The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans von Holth, Jerrah K, Fritschi, Sarah K, Wang, Chanung, Pedersen, Nigel P, Cirrito, John R, Mahan, Thomas E, Finn, Mary Beth, Manis, Melissa, Geerling, Joel C, Fuller, Patrick M, Lucey, Brendan P, Holtzman, David M

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TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model von Wang, Yaming, Cella, Marina, Mallinson, Kaitlin, Ulrich, Jason D., Young, Katherine L., Robinette, Michelle L., Gilfillan, Susan, Krishnan, Gokul M., Sudhakar, Shwetha, Zinselmeyer, Bernd H., Holtzman, David M., Cirrito, John R., Colonna, Marco

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TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques von Wang, Yaming, Ulland, Tyler K, Ulrich, Jason D, Song, Wilbur, Tzaferis, John A, Hole, Justin T, Yuan, Peng, Mahan, Thomas E, Shi, Yang, Gilfillan, Susan, Cella, Marina, Grutzendler, Jaime, DeMattos, Ronald B, Cirrito, John R, Holtzman, David M, Colonna, Marco

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Neuronal activity regulates extracellular tau in vivo von Yamada, Kaoru, Holth, Jerrah K, Liao, Fan, Stewart, Floy R, Mahan, Thomas E, Jiang, Hong, Cirrito, John R, Patel, Tirth K, Hochgräfe, Katja, Mandelkow, Eva-Maria, Holtzman, David M

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Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer’s disease model von Sanchez, Pascal E, Zhu, Lei, Verret, Laure, Vossel, Keith A, Orr, Anna G, Cirrito, John R, Devidze, Nino, Ho, Kaitlyn, Yu, Gui-Qiu, Palop, Jorge J, Mucke, Lennart

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Chronic Optogenetic Activation Augments Aβ Pathology in a Mouse Model of Alzheimer Disease von Yamamoto, Kaoru, Tanei, Zen-ichi, Hashimoto, Tadafumi, Wakabayashi, Tomoko, Okuno, Hiroyuki, Naka, Yasushi, Yizhar, Ofer, Fenno, Lief E., Fukayama, Masashi, Bito, Haruhiko, Cirrito, John R., Holtzman, David M., Deisseroth, Karl, Iwatsubo, Takeshi

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Amyloid-beta oligomerization in Alzheimer dementia versus high-pathology controls von Esparza, Thomas J., Zhao, Hanzhi, Cirrito, John R., Cairns, Nigel J., Bateman, Randall J., Holtzman, David M., Brody, David L.

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Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer's disease von Roh, Jee Hoon, Jiang, Hong, Finn, Mary Beth, Stewart, Floy R, Mahan, Thomas E, Cirrito, John R, Heda, Ashish, Snider, B Joy, Li, Mingjie, Yanagisawa, Masashi, de Lecea, Luis, Holtzman, David M

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Real-time environmental surveillance of SARS-CoV-2 aerosols von Puthussery, Joseph V., Ghumra, Dishit P., McBrearty, Kevin R., Doherty, Brookelyn M., Sumlin, Benjamin J., Sarabandi, Amirhossein, Mandal, Anushka Garg, Shetty, Nishit J., Gardiner, Woodrow D., Magrecki, Jordan P., Brody, David L., Esparza, Thomas J., Bricker, Traci L., Boon, Adrianus C. M., Yuede, Carla M., Cirrito, John R., Chakrabarty, Rajan K.

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Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice von Kraft, Andrew W., Hu, Xiaoyan, Yoon, Hyejin, Yan, Ping, Xiao, Qingli, Wang, Yan, Gil, So Chon, Brown, Jennifer, Wilhelmsson, Ulrika, Restivo, Jessica L., Cirrito, John R., Holtzman, David M., Kim, Jungsu, Pekny, Milos, Lee, Jin‐Moo

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Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans von Cirrito, John R, Disabato, Brianne M, Restivo, Jessica L, Verges, Deborah K, Goebel, Whitney D, Sathyan, Anshul, Hayreh, Davinder, D'Angelo, Gina, Benzinger, Tammie, Yoon, Hyejin, Kim, Jungsu, Morris, John C, Mintun, Mark A, Sheline, Yvette I

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Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease von Born, Heather A, Kim, Ji-Yoen, Savjani, Ricky R, Das, Pritam, Dabaghian, Yuri A, Guo, Qinxi, Yoo, Jong W, Schuler, Dorothy R, Cirrito, John R, Zheng, Hui, Golde, Todd E, Noebels, Jeffrey L, Jankowsky, Joanna L

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Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification von Izzo, Nicholas J., Yuede, Carla M., LaBarbera, Kelsie M., Limegrover, Colleen S., Rehak, Courtney, Yurko, Raymond, Waybright, Lora, Look, Gary, Rishton, Gilbert, Safferstein, Hank, Hamby, Mary E., Williams, Claire, Sadlek, Kelsey, Edwards, Hannah M., Davis, Charles S., Grundman, Michael, Schneider, Lon S., DeKosky, Steven T., Chelsky, Daniel, Pike, Ian, Henstridge, Christopher, Blennow, Kaj, Zetterberg, Henrik, LeVine, Harry, Spires‐Jones, Tara L., Cirrito, John R., Catalano, Susan M.

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Role of Phosphatidylinositol Clathrin Assembly Lymphoid-Myeloid Leukemia (PICALM) in Intracellular Amyloid Precursor Protein (APP) Processing and Amyloid Plaque Pathogenesis von Xiao, Qingli, Gil, So-Chon, Yan, Ping, Wang, Yan, Han, Sharon, Gonzales, Ernie, Perez, Ronaldo, Cirrito, John R., Lee, Jin-Moo

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Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice von Han, Byung Hee, Zhou, Meng-liang, Johnson, Andrew W., Singh, Itender, Liao, Fan, Vellimana, Ananth K., Nelson, James W., Milner, Eric, Cirrito, John R., Basak, Jacob, Yoo, Min, Dietrich, Hans H., Holtzman, David M., Zipfel, Gregory Joseph

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A spectrum of exercise training reduces soluble Aβ in a dose-dependent manner in a mouse model of Alzheimer's disease von Moore, Kaitlin M, Girens, Renee E, Larson, Sara K, Jones, Maria R, Restivo, Jessica L, Holtzman, David M, Cirrito, John R, Yuede, Carla M, Zimmerman, Scott D, Timson, Benjamin F

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Characterizing the Appearance and Growth of Amyloid Plaques in APP/PS1 Mice von Yan, Ping, Bero, Adam W, Cirrito, John R, Xiao, Qingli, Hu, Xiaoyan, Wang, Yan, Gonzales, Ernesto, Holtzman, David M, Lee, Jin-Moo

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Acute stress increases interstitial fluid amyloid-β via corticotropin-releasing factor and neuronal activity von Kang, Jae-Eun, Cirrito, John R, Dong, Hongxin, Csernansky, John G, Holtzman, David M

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AMPA-ergic regulation of amyloid-β levels in an Alzheimer's disease mouse model von Hettinger, Jane C, Lee, Hyo, Bu, Guojun, Holtzman, David M, Cirrito, John R

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Bad Ac-etylated Tau von Hettinger, Jane C., Cirrito, John R.

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