Discovery of 2‑[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro‑1H‑isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP‑1... von Papeo, Gianluca, Posteri, Helena, Borghi, Daniela, Busel, Alina A., Caprera, Francesco, Casale, Elena, Ciomei, Marina, Cirla, Alessandra, Corti, Emiliana, D’Anello, Matteo, Fasolini, Marina, Forte, Barbara, Galvani, Arturo, Isacchi, Antonella, Khvat, Alexander, Krasavin, Mikhail Y., Lupi, Rosita, Orsini, Paolo, Perego, Rita, Pesenti, Enrico, Pezzetta, Daniele, Rainoldi, Sonia, Riccardi-Sirtori, Federico, Scolaro, Alessandra, Sola, Francesco, Zuccotto, Fabio, Felder, Eduard R., Donati, Daniele, Montagnoli, Alessia

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3-Aminopyrazole Inhibitors of CDK2/Cyclin A as Antitumor Agents. 1. Lead Finding von Pevarello, Paolo, Brasca, Maria Gabriella, Amici, Raffaella, Orsini, Paolo, Traquandi, Gabriella, Corti, Luca, Piutti, Claudia, Sansonna, Pietro, Villa, Manuela, Pierce, Betsy S, Pulici, Maurizio, Giordano, Patrizia, Martina, Katia, Fritzen, Edward L, Nugent, Richard A, Casale, Elena, Cameron, Alexander, Ciomei, Marina, Roletto, Fulvia, Isacchi, Antonella, Fogliatto, GianPaolo, Pesenti, Enrico, Pastori, Wilma, Marsiglio, Aurelio, Leach, Karen L, Clare, Paula M, Fiorentini, Francesco, Varasi, Mario, Vulpetti, Anna, Warpehoski, Martha A

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Optimization of 6,6-dimethyl pyrrolo[3,4- c]pyrazoles: Identification of PHA-793887, a potent CDK inhibitor suitable for intravenous dosing von Brasca, Maria Gabriella, Albanese, Clara, Alzani, Rachele, Amici, Raffaella, Avanzi, Nilla, Ballinari, Dario, Bischoff, James, Borghi, Daniela, Casale, Elena, Croci, Valter, Fiorentini, Francesco, Isacchi, Antonella, Mercurio, Ciro, Nesi, Marcella, Orsini, Paolo, Pastori, Wilma, Pesenti, Enrico, Pevarello, Paolo, Roussel, Patrick, Varasi, Mario, Volpi, Daniele, Vulpetti, Anna, Ciomei, Marina

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3-Aminopyrazole Inhibitors of CDK2/Cyclin A as Antitumor Agents. 2. Lead Optimization von Pevarello, Paolo, Brasca, Maria Gabriella, Orsini, Paolo, Traquandi, Gabriella, Longo, Antonio, Nesi, Marcella, Orzi, Fabrizio, Piutti, Claudia, Sansonna, Pietro, Varasi, Mario, Cameron, Alexander, Vulpetti, Anna, Roletto, Fulvia, Alzani, Rachele, Ciomei, Marina, Albanese, Clara, Pastori, Wilma, Marsiglio, Aurelio, Pesenti, Enrico, Fiorentini, Francesco, Bischoff, Jim R, Mercurio, Ciro

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Entrectinib, a Pan-TRK, ROS1, and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications von Ardini, Elena, Menichincheri, Maria, Banfi, Patrizia, Bosotti, Roberta, De Ponti, Cristina, Pulci, Romana, Ballinari, Dario, Ciomei, Marina, Texido, Gemma, Degrassi, Anna, Avanzi, Nilla, Amboldi, Nadia, Saccardo, Maria Beatrice, Casero, Daniele, Orsini, Paolo, Bandiera, Tiziano, Mologni, Luca, Anderson, David, Wei, Ge, Harris, Jason, Vernier, Jean-Michel, Li, Gang, Felder, Eduard, Donati, Daniele, Isacchi, Antonella, Pesenti, Enrico, Magnaghi, Paola, Galvani, Arturo

