Characterization of Alisertib (MLN8237), an Investigational Small-Molecule Inhibitor of Aurora A Kinase Using Novel In Vivo Pharmacodynamic Assays von MANFREDI, Mark G, ECSEDY, Jeffrey A, WYSONG, Deborah R, JANOWICK, David A, HYER, Marc L, LEROY, Patrick J, GERSHMAN, Rachel E, SILVA, Matthew D, GERMANOS, Melissa S, BOLEN, Joseph B, CLAIBORNE, Christopher F, SELLS, Todd B, CHAKRAVARTY, Arijit, SILVERMAN, Lee, MENGKUN ZHANG, HOAR, Kara M, STROUD, Stephen G, WEI CHEN, SHINDE, Vaishali, HUCK, Jessica J

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Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ von Brownell, James E., Sintchak, Michael D., Gavin, James M., Liao, Hua, Bruzzese, Frank J., Bump, Nancy J., Soucy, Teresa A., Milhollen, Michael A., Yang, Xiaofeng, Burkhardt, Anne L., Ma, Jingya, Loke, Huay-Keng, Lingaraj, Trupti, Wu, Dongyun, Hamman, Kristin B., Spelman, James J., Cullis, Courtney A., Langston, Steven P., Vyskocil, Stepan, Sells, Todd B., Mallender, William D., Visiers, Irache, Li, Ping, Claiborne, Christopher F., Rolfe, Mark, Bolen, Joseph B., Dick, Lawrence R.

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Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase von Manfredi, Mark G, Ecsedy, Jeffrey A, Meetze, Kristan A, Balani, Suresh K, Burenkova, Olga, Chen, Wei, Galvin, Katherine M, Hoar, Kara M, Huck, Jessica J, LeRoy, Patrick J, Ray, Emily T, Sells, Todd B, Stringer, Bradley, Stroud, Stephen G, Vos, Tricia J, Weatherhead, Gabriel S, Wysong, Deborah R, Zhang, Mengkun, Bolen, Joseph B, Claiborne, Christopher F

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MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors von Sells, Todd B., Chau, Ryan, Ecsedy, Jeffrey A., Gershman, Rachel E., Hoar, Kara, Huck, Jessica, Janowick, David A., Kadambi, Vivek J., LeRoy, Patrick J., Stirling, Matthew, Stroud, Stephen G., Vos, Tricia J., Weatherhead, Gabriel S., Wysong, Deborah R., Zhang, Mengkun, Balani, Suresh K., Bolen, Joseph B., Manfredi, Mark G., Claiborne, Christopher F.

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Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel von Beshore, Douglas C., Liverton, Nigel J., McIntyre, Charles J., Claiborne, Christopher F., Libby, Brian, Culberson, J. Christopher, Salata, Joseph J., Regan, Christopher P., Lynch, Joseph J., Kiss, Laszlo, Spencer, Robert H., Kane, Stephanie A., White, Rebecca B., Yeh, Suzie, Hartman, George D., Dinsmore, Christopher J.

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Cyclic benzamidines as orally efficacious NR2B-selective NMDA receptor antagonists von Nguyen, Kevin T., Claiborne, Christopher F., McCauley, John A., Libby, Brian E., Claremon, David A., Bednar, Rodney A., Mosser, Scott D., Gaul, Stanley L., Connolly, Thomas M., Condra, Cindra L., Bednar, Bohumil, Stump, Gary L., Lynch, Joseph J., Koblan, Kenneth S., Liverton, Nigel J.

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Synthesis and biological evaluation of imidazole-based small molecule antagonists of the melanocortin 4 receptor (MC4-R) von MARSILJE, Thomas H, ROSES, Jonathan B, DANIELS, J. Scott, PING LI, LIJUN WU, PATANE, Michael A, CLAIBORNE, Christopher F, CALDERWOOD, Emily F, STROUD, Stephen G, FORSYTH, Nancy E, BLACKBURN, Christopher, YOWE, David L, MIAO, Wenyan, DRABIC, Stacey V, BOHANE, Marie D

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Identification and structure–activity relationships of a new series of Melanocortin-4 receptor antagonists von Vos, Tricia J., Balani, Suresh, Blackburn, Christopher, Chau, Ryan W., Danca, M. Diana, Drabic, Stacey V., Farrer, Cheryl A., Patane, Michael A., Stroud, Stephen G., Yowe, David L., Claiborne, Christopher F.

