Of mice, or men: TLR4 signaling in HIV pathogenesis von Acosta, Reyes, Claiborne, Daniel T

Volltext

HIV-1 variants are archived throughout infection and persist in the reservoir von Brooks, Kelsie, Jones, Bradley R, Dilernia, Dario A, Wilkins, Daniel J, Claiborne, Daniel T, McInally, Samantha, Gilmour, Jill, Kilembe, William, Joy, Jeffrey B, Allen, Susan A, Brumme, Zabrina L, Hunter, Eric

Volltext

Role of transmitted Gag CTL polymorphisms in defining replicative capacity and early HIV-1 pathogenesis von Prince, Jessica L, Claiborne, Daniel T, Carlson, Jonathan M, Schaefer, Malinda, Yu, Tianwei, Lahki, Shabir, Prentice, Heather A, Yue, Ling, Vishwanathan, Sundaram A, Kilembe, William, Goepfert, Paul, Price, Matthew A, Gilmour, Jill, Mulenga, Joseph, Farmer, Paul, Derdeyn, Cynthia A, Tang, Jiaming, Heckerman, David, Kaslow, Richard A, Allen, Susan A, Hunter, Eric

Volltext

Selection bias at the heterosexual HIV-1 transmission bottleneck von Carlson, Jonathan M., Schaefer, Malinda, Monaco, Daniela C., Batorsky, Rebecca, Claiborne, Daniel T., Prince, Jessica, Deymier, Martin J., Ende, Zachary S., Klatt, Nichole R., DeZiel, Charles E., Lin, Tien-Ho, Peng, Jian, Seese, Aaron M., Shapiro, Roger, Frater, John, Ndung'u, Thumbi, Tang, Jianming, Goepfert, Paul, Gilmour, Jill, Price, Matt A., Kilembe, William, Heckerman, David, Goulder, Philip J.R., Allen, Todd M., Allen, Susan, Hunter, Eric

Volltext

Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis von Zhou, Wei, Liu, Heng, Yuan, Zhe, Zundell, Joseph, Towers, Martina, Lin, Jianhuang, Lombardi, Simona, Nie, Hao, Murphy, Brennah, Yang, Tyler, Wang, Chen, Liao, Liping, Goldman, Aaron R., Kannan, Toshitha, Kossenkov, Andrew V., Drapkin, Ronny, Montaner, Luis J., Claiborne, Daniel T., Zhang, Nan, Wu, Shuai, Zhang, Rugang

Volltext

Dual CD4-based CAR T cells with distinct costimulatory domains mitigate HIV pathogenesis in vivo von Maldini, Colby R., Claiborne, Daniel T., Okawa, Ken, Chen, Tao, Dopkin, Derrick L., Shan, Xiaochuan, Power, Karen A., Trifonova, Radiana T., Krupp, Katharine, Phelps, Meredith, Vrbanac, Vladimir D., Tanno, Serah, Bateson, Timothy, Leslie, George J., Hoxie, James A., Boutwell, Christian L., Riley, James L., Allen, Todd M.

Volltext

Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade von Nie, Hao, Saini, Pratima, Miyamoto, Taito, Liao, Liping, Zielinski, Rafal J., Liu, Heng, Zhou, Wei, Wang, Chen, Murphy, Brennah, Towers, Martina, Yang, Tyler, Qi, Yuan, Kannan, Toshitha, Kossenkov, Andrew, Tateno, Hiroaki, Claiborne, Daniel T., Zhang, Nan, Abdel-Mohsen, Mohamed, Zhang, Rugang

Volltext

High frequency CCR5 editing in human hematopoietic stem progenitor cells protects xenograft mice from HIV infection von Claiborne, Daniel T., Detwiler, Zachary, Docken, Steffen S., Borland, Todd D., Cromer, Deborah, Simkhovich, Amanda, Ophinni, Youdiil, Okawa, Ken, Bateson, Timothy, Chen, Tao, Hudson, Wesley, Trifonova, Radiana, Davenport, Miles P., Ho, Tony W., Boutwell, Christian L., Allen, Todd M.

Volltext

Replicative fitness of transmitted HIV-1 drives acute immune activation, proviral load in memory CD4⁺ T cells, and disease progression von Claiborne, Daniel T., Prince, Jessica L., Scully, Eileen, Macharia, Gladys, Micci, Luca, Lawson, Benton, Kopycinski, Jakub, Deymier, Martin J., Vanderford, Thomas H., Nganou-Makamdop, Krystelle, Ende, Zachary, Brooks, Kelsie, Tang, Jianming, Yu, Tianwei, Lakhi, Shabir, Kilembe, William, Silvestri, Guido, Douek, Daniel, Goepfert, Paul A., Price, Matthew A., Allen, Susan A., Paiardini, Mirko, Altfeld, Marcus, Gilmour, Jill, Hunter, Eric

Volltext

Protective HLA alleles are associated with reduced LPS levels in acute HIV infection with implications for immune activation and pathogenesis von Claiborne, Daniel T, Scully, Eileen P, Palmer, Christine D, Prince, Jessica L, Macharia, Gladys N, Kopycinski, Jakub, Michelo, Clive M, Wiener, Howard W, Parker, Rachel, Nganou-Makamdop, Krystelle, Douek, Daniel, Altfeld, Marcus, Gilmour, Jill, Price, Matt A, Tang, Jianming, Kilembe, William, Allen, Susan A, Hunter, Eric