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The Basic Domain in HIV-1 Tat Protein as a Target for Polysulfonated Heparin-mimicking Extracellular Tat Antagonists von Rusnati, M, Tulipano, G, Urbinati, C, Tanghetti, E, Giuliani, R, Giacca, M, Ciomei, M, Corallini, A, Presta, M

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Antitumor Efficacy of Edotecarin as a Single Agent and in Combination with Chemotherapy Agents in a Xenograft Model von CIOMEI, Marina, CROCI, Valter, CIAVOLELLA, Antonella, BALLINARI, Dario, PESENTI, Enrico

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Antitumor activity of edotecarin in breast carcinoma models von CIOMEI, Marina, CROCI, Valter, STELLARI, Fabio, AMBOLDI, Nadia, GIAVARINI, Rosa, PESENTI, Enrico

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Efficacy of PHA-848125, a Cyclin-Dependent Kinase Inhibitor, on the K-RasG12DLA2 Lung Adenocarcinoma Transgenic Mouse Model: Evaluation by Multimodality Imaging von Degrassi, Anna, Russo, Micaela, Nanni, Cristina, Patton, Veronica, Alzani, Rachele, Giusti, Anna M., Fanti, Stefano, Ciomei, Marina, Pesenti, Enrico, Texido, Gemma

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Phase IIa safety and efficacy of milciclib, a pan-cyclin dependent kinase inhibitor, in unresectable, sorafenib-refractory or -intolerant hepatocellular carcinoma patients von Villa, Erica, Piscaglia, Fabio, Geva, Rabit, Dalecos, George, Papatheodoridis, George, Ciomei, Marina, Davite, Christina, Crivori, Patrizia, Palejwala, Vaseem, Jacob, Jules, Hamzeh, Fayez, Shailubhai, Kunwar, Santoro, Armando, Sangiovanni, Angelo

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Abstract 4843: NMS-P293, a PARP-1 selective inhibitor with no trapping activity and high CNS penetration, possesses potent in vivo efficacy and represents a novel therapeutic optio... von Montagnoli, Alessia, Papeo, Gianluca, Rainoldi, Sonia, Caprera, Francesco, Ciomei, Marina, Felder, Eduard, Donati, Daniele, Isacchi, Antonella, Galvani, Arturo

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Abstract 1324: NMS-P088, a novel FLT3, KIT and CSF1R inhibitor, is a promising clinical candidate for AML and CMML treatment von Ciomei, Marina, Ardini, Elena, Gianellini, Laura, Borleri, GianMaria, Romero, Gemma Texido, Ceruti, Roberta, Pastori, Wilma, Avanzi, Nilla, Casero, Daniele, Gnocchi, Paola, Borgia, Andrea Lombardi, Lussana, Federico, Rambaldi, Alessandro, Galvani, Arturo, Isacchi, Antonella

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Identification of N,1,4,4-Tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (PHA-848125), a Potent, Orally Available C... von Brasca, Maria Gabriella, Amboldi, Nadia, Ballinari, Dario, Cameron, Alexander, Casale, Elena, Cervi, Giovanni, Colombo, Maristella, Colotta, Francesco, Croci, Valter, D’Alessio, Roberto, Fiorentini, Francesco, Isacchi, Antonella, Mercurio, Ciro, Moretti, Walter, Panzeri, Achille, Pastori, Wilma, Pevarello, Paolo, Quartieri, Francesca, Roletto, Fulvia, Traquandi, Gabriella, Vianello, Paola, Vulpetti, Anna, Ciomei, Marina

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Discovery of Stereospecific PARP‑1 Inhibitor Isoindolinone NMS-P515 von Papeo, Gianluca, Orsini, Paolo, Avanzi, Nilla R, Borghi, Daniela, Casale, Elena, Ciomei, Marina, Cirla, Alessandra, Desperati, Viviana, Donati, Daniele, Felder, Eduard R, Galvani, Arturo, Guanci, Marco, Isacchi, Antonella, Posteri, Helena, Rainoldi, Sonia, Riccardi-Sirtori, Federico, Scolaro, Alessandra, Montagnoli, Alessia

