIU, MERTZMAN, Michael, MORGANELLI, Philip, LIANHONG XU, HONG YE, JENNIFER ZHANG, MATLES, Mike, MURRAY, Bernard P, LEAVITT, Stephanie A, MWANGI, Judy, JINGYU ZHANG, HASHASH, Ahmad, KRAWCZYK, Steve H, BIDGOOD, Alison M, APPLEBY, Todd C, WATKINS, William J, LEE, Yu-Jen, MABERY, Eric M, YANG TIAN, BYUN, Daniel, CANALES, Eda, CLARKE, Michael O, DOERFFLER, Edward

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A Small-Molecule Inhibitor of Hepatitis C Virus Infectivity von BUSH, Caroline O, POKROVSKII, Maria V, PAGRATIS, Nikos, WEIDONG ZHONG, DELANEY, William E, PAULSON, Matthew S, BERAN, Rudolf K. F, SAITO, Roland, MORGANELLI, Philip, CANALES, Eda, CLARKE, Michael O, LAZERWITH, Scott E, GOLDE, Justin, REID, Brian G, BABAOGLU, Kerim

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Synthesis of 1-amino-2-vinylcyclopropane-1-phosphinates. Conversion of a phosphonate to phosphinates von Pyun, Hyung-Jung, Clarke, Michael O., Cho, Aesop, Casarez, Anthony, Ji, Mingzhe, Fardis, Maria, Pastor, Richard, Sheng, X. Christopher, Kim, Choung U.

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Discovery of GS-7682, a Novel 4′-Cyano-Modified C‑Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys von Siegel, Dustin S., Hui, Hon C., Pitts, Jared, Vermillion, Meghan S., Ishida, Kazuya, Rautiola, Davin, Keeney, Michael, Irshad, Hammad, Zhang, Lijun, Chun, Kwon, Chin, Gregory, Goyal, Bindu, Doerffler, Edward, Yang, Hai, Clarke, Michael O., Palmiotti, Chris, Vijjapurapu, Arya, Riola, Nicholas C., Stray, Kirsten, Murakami, Eisuke, Ma, Bin, Wang, Ting, Zhao, Xiaofeng, Xu, Yili, Lee, Gary, Marchand, Bruno, Seung, Minji, Nayak, Arabinda, Tomkinson, Adrian, Kadrichu, Nani, Ellis, Scott, Barauskas, Ona, Feng, Joy Y., Perry, Jason K., Perron, Michel, Bilello, John P., Kuehl, Philip J., Subramanian, Raju, Cihlar, Tomas, Mackman, Richard L.

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Discovery of β-d-2′-deoxy-2′-α-fluoro-4′-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitocho... von Clarke, Michael O., Mackman, Richard, Byun, Daniel, Hui, Hon, Barauskas, Ona, Birkus, Gabriel, Chun, Byoung-Kwon, Doerffler, Edward, Feng, Joy, Karki, Kapil, Lee, Gary, Perron, Michel, Siegel, Dustin, Swaminathan, Swami, Lee, William

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Discovery of GS-9669, a Thumb Site II Non-Nucleoside Inhibitor of NS5B for the Treatment of Genotype 1 Chronic Hepatitis C Infection von Lazerwith, Scott E., Lew, Willard, Zhang, Jennifer, Morganelli, Philip, Liu, Qi, Canales, Eda, Clarke, Michael O., Doerffler, Edward, Byun, Daniel, Mertzman, Michael, Ye, Hong, Chong, Lee, Xu, Lianhong, Appleby, Todd, Chen, Xiaowu, Fenaux, Martijn, Hashash, Ahmad, Leavitt, Stephanie A., Mabery, Eric, Matles, Mike, Mwangi, Judy W., Tian, Yang, Lee, Yu-Jen, Zhang, Jingyu, Zhu, Christine, Murray, Bernard P., Watkins, William J.

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Discovery of GS-9451: An acid inhibitor of the hepatitis C virus NS3/4A protease von Christopher Sheng, X., Appleby, Todd, Butler, Thomas, Cai, Ruby, Chen, Xiaowu, Cho, Aesop, Clarke, Michael O., Cottell, Jeromy, Delaney, William E., Doerffler, Edward, Link, John, Ji, Mingzhe, Pakdaman, Rowchanak, Pyun, Hyung-Jung, Wu, Qiaoyin, Xu, Jie, Kim, Choung U.

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Discovery of a 2′-fluoro-2′-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties von Kirschberg, Thorsten A., Metobo, Sammy, Clarke, Michael O., Aktoudianakis, Vangelis, Babusis, Darius, Barauskas, Ona, Birkus, Gabriel, Butler, Thomas, Byun, Daniel, Chin, Gregory, Doerffler, Edward, Edwards, Thomas E., Fenaux, Martijn, Lee, Rick, Lew, Willard, Mish, Michael R., Murakami, Eisuke, Park, Yeojin, Squires, Neil H., Tirunagari, Neeraj, Wang, Ting, Whitcomb, Mark, Xu, Jie, Yang, Huiling, Ye, Hong, Zhang, Lijun, Appleby, Todd C., Feng, Joy Y., Ray, Adrian S., Cho, Aesop, Kim, Choung U.

