Rapid and sensitive analysis of reduced and oxidized coenzyme Q10 in human plasma by ultra performance liquid chromatography-tandem mass spectrometry and application to studies in... von Claessens, Adam J, Yeung, Catherine K, Risler, Linda J, Phillips, Brian R, Himmelfarb, Jonathan, Shen, Danny D

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CYP2D6 Mediates 4-Hydroxylation of Clonidine In Vitro: Implication for Pregnancy-Induced Changes in Clonidine Clearance von Claessens, Adam J., Risler, Linda J., Eyal, Sara, Shen, Danny D., Easterling, Thomas R., Hebert, Mary F.

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Potential contribution of cytochrome P450 2B6 to hepatic 4-hydroxycyclophosphamide formation in vitro and in vivo von Raccor, Brianne S, Claessens, Adam J, Dinh, Jean C, Park, Julie R, Hawkins, Douglas S, Thomas, Sushma S, Makar, Karen W, McCune, Jeannine S, Totah, Rheem A

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Coenzyme Q10 dose-escalation study in hemodialysis patients: safety, tolerability, and effect on oxidative stress von Yeung, Catherine K, Billings, 4th, Frederic T, Claessens, Adam J, Roshanravan, Baback, Linke, Lori, Sundell, Mary B, Ahmad, Suhail, Shao, Baohai, Shen, Danny D, Ikizler, T Alp, Himmelfarb, Jonathan

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Open data and digital morphology von Davies, Thomas G., Rahman, Imran A., Lautenschlager, Stephan, Cunningham, John A., Asher, Robert J., Barrett, Paul M., Bates, Karl T., Bengtson, Stefan, Benson, Roger B. J., Boyer, Doug M., Braga, José, Bright, Jen A., Claessens, Leon P. A. M., Cox, Philip G., Dong, Xi-Ping, Evans, Alistair R., Falkingham, Peter L., Friedman, Matt, Garwood, Russell J., Goswami, Anjali, Hutchinson, John R., Jeffery, Nathan S., Johanson, Zerina, Lebrun, Renaud, Martínez-Pérez, Carlos, Marugán-Lobón, Jesús, O'Higgins, Paul M., Metscher, Brian, Orliac, Maëva, Rowe, Timothy B., Rücklin, Martin, Sánchez-Villagra, Marcelo R., Shubin, Neil H., Smith, Selena Y., Starck, J. Matthias, Stringer, Chris, Summers, Adam P., Sutton, Mark D., Walsh, Stig A., Weisbecker, Vera, Witmer, Lawrence M., Wroe, Stephen, Yin, Zongjun, Rayfield, Emily J., Donoghue, Philip C. J.

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RecQ helicases in the malaria parasite Plasmodium falciparum affect genome stability, gene expression patterns and DNA replication dynamics von Claessens, Antoine, Harris, Lynne M, Stanojcic, Slavica, Chappell, Lia, Stanton, Adam, Kuk, Nada, Veneziano-Broccia, Pamela, Sterkers, Yvon, Rayner, Julian C, Merrick, Catherine J

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Long read assemblies of geographically dispersed Plasmodium falciparum isolates reveal highly structured subtelomeres von Otto, Thomas D, Böhme, Ulrike, Sanders, Mandy, Reid, Adam, Bruske, Ellen I, Duffy, Craig W, Bull, Pete C, Pearson, Richard D, Abdi, Abdirahman, Dimonte, Sandra, Stewart, Lindsay B, Campino, Susana, Kekre, Mihir, Hamilton, William L, Claessens, Antoine, Volkman, Sarah K, Ndiaye, Daouda, Amambua-Ngwa, Alfred, Diakite, Mahamadou, Fairhurst, Rick M, Conway, David J, Franck, Matthias, Newbold, Chris I, Berriman, Matt