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A Phase I/II Study of NMS-03592088, a FLT3, KIT and CSF1R Inhibitor, in Patients with Relapsed or Refractory AML or CMML von Ciomei, Marina, Zanetta, Lucia, Lussana, Federico, Ravelli, Erika, Fiorentini, Francesco, Bosotti, Roberta, Ardini, Elena, Lombardi Borgia, Andrea, Pulci, Romana, Gatto, Rosalinda, Di Sanzo, Alessandro, Colajori, Elena, Davite, Cristina, Galvani, Arturo, Gan, Frank Xiaodong, Rossi, Giuseppe, Della Porta, Matteo Giovanni, Cairoli, Roberto, Rambaldi, Alessandro, Isacchi, Antonella

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Abstract 4785: NMS-E668, a highly potent orally available RET inhibitor with selectivity towards VEGFR2 and demonstrated antitumor efficacy in multiple RET-driven cancer models von Ardini, Elena, Banfi, Patrizia, Avanzi, Nilla, Ciomei, Marina, Polucci, Paolo, Cirla, Alessandra, D'Anello, Matteo, Borgia, Andrea Lombardi, Motto, Ilaria, Cristiani, Cinzia, Ballinari, Dario, Felder, Eduard, Donati, Daniele, Galvani, Arturo, Isacchi, Antonella, Menichincheri, Maria

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Abstract 805: NMS-P088, a FLT3-KIT-CSF-1R inhibitor with activity on FLT3 F691L as a novel agent in AML von Ciomei, Marina, Ardini, Elena, Texido, Gemma, Alzani, Rachele, Pastori, Wilma, Ballinari, Dario, Cribioli, Sabrina, Gasparri, Fabio, Avanzi, Nilla, Casero, Daniele, Donati, Daniele, Galvani, Arturo, Borgia, Andrea Lombardi, Isacchi, Antonella

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Abstract 1223: NMS-P293, a novel potent and selective PARP-1 inhibitor with high antitumor efficacy and tolerability von Montagnoli, Alessia, Rainoldi, Sonia, Ciavolella, Antonella, Ballinari, Dario, Caprera, Francesco, Ceriani, Lucio, Lupi, Rosita, Ciomei, Marina, Felder, Eduard, Isacchi, Antonella, Donati, Daniele, Galvani, Arturo, Papeo, Gianluca

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Abstract 734: Thienoindoles: New highly promising agents for antibody-drug conjugates generation von Caruso, Michele, Gasparri, Fabio, Valsasina, Barbara, Albanese, Clara, Beria, Italo, Candiani, Ilaria, Ciomei, Marina, Colombo, Nicoletta, Cribioli, Sabrina, Cucchi, Ulisse, Felder, Eduard, Fraietta, Ivan, Galvani, Arturo, Isacchi, Antonella, Marsiglio, Aurelio, Orsini, Paolo, Perego, Rita, Rizzi, Simona, Tomasi, Attilio, Troiani, Sonia, Visco, Carlo, Donati, Daniele

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Abstract 5163: Characterization of NMS-E194, a selective and potent PERK inhibitor with efficacy in the KMS-11 multiple myeloma von Perrera, Claudia, Pulici, Maurizio, Carenzi, Davide, Motto, Ilaria, Fasolini, Marina, Casale, Elena, Depaolini, Stefania Re, Rizzi, Simona, Asa, Daniela, Roletto, Fulvia, Bindi, Simona, Casero, Daniele, Banfi, Patrizia, Ardini, Elena, Amboldi, Nadia, Ballinari, Dario, Gasparri, Fabio, Cribioli, Sabrina, Mancini, Laura, Ciomei, Marina, Donati, Daniele, Felder, Eduard, Galvani, Arturo, Isacchi, Antonella, Valsasina, Barbara

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