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Discovery of GS-9256: A novel phosphinic acid derived inhibitor of the hepatitis C virus NS3/4A protease with potent clinical activity von Sheng, X. Christopher, Casarez, Anthony, Cai, Ruby, Clarke, Michael O., Chen, Xiaowu, Cho, Aesop, Delaney, William E., Doerffler, Edward, Ji, Mingzhe, Mertzman, Michael, Pakdaman, Rowchanak, Pyun, Hyung-Jung, Rowe, Tanisha, Wu, Qiaoyin, Xu, Jie, Kim, Choung U.

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The Practical Synthesis of a Novel and Highly Potent Analogue of Bryostatin von Wender, Paul A, Baryza, Jeremy L, Bennett, Chad E, Bi, F. Christopher, Brenner, Stacey E, Clarke, Michael O, Horan, Joshua C, Kan, Cindy, Lacôte, Emmanuel, Lippa, Blaise, Nell, Peter G, Turner, Tim M

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Novel, potent, and orally bioavailable phosphinic acid inhibitors of the hepatitis C virus NS3 protease von Clarke, Michael O., Chen, Xiaowu, Cho, Aesop, Delaney, William E., Doerffler, Edward, Fardis, Maria, Ji, Mingzhe, Mertzman, Michael, Pakdaman, Rowchanak, Pyun, Hyun-Jun, Rowe, Tanisha, Yang, Cheng Y., Sheng, X. Christopher, Kim, Choung U.

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Novel, potent and orally bioavailable indolizidinone-derived inhibitors of the hepatitis C virus NS3 protease von Clarke, Michael O., Byun, Daniel, Chen, Xiaowu, Doerffler, Edward, Leavitt, Stephanie A., Sheng, X. Christopher, Yang, Cheng Y., Kim, Choung U.

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Role of the A-Ring of Bryostatin Analogues in PKC Binding:  Synthesis and Initial Biological Evaluation of New A-Ring-Modified Bryologs von Wender, Paul A, Clarke, Michael O, Horan, Joshua C

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Optimization of Pharmacokinetics through Manipulation of Physicochemical Properties in a Series of HCV Inhibitors von Lazerwith, Scott E, Bahador, Gina, Canales, Eda, Cheng, Guofeng, Chong, Lee, Clarke, Michael O, Doerffler, Edward, Eisenberg, Eugene J, Hayes, Jaclyn, Lu, Bing, Liu, Qi, Matles, Mike, Mertzman, Michael, Mitchell, Michael L, Morganelli, Philip, Murray, Bernard P, Robinson, Margaret, Strickley, Robert G, Tessler, Megan, Tirunagari, Neeraj, Wang, Jianhong, Wang, Yujin, Zhang, Jennifer R, Zheng, Xubin, Zhong, Weidong, Watkins, William J

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Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys von Warren, Travis K., Jordan, Robert, Lo, Michael K., Ray, Adrian S., Mackman, Richard L., Soloveva, Veronica, Siegel, Dustin, Perron, Michel, Bannister, Roy, Hui, Hon C., Larson, Nate, Strickley, Robert, Wells, Jay, Stuthman, Kelly S., Van Tongeren, Sean A., Garza, Nicole L., Donnelly, Ginger, Shurtleff, Amy C., Retterer, Cary J., Gharaibeh, Dima, Zamani, Rouzbeh, Kenny, Tara, Eaton, Brett P., Grimes, Elizabeth, Welch, Lisa S., Gomba, Laura, Wilhelmsen, Catherine L., Nichols, Donald K., Nuss, Jonathan E., Nagle, Elyse R., Kugelman, Jeffrey R., Palacios, Gustavo, Doerffler, Edward, Neville, Sean, Carra, Ernest, Clarke, Michael O., Zhang, Lijun, Lew, Willard, Ross, Bruce, Wang, Queenie, Chun, Kwon, Wolfe, Lydia, Babusis, Darius, Park, Yeojin, Stray, Kirsten M., Trancheva, Iva, Feng, Joy Y., Barauskas, Ona, Xu, Yili, Wong, Pamela, Braun, Molly R., Flint, Mike, McMullan, Laura K., Chen, Shan-Shan, Fearns, Rachel, Swaminathan, Swami, Mayers, Douglas L., Spiropoulou, Christina F., Lee, William A., Nichol, Stuart T., Cihlar, Tomas, Bavari, Sina

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Análogos de carba-nucleósido 2-sustituidos para el tratamiento antiviral von CLARKE, Michael O' Neil Hanrahan

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