Volltext

Transmitted virus fitness and host T cell responses collectively define divergent infection outcomes in two HIV-1 recipients von Yue, Ling, Pfafferott, Katja J, Baalwa, Joshua, Conrod, Karen, Dong, Catherine C, Chui, Cecilia, Rong, Rong, Claiborne, Daniel T, Prince, Jessica L, Tang, Jianming, Ribeiro, Ruy M, Cormier, Emmanuel, Hahn, Beatrice H, Perelson, Alan S, Shaw, George M, Karita, Etienne, Gilmour, Jill, Goepfert, Paul, Derdeyn, Cynthia A, Allen, Susan A, Borrow, Persephone, Hunter, Eric

Volltext

A VRC13-like bNAb response is associated with complex escape pathways in HIV-1 envelope von Joshi, Vinita R, Claiborne, Daniel T, Pack, Melissa L, Power, Karen A, Newman, Ruchi M, Batorsky, Rebecca, Bean, David J, Goroff, Matthew S, Lingwood, Daniel, Seaman, Michael S, Rosenberg, Eric, Allen, Todd M

Volltext

Immunosuppressant therapy averts rejection of allogeneic FKBP1A-disrupted CAR-T cells von Maldini, Colby R., Messana, Angelica C., Bendet, Paula B., Camblin, Adam J., Musenge, Faith M., White, Moriah L., Rocha, Joseph J., Coholan, Lindsey J., Karaca, Cisem, Li, Frederick, Yan, Bo, Vrbanac, Vladimir D., Marte, Emily, Claiborne, Daniel T., Boutwell, Christian L., Allen, Todd M.

Volltext

Balance between transmitted HLA preadapted and nonassociated polymorphisms is a major determinant of HIV-1 disease progression von Mónaco, Daniela C, Dilernia, Dario A, Fiore-Gartland, Andrew, Yu, Tianwei, Prince, Jessica L, Dennis, Kristine K, Qin, Kai, Schaefer, Malinda, Claiborne, Daniel T, Kilembe, William, Tang, Jianming, Price, Matt A, Farmer, Paul, Gilmour, Jill, Bansal, Anju, Allen, Susan, Goepfert, Paul, Hunter, Eric

Volltext

Innate Immune Reconstitution in Humanized Bone Marrow-Liver-Thymus (HuBLT) Mice Governs Adaptive Cellular Immune Function and Responses to HIV-1 Infection von Garcia-Beltran, Wilfredo F, Claiborne, Daniel T, Maldini, Colby R, Phelps, Meredith, Vrbanac, Vladimir, Karpel, Marshall E, Krupp, Katharine L, Power, Karen A, Boutwell, Christian L, Balazs, Alejandro B, Tager, Andrew M, Altfeld, Marcus, Allen, Todd M

Volltext

Mutagenesis of tyrosine and di-leucine motifs in the HIV-1 envelope cytoplasmic domain results in a loss of Env-mediated fusion and infectivity von Bhakta, Sushma J, Shang, Liang, Prince, Jessica L, Claiborne, Daniel T, Hunter, Eric

Volltext

Immunization of BLT Humanized Mice Redirects T Cell Responses to Gag and Reduces Acute HIV-1 Viremia von Claiborne, Daniel T, Dudek, Timothy E, Maldini, Colby R, Power, Karen A, Ghebremichael, Musie, Seung, Edward, Mellors, Elizabeth F, Vrbanac, Vladimir D, Krupp, Katharine, Bisesi, Abigail, Tager, Andrew M, Knipe, David M, Boutwell, Christian L, Allen, Todd M

Volltext

An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression von Indeglia, Alexandra, Leung, Jessica C, Miller, Sven A, Leu, Julia I-Ju, Dougherty, James F, Clarke, Nicole L, Kirven, Nicole A, Shao, Chunlei, Ke, Lei, Lovell, Scott, Barnoud, Thibaut, Lu, David Y, Lin, Cindy, Kannan, Toshitha, Battaile, Kevin P, Yang, Tyler Hong Loong, Batista Oliva, Isabela, Claiborne, Daniel T, Vogel, Peter, Liu, Lijun, Liu, Qin, Nefedova, Yulia, Cassel, Joel, Auslander, Noam, Kossenkov, Andrew V, Karanicolas, John, Murphy, Maureen E

Volltext

Impact of HLA-B81-Associated Mutations in HIV-1 Gag on Viral Replication Capacity von Wright, Jaclyn K, Naidoo, Vanessa L, Brumme, Zabrina L, Prince, Jessica L, Claiborne, Daniel T, Goulder, Philip J. R, Brockman, Mark A, Hunter, Eric, Ndung'u, Thumbi

Volltext

HLA Class I Downregulation by HIV-1 Variants from Subtype C Transmission Pairs von Ende, Zachary, Deymier, Martin J, Claiborne, Daniel T, Prince, Jessica L, Mónaco, Daniela C, Kilembe, William, Allen, Susan A, Hunter, Eric

Volltext