Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core von Sivaprakasam, Prasanna, Han, Xiaojun, Civiello, Rita L, Jacutin-Porte, Swanee, Kish, Kevin, Pokross, Matt, Lewis, Hal A, Ahmed, Nazia, Szapiel, Nicolas, Newitt, John A, Baldwin, Eric T, Xiao, Hong, Krause, Carol M, Park, Hyunsoo, Nophsker, Michelle, Lippy, Jonathan S, Burton, Catherine R, Langley, David R, Macor, John E, Dubowchik, Gene M

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Synthesis and SAR of calcitonin gene-related peptide (CGRP) antagonists containing substituted aryl-piperazines and piperidines von Civiello, Rita L., Han, Xiaojun, Beno, Brett R., Chaturvedula, Prasad V., Herbst, John J., Xu, Cen, Conway, Charles M., Macor, John E., Dubowchik, Gene M.

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Respiratory syncytial virus fusion inhibitors. Part 7: Structure–activity relationships associated with a series of isatin oximes that demonstrate antiviral activity in vivo von Sin, Ny, Venables, Brian L., Combrink, Keith D., Gulgeze, H. Belgin, Yu, Kuo-Long, Civiello, Rita L., Thuring, Jan, Wang, X. Alan, Yang, Zheng, Zadjura, Lisa, Marino, Anthony, Kadow, Kathleen F., Cianci, Christopher W., Clarke, Junius, Genovesi, Eugene V., Medina, Ivette, Lamb, Lucinda, Krystal, Mark, Meanwell, Nicholas A.

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Orally Active Fusion Inhibitor of Respiratory Syncytial Virus von Cianci, Christopher, Yu, Kuo-Long, Combrink, Keith, Sin, Ny, Pearce, Bradley, Wang, Alan, Civiello, Rita, Voss, Stacey, Luo, Guangxiang, Kadow, Kathy, Genovesi, Eugene V, Venables, Brian, Gulgeze, Hatice, Trehan, Ashok, James, Jennifer, Lamb, Lucinda, Medina, Ivette, Roach, Julia, Yang, Zheng, Zadjura, Lisa, Colonno, Richard, Clark, Junius, Meanwell, Nicholas, Krystal, Mark

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The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 2 von Han, Xiaojun, Civiello, Rita L., Conway, Charles M., Cook, Deborah A., Davis, Carl D., Degnan, Andrew P., Jiang, Xiang-Jun, Macci, Robert, Mathias, Neil R., Moench, Paul, Pin, Sokhom S., Schartman, Richard, Signor, Laura J., Thalody, George, Tora, George, Whiterock, Valerie, Xu, Cen, Macor, John E., Dubowchik, Gene M.

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Catalytic Asymmetric Syntheses of α-Amino and α-Hydroxyl Acid Derivatives von Han, Xiaojun, Jiang, Xiang-Jun, Civiello, Rita L, Degnan, Andrew P, Chaturvedula, Prasad V, Macor, John E, Dubowchik, Gene M

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The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 1 von Han, Xiaojun, Civiello, Rita L., Conway, Charles M., Cook, Deborah A., Davis, Carl D., Macci, Robert, Pin, Sokhom S., Ren, Shelly X., Schartman, Richard, Signor, Laura J., Thalody, George, Widmann, Kimberly A., Xu, Cen, Chaturvedula, Prasad V., Macor, John E., Dubowchik, Gene M.

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Respiratory syncytial virus fusion inhibitors. Part 4: Optimization for oral bioavailability von Yu, Kuo-Long, Sin, Ny, Civiello, Rita L., Wang, X. Alan, Combrink, Keith D., Gulgeze, H. Belgin, Venables, Brian L., Wright, J.J. Kim, Dalterio, Richard A., Zadjura, Lisa, Marino, Anthony, Dando, Sandra, D’Arienzo, Celia, Kadow, Kathleen F., Cianci, Christopher W., Li, Zhufang, Clarke, Junius, Genovesi, Eugene V., Medina, Ivette, Lamb, Lucinda, Colonno, Richard J., Yang, Zheng, Krystal, Mark, Meanwell, Nicholas A.

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Respiratory syncytial virus fusion inhibitors. Part 5: Optimization of benzimidazole substitution patterns towards derivatives with improved activity von Wang, Xiangdong Alan, Cianci, Christopher W., Yu, Kuo-Long, Combrink, Keith D., Thuring, Jan W., Zhang, Yi, Civiello, Rita L., Kadow, Kathleen F., Roach, Julia, Li, Zhufang, Langley, David R., Krystal, Mark, Meanwell, Nicholas A.

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Catalytic Asymmetric Syntheses of Tyrosine Surrogates von Han, Xiaojun, Civiello, Rita L, Fang, Haiquang, Wu, Dedong, Gao, Qi, Chaturvedula, Prasad V, Macor, John E, Dubowchik, Gene M

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Respiratory syncytial virus fusion inhibitors. Part 6: An examination of the effect of structural variation of the benzimidazol-2-one heterocycle moiety von Combrink, Keith D., Gulgeze, H. Belgin, Thuring, Jan W., Yu, Kuo-Long, Civiello, Rita L., Zhang, Yi, Pearce, Bradley C., Yin, Zhiwei, Langley, David R., Kadow, Kathleen F., Cianci, Christopher W., Li, Zhufang, Clarke, Junius, Genovesi, Eugene V., Medina, Ivette, Lamb, Lucinda, Yang, Zheng, Zadjura, Lisa, Krystal, Mark, Meanwell, Nicholas A.

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Syntheses of aza and fluorine-substituted 3-(piperidin-4-yl)-4,5-dihydro-1H-benzo[d][1,3]diazepin-2(3H)-ones von Han, Xiaojun, Civiello, Rita L., Mercer, Stephen E., Macor, John E., Dubowchik, Gene M.

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Fundamental structure–Activity relationships associated with a new structural class of respiratory syncytial virus inhibitor von Yu, Kuo-Long, Zhang, Yi, Civiello, Rita L., Kadow, Kathleen F., Cianci, Christopher, Krystal, Mark, Meanwell, Nicholas A.

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Respiratory syncytial virus fusion inhibitors. Part 3: Water-soluble benzimidazol-2-one derivatives with antiviral activity in vivo von Yu, Kuo-Long, Wang, Xiangdong Alan, Civiello, Rita L., Trehan, Ashok K., Pearce, Bradley C., Yin, Zhiwei, Combrink, Keith D., Gulgeze, H. Belgin, Zhang, Yi, Kadow, Kathleen F., Cianci, Christopher W., Clarke, Junius, Genovesi, Eugene V., Medina, Ivette, Lamb, Lucinda, Wyde, Philip R., Krystal, Mark, Meanwell, Nicholas A.

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Respiratory syncytial virus inhibitors. Part 2: Benzimidazol-2-one derivatives von YU, Kuo-Long, YI ZHANG, CIANCI, Christopher W, KRYSTAL, Mark, MEANWELL, Nicholas A, CIVIELLO, Rita L, TREHAN, A. Ashok K, PEARCE, Bradley C, ZHIWEI YIN, COMBRINK, Keith D, GULGEZE, H. Belgin, WANG, Xiangdong Alan, KADOW, Kathleen F

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Asymmetric Synthesis of Sesaminone:  Confirmation of Its Structure and Determination of Its Absolute Configuration von Maioli, Andrew T, Civiello, Rita L, Foxman, Bruce M, Gordon, Dana M

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An efficient synthesis of N-arylated, orthogonally protected racemic aspartates von Luo, Guanglin, Chen, Ling, Civiello, Rita, Dubowchik, Gene M.

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Calcitonin gene-related peptide (CGRP) receptor antagonists: Pyridine as a replacement for a core amide group von Luo, Guanglin, Chen, Ling, Civiello, Rita, Pin, Sokhom S., Xu, Cen, Kostich, Walter, Kelley, Michelle, Conway, Charles M., Macor, John E., Dubowchik, Gene M.

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Corrigendum to “The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 2” [Bioorg. Med. Chem. Lett. 23 (2013) 1... von Han, Xiaojun, Civiello, Rita L., Conway, Charles M., Cook, Deborah A., Davis, Carl D., Degnan, Andrew P., Jiang, Xiang-Jun, Macci, Robert, Mathias, Neil R., Moench, Paul, Pin, Sokhom S., Schartman, Richard, Signor, Laura J., Thalody, George, Tora, George, Whiterock, Valerie, Xu, Cen, Macor, John E., Dubowchik, Gene M.

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Syntheses of aza and fluorine-substituted 3-(piperidin-4-yl)-4,5-dihydro-1 H-benzo[ d][1,3]diazepin-2(3 H)-ones von Han, Xiaojun, Civiello, Rita L., Mercer, Stephen E., Macor, John E., Dubowchik, Gene M.

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