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Association analyses identify 31 new risk loci for colorectal cancer susceptibility von Law, Philip J., Timofeeva, Maria, Fernandez-Rozadilla, Ceres, Broderick, Peter, Studd, James, Fernandez-Tajes, Juan, Farrington, Susan, Svinti, Victoria, Palles, Claire, Orlando, Giulia, Sud, Amit, Holroyd, Amy, Penegar, Steven, Theodoratou, Evropi, Vaughan-Shaw, Peter, Campbell, Harry, Zgaga, Lina, Hayward, Caroline, Campbell, Archie, Harris, Sarah, Deary, Ian J., Starr, John, Gatcombe, Laura, Pinna, Maria, Briggs, Sarah, Martin, Lynn, Jaeger, Emma, Sharma-Oates, Archana, East, James, Leedham, Simon, Arnold, Roland, Johnstone, Elaine, Wang, Haitao, Kerr, David, Kerr, Rachel, Maughan, Tim, Kaplan, Richard, Al-Tassan, Nada, Palin, Kimmo, Hänninen, Ulrika A., Cajuso, Tatiana, Tanskanen, Tomas, Kondelin, Johanna, Kaasinen, Eevi, Sarin, Antti-Pekka, Eriksson, Johan G., Rissanen, Harri, Knekt, Paul, Pukkala, Eero, Jousilahti, Pekka, Salomaa, Veikko, Ripatti, Samuli, Palotie, Aarno, Renkonen-Sinisalo, Laura, Lepistö, Anna, Böhm, Jan, Mecklin, Jukka-Pekka, Buchanan, Daniel D., Win, Aung-Ko, Hopper, John, Jenkins, Mark E., Lindor, Noralane M., Newcomb, Polly A., Gallinger, Steven, Duggan, David, Casey, Graham, Hoffmann, Per, Nöthen, Markus M., Jöckel, Karl-Heinz, Easton, Douglas F., Pharoah, Paul D. P., Peto, Julian, Canzian, Federico, Swerdlow, Anthony, Eeles, Rosalind A., Kote-Jarai, Zsofia, Muir, Kenneth, Pashayan, Nora, Harkin, Andrea, Allan, Karen, McQueen, John, Paul, James, Iveson, Timothy, Saunders, Mark, Butterbach, Katja, Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Kirac, Iva, Matošević, Petar, Hofer, Philipp, Brezina, Stefanie, Gsur, Andrea, Cheadle, Jeremy P., Aaltonen, Lauri A., Tomlinson, Ian, Houlston, Richard S., Dunlop, Malcolm G.

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Large-scale transcriptome-wide association study identifies new prostate cancer risk regions von Mancuso, Nicholas, Gayther, Simon, Gusev, Alexander, Zheng, Wei, Penney, Kathryn L., Kote-Jarai, Zsofia, Eeles, Rosalind, Freedman, Matthew, Haiman, Christopher, Pasaniuc, Bogdan

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Genetically proxied glucose-lowering drug target perturbation and risk of cancer: a Mendelian randomisation analysis von Yarmolinsky, James, Bouras, Emmanouil, Constantinescu, Andrei, Burrows, Kimberley, Bull, Caroline J., Vincent, Emma E., Martin, Richard M., Dimopoulou, Olympia, Lewis, Sarah J., Moreno, Victor, Vujkovic, Marijana, Chang, Kyong-Mi, Voight, Benjamin F., Tsao, Philip S., Gunter, Marc J., Hampe, Jochen, Pellatt, Andrew J., Pharoah, Paul D. P., Schoen, Robert E., Gallinger, Steven, Jenkins, Mark A., Pai, Rish K., Gill, Dipender, Tsilidis, Kostas K.