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Identification of 2-{2-[2-(5-Bromo-2- methoxyphenyl)-ethyl]-3-fluorophenyl}-4,5-dihydro-1H-imidazole (ML00253764), a Small Molecule Melanocortin 4 Receptor Antagonist That Effectiv... von Vos, Tricia J, Caracoti, Andrei, Che, Jennifer L, Dai, Mingshi, Farrer, Cheryl A, Forsyth, Nancy E, Drabic, Stacey V, Horlick, Robert A, Lamppu, Diana, Yowe, David L, Balani, Suresh, Li, Ping, Zeng, Hang, Joseph, Ingrid B. J. K, Rodriguez, Luis E, Maguire, Martin P, Patane, Michael A, Claiborne, Christopher F

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Identification and Characterization of 4-Methylbenzyl 4-[(Pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an Orally Bioavailable, Brain Penetrant NR2B Selective N-Methyl-d-Asp... von Liverton, Nigel J, Bednar, Rodney A, Bednar, Bohumil, Butcher, John W, Claiborne, Christopher F, Claremon, David A, Cunningham, Michael, DiLella, Anthony G, Gaul, Stanley L, Libby, Brian E, Lyle, Elizabeth A, Lynch, Joseph J, McCauley, John A, Mosser, Scott D, Nguyen, Kevin T, Stump, Gary L, Sun, Hong, Wang, Hao, Yergey, James, Koblan, Kenneth S

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Olefin Metathesis in Cyclic Ether Formation. Direct Conversion of Olefinic Esters to Cyclic Enol Ethers with Tebbe-Type Reagents von Nicolaou, K. C, Postema, Maarten H. D, Claiborne, Christopher F

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An efficient synthesis of tetrasubstituted imidazoles from N-(2-Oxo)-amides von Claiborne, Christopher F., Liverton, Nigel J., Nguyen, Kevin T.

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An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer von Soucy, Teresa A., Smith, Peter G., Milhollen, Michael A., Berger, Allison J., Gavin, James M., Adhikari, Sharmila, Brownell, James E., Burke, Kristine E., Cardin, David P., Critchley, Stephen, Cullis, Courtney A., Doucette, Amanda, Garnsey, James J., Gaulin, Jeffrey L., Gershman, Rachel E., Lublinsky, Anna R., McDonald, Alice, Mizutani, Hirotake, Narayanan, Usha, Olhava, Edward J., Peluso, Stephane, Rezaei, Mansoureh, Sintchak, Michael D., Talreja, Tina, Thomas, Michael P., Traore, Tary, Vyskocil, Stepan, Weatherhead, Gabriel S., Yu, Jie, Zhang, Julie, Dick, Lawrence R., Claiborne, Christopher F., Rolfe, Mark, Bolen, Joseph B., Langston, Steven P.

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Synthesis of Novel Taxoids von Nicolaou, K. C, Claiborne, Christopher F, Nantermet, Philippe G, Couladouros, Elias A, Sorensen, Erik J

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Design and Synthesis of Potent, Selective, and Orally Bioavailable Tetrasubstituted Imidazole Inhibitors of p38 Mitogen-Activated Protein Kinase von Liverton, Nigel J, Butcher, John W, Claiborne, Christopher F, Claremon, David A, Libby, Brian E, Nguyen, Kevin T, Pitzenberger, Steven M, Selnick, Harold G, Smith, Garry R, Tebben, Andrew, Vacca, Joseph P, Varga, Sandor L, Agarwal, Lily, Dancheck, Kim, Forsyth, Amy J, Fletcher, Daniel S, Frantz, Betsy, Hanlon, William A, Harper, Coral F, Hofsess, Scott J, Kostura, Matthew, Lin, Jiunn, Luell, Sylvie, O'Neill, Edward A, Orevillo, Chad J, Pang, Margaret, Parsons, Janey, Rolando, Anna, Sahly, Yousif, Visco, Denise M, O'Keefe, Stephen J

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AURORA KINASE INHIBITORS FOR INHIBITING MITOTIC PROGRESSION von Stroud, Stephen G, Claiborne, Christopher F, Sells, Todd B

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Aurora kinase inhibitors for inhibiting mitotic progression von Stroud, Stephen G, Claiborne, Christopher F, Sells, Todd B

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Case Study of Aurora‐A Inhibitor MLN8054 von Claiborne, Christopher F, Manfredi, Mark G

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AURORA KINASE INHIBITORS FOR INHIBITING MITOTIC PROGRESSION von Stroud, Stephen G, Claiborne, Christopher F, Sells, Todd B

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Aurora kinase inhibitors for inhibiting mitotic progression von Stroud, Stephen G, Claiborne, Christopher F, Sells, Todd B

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