The Discovery of Ezetimibe:  A View from Outside the Receptor von Clader, John W

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HIV-1 Escape from a Small Molecule, CCR5-Specific Entry Inhibitor Does Not Involve CXCR4 Use von Trkola, Alexandra, Kuhmann, Shawn E., Strizki, Julie M., Maxwell, Elizabeth, Ketas, Tom, Morgan, Tom, Pugach, Pavel, Xu, Serena, Wojcik, Lisa, Tagat, Jayaram, Palani, Anandan, Shapiro, Sherry, Clader, John W., McCombie, Stuart, Reyes, Gregory R., Baroudy, Bahige M., Moore, John P.

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Analysis of the Mechanism by Which the Small-Molecule CCR5 Antagonists SCH-351125 and SCH-350581 Inhibit Human Immunodeficiency Virus Type 1 Entry von Tsamis, Fotini, Gavrilov, Svetlana, Kajumo, Francis, Seibert, Christoph, Kuhmann, Shawn, Ketas, Tom, Trkola, Alexandra, Palani, Anadan, Clader, John W, Tagat, Jayaram R, McCombie, Stuart, Baroudy, Bahige, Moore, John P, Sakmar, Thomas P, Dragic, Tatjana

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SCH-C (SCH 351125), An Orally Bioavailable, Small Molecule Antagonist of the Chemokine Receptor CCR5, is a Potent Inhibitor of HIV-1 Infection in vitro and in vivo von Strizki, Julie M., Xu, Serena, Wagner, Nicole E., Wojcik, Lisa, Liu, Jia, Hou, Yan, Endres, Michael, Palani, Anandan, Shapiro, Sherry, Clader, John W., Greenlee, William J., Tagat, Jayaram R., McCombie, Stuart, Cox, Kathleen, Fawzi, Ahmad B., Chou, Chuan-Chu, Pugliese-Sivo, Catherine, Davies, Liza, Moreno, Mary E., Ho, David D., Trkola, Alexandra, Stoddart, Cheryl A., Moore, John P., Reyes, Gregory R., Baroudy, Bahige M.

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Discovery of Orally Efficacious Melanin-Concentrating Hormone Receptor-1 Antagonists as Antiobesity Agents. Synthesis, SAR, and Biological Evaluation of Bicyclo[3.1.0]hexyl Ureas von McBriar, Mark D, Guzik, Henry, Shapiro, Sherry, Paruchova, Jaroslava, Xu, Ruo, Palani, Anandan, Clader, John W, Cox, Kathleen, Greenlee, William J, Hawes, Brian E, Kowalski, Timothy J, O'Neill, Kim, Spar, Brian D, Weig, Blair, Weston, Daniel J, Farley, Constance, Cook, John

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Discovery of Bicycloalkyl Urea Melanin Concentrating Hormone Receptor Antagonists:  Orally Efficacious Antiobesity Therapeutics von McBriar, Mark D, Guzik, Henry, Xu, Ruo, Paruchova, Jaroslava, Li, Shengjian, Palani, Anandan, Clader, John W, Greenlee, William J, Hawes, Brian E, Kowalski, Timothy J, O'Neill, Kim, Spar, Brian, Weig, Blair

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Biaryl Ureas as Potent and Orally Efficacious Melanin Concentrating Hormone Receptor 1 Antagonists for the Treatment of Obesity von Palani, Anandan, Shapiro, Sherry, McBriar, Mark D, Clader, John W, Greenlee, William J, Spar, Brian, Kowalski, Timothy J, Farley, Constance, Cook, John, van Heek, Margaret, Weig, Blair, O'Neill, Kim, Graziano, Michael, Hawes, Brian

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Synthesis, SAR, and Biological Evaluation of Oximino-Piperidino-Piperidine Amides. 1. Orally Bioavailable CCR5 Receptor Antagonists with Potent Anti-HIV Activity von Palani, Anandan, Shapiro, Sherry, Josien, Hubert, Bara, Thomas, Clader, John W, Greenlee, William J, Cox, Kathleen, Strizki, Julie M, Baroudy, Bahige M

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Discovery of 1-(4-Fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)- hydroxypropyl]-(4S)-(4-hydroxyphenyl)-2-azetidinone (SCH 58235):  A Designed, Potent, Orally Active Inhibitor of Chol... von Rosenblum, Stuart B, Huynh, Tram, Afonso, Adriano, Davis, Harry R, Yumibe, Nathan, Clader, John W, Burnett, Duane A

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2-Azetidinones as Inhibitors of Cholesterol Absorption von Burnett, Duane A, Caplen, Mary Ann, Davis, Harry R, Burrier, Robert E, Clader, John W

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Design and synthesis of piperidinyl piperidine analogues as potent and selective M 2 muscarinic receptor antagonists von Wang, Yuguang, Chackalamannil, Samuel, Hu, Zhiyong, Clader, John W, Greenlee, William, Billard, William, Binch, Herbert, Crosby, Gordon, Ruperto, Vilma, Duffy, Ruth A, McQuade, Robert, Lachowicz, Jean E

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Bicyclic[4.1.0]heptanes as phenyl replacements for melanin concentrating hormone receptor antagonists von Xu, Ruo, Li, Shengjian, Paruchova, Jaroslava, McBriar, Mark D., Guzik, Henry, Palani, Anandan, Clader, John W., Cox, Kathleen, Greenlee, William J., Hawes, Brian E., Kowalski, Timothy J., O’Neill, Kim, Spar, Brian D., Weig, Blair, Weston, Daniel J.

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Oximino-piperidino-piperidine-based CCR5 antagonists. Part 2: synthesis, SAR and biological evaluation of symmetrical heteroaryl carboxamides von Palani, Anandan, Shapiro, Sherry, Clader, John W., Greenlee, William J., Vice, Susan, McCombie, Stuart, Cox, Kathleen, Strizki, Julie, Baroudy, Bahige M.

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2-Azetidinone Cholesterol Absorption Inhibitors:  Structure−Activity Relationships on the Heterocyclic Nucleus von Clader, John W, Burnett, Duane A, Caplen, Mary Ann, Domalski, Martin S, Dugar, Sundeep, Vaccaro, Wayne, Sher, Rosy, Browne, Margaret E, Zhao, Hongrong, Burrier, Robert E, Salisbury, Brian, Davis, Harry R

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Biaryl diamides as potent melanin concentrating hormone receptor 1 antagonists von Palani, Anandan, Shapiro, Sherry, McBriar, Mark D., Clader, John W., Greenlee, William J., O’Neill, Kim, Hawes, Brian

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Optimization of purine based PDE1/PDE5 inhibitors to a potent and selective PDE5 inhibitor for the treatment of male ED von Boyle, Craig D., Xu, Ruo, Asberom, Theodros, Chackalamannil, Samuel, Clader, John W., Greenlee, William J., Guzik, Henry, Hu, Yuequing, Hu, Zhiyong, Lankin, Claire M., Pissarnitski, Dmitri A., Stamford, Andrew W., Wang, Yuguang, Skell, Jeffrey, Kurowski, Stanley, Vemulapalli, Subbarao, Palamanda, Jairam, Chintala, Madhu, Wu, Ping, Myers, Joyce, Wang, Peng

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Biological evaluation and interconversion studies of rotamers of SCH 351125, an orally bioavailable CCR5 antagonist von Palani, Anandan, Shapiro, Sherry, Clader, John W., Greenlee, William J., Blythin, David, Cox, Kathleen, Wagner, Nicole E., Strizki, Julie, Baroudy, Bahige M., Dan, Niya

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SAR development of polycyclic guanine derivatives targeted to the discovery of a selective PDE5 inhibitor for treatment of erectile dysfunction von PISSARNITSKI, Dmitri A, ASBEROM, Theodros, PALAMANDA, Jairam, STAMFORD, Andrew W, VEMULAPALLI, Subbarao, YUGUANG WANG, PENG WANG, PING WU, RUO XU, BOYLE, Craig D, CHACKALAMANNIL, Samuel, CHINTALA, Madhu, CLADER, John W, GREENLEE, William J, YUEQING HU, KUROWSKI, Stanley, MYERS, Joyce

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Synthesis of iodinated biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors von Burnett, Duane A, Caplen, Mary Ann, Domalski, Martin S, Browne, Margaret E, Davis, Jr, Harry R, Clader, John W

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Synthesis of C3 Heteroatom-Substituted Azetidinones That Display Potent Cholesterol Absorption Inhibitory Activity von McKittrick, Brian A, Ma, Ke, Huie, Keith, Yumibe, Nathan, Davis, Harry, Clader, John W, Czarniecki, Michael, McPhail, Andrew T

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