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Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma von Went, Molly, Sud, Amit, Försti, Asta, Halvarsson, Britt-Marie, Weinhold, Niels, Kimber, Scott, van Duin, Mark, Thorleifsson, Gudmar, Holroyd, Amy, Johnson, David C., Li, Ni, Orlando, Giulia, Law, Philip J., Ali, Mina, Chen, Bowang, Mitchell, Jonathan S., Gudbjartsson, Daniel F., Kuiper, Rowan, Stephens, Owen W., Bertsch, Uta, Broderick, Peter, Campo, Chiara, Bandapalli, Obul R, Einsele, Hermann, Gregory, Walter A., Gullberg, Urban, Hillengass, Jens, Hoffmann, Per, Jackson, Graham H., Jöckel, Karl-Heinz, Johnsson, Ellinor, Kristinsson, Sigurður Y., Mellqvist, Ulf-Henrik, Nahi, Hareth, Easton, Douglas, Pharoah, Paul, Dunning, Alison, Peto, Julian, Canzian, Federico, Swerdlow, Anthony, Eeles, Rosalind A., Kote-Jarai, ZSofia, Muir, Kenneth, Pashayan, Nora, Nickel, Jolanta, Nöthen, Markus M., Rafnar, Thorunn, Ross, Fiona M., da Silva Filho, Miguel Inacio, Thomsen, Hauke, Turesson, Ingemar, Vangsted, Annette, Andersen, Niels Frost, Waage, Anders, Walker, Brian A., Wihlborg, Anna-Karin, Broyl, Annemiek, Davies, Faith E., Thorsteinsdottir, Unnur, Langer, Christian, Hansson, Markus, Goldschmidt, Hartmut, Kaiser, Martin, Sonneveld, Pieter, Stefansson, Kari, Morgan, Gareth J., Hemminki, Kari, Nilsson, Björn, Houlston, Richard S.

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Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia von Vijayakrishnan, Jayaram, Studd, James, Broderick, Peter, Kinnersley, Ben, Holroyd, Amy, Law, Philip J., Kumar, Rajiv, Allan, James M., Harrison, Christine J., Moorman, Anthony V., Vora, Ajay, Roman, Eve, Rachakonda, Sivaramakrishna, Kinsey, Sally E., Sheridan, Eamonn, Thompson, Pamela D., Irving, Julie A., Koehler, Rolf, Hoffmann, Per, Nöthen, Markus M., Heilmann-Heimbach, Stefanie, Jöckel, Karl-Heinz, Easton, Douglas F., Pharaoh, Paul D. P., Dunning, Alison M., Peto, Julian, Canzian, Frederico, Swerdlow, Anthony, Eeles, Rosalind A., Kote-Jarai, ZSofia, Muir, Kenneth, Pashayan, Nora, Greaves, Mel, Zimmerman, Martin, Bartram, Claus R., Schrappe, Martin, Stanulla, Martin, Hemminki, Kari, Houlston, Richard S.

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An integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk von Wu, Lang, Yang, Yaohua, Guo, Xingyi, Shu, Xiao-Ou, Cai, Qiuyin, Shu, Xiang, Li, Bingshan, Tao, Ran, Wu, Chong, Nikas, Jason B., Sun, Yanfa, Zhu, Jingjing, Roobol, Monique J., Giles, Graham G., Brenner, Hermann, John, Esther M., Clements, Judith, Grindedal, Eli Marie, Park, Jong Y., Stanford, Janet L., Kote-Jarai, Zsofia, Haiman, Christopher A., Eeles, Rosalind A., Zheng, Wei, Long, Jirong

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Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study von Morales Berstein, Fernanda, McCartney, Daniel L, Lu, Ake T, Tsilidis, Konstantinos K, Bouras, Emmanouil, Haycock, Philip, Burrows, Kimberley, Phipps, Amanda I, Buchanan, Daniel D, Cheng, Iona, Martin, Richard M, Davey Smith, George, Relton, Caroline L, Horvath, Steve, Marioni, Riccardo E, Richardson, Tom G, Richmond, Rebecca C

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Observational and genetic associations between cardiorespiratory fitness and cancer: a UK Biobank and international consortia study von Watts, Eleanor L., Gonzales, Tomas I., Strain, Tessa, Saint-Maurice, Pedro F., Bishop, D. Timothy, Chanock, Stephen J., Johansson, Mattias, Keku, Temitope O., Le Marchand, Loic, Moreno, Victor, Newcomb, Polly A., Newton, Christina C., Pai, Rish K., Purdue, Mark P., Ulrich, Cornelia M., Smith-Byrne, Karl, Van Guelpen, Bethany, Day, Felix R., Wijndaele, Katrien, Wareham, Nicholas J., Matthews, Charles E., Moore, Steven C., Brage, Soren

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National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based stud... von Taddei, Cristina, Jackson, Rod, Zhou, Bin, Bixby, Honor, Danaei, Goodarz, Di Cesare, Mariachiara, Kuulasmaa, Kari, Hajifathalian, Kaveh, Bentham, James, Bennett, James E, Aekplakorn, Wichai, Cifkova, Renata, Dallongeville, Jean, DeBacquer, Dirk, Giampaoli, Simona, Gudnason, Vilmundur, Khang, Young-Ho, Laatikainen, Tiina, Mann, JimI, Marques-Vidal, Pedro, Mensah, George A, Müller-Nurasyid, Martina, Ninomiya, Toshiharu, Petkeviciene, Janina, Rodríguez-Artalejo, Fernando, Servais, Jennifer, Söderberg, Stefan, Stavreski, Bill, Wilsgaard, Tom, Zdrojewski, Tomasz, Zhao, Dong, Stevens, Gretchen A, Savin, Stefan, Cowan, Melanie J, Riley, Leanne M, Ezzati, Majid, Adams, Robert J, Ahrens, Wolfgang, Amouyel, Philippe, Amuzu, Antoinette, Anderssen, Sigmund A, Ariansen, Inger, Arveiler, Dominique, Aspelund, Thor, Auvinen, Juha, Avdicová, Mária, Banach, Maciej, Bandosz, Piotr, Banegas, José R, Barbagallo, Carlo M, Bata, Iqbal, Baur, Louise A, Beaglehole, Robert, Bernotiene, Gailute, Bi, Yufang, Bienek, Asako, Björkelund, Cecilia, Bo, Simona, Boehm, Bernhard O, Bonaccio, Marialaura, Bongard, Vanina, Borchini, Rossana, Borghs, Herman, Breckenkamp, Juergen, Brenner, Hermann, Bruno, Graziella, Busch, Markus A, Cabrera de León, Antonio, Capuano, Vincenzo, Casanueva, Felipe F, Casas, Juan-Pablo, Caserta, Carmelo A, Censi, Laura, Chen, Fangfang, Chen, Shuohua, Chirlaque, María-Dolores, Cho, Belong, Cho, Yumi, Chudek, Jerzy, Claessens, Frank, Clarke, Janine, Clays, Els, Cooper, Cyrus, Costanzo, Simona, Cottel, Dominique, Cowell, Chris, Crujeiras, Ana B, Cui, Liufu, D'Arrigo, Graziella, Dauchet, Luc, De Backer, Guy, De Bacquer, Dirk, de Gaetano, Giovanni, De Henauw, Stefaan, De Smedt, Delphine, Dennison, Elaine, Deschamps, Valérie, DiCastelnuovo, Augusto, Dobson, Annette J, Donfrancesco, Chiara

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Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility von Sud, Amit, Thomsen, Hauke, Law, Philip J., Försti, Asta, Filho, Miguel Inacio da Silva, Holroyd, Amy, Broderick, Peter, Orlando, Giulia, Lenive, Oleg, Wright, Lauren, Cooke, Rosie, Easton, Douglas, Pharoah, Paul, Dunning, Alison, Peto, Julian, Canzian, Federico, Eeles, Rosalind, Kote-Jarai, ZSofia, Muir, Kenneth, Pashayan, Nora, Hoffmann, Per, Nöthen, Markus M., Jöckel, Karl-Heinz, Strandmann, Elke Pogge von, Lightfoot, Tracy, Kane, Eleanor, Roman, Eve, Lake, Annette, Montgomery, Dorothy, Jarrett, Ruth F., Swerdlow, Anthony J., Engert, Andreas, Orr, Nick, Hemminki, Kari, Houlston, Richard S.

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Evaluating approaches for constructing polygenic risk scores for prostate cancer in men of African and European ancestry von Darst, Burcu F, Shen, Jiayi, Madduri, Ravi K, Rodriguez, Alexis A, Xiao, Yukai, Sheng, Xin, Saunders, Edward J, Dadaev, Tokhir, Brook, Mark N, Hoffmann, Thomas J, Muir, Kenneth, Wan, Peggy, Le Marchand, Loic, Wilkens, Lynne, Wang, Ying, Schleutker, Johanna, MacInnis, Robert J, Cybulski, Cezary, Neal, David E, Nordestgaard, Borge G, Nielsen, Sune F, Batra, Jyotsna, Clements, Judith A, Gronberg, Henrik, Pashayan, Nora, Travis, Ruth C, Park, Jong Y, Albanes, Demetrius, Weinstein, Stephanie, Mucci, Lorelei A, Hunter, David J, Penney, Kathryn L, Tangen, Catherine M, Hamilton, Robert J, Parent, Marie-Elise, Stanford, Janet L, Koutros, Stella, Wolk, Alicja, Sorensen, Karina D, Blot, William J, Yeboah, Edward D, Mensah, James E, Lu, Yong-Jie, Schaid, Daniel J, Thibodeau, Stephen N, West, Catharine M, Maier, Christiane, Kibel, Adam S, Cancel-Tassin, Geraldine, Menegaux, Florence, John, Esther M, Grindedal, Eli Marie, Khaw, Kay-Tee, Ingles, Sue A, Vega, Ana, Rosenstein, Barry S, Teixeira, Manuel R, Kogevinas, Manoli, Cannon-Albright, Lisa, Huff, Chad, Multigner, Luc, Kaneva, Radka, Leach, Robin J, Brenner, Hermann, Hsing, Ann W, Kittles, Rick A, Murphy, Adam B, Logothetis, Christopher J, Neuhausen, Susan L, Isaacs, William B, Nemesure, Barbara, Hennis, Anselm J, Carpten, John, Pandha, Hardev, De Ruyck, Kim, Xu, Jianfeng, Razack, Azad, Teo, Soo-Hwang, Newcomb, Lisa F, Fowke, Jay H, Neslund-Dudas, Christine, Rybicki, Benjamin A, Gamulin, Marija, Usmani, Nawaid, Claessens, Frank, Gago-Dominguez, Manuela, Castelao, Jose Esteban, Townsend, Paul A, Crawford, Dana C, Petrovics, Gyorgy, Casey, Graham, Roobol, Monique J, Hu, Jennifer F, Berndt, Sonja I, van den Eeden, Stephen K, Easton, Douglas F, Chanock, Stephen J, Cook, Michael B, Wiklund, Fredrik, Witte, John S

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Identification of Novel Susceptibility Loci and Genes for Prostate Cancer Risk: A Transcriptome-Wide Association Study in Over 140,000 European Descendants von Wu, Lang, Wang, Jifeng, Cai, Qiuyin, Cavazos, Taylor B, Emami, Nima C, Long, Jirong, Shu, Xiao-Ou, Lu, Yingchang, Guo, Xingyi, Bauer, Joshua A, Pasaniuc, Bogdan, Penney, Kathryn L, Freedman, Matthew L, Kote-Jarai, Zsofia, Witte, John S, Haiman, Christopher A, Eeles, Rosalind A, Zheng, Wei

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Additional SNPs improve risk stratification of a polygenic hazard score for prostate cancer von Karunamuni, RA, Huynh-Le, M-P, Fan, CC, Thompson, W, Eeles, RA, Kote-Jarai, Z, Muir, K, Lophatananon, A, Schleutker, J, Pashayan